Abstract
Rationale
Binge drinking (i.e. excessive episodic alcohol consumption) among young adults has been associated with deleterious consequences, notably at the cognitive and brain levels. These behavioural impairments and brain alterations have a direct impact on psychological and interpersonal functioning, but they might also be involved in the transition towards severe alcohol use disorders. Development of effective rehabilitation programs to reduce these negative effects as they emerge thus constitutes a priority in subclinical populations.
Objectives
The present study tested the behavioural and electrophysiological impact of neurocognitive stimulation (i.e. transcranial direct current stimulation (tDCS) applied during a cognitive task) to improve attention and inhibition abilities in young binge drinkers.
Methods
Two groups (20 binge drinkers and 20 non-binge drinkers) performed two sessions in a counterbalanced order. Each session consisted of an inhibition task (i.e. Neutral Go/No-Go) while participants received left frontal tDCS or sham stimulation, immediately followed by an Alcohol-related Go/No-Go task, while both behavioural and electrophysiological measures were recorded.
Results
No significant differences were observed between groups or sessions (tDCS versus sham stimulation) at the behavioural level. However, electrophysiological measurements during the alcohol-related inhibition task revealed a specific effect of tDCS on attentional resource mobilization (indexed by the N2 component) in binge drinkers, whereas later inhibition processes (indexed by the P3 component) remained unchanged in this population.
Conclusions
The present findings indicate that tDCS can modify the electrophysiological correlates of cognitive processes in binge drinking. While the impact of such brain modifications on actual neuropsychological functioning and alcohol consumption behaviours remains to be determined, these results underline the potential interest of developing neurocognitive stimulation approaches in this population.
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Notes
Complementary statistical analyses, including gender as a between-subject factor for all experimental variables (alcohol consumption, behavioural and electrophysiological measures), did not show any significant difference between females and males, either for the whole sample or within BD/non-BD groups.
References
Babor TF, Higgins-Biddle JC, Saunders JB, Monteiro MG (2001) AUDIT: The Alcohol Use Disorders Identification Test : Guidelines for Use in Primary Health Care. World Health Organization, Geneva.
Beck AT, Steer RA, Brown GK (1996) Beck Depression Inventory manual. Psychological Corporation, San Antonio
Billieux J, Rochat L, Ceschi G, Carre A, Offerlin-Meyer I, Defeldre AC, Khazaal Y, Besche-Richard C, Van der Linden M (2012) Validation of a short French version of the UPPS-P impulsive behavior scale. Compr Psychiatry 53:609–615. https://doi.org/10.1016/j.comppsych.2011.09.001
Boggio PS, Sultani N, Fecteau S, Merabet L, Mecca T, Pascual-Leone A, Basaglia A, Fregni F (2008) Prefrontal cortex modulation using transcranial DC stimulation reduces alcohol craving: a double-blind, sham-controlled study. Drug Alcohol Depend 92:55–60. https://doi.org/10.1016/j.drugalcdep.2007.06.011
Bonomo YA, Bowes G, Coffey C, Carlin JB, Patton GC (2004) Teenage drinking and the onset of alcohol dependence: a cohort study over seven years. Addiction 99:1520–1528. https://doi.org/10.1111/j.1360-0443.2004.00846.x
Botvinick MM, Braver TS, Barch DM, Carter CS, Cohen JD (2001) Conflict monitoring and cognitive control. Psychol Rev 108:624–652. https://doi.org/10.1037/0033-295x.108.3.624
Bruin KJ, Wijers AA, van Staveren AS (2001) Response priming in a go/nogo task: do we have to explain the go/nogo N2 effect in terms of response activation instead of inhibition? Clin Neurophysiol 112:1660–1671. https://doi.org/10.1016/s1388-2457(01)00601-0
