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18-05-2019

Latent Profiles of Cognitive and Interpersonal Risk Factors for Adolescent Depression and Implications for Personalized Treatment

Auteurs: Meredith Gunlicks-Stoessel, Dikla Eckshtain, Susanne Lee, Kristina Reigstad, Laura Mufson, John Weisz

Gepubliceerd in: Research on Child and Adolescent Psychopathology | Uitgave 12/2019

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Abstract

A personalized approach to treatment with patients being matched to the best-fit treatment has been proposed as one possible solution to the currently modest treatment response rates for adolescent depression. Personalized treatment involves identifying and characterizing subgroups likely to respond differently to different treatments. We investigated the feasibility of this approach, by focusing on two key risk factors that are the purported treatment targets of cognitive behavioral therapy (CBT) and interpersonal psychotherapy for depressed adolescents (IPT-A): negative unrealistic cognitions and interpersonal relationship difficulties, respectively. We sought to learn whether subgroups high and low on the two risk factors, respectively, might be identified in a large sample of depressed, treatment-seeking adolescents. Latent class analysis (LCA) was conducted on measures of the two risk factors among 431 adolescents (age 12–17) in the Treatment for Adolescents with Depression Study. LCA identified three classes: (1) adolescents with high levels of problems in both family relationships and cognitions (21.6% of sample), (2) adolescents with moderate levels of problems in both domains (52.4%), and (3) adolescents with low levels of problems in both domains (26.0%). These subgroups did not predict treatment outcome with CBT or CBT + fluoxetine (COMB). The results challenge a current assumption about how treatments could be personalized, and they support a multi-causal model of depression rather than a risk-factor-specific model. Strategies other than risk factor-based personalizing for case assignment to CBT vs. IPT-A are discussed.
Voetnoten
1
Mixed models including race and SES in addition to age and gender as covariates yielded similar results. Because of the smaller sample size from missing data in race and SES, results using only age and gender as covariates are reported.
 
Literatuur
go back to reference Ackerson, J., Scogin, F., McKendree-Smith, N., & Lyman, R. D. (1998). Cognitive bibliotherapy for mild and moderate adolescent depressive symptomatology. Journal of Consulting and Clinical Psychology, 66(4), 685–690.PubMed Ackerson, J., Scogin, F., McKendree-Smith, N., & Lyman, R. D. (1998). Cognitive bibliotherapy for mild and moderate adolescent depressive symptomatology. Journal of Consulting and Clinical Psychology, 66(4), 685–690.PubMed
go back to reference Akaike, H. (1987). Factor analysis and AIC. Psychometrika, 52, 317–332. Akaike, H. (1987). Factor analysis and AIC. Psychometrika, 52, 317–332.
go back to reference American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association.
go back to reference Auerbach, R. P., & Ho, M. H. (2012). A cognitive-interpersonal model of adolescent depression: The impact of family conflict and depressogenic cognitive stypes. Journal of Clinical Child and Adolescent Psychology, 41, 792–802.PubMed Auerbach, R. P., & Ho, M. H. (2012). A cognitive-interpersonal model of adolescent depression: The impact of family conflict and depressogenic cognitive stypes. Journal of Clinical Child and Adolescent Psychology, 41, 792–802.PubMed
go back to reference Berenbaum, H. (2013). Classification and psychopathology research. Journal of Abnormal Psychology, 122, 894–901.PubMed Berenbaum, H. (2013). Classification and psychopathology research. Journal of Abnormal Psychology, 122, 894–901.PubMed
go back to reference Brent, D. A., Holder, D., Kolko, D., Birmaher, B., Baugher, M., Roth, C., ... Johnson, B. A. (1997). A clinical psychotherapy trial for adolescent depression comparing cognitive, family, and supportive therapy. Archives of General Psychiatry, 54, 877–885.PubMed Brent, D. A., Holder, D., Kolko, D., Birmaher, B., Baugher, M., Roth, C., ... Johnson, B. A. (1997). A clinical psychotherapy trial for adolescent depression comparing cognitive, family, and supportive therapy. Archives of General Psychiatry, 54, 877–885.PubMed
go back to reference Clarke, G., Rohde, P., Lewinsohn, P., Hops, H., & Seeley, J. (1999). Cognitive-behavioral treatment of adolescent depression: Efficacy of acute group treatment and booster sessions. Journal of the American Academy of Child & Adolescent Psychiatry, 38, 272–279. Clarke, G., Rohde, P., Lewinsohn, P., Hops, H., & Seeley, J. (1999). Cognitive-behavioral treatment of adolescent depression: Efficacy of acute group treatment and booster sessions. Journal of the American Academy of Child & Adolescent Psychiatry, 38, 272–279.
