Skip to main content
main-content
Top

Tip

Swipe om te navigeren naar een ander artikel

01-01-2015 | Quantitative Methods Special Section | Uitgave 1/2015

Quality of Life Research 1/2015

Joint models for predicting transplant-related mortality from quality of life data

Tijdschrift:
Quality of Life Research > Uitgave 1/2015
Auteurs:
Norma Terrin, Angie Mae Rodday, Susan K. Parsons

Abstract

Purpose

To test whether longitudinally measured health-related quality of life (HRQL) predicts transplant-related mortality (TRM) in pediatric hematopoietic stem cell transplant (HSCT).

Methods

The predictors of interest were emotional functioning, physical functioning, role functioning, and global HRQL, as rated by the parent about the child up to 6 times over 12 months of follow-up and measured by the Child Health Ratings Inventories. We used joint models, specifically shared parameter models, with time to TRM as the outcome of interest and other causes of mortality as a competing risk, via the JM software package in R. Choosing shared parameter models instead of standard survival models, such as Cox models with time-dependent covariates, enabled us to address measurement error in the HRQL trajectories and appropriately handle missing data. The nonlinear trajectories for each HRQL domain were modeled by random spline functions. The survival submodels were adjusted for baseline patient, family, and transplant characteristics.

Results

Hazard ratios per one-half standard deviation difference in emotional, physical, and role functioning, and global HRQL were 0.61 (95 % CI 0.46–0.81; p < 0.001), 0.70 (0.51–0.96; p = 0.03), 0.54 (0.34–0.85; p = 0.007), and 0.57 (0.41–0.79; p < 0.001), respectively.

Conclusions

HRQL trajectories were predictive of TRM in pediatric HSCT, even after adjusting the survival outcome for baseline characteristics.

Log in om toegang te krijgen

Met onderstaand(e) abonnement(en) heeft u direct toegang:

BSL Podotherapeut Totaal

Binnen de bundel kunt u gebruik maken van boeken, tijdschriften, e-learnings, web-tv's en uitlegvideo's. BSL Podotherapeut Totaal is overal toegankelijk; via uw PC, tablet of smartphone.

Literatuur
Over dit artikel

Andere artikelen Uitgave 1/2015

Quality of Life Research 1/2015 Naar de uitgave