Bühler M, Mann K (2011) Alcohol and the human brain: a systematic review of different neuroimaging methods. Alcohol Clin Exp Res 35:1771–1793. https://doi.org/10.1111/j.1530-0277.2011.01540.x
Campanella S, Noël X (2016) On the usefulness of action tendencies training and brain stimulation in the modification of alcohol use disorders. A commentary on “electrophysiological and behavioral effects of combined transcranial direct current stimulation and alcohol approach bias retraining in hazardous drinkers” by den Uyl, Gladwin, and Wiers (ACER, 2016). Alcohol Clin Exp Res 40:2516–2518. https://doi.org/10.1111/acer.13238
Campanella S, Peigneux P, Petit G, Lallemand F, Saeremans M, Noël X, Metens T, Nouali M, De Tiège X, De Witte P, Ward R, Verbanck P (2013) Increased cortical activity in binge drinkers during working memory task: a preliminary assessment through a functional magnetic resonance imaging study. PLoS One 8:e62260. https://doi.org/10.1371/journal.pone.0062260
Campanella S, Schroder E, Monnart A, Vanderhasselt MA, Duprat R, Rabijns M, Kornreich C, Verbanck P, Baeken C (2017) Transcranial direct current stimulation over the right frontal inferior cortex decreases neural activity needed to achieve inhibition: a double-blind ERP study in a male population. Clin EEG Neurosci 48:176–188. https://doi.org/10.1177/1550059416645977
Campanella S, Schroder E, Vanderhasselt MA, Baeken C, Kornreich C, Verbanck P, Burle B (2018) Short-term impact of tDCS over the right inferior frontal cortex on impulsive responses in a Go/No-go task. Clin EEG Neurosci 49:398–406. https://doi.org/10.1177/1550059418777404
Carbia C, López-Caneda E, Corral M, Cadaveira F (2018) A systematic review of neuropsychological studies involving young binge drinkers. Neurosci Biobehav Rev 90:332–349. https://doi.org/10.1016/j.neubiorev.2018.04.013
Chikazoe J (2010) Localizing performance of go/no-go tasks to prefrontal cortical subregions. Curr Opin Psychiatry 23:267–272. https://doi.org/10.1097/YCO.0b013e3283387a9f
Crego A, Holguín SR, Parada M, Mota N, Corral M, Cadaveira F (2009) Binge drinking affects attentional and visual working memory processing in young university students. Alcohol Clin Exp Res 33:1870–1879. https://doi.org/10.1111/j.1530-0277.2009.01025.x
Crego A, Cadaveira F, Parada M, Corral M, Caamaño-Isorna F, Rodríguez-Holguín S (2012) Increased amplitude of P3 event-related potential in young binge drinkers. Alcohol 46:415–425. https://doi.org/10.1016/j.alcohol.2011.10.002
Cunillera T, Brignani D, Cucurell D, Fuentemilla L, Miniussi C (2016) The right inferior frontal cortex in response inhibition: a tDCS-ERP co-registration study. Neuroimage 140:66–75. https://doi.org/10.1016/j.neuroimage.2015.11.044
Czapla M, Simon JJ, Friederich H-C, Herpertz SC, Zimmermann P, Loeber S (2015) Is binge drinking in young adults associated with an alcohol-specific impairment of response inhibition. Eur Addict Res 21:105–113. https://doi.org/10.1159/000367939
da Silva MC, Conti CL, Klauss J, Alves LG, do Nascimento Cavalcante HM, Fregni F, Nitsche MA, Nakamura-Palacios EM (2013) Behavioral effects of transcranial Direct Current Stimulation (tDCS) induced dorsolateral prefrontal cortex plasticity in alcohol dependence. J Physiol Paris 107:493–502. https://doi.org/10.1016/j.jphysparis.2013.07.003
Dedoncker J, Brunoni AR, Baeken C, Vanderhasselt MA (2016) A systematic review and meta-analysis of the effects of transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex in healthy and neuropsychiatric samples: influence of stimulation parameters. Brain Stimul 9(4):501–517. https://doi.org/10.1016/j.brs.2016.04.006
den Uyl TE, Gladwin TE, Wiers RW (2015) Transcranial direct current stimulation, implicit alcohol associations and craving. Biol Psychol 105:37–42. https://doi.org/10.1016/j.biopsycho.2014.12.004
den Uyl TE, Gladwin TE, Wiers RW (2016) Electrophysiological and behavioral effects of combined transcranial Direct Current Stimulation and alcohol approach bias retraining in hazardous drinkers. Alcohol Clin Exp Res 40:2124–2133. https://doi.org/10.1111/acer.13171