go back to reference Cuthbert, B. N., & Kozak, M. J. (2013). Constructing constructs for psychopathology: The NIMH research domain criteria. Journal of Abnormal Psychology, 122, 928–937.PubMed Cuthbert, B. N., & Kozak, M. J. (2013). Constructing constructs for psychopathology: The NIMH research domain criteria. Journal of Abnormal Psychology, 122, 928–937.PubMed
go back to reference Feeny, N. C., Silva, S. G., Reinecke, M. A., McNulty, S., Findling, R. L., Rohde, P., ... March, J. S. (2009). An exploratory analysis of the impact of family functioning on treatment for depression in adolescents. Journal of Clinical Child and Adolescent Psychology, 38, 814–825. Feeny, N. C., Silva, S. G., Reinecke, M. A., McNulty, S., Findling, R. L., Rohde, P., ... March, J. S. (2009). An exploratory analysis of the impact of family functioning on treatment for depression in adolescents. Journal of Clinical Child and Adolescent Psychology, 38, 814–825.
go back to reference Feng, Z. D., & McCulloch, C. E. (1996). Using bootstrap likelihood ratios in finite mixture models. Journal of the Royal Statistical Society, 58(Series B, 609–617. Feng, Z. D., & McCulloch, C. E. (1996). Using bootstrap likelihood ratios in finite mixture models. Journal of the Royal Statistical Society, 58(Series B, 609–617.
go back to reference Garber, J., Weiss, B., & Shanley, N. (1993). Cognition, depressive symptoms, and development in adolescents. Journal of Abnormal Psychology, 102, 47–57.PubMed Garber, J., Weiss, B., & Shanley, N. (1993). Cognition, depressive symptoms, and development in adolescents. Journal of Abnormal Psychology, 102, 47–57.PubMed
go back to reference Gladstone, T. R. G., & Kaslow, N. J. (1995). Depression and attributions in children and adolescents: A meta-analytic review. Journal of Abnormal Child Psychology, 23, 597–606.PubMed Gladstone, T. R. G., & Kaslow, N. J. (1995). Depression and attributions in children and adolescents: A meta-analytic review. Journal of Abnormal Child Psychology, 23, 597–606.PubMed
go back to reference Glied, S., & Pine, D. S. (2002). Consequences and correlates of adolescent depression. Archives of Pediatric Adolescent Medicine, 156, 1009–1014. Glied, S., & Pine, D. S. (2002). Consequences and correlates of adolescent depression. Archives of Pediatric Adolescent Medicine, 156, 1009–1014.
