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01-07-2008 | Original Paper

Level of Functioning in Autism Spectrum Disorders: Phenotypic Congruence Among Affected Siblings

Auteurs: Robin P. Goin-Kochel, Carla A. Mazefsky, Brien P. Riley

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2008

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Abstract

Little evidence supports that siblings with autism exhibit the same behaviors; however, some findings suggest that level of functioning shows familial aggregation. We tested this notion among multiplex families participating with the Autism Genetic Resource Exchange (AGRE) Consortium, using scores on the Peabody Picture Vocabulary Test—Third Edition (N = 204 families), the Ravens Colored Progressive Matrices (N = 226 families), and the Vineland Adaptive Behavior Scales (N = 348 families). Intraclass Correlation Coefficients revealed that siblings with autism/autism spectrum disorders (ASD) were more similar on measures of verbal and nonverbal IQ and adaptive functioning than were unrelated children with autism/ASD. Preliminary twin correlations indicated strong genetic effects for some skill domains and the influence of shared environmental factors for others.
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Metagegevens
Titel
Level of Functioning in Autism Spectrum Disorders: Phenotypic Congruence Among Affected Siblings
Auteurs
Robin P. Goin-Kochel
Carla A. Mazefsky
Brien P. Riley
Publicatiedatum
01-07-2008
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 6/2008
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-007-0476-z