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10-07-2018

Is there an association between early weight status and utility-based health-related quality of life in young children?

Tijdschrift:
Quality of Life Research
Auteurs:
Eng Joo Tan, Victoria Brown, Stavros Petrou, Mario D’Souza, Marjory L. Moodie, Li Ming Wen, Louise A. Baur, Chris Rissel, Alison J. Hayes
Belangrijke opmerkingen

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s11136-018-1932-2) contains supplementary material, which is available to authorized users.

Abstract

Purpose

Few studies focus on the health-related quality of life (HRQoL) of preschool children with overweight or obesity. This is relevant for evaluation of obesity prevention trials using a quality-adjusted life year (QALY) framework. This study examined the association between weight status in the preschool years and HRQoL at age 5 years, using a preference-based instrument.

Methods

HRQoL [based on parent proxy version of the Health Utilities Index Mark 3 (HUI3)] and weight status were measured in children born in Australia between 2007 and 2009. Children’s health status was scored across eight attributes of the HUI3—vision, hearing, speech, ambulation, dexterity, emotion, cognition and pain, and these were used to calculate a multi-attribute utility score. Ordinary least squares (OLS), Tobit and two-part regressions were used to model the association between weight status and multi-attribute utility.

Results

Of the 368 children for whom weight status and HUI3 data were available, around 40% had overweight/obesity. After adjusting for child’s sex, maternal education, marital status and household income, no significant association between weight status in the preschool years and multi-attribute utility scores at 5 years was found.

Conclusions

Alternative approaches for capturing the effects of weight status in the preschool years on preference-based HRQoL outcomes should be tested. The application of the QALY framework to economic evaluations of obesity-related interventions in young children should also consider longitudinal effects over the life-course.
Clinical Trial Registration The Healthy Beginnings Trial was registered with the Australian Clinical Trial Registry (ACTRNO12607000168459).

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Extra materiaal
Supplementary material 1 (PDF 107 KB)
11136_2018_1932_MOESM1_ESM.pdf
Literatuur
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