den Uyl TE, Gladwin TE, Rinck M, Lindenmeyer J, Wiers RW (2017) A clinical trial with combined transcranial direct current stimulation and alcohol approach bias retraining: clinical trial tDCS and CBM. Addict Biol 22:1632–1640. https://doi.org/10.1111/adb.12463
den Uyl TE, Gladwin TE, Lindenmeyer J, Wiers RW (2018) A clinical trial with combined transcranial direct current stimulation and attentional bias modification in alcohol-dependent patients. Alcohol Clin Exp Res 42:1961–1969. https://doi.org/10.1111/acer.13841
Ditye T, Jacobson L, Walsh V, Lavidor M (2012) Modulating behavioral inhibition by tDCS combined with cognitive training. Exp Brain Res 219:363–368. https://doi.org/10.1007/s00221-012-3098-4
Donkers FC, Van Boxtel GJ (2004) The N2 in go/no-go tasks reflects conflict monitoring not response inhibition. Brain Cogn 56:165–176. https://doi.org/10.1016/j.bandc.2004.04.005
Dubreuil-Vall L, Chau P, Ruffini G, Widge AS, Camprodon JA (2019) tDCS to the left DLPFC modulates cognitive and physiological correlates of executive function in a state-dependent manner. Brain Stimul, In press. https://doi.org/10.1016/j.brs.2019.06.006
Ehlers CL, Phillips E, Finnerman G, Gilder D, Lau P, Criado J (2007) P3 components and adolescent binge drinking in Southwest California Indians. Neurotoxicol Teratol 29:153–163. https://doi.org/10.1016/j.ntt.2006.11.013
Elmasry J, Loo C, Martin D (2015) A systematic review of transcranial electrical stimulation combined with cognitive training. Restor Neurol Neurosci 33:263–278. https://doi.org/10.3233/rnn-140473
Field M, Schoenmakers T, Wiers RW (2008) Cognitive processes in alcohol binges: a review and research agenda. Curr Drug Abuse Rev 1:263–279. https://doi.org/10.2174/1874473710801030263
Filmer HL, Varghese E, Hawkins GE, Mattingley JB, Dux PE (2017) Improvements in attention and decision-making following combined behavioral training and brain stimulation. Cereb Cortex 27:3675–3682. https://doi.org/10.1093/cercor/bhw189
Friehs MA, Frings C (2018) Pimping inhibition: anodal tDCS enhances stop-signal reaction time. J Exp Psychol Hum Percept Perform 44:1933–1945. https://doi.org/10.1037/xhp0000579
Gill J, Shah-Basak PP, Hamilton R (2015) It's the thought that counts: examining the task-dependent effects of transcranial direct current stimulation on executive function. Brain Stimul 8:253–259. https://doi.org/10.1016/j.brs.2014.10.018
Goldstein RZ, Volkow ND (2011) Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. Nat Rev Neurosci 12:652–669. https://doi.org/10.1038/nrn3119
Heeren A, Billieux J, Philippot P, De Raedt R, Baeken C, de Timary P, Maurage P, Vanderhasselt MA (2017) Impact of transcranial direct current stimulation on attentional bias for threat: a proof-of-concept study among individuals with social anxiety disorder. Soc Cogn Affect Neurosci 12:251–260. https://doi.org/10.1093/scan/nsw119
Henges AL, Marczinski CA (2012) Impulsivity and alcohol consumption in young social drinkers. Addict Behav 37:217–220. https://doi.org/10.1016/j.addbeh.2011.09
Herman AM, Critchley HD, Duka T (2018) Binge drinking is associated with attenuated frontal and parietal activation during successful response inhibition in fearful context. Eur J Neurosci 50:2297–2310. https://doi.org/10.1111/ejn.14108
Hermens DF, Lee RSC, De Regt T, Lagopoulos J, Naismith SL, Scott EM, Hickie IB (2013) Neuropsychological functioning is compromised in binge drinking young adults with depression. Psychiatry Res 210:256–262. https://doi.org/10.1016/j.psychres.2013.05.001
Holcomb LA, Huang S, Cruz SM, Marinkovic K (2019) Neural oscillatory dynamics of inhibitory control in young adult binge drinkers. Biol Psychol 107732. https://doi.org/10.1016/j.biopsycho.2019.107732
Horvath JC, Forte JD, Carter O (2015) Quantitative review finds no evidence of cognitive effects in healthy populations from single-session transcranial direct current stimulation (tDCS). Brain Stimul 8(3):535–550. https://doi.org/10.1016/j.brs.2015.01.400
