Biochemical and Biophysical Research Communications
Regular ArticleLow Doses of EPO Activate MAP Kinases but Not JAK2–STAT5 in Rat Vascular Smooth Muscle Cells
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Erythropoietin and Nonhematopoietic Effects
2017, American Journal of the Medical SciencesCitation Excerpt :However, exogenous EPO elicits physiological effects in the normal kidney not primarily associated with tissue protection, and this could have important implications in certain clinical situations.26,34,35 One important EPO target is the vascular smooth muscle cell where EPO increases intracellular calcium and causes contraction of vascular smooth muscle cell in vitro and constriction in vivo, thus significantly increasing peripheral vascular resistance.29,36 Clinically, EPO has variable effects on systemic blood pressure and vascular resistance.
EPO gene expression promotes proliferation, migration and invasion via the p38MAPK/AP-1/MMP-9 pathway by p21WAF1 expression in vascular smooth muscle cells
2015, Cellular SignallingCitation Excerpt :Several reasons have been suggested for the complicating and proliferative effects of EPO on vascular smooth muscle cells (VSMCs). The EPO treatment-induced proliferation of VSMCs has been documented in several signaling pathways, in phospholipase C (PLC) activity, and in the inhibitory effect of apoptotic action [15–19]. However, the roles and molecular mechanisms of migration, invasion, and cell-cycle regulation in VSMCs in response to EPO are yet to be formally investigated.
Experimental acute myocardial infarction in rats: HIF-1α, caspase-3, erythropoietin and erythropoietin receptor expression and the cardioprotective effects of two different erythropoietin doses
2013, Acta HistochemicaCitation Excerpt :The protective effects of Epo against tissue ischemia are mediated by erythropoietin receptor (EpoR) (Brines et al., 2004). In addition to erythroid progenitor cells, a varied group of cells including neurons, endothelial cells, vascular smooth muscle cells, and cardiac myocytes, express EpoR (Anagnostou et al., 1994; Digicaylioglu et al., 1995; Akimoto et al., 2000; Ogilvie et al., 2000; Ammarguellat et al., 2001; Digicaylioglu and Lipton, 2001; Tramontano et al., 2003; Jelkmann and Wagner, 2004; Marti, 2004). The cardioprotective effects of Epo have become a topical issue after detection of EpoR expression on cardiomyocytes (Marzo et al., 2008).
American ginseng inhibits vascular smooth muscle cell proliferation via suppressing Jak/Stat pathway
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Current address: Clinical Research Institute of Montreal–Experimental Hypertension, 110 Pine Avenue West, Montreal, Québec, Canada H2W 1R7.
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