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Anti-HIV Activityin Vitroof MGN-3, an Activated Arabinoxylane from Rice Bran,☆☆

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Abstract

MGN-3, an arabinoxylane from rice bran that has been enzymatically modified with extract fromHyphomycetes mycelia,was tested for anti-HIV activityin vitro.MGN-3 activity against HIV-1 (SF strain) was examined in primary cultures of peripheral blood mononuclear cells. MGN-3 inhibited HIV-I replication by: (1) inhibition of HIV-1 p24 antigen production in a dose dependent manner—MGN-3 at concentrations of 12.5, 25, 50, and 100 μg/ml showed 18.3, 42.8, 59, and 75% reduction in p24 antigen, respectively; and (2) inhibition of syncytia formation maximized (75%) at concentrations of 100 μg/ml. Further studies showed that ingestion of MGN-3 at concentration of 15 mg/kg/day resulted in a significant increase in T and B cell mitogen response at 2 months after treatment: 146% for PHA, 140% for Con A, and 136.6% for PWM mitogen. We conclude that MGN-3 possesses potent anti-HIV activity and in the absence of any notable side effects, MGN-3 shows promise as an agent for treating patients with AIDS.

References (18)

  • C.A.B. Boucher et al.

    Lancet

    (1990)
  • S. Gollapudi et al.

    Biochem. Biophys. Res. Commun.

    (1995)
  • S. Takenaka

    Chemosphere

    (1992)
  • Ghoneum, M. Manattala, G....
  • Ghoneum, M. 1995, Abstract Cancer: The Interference between Basic and Applied Research, Baltimore,...
  • V.A. Johnson et al.

    Techniques in HIV Research

    (1990)
  • B.A. Larder et al.

    Science

    (1989)
  • A.J. Japour et al.

    J. Infect. Dis.

    (1995)
There are more references available in the full text version of this article.

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Data presented at XI International Conference on AIDS, Vancouver, BC, Canada, July 7–12, 1996.

☆☆

Aldovini, A.B. D. Walker

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