Skip to main content
Top
Gepubliceerd in: Quality of Life Research 5/2020

18-01-2020

International validation of the EORTC CAT Core: a new adaptive instrument for measuring core quality of life domains in cancer

Auteurs: Morten Aa. Petersen, Neil K. Aaronson, Thierry Conroy, Anna Costantini, Johannes M. Giesinger, Eva Hammerlid, Bernhard Holzner, Colin D. Johnson, Jacobien M. Kieffer, Marieke van Leeuwen, Sandra Nolte, John K. Ramage, Krzysztof A. Tomaszewski, Annika Waldmann, Teresa Young, Paola Zotti, Mogens Groenvold, on behalf of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group

Gepubliceerd in: Quality of Life Research | Uitgave 5/2020

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Background

The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group (QLG) has developed computerised adaptive tests (CATs) for the 14 functional and symptom domains of the EORTC QLQ-C30 quality of life questionnaire. This is expected to optimise measurement precision, relevance to patients and flexibility. Here, we present the first international validation of the EORTC CAT Core.

Methods

A heterogeneous sample of 699 cancer patients scheduled for chemotherapy and/or radiotherapy was recruited across seven European countries. The EORTC CAT Core and all QLQ-C30 items were administered to participants before and after initiating treatment. Correlations between CAT and QLQ-C30 scores and floor/ceiling effects were calculated. Using several grouping variables, relative validity (cross-sectional known groups difference), responsiveness (changes over time) and relative sample size requirements of the CAT compared to the QLQ-C30 were estimated.

Results

Correlations of the CAT and QLQ-C30 ranged from 0.81 to 0.93 across domains. The mean relative reduction in floor and ceiling effects using the CAT was 42% (range 3–99%). Analyses of known groups validity and responsiveness indicated that, across domains, mean sample size requirements for the CAT were 72% and 70%, respectively, of those using the QLQ-C30.