go back to reference Gotlib, I. H., Lewinsohn, P. M., Seeley, J. R., Rohde, P., & Redner, J. E. (1993). Negative cognitions and attributional style in depressed adolescents: An examination of stability and specificity. Journal of Abnormal Psychology, 102, 607–615.PubMed Gotlib, I. H., Lewinsohn, P. M., Seeley, J. R., Rohde, P., & Redner, J. E. (1993). Negative cognitions and attributional style in depressed adolescents: An examination of stability and specificity. Journal of Abnormal Psychology, 102, 607–615.PubMed
go back to reference Hammen, C. (1991). The generation of stress in the course of unipolar depression. Journal of Abnormal Psychology, 100, 555–561.PubMed Hammen, C. (1991). The generation of stress in the course of unipolar depression. Journal of Abnormal Psychology, 100, 555–561.PubMed
go back to reference Jacobs, R. H., Silva, S. G., Reinecke, M. A., Curry, J. F., Ginsburg, G. S., & Kratochvil, C. J. (2009). Dysfunctional attitudes scale perfectionism: A predictor and partial mediator of acute treatment outcome among clinically depressed adolescents. Journal of Clinical Child and Adolescent Psychology, 38, 803–813.PubMedPubMedCentral Jacobs, R. H., Silva, S. G., Reinecke, M. A., Curry, J. F., Ginsburg, G. S., & Kratochvil, C. J. (2009). Dysfunctional attitudes scale perfectionism: A predictor and partial mediator of acute treatment outcome among clinically depressed adolescents. Journal of Clinical Child and Adolescent Psychology, 38, 803–813.PubMedPubMedCentral
go back to reference Kaslow, N. J., Stark, K. D., Printz, B., Livingston, R., & Tsai, S. L. (1992). Cognitive triad inventory for children: Development and relation to depression and anxiety. Journal of Clinical Child Psychology, 21(4), 339–347. Kaslow, N. J., Stark, K. D., Printz, B., Livingston, R., & Tsai, S. L. (1992). Cognitive triad inventory for children: Development and relation to depression and anxiety. Journal of Clinical Child Psychology, 21(4), 339–347.
go back to reference Kendler, K. S. (2008). Explanatory models for psychiatric illness. American Journal of Psychiatry, 165, 695–702.PubMed Kendler, K. S. (2008). Explanatory models for psychiatric illness. American Journal of Psychiatry, 165, 695–702.PubMed
go back to reference Kingery, J. N., Kepley, H. O., Ginsburg, G. S., Walkup, J. T., Silva, S. G., Hoyle, R. H., ... March, J. S. (2009). Factor structure and psychometric properties of the Children’s negative cognitive error questionnaire with a clinically depressed adolescent sample. Journal of Clinical Child and Adolescent Psychology, 38, 768–780. Kingery, J. N., Kepley, H. O., Ginsburg, G. S., Walkup, J. T., Silva, S. G., Hoyle, R. H., ... March, J. S. (2009). Factor structure and psychometric properties of the Children’s negative cognitive error questionnaire with a clinically depressed adolescent sample. Journal of Clinical Child and Adolescent Psychology, 38, 768–780.
go back to reference Kraemer, H. C., Wilson, G. T., Fairburn, C. C., & Agras, W. S. (2002). Mediators and moderators of treatment effects in randomized clinical trials. Archives of General Psychiatry, 59, 877–884.PubMed Kraemer, H. C., Wilson, G. T., Fairburn, C. C., & Agras, W. S. (2002). Mediators and moderators of treatment effects in randomized clinical trials. Archives of General Psychiatry, 59, 877–884.PubMed
go back to reference Leitenberg, H., Yost, L. W., & Carroll-Wilson, M. (1986). Negative cognitive errors in children: Questionnaire development, normative data, and comparisons between children with and without self-reported symptoms of depression, low self-esteem, and evaluation anxiety. Journal of Consulting and Clinical Psychology, 54(4), 528–536.PubMed Leitenberg, H., Yost, L. W., & Carroll-Wilson, M. (1986). Negative cognitive errors in children: Questionnaire development, normative data, and comparisons between children with and without self-reported symptoms of depression, low self-esteem, and evaluation anxiety. Journal of Consulting and Clinical Psychology, 54(4), 528–536.PubMed
go back to reference Lewinsohn, P. M., Clarke, G. N., Hops, H., & Andrews, J. (1990). Cognitive-behavioral treatment of depressed adolescents. Behavior Therapy, 21, 385–401. Lewinsohn, P. M., Clarke, G. N., Hops, H., & Andrews, J. (1990). Cognitive-behavioral treatment of depressed adolescents. Behavior Therapy, 21, 385–401.