Houston RJ, Schlienz NJ (2018) Event-related potentials as biomarkers of behavior change mechanisms in substance use disorder treatment. Biol Psychiatry Cogn Neurosci Neuroimaging 3:30–40. https://doi.org/10.1016/j.bpsc.2017.09.006
Imburgio MJ, Orr JM (2018) Effects of prefrontal tDCS on executive function: methodological considerations revealed by meta-analysis. Neuropsychologia 117:156–166. https://doi.org/10.1016/j.neuropsychologia.2018.04.022
Jacobson L, Ezra A, Berger U, Lavidor M (2012) Modulating oscillatory brain activity correlates of behavioral inhibition using transcranial direct current stimulation. Clin Neurophysiol 123(5):979–984. https://doi.org/10.1016/j.clinph.2011.09.016
Klauss J, Penido Pinheiro LC, Silva Merlo BL, Correia Santos GDA, Fregni F, Nitsche MA, Miyuki Nakamura-Palacios E (2014) A randomized controlled trial of targeted prefrontal cortex modulation with tDCS in patients with alcohol dependence. Int J Neuropsychopharmacol 17:1793–1803. https://doi.org/10.1017/S1461145714000984
Klauss J, Anders QS, Felippe LV, Nitsche MA, Nakamura-Palacios EM (2018) Multiple sessions of transcranial Direct Current Stimulation (tDCS) reduced craving and relapses for alcohol use: a randomized placebo-controlled trial in alcohol use disorder. Front Pharmacol 9:716. https://doi.org/10.3389/fphar.2018.00716
Knight RT (1991) Evoked potential studies of attention capacity in human frontal lobe lesions. In: Levin HS, Eisenberg HM, Benton AL (eds) Frontal lobe function and dysfunction. Oxford University Press, New York, pp 139–153
Koob GF (2014) Neurocircuitry of alcohol addiction: synthesis from animal models. Handb Clin Neurol 125:33–54. https://doi.org/10.1016/B978-0-444-62619-6.00003-3
Kraus, L, Guttormsson, U, Leifman, H, Arpa, S, Molinaro, S, Monshouwer, K, Hibell, B (2016) ESPAD Report 2015. Results from the European School Survey Project on alcohol and other drugs. Lisbon: European Monitoring Centre for Drugs and Drug Addiction and the European School Survey Project on Alcohol and Other Drugs
Kreusch F, Quertemont E, Vilenne A, Hansenne M (2014) Alcohol abuse and ERP components in Go/No-go tasks using alcohol-related stimuli: impact of alcohol avoidance. Int J Psychophysiol 94:92–99. https://doi.org/10.1016/j.ijpsycho.2014.08.001
Lannoy S, D’Hondt F, Dormal V, Billieux J, Maurage P (2017) Electrophysiological correlates of performance monitoring in binge drinking: impaired error-related but preserved feedback processing. Clin Neurophysiol 128:2110–2121. https://doi.org/10.1016/j.clinph.2017.08.005
Lannoy S, Maurage P, D’Hondt F, Billieux J, Dormal V (2018) Executive impairments in binge drinking: evidence for a specific performance monitoring difficulty during alcohol-related processing. Eur Addict Res 24:118–127. https://doi.org/10.1159/000490492
Lannoy S, Dormal V, Billieux J, Brion M, D’Hondt F, Maurage P (2019) A dual-process exploration of binge drinking: evidence through behavioral and electrophysiological findings. Addict Biol In press. https://doi.org/10.1111/adb.12685
Lapenta OM, Di Sierve K, de Macedo EC, Fregni F, Boggio PS (2014) Transcranial direct current stimulation modulates ERP-indexed inhibitory control and reduces food consumption. Appetite 83:42–48. https://doi.org/10.1016/j.appet.2014.08.005
Li LM, Violante IR, Leech R, Ross E, Hampshire A, Opitz A, Rothwell JC, Carmichael DW, Sharp DJ (2019) Brain state and polarity dependent modulation of brain networks by transcranial direct current stimulation. Hum Brain Mapp 40(3):904–915. https://doi.org/10.1002/hbm.24420
López-Caneda E, Cadaveira F, Crego A, Gómez-Suárez A, Corral M, Parada M, Caamaño-Isorna F, Rodriguez Holguin S (2012) Hyperactivation of right inferior frontal cortex in young binge drinkers during response inhibition: a follow-up study. Addiction 107:1796–1808. https://doi.org/10.1111/j.1360-0443.2012.03908.x
