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Journal of Autism and Developmental Disorders

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07-02-2020 | Original Paper

Light-Adapted Electroretinogram Differences in Autism Spectrum Disorder

Auteurs: Paul A. Constable, Edward R. Ritvo, Ariella R. Ritvo, Irene O. Lee, Morgan L. McNair, Dylan Stahl, Jane Sowden, Stephen Quinn, David H. Skuse, Dorothy A. Thompson, James C. McPartland

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 8/2020

Abstract

Light-adapted (LA) electroretinograms (ERGs) from 90 individuals with autism spectrum disorder (ASD), mean age (13.0 ± 4.2), were compared to 87 control subjects, mean age (13.8 ± 4.8). LA-ERGs were produced by a random series of nine different Troland based, full-field flash strengths and the ISCEV standard flash at 2/s on a 30 cd m⁻² white background. A random effects mixed model analysis showed the ASD group had smaller b- and a-wave amplitudes at high flash strengths (p < .001) and slower b-wave peak times (p < .001). Photopic hill models showed the peaks of the component Gaussian (p = .035) and logistic functions (p = .014) differed significantly between groups. Retinal neurophysiology assessed by LA-ERG provides insight into neural development in ASD.

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Titel: Light-Adapted Electroretinogram Differences in Autism Spectrum Disorder
Auteurs: Paul A. Constable
Edward R. Ritvo
Ariella R. Ritvo
Irene O. Lee
Morgan L. McNair
Dylan Stahl
Jane Sowden
Stephen Quinn
David H. Skuse
Dorothy A. Thompson
James C. McPartland
Publicatiedatum: 07-02-2020
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 8/2020
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-020-04396-5

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