go back to reference Littell, R. C., Milliken, G. A., Stroup, W. W., Wolfinger, R. D., & Schabenberger, O. (2006). SAS for mixed models (2nd ed.). Cary: SAS Institute. Littell, R. C., Milliken, G. A., Stroup, W. W., Wolfinger, R. D., & Schabenberger, O. (2006). SAS for mixed models (2nd ed.). Cary: SAS Institute.
go back to reference Lo, Y., Mendall, N. R., & Rubin, D. B. (2001). Testing the number of components in a normal mixture. Biometrika, 88, 767–778. Lo, Y., Mendall, N. R., & Rubin, D. B. (2001). Testing the number of components in a normal mixture. Biometrika, 88, 767–778.
go back to reference Marton, P., & Kutcher, S. (1993). The prevalence of cognitive distortion in depressed adolescents. Journal of Psychiatry and Neuroscience, 20, 33–38. Marton, P., & Kutcher, S. (1993). The prevalence of cognitive distortion in depressed adolescents. Journal of Psychiatry and Neuroscience, 20, 33–38.
go back to reference Mufson, L., Dorta, K. P., Moreau, D., & Weissman, M. M. (2004). Interpersonal psychotherapy for depressed adolescents (2nd ed.). New York: Guilford Press. Mufson, L., Dorta, K. P., Moreau, D., & Weissman, M. M. (2004). Interpersonal psychotherapy for depressed adolescents (2nd ed.). New York: Guilford Press.
go back to reference Muthen, L. K., & Muthen, B. O. (2010). Mplus User's Guide (6th ed.). Los Angeles. Muthen, L. K., & Muthen, B. O. (2010). Mplus User's Guide (6th ed.). Los Angeles.
go back to reference Ng, M. Y., & Weisz, J. R. (2016). Annual research review: Building a science of personalized intervention for youth mental health. Journal of Child Psychology & Psychiatry, 57, 216–236. Ng, M. Y., & Weisz, J. R. (2016). Annual research review: Building a science of personalized intervention for youth mental health. Journal of Child Psychology & Psychiatry, 57, 216–236.
go back to reference Poznanski, E. O., & Mokros, H. B. (1996). The Children's depression rating scale - revised (CDRS-R). Los Angeles: Western Psychological Services. Poznanski, E. O., & Mokros, H. B. (1996). The Children's depression rating scale - revised (CDRS-R). Los Angeles: Western Psychological Services.
go back to reference Poznanski, E. O., Miller, E., Salguero, C., & Kelsh, R. C. (1984). Preliminary studies of the reliability and validity of the Children's depression rating scale. Journal of the American Academy of Child and Adolescent Psychiatry, 23, 191–197. Poznanski, E. O., Miller, E., Salguero, C., & Kelsh, R. C. (1984). Preliminary studies of the reliability and validity of the Children's depression rating scale. Journal of the American Academy of Child and Adolescent Psychiatry, 23, 191–197.
go back to reference Robin, A. L., & Foster, S. L. (1989). Negotiating parent-adolescent conflict: A behavioral-family systems approach. New York: Guilford. Robin, A. L., & Foster, S. L. (1989). Negotiating parent-adolescent conflict: A behavioral-family systems approach. New York: Guilford.
go back to reference Robin, A. L., & Weiss, J. G. (1980). Criterion-related validity of behavioral and self-report measures of problem-solving communication skills in distressed and non-distressed parent-adolescent dyads. Behavioral Assessment, 2, 339–352. Robin, A. L., & Weiss, J. G. (1980). Criterion-related validity of behavioral and self-report measures of problem-solving communication skills in distressed and non-distressed parent-adolescent dyads. Behavioral Assessment, 2, 339–352.