López-Caneda E, Cadaveira F, Crego A, Doallo S, Corral M, Gomez-Suárez A, Rodriguez Holguin S (2013) Effects of a persistent binge drinking pattern of alcohol consumption in young people: a follow-up study using event-related potentials. Alcohol Alcohol 48:464–471. https://doi.org/10.1093/alcalc/agt046
López-Caneda E, Rodríguez Holguín S, Corral M, Doallo S, Cadaveira F (2014) Evolution of the binge drinking pattern in college students: neurophysiological correlates. Alcohol 48:407–418. https://doi.org/10.1016/j.alcohol.2014.01.009
Maurage P, Pesenti M, Philippot P, Joassin F, Campanella S (2009) Latent deleterious effects of binge drinking over a short period of time revealed only by electrophysiological measures. J Psychiatry Neurosci 34:111–118. https://doi.org/10.1016/S1053-8119(09)70040-0
Maurage P, Joassin F, Speth A, Modave J, Philippot P, Campanella S (2012) Cerebral effects of binge drinking: respective influences of global alcohol intake and consumption pattern. Clin Neurophysiol 123:892–901. https://doi.org/10.1016/j.clinph.2011.09.018
Maurage P, Petit G, Campanella S (2013) Pathways to alcohol-induced brain impairment in young people: a review by Hermens et al. 2013. Cortex 49:1155–1159. https://doi.org/10.1016/j.cortex.2012.12.015
Moselhy HF, Georgiou G, Kahn A (2001) Frontal lobe changes in alcoholism: a review of the literature. Alcohol Alcohol 36:357–368. https://doi.org/10.1093/alcalc/36.5.357
Nieuwenhuis S, Yeung N, Van Den Wildenberg W, Ridderinkhof KR (2003) Electrophysiological correlates of anterior cingulate function in a go/no-go task: effects of response conflict and trial type frequency. Cogn Affect Behav Neurosci 3:17–26
Noël X, Bechara A, Brevers D, Verbanck P, Campanella S (2010) Alcoholism and the loss of willpower: a neurocognitive perspective. J Psychophysiol 24:240–248. https://doi.org/10.1027/0269-8803/a000037
Norman AL, Pulido C, Squeglia LM, Spadoni AD, Paulus MP, Tapert SF (2011) Neural activation during inhibition predicts initiation of substance use in adolescence. Drug Alcohol Depend 119:216–223. https://doi.org/10.1016/j.drugalcdep.2011.06.019
Park S, Kim MS (2018) An event-related potential study of spatial working memory in binge drinking college students. PLoS One 13:e0203696. https://doi.org/10.1371/journal.pone.0203696
Petit G, Kornreich C, Noël X, Verbanck P, Campanella S (2012) Alcohol-related context modulates performance of social drinkers in a visual Go/No-Go task: a preliminary assessment of event-related potentials. PLoS One 7:e37466. https://doi.org/10.1371/journal.pone.0037466
Petit G, Kornreich C, Dan B, Verbanck P, Campanella S (2014) Electrophysiological correlates of alcohol-and non-alcohol-related stimuli processing in binge drinkers: a follow-up study. J Psychopharmacol 28:1041–1052. https://doi.org/10.1177/0269881114545663
Polich J (2004) Clinical application of the P300 event-related brain potential. Phys Med Rehabil Clin N Am 15:133–161. https://doi.org/10.1016/S1047-9651(03)00109-8
Robinson TE, Berridge KC (2001) Incentive-sensitization and addiction. Addiction 96:103–114. https://doi.org/10.1080/09652140020016996
Rochat L, Maurage P, Heeren A, Billieux J (2019) Let's open the decision-making umbrella: a framework for conceptualizing and assessing features of impaired decision making in addiction. Neuropsychol Rev 29:27–51. https://doi.org/10.1007/s11065-018-9387-3
Sallard E, Mouthon M, De Pretto M, Spierer L (2018) Modulation of inhibitory control by prefrontal anodal tDCS: a crossover double-blind sham-controlled fMRI study. PLoS One 13:e0194936. https://doi.org/10.1371/journal.pone.0194936
Sathappan AV, Luber BM, Lisanby SH (2018) The dynamic duo: combining noninvasive brain stimulation with cognitive interventions. Prog Neuro-Psychopharmacol Biol Psychiatry 89:347–360. https://doi.org/10.1016/j.pnpbp.2018.10.006
Shiffrin RM, Schneider W (1977) Controlled and automatic human information processing: II. Perceptual learning, automatic attending and a general theory. Psychol Rev 84:27–190. https://doi.org/10.1037/0033-295X.84.2.127
