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Gepubliceerd in: Journal of Autism and Developmental Disorders 3/2006

01-04-2006

Is There a ‘Regressive Phenotype’ of Autism Spectrum Disorder Associated with the Measles-Mumps-Rubella Vaccine? A CPEA Study

Auteurs: Jennifer Richler, Rhiannon Luyster, Susan Risi, Wan-Ling Hsu, Geraldine Dawson, Raphael Bernier, Michelle Dunn, Susan Hepburn, Susan L. Hyman, William M. McMahon, Julie Goudie-Nice, Nancy Minshew, Sally Rogers, Marian Sigman, M. Anne Spence, Wendy A. Goldberg, Helen Tager-Flusberg, Fred R. Volkmar, Catherine Lord

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 3/2006

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Abstract

A multi-site study of 351 children with Autism Spectrum Disorders (ASD) and 31 typically developing children used caregiver interviews to describe the children’s early acquisition and loss of social-communication milestones. For the majority of children with ASD who had experienced a regression, pre-loss development was clearly atypical. Children who had lost skills also showed slightly poorer outcomes in verbal IQ and social reciprocity, a later mean age of onset of autistic symptoms, and more gastrointestinal symptoms than children with ASD and no regression. There was no evidence that onset of autistic symptoms or of regression was related to measles-mumps-rubella vaccination. The implications of these findings for the existence of a ‘regressive phenotype’ of ASD are discussed.
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Metagegevens
Titel
Is There a ‘Regressive Phenotype’ of Autism Spectrum Disorder Associated with the Measles-Mumps-Rubella Vaccine? A CPEA Study
Auteurs
Jennifer Richler
Rhiannon Luyster
Susan Risi
Wan-Ling Hsu
Geraldine Dawson
Raphael Bernier
Michelle Dunn
Susan Hepburn
Susan L. Hyman
William M. McMahon
Julie Goudie-Nice
Nancy Minshew
Sally Rogers
Marian Sigman
M. Anne Spence
Wendy A. Goldberg
Helen Tager-Flusberg
Fred R. Volkmar
Catherine Lord
Publicatiedatum
01-04-2006
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 3/2006
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-005-0070-1

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