go back to reference Rude, S. S., & Rehm, L. P. (1991). Response to treatments for depression: The role of initial status on targeted cognitive and behavioral skills. Clinical Psychology Review, 11, 493–514. Rude, S. S., & Rehm, L. P. (1991). Response to treatments for depression: The role of initial status on targeted cognitive and behavioral skills. Clinical Psychology Review, 11, 493–514.
go back to reference Safford, S. M., Alloy, L. B., Abramson, L. Y., & Crossfield, A. G. (2007). Negative cognitive style as a predictor of negative life events in depression-prone individuals: A test of the stress generation hypothesis. Journal of Affective Disorders, 99, 147–154.PubMed Safford, S. M., Alloy, L. B., Abramson, L. Y., & Crossfield, A. G. (2007). Negative cognitive style as a predictor of negative life events in depression-prone individuals: A test of the stress generation hypothesis. Journal of Affective Disorders, 99, 147–154.PubMed
go back to reference SAS Institute Inc. (2008). SAS/STAT® 9.2 User’s Guide. Cary, NC: SAS Institute Inc. SAS Institute Inc. (2008). SAS/STAT® 9.2 User’s Guide. Cary, NC: SAS Institute Inc.
go back to reference Schwarz, G. (1978). Estimating the dimension of a model. The Annals of Statistics, 6, 461–464. Schwarz, G. (1978). Estimating the dimension of a model. The Annals of Statistics, 6, 461–464.
go back to reference Sclove, L. S. (1987). Application of a model-selection criteria to some problems in multivariate analysis. Psychometrika, 52, 333–343. Sclove, L. S. (1987). Application of a model-selection criteria to some problems in multivariate analysis. Psychometrika, 52, 333–343.
go back to reference Seligman, M. E., Peterson, C., Kaslow, N. J., Tanenbaum, R. L., Alloy, L. B., & Abrasmson, L. (1984). Attributional style and depressive symptoms among children. Journal of Abnormal Psychology, 93, 235–238.PubMed Seligman, M. E., Peterson, C., Kaslow, N. J., Tanenbaum, R. L., Alloy, L. B., & Abrasmson, L. (1984). Attributional style and depressive symptoms among children. Journal of Abnormal Psychology, 93, 235–238.PubMed
go back to reference Simon, G. E., & Perlis, R. H. (2010). Personalized medicine for depression: Can we match patients with treatments? American Journal of Psychiatry, 167, 1445–1455.PubMed Simon, G. E., & Perlis, R. H. (2010). Personalized medicine for depression: Can we match patients with treatments? American Journal of Psychiatry, 167, 1445–1455.PubMed
go back to reference Skinner, H. A., Steinhauer, P., & Santa-Barbara, J. (1983). The family assessment measure. Canadian Journal of Community Mental Health Expectations, 2, 91–105. Skinner, H. A., Steinhauer, P., & Santa-Barbara, J. (1983). The family assessment measure. Canadian Journal of Community Mental Health Expectations, 2, 91–105.
go back to reference TADS Team. (2003). Treatment for adolescents with depression study (TADS): Rationale, design, and methods. Journal of the American Academy of Child & Adolescent Psychiatry, 42, 531–542. TADS Team. (2003). Treatment for adolescents with depression study (TADS): Rationale, design, and methods. Journal of the American Academy of Child & Adolescent Psychiatry, 42, 531–542.
go back to reference TADS Team. (2005). The treatment for adolescents with depression study (TADS): Demographic and clinical characteristics. American Academy of Child and Adolescent Psychiatry, 44(1), 28–40. TADS Team. (2005). The treatment for adolescents with depression study (TADS): Demographic and clinical characteristics. American Academy of Child and Adolescent Psychiatry, 44(1), 28–40.
go back to reference TADS Team. (2007). The treatment for adolescents with depression study (TADS): Long-term effectiveness and safety outcomes. Archives of General Psychiatry, 64, 1132–1144. TADS Team. (2007). The treatment for adolescents with depression study (TADS): Long-term effectiveness and safety outcomes. Archives of General Psychiatry, 64, 1132–1144.