Smith JL, Johnstone SJ, Barry RJ (2007) Response priming in the Go/NoGo task: the N2 reflects neither inhibition nor conflict. Clin Neurophysiol 118(2):343–355. https://doi.org/10.1016/j.clinph.2006.09.027
Smith JL, Jamadar S, Provost AL, Michie PT (2013) Motor and non-motor inhibition in the Go/NoGo task: an ERP and fMRI study. Int J Psychophysiol 87:244–253. https://doi.org/10.1016/j.ijpsycho.2012.07.185
Spagnolo PA, Goldman D (2016) Neuromodulation interventions for addictive disorders: challenges, promise, and roadmap for future research. Brain 140:1183–1203. https://doi.org/10.1093/brain/aww284
Spielberger, DC, Gorsuch, RL, Lushene, R, Vagg, PR, Jacobs, GA (1983) Manual for the State-Trait Anxiety Inventory. Palo Alto: Consulting Psychology Press
Stavro K, Pelletier J, Potvin S (2013) Widespread and sustained cognitive deficits in alcoholism: a meta-analysis. Addict Biol 18:203–213. https://doi.org/10.1111/j.1369-1600.2011.00418.x
Sutton S, Braren M, Zubin J, John ER (1965) Information delivery and the sensory evoked potential. Science 150:1187–1188. https://doi.org/10.1126/science.155.3768.1436
Townshend JM, Duka T (2005) Binge drinking, cognitive performance and mood in a population of young social drinkers. Alcohol Clin Exp Res 29:317–325. https://doi.org/10.1097/01.ALC.0000156453.05028.F5
Viner RM, Taylor B (2007) Adult outcomes of binge drinking in adolescence: findings from a UK national birth cohort. J Epidemiol Community Health 61:902–907. https://doi.org/10.1136/jech.2005.038117
Vocat R, Pourtois G, Vuilleumier P (2008) Unavoidable errors: a spatio-temporal analysis of time-course and neural sources of evoked potentials associated with error processing in a speeded task. Neuropsychologia 46:2545–2555. https://doi.org/10.1016/j.neuropsychologia.2008.04.006
Volkow ND, Baler RD (2015) NOW vs LATER brain circuits: implications for obesity and addiction. Trends Neurosci 38:345–352. https://doi.org/10.1016/j.tins.2015.04.002
Volkow ND, Wang G, Fowler JS, Tomasi D (2012) Addiction circuitry in the human brain. Annu Rev Pharmacol Toxicol 52:321–336. https://doi.org/10.1146/annurev-pharmtox-010611-134625
Watson TD, Newton-Mora M, Pirkle J (2016) Event-related potential correlates of processing alcohol-related pictures in young adult binge drinkers. Am J Drug Alcohol Abuse 42:77–87. https://doi.org/10.3109/00952990.2015.1099660
Wessel JR, Aron AR (2015) It's not too late: the onset of the frontocentral P3 indexes successful response inhibition in the stop-signal paradigm. Psychophysiol 52(4):472–480. https://doi.org/10.1111/psyp.12374
Wiers RW, Bartholow BD, van den Wildenberg E, Thush C, Engels RCME, Sher KJ, Grenard J, Ames SL, Stacy AW (2007) Automatic and controlled processes and the development of addictive behaviors in adolescents: a review and a model. Pharmacol Biochem Behav 86:263–283. https://doi.org/10.1016/j.pbb.2006.09.021
Wiers RW, Boffo M, Field M (2018) What’s in a trial? On the importance of distinguishing between experimental lab studies and randomized controlled trials: The case of cognitive bias modification and alcohol use disorders. J Stud Alcohol Drugs 79:333–343. https://doi.org/10.15288/jsad.2018.79.333
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We thank Laura Ninane, Celia Rotha and Stéphane Acke for their help in data collection.
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Pierre Maurage (Senior Research Associate) is funded by the Belgian Fund for Scientific Research (F.R.S.-FNRS, Belgium), and this research has been supported by a grant from the Fondation pour la Recherche en Alcoologie (FRA), but these funds did not exert any editorial direction or censorship on any part of this article.
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Dormal, V., Lannoy, S., Bollen, Z. et al. Can we boost attention and inhibition in binge drinking? Electrophysiological impact of neurocognitive stimulation. Psychopharmacology 237, 1493–1505 (2020). https://doi.org/10.1007/s00213-020-05475-2
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DOI: https://doi.org/10.1007/s00213-020-05475-2