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Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-07-2008 | Original Paper

Level of Functioning in Autism Spectrum Disorders: Phenotypic Congruence Among Affected Siblings

Auteurs: Robin P. Goin-Kochel, Carla A. Mazefsky, Brien P. Riley

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2008

Abstract

Little evidence supports that siblings with autism exhibit the same behaviors; however, some findings suggest that level of functioning shows familial aggregation. We tested this notion among multiplex families participating with the Autism Genetic Resource Exchange (AGRE) Consortium, using scores on the Peabody Picture Vocabulary Test—Third Edition (N = 204 families), the Ravens Colored Progressive Matrices (N = 226 families), and the Vineland Adaptive Behavior Scales (N = 348 families). Intraclass Correlation Coefficients revealed that siblings with autism/autism spectrum disorders (ASD) were more similar on measures of verbal and nonverbal IQ and adaptive functioning than were unrelated children with autism/ASD. Preliminary twin correlations indicated strong genetic effects for some skill domains and the influence of shared environmental factors for others.

vorige artikel Characteristics Associated with Presence of Depressive Symptoms in Adults with Autism Spectrum Disorder

volgende artikel Sex-typical Play: Masculinization/Defeminization in Girls with an Autism Spectrum Condition

This information was not provided for the motor-skills domain.

The AGRE Consortium includes: Dan Geschwind, M.D., Ph.D., UCLA, Los Angeles, CA, USA; Maja Bucan, Ph.D., University of Pennsylvania, Philadelphia, PA, USA; W. Ted Brown, M.D., Ph.D., F.A.C.M.G., N.Y.S. Institute for Basic Research in Developmental Disabilities, Long Island, NY, USA; Rita M. Cantor, Ph.D., UCLA School of Medicine, Los Angeles, CA, USA; John N. Constantino, M.D., Washington University School of Medicine, St. Louis, MO, USA; T. Conrad Gilliam, Ph.D., University of Chicago, Chicago, IL, USA; Clara Lajonchere, Ph.D, Cure Autism Now, Los Angeles, CA; David H. Ledbetter, Ph.D., Emory University, Atlanta, GA; Christa Lese-Martin, Ph.D., Emory University, Atlanta, GA, USA; Janet Miller, J.D., Ph.D., Cure Autism Now, Los Angeles, CA; Stanley F. Nelson, M.D., UCLA School of Medicine, Los Angeles, CA, USA; Gerard D. Schellenberg, Ph.D., University of Washington, Seattle, WA; Carol A. Samango-Sprouse, Ed.D., George Washington University, Washington, D.C.; Sarah Spence, M.D., Ph.D., UCLA, Los Angeles, CA, USA; Matthew State, M.D., Ph.D., Yale University , New Haven, CT, USA; Rudolph E. Tanzi, Ph.D., Massachusetts General Hospital, Boston, MA, USA.

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Titel: Level of Functioning in Autism Spectrum Disorders: Phenotypic Congruence Among Affected Siblings
Auteurs: Robin P. Goin-Kochel
Carla A. Mazefsky
Brien P. Riley
Publicatiedatum: 01-07-2008
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 6/2008
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-007-0476-z

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