go back to reference TADS Team. (2009). The treatment for adolescents with depression study (TADS): Outcomes over 1 year of naturalistic follow-up. American Journal of Psychiatry, 166, 1141–1149. TADS Team. (2009). The treatment for adolescents with depression study (TADS): Outcomes over 1 year of naturalistic follow-up. American Journal of Psychiatry, 166, 1141–1149.
go back to reference Weersing, V. R., & Gonzalez, A. (2009). Effectiveness of interventions for adolescent depression: Reason for hope or cause for concern? Handbook of depression in adolescents, 589–616. Weersing, V. R., & Gonzalez, A. (2009). Effectiveness of interventions for adolescent depression: Reason for hope or cause for concern? Handbook of depression in adolescents, 589–616.
go back to reference Weersing, V., Jeffreys, M., Do, M., Schwartz, K., & Bolano, C. (2017). Evidence base update of psychosocial treatments for child and adolescent depression. Journal of Clinical Child and Adolescent Psychology, 46, 11–43.PubMed Weersing, V., Jeffreys, M., Do, M., Schwartz, K., & Bolano, C. (2017). Evidence base update of psychosocial treatments for child and adolescent depression. Journal of Clinical Child and Adolescent Psychology, 46, 11–43.PubMed
go back to reference Weissman, A., & Beck, A. T. (1978). Development and validation of the Dysfunctional Attitudes Scale. Paper presented at the Association for the Advancement of behavior therapy, Chicago, IL. Weissman, A., & Beck, A. T. (1978). Development and validation of the Dysfunctional Attitudes Scale. Paper presented at the Association for the Advancement of behavior therapy, Chicago, IL.
go back to reference Weisz, J. R., McCarty, C. A., & Valeri, S. M. (2006). Effects of psychotherapy for depression in children and adolescents: A meta-analysis. Psychological Bulletin, 132, 132–149. Weisz, J. R., McCarty, C. A., & Valeri, S. M. (2006). Effects of psychotherapy for depression in children and adolescents: A meta-analysis. Psychological Bulletin, 132, 132–149.
go back to reference Weisz, J. R., Kuppens, S., Ng, M. Y., Eckshtain, D., Ugueto, A. M., Vaughn-Coaxum, R., ... Fordwood, S. R. (2017). What five decades of research tells us about the effects of youth psychological therapy: A multilevel meta-analysis and implications for science and practice. American Psychologist, 72, 79–117.PubMed Weisz, J. R., Kuppens, S., Ng, M. Y., Eckshtain, D., Ugueto, A. M., Vaughn-Coaxum, R., ... Fordwood, S. R. (2017). What five decades of research tells us about the effects of youth psychological therapy: A multilevel meta-analysis and implications for science and practice. American Psychologist, 72, 79–117.PubMed
go back to reference Williams, S., Connolly, J., & Segal, Z. V. (2001). Intimacy in relationships and cognitive vulnerability to depression in adolescent girls. Cognitive Therapy and Research, 25, 477–496. Williams, S., Connolly, J., & Segal, Z. V. (2001). Intimacy in relationships and cognitive vulnerability to depression in adolescent girls. Cognitive Therapy and Research, 25, 477–496.
Metagegevens
Titel
Latent Profiles of Cognitive and Interpersonal Risk Factors for Adolescent Depression and Implications for Personalized Treatment
Auteurs
Meredith Gunlicks-Stoessel
Dikla Eckshtain
Susanne Lee
Kristina Reigstad
Laura Mufson
John Weisz
Publicatiedatum
18-05-2019
Uitgeverij
Springer US
Gepubliceerd in
Research on Child and Adolescent Psychopathology / Uitgave 12/2019
Print ISSN: 2730-7166
Elektronisch ISSN: 2730-7174
DOI
https://doi.org/10.1007/s10802-019-00552-3