Swipe om te navigeren naar een ander artikel
The online version of this article (doi:10.1007/s10803-012-1540-x) contains supplementary material, which is available to authorized users.
We analyzed data from case groups of 538 children with autism spectrum disorders (ASD) and 163 with developmental delays (DD), and from 421 typically developing controls to assess associations with maternal influenza or fever during pregnancy. Exposure information was obtained by telephone interviews, and outcomes were clinically confirmed. Though neither ASD nor DD was associated with influenza, both were associated with maternal fever during pregnancy: OR’s (odds ratios) were 2.12 (95 % CI 1.17, 3.84) and 2.50 (95 % CI 1.20, 5.20) respectively. However, the fever-associated ASD risk was attenuated among mothers who reported taking antipyretic medications (OR = 1.30, 95 % CI 0.59, 2.84), but remained elevated for those who did not (OR = 2.55, 95 % CI 1.30, 4.99).
Log in om toegang te krijgen
Met onderstaand(e) abonnement(en) heeft u direct toegang:
Supplementary material 1 (DOC 44 kb)10803_2012_1540_MOESM1_ESM.doc
Abdallah, M. W., Larsen, N., Grove, J., Norgaard-Pedersen, B., Thorsen, P., Mortensen, E. L., et al. (2011). Amniotic fluid inflammatory cytokines: Potential markers of immunologic dysfunction in autism spectrum disorders. World Journal of Biology Psychiatry. doi: 10.3109/15622975.2011.639803
CDC. http://www.cdc.gov/flu/about/season/flu-season.htm. From CDC.
Deykin, E. Y., & MacMahon, B. (1979). Viral exposure and autism. American Journal of Epidemiology, 109(6), 628–638. PubMed
Libbey, J. E., Sweeten, T. L., McMahon, W. M., & Fujinami, R. S. (2005). Autistic disorder and viral infections. Journal for Neurovirology, 11(1), 1–10. CrossRef
Lieberman, E., Eichenwald, E., Mathur, G., Richardson, D., Heffner, L., & Cohen, A. (2000). Intrapartum fever and unexplained seizures in term infants. Pediatrics, 106(5), 983–988. PubMed
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr, Leventhal, B. L., DiLavore, P. C., et al. (2000). The Autism Diagnostic Observation Schedule-Generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223. PubMedCrossRef
Meyer, U., Schwendener, S., Feldon, J., & Yee, B. K. (2006). Prenatal and postnatal maternal contributions in the infection model of schizophrenia. Experimental Brain Research, 173(2), 243–257. CrossRef
Mullen, E. M. (1995). Mullen Scales of Early Learning. Circle Pines MN: American Guidance Services Inc.
Patterson, P. H. (2011). Maternal infection and immune involvement in autism. Trends Molecular Medicine.
SAS. (2002). SAS (Statistical Analysis Software). 9.1.3 ed. Cary, NC; Statistical Analysis Software Institute.
Shi, L., Fatemi, S. H., Sidwell, R. W., & Patterson, P. H. (2003). Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring. Journal of Neuroscience, 23(1), 297–302. PubMed
Sparrow, S. S., Balla, D. A., & Cicchetti, D. V. (1984). Vineland Adaptive Behavior Scales Interview Edition Expanded Form Manual. Circle Pines: American Guidance Services Inc.
- Is Maternal Influenza or Fever During Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study
Robin L. Hansen
- Springer US