Conclusions

The EORTC CAT Core measures the same domains as the QLQ-C30 with reduced floor/ceiling effects. The CAT generally facilitated the use of smaller samples (about 30% smaller on average) without loss of power compared to the QLQ-C30. Based on this study, the EORTC QLG will release the EORTC CAT Core for general use.
Literatuur
1.
go back to reference Wainer, H. (2000). Computerized adaptive testing: A primer (2nd). Mahwah, New Jersey: Lawrence Erlbaum Associates Inc.CrossRef Wainer, H. (2000). Computerized adaptive testing: A primer (2nd). Mahwah, New Jersey: Lawrence Erlbaum Associates Inc.CrossRef
2.
go back to reference Fayers, P. & on behalf of the EORTC Quality of Life Group and of the Quality of Life Unit. (2002). Quality of life research within the EORTC-the EORTC QLQ-C30. European Journal of Cancer,38(Suppl 4), S125–S133.PubMedCrossRef Fayers, P. & on behalf of the EORTC Quality of Life Group and of the Quality of Life Unit. (2002). Quality of life research within the EORTC-the EORTC QLQ-C30. European Journal of Cancer,38(Suppl 4), S125–S133.PubMedCrossRef
3.
go back to reference Petersen, M Aa, Aaronson, N. K., Arraras, J. I., Chie, W.-C., Conroy, T., Costantini, A., et al. (2018). The EORTC CAT Core—The computer adaptive version of the EORTC QLQ-C30 questionnaire. European Journal of Cancer,100, 8–16.PubMedCrossRef Petersen, M Aa, Aaronson, N. K., Arraras, J. I., Chie, W.-C., Conroy, T., Costantini, A., et al. (2018). The EORTC CAT Core—The computer adaptive version of the EORTC QLQ-C30 questionnaire. European Journal of Cancer,100, 8–16.PubMedCrossRef
4.
go back to reference Dirven, L., Groenvold, M., Taphoorn, M. J. B., Conroy, T., Tomaszewski, K. A., Young, T., et al. (2017). Psychometric evaluation of an item bank for computerized adaptive testing of the EORTC QLQ-C30 cognitive functioning dimension in cancer patients. Quality of Life Research,26, 2919–2929.PubMedPubMedCentralCrossRef Dirven, L., Groenvold, M., Taphoorn, M. J. B., Conroy, T., Tomaszewski, K. A., Young, T., et al. (2017). Psychometric evaluation of an item bank for computerized adaptive testing of the EORTC QLQ-C30 cognitive functioning dimension in cancer patients. Quality of Life Research,26, 2919–2929.PubMedPubMedCentralCrossRef
5.
go back to reference Dirven, L., Taphoorn, M. J., Groenvold, M., Habets, E. J. J., Aaronson, N. K., Conroy, T., et al. (2017). Development of an item bank for computerized adaptive testing of self-reported cognitive difficulty in cancer patients. Neuro-Oncology Practice,4(3), 189–196.PubMedPubMedCentralCrossRef Dirven, L., Taphoorn, M. J., Groenvold, M., Habets, E. J. J., Aaronson, N. K., Conroy, T., et al. (2017). Development of an item bank for computerized adaptive testing of self-reported cognitive difficulty in cancer patients. Neuro-Oncology Practice,4(3), 189–196.PubMedPubMedCentralCrossRef
6.
go back to reference Gamper, E. M., Groenvold, M., Petersen, M Aa, Young, T., Costantini, A., Aaronson, N., et al. (2014). The EORTC emotional functioning computer adaptive test (CAT): phase I-III of a cross-cultural item bank development. Psycho-Oncology,23, 397–403.PubMedCrossRef Gamper, E. M., Groenvold, M., Petersen, M Aa, Young, T., Costantini, A., Aaronson, N., et al. (2014). The EORTC emotional functioning computer adaptive test (CAT): phase I-III of a cross-cultural item bank development. Psycho-Oncology,23, 397–403.PubMedCrossRef
7.
go back to reference Gamper, E. M., Petersen, M. Aa., Aaronson, N., Costantini, A., Giesinger, J. M., Holzner, B. et al (2016). Development of an item bank for the EORTC Role Functioning Computer Adaptive Test (EORTC RF-CAT). Health Qual Life Outcomes, 14, 72PubMedPubMedCentralCrossRef Gamper, E. M., Petersen, M. Aa., Aaronson, N., Costantini, A., Giesinger, J. M., Holzner, B. et al (2016). Development of an item bank for the EORTC Role Functioning Computer Adaptive Test (EORTC RF-CAT). Health Qual Life Outcomes, 14, 72PubMedPubMedCentralCrossRef
8.
go back to reference Giesinger, J. M., Petersen, M. A., Groenvold, M., Aaronson, N. K., Arraras, J. I., Conroy, T., et al. (2011). Cross-cultural development of an item list for computer-adaptive testing of fatigue in oncological patients. Health Qual Life Outcomes,9(19), 19.PubMedPubMedCentralCrossRef Giesinger, J. M., Petersen, M. A., Groenvold, M., Aaronson, N. K., Arraras, J. I., Conroy, T., et al. (2011). Cross-cultural development of an item list for computer-adaptive testing of fatigue in oncological patients. Health Qual Life Outcomes,9(19), 19.PubMedPubMedCentralCrossRef
9.
go back to reference Petersen, M Aa, Groenvold, M., Aaronson, N. K., Chie, W.-C., Conroy, T., Costantini, A., et al. (2010). Development of computerised adaptive testing (CAT) for the EORTC QLQ-C30 dimensions—General approach and initial results for physical functioning. European Journal of Cancer,46, 1352–1358.PubMedCrossRef Petersen, M Aa, Groenvold, M., Aaronson, N. K., Chie, W.-C., Conroy, T., Costantini, A., et al. (2010). Development of computerised adaptive testing (CAT) for the EORTC QLQ-C30 dimensions—General approach and initial results for physical functioning. European Journal of Cancer,46, 1352–1358.PubMedCrossRef
10.
go back to reference Petersen, M Aa, Groenvold, M., Aaronson, N. K., Chie, W.-C., Conroy, T., Costantini, A., et al. (2011). Development of computerized adaptive testing (CAT) for the EORTC QLQ-C30 physical functioning dimension. Quality of Life Research,20(4), 479–490.PubMedCrossRef Petersen, M Aa, Groenvold, M., Aaronson, N. K., Chie, W.-C., Conroy, T., Costantini, A., et al. (2011). Development of computerized adaptive testing (CAT) for the EORTC QLQ-C30 physical functioning dimension. Quality of Life Research,20(4), 479–490.PubMedCrossRef
11.
go back to reference Petersen, M Aa, Giesinger, J. M., Holzner, B., Arraras, J. I., Conroy, T., Gamper, E. M., et al. (2013). Psychometric evaluation of the EORTC computerized adaptive test (CAT) fatigue item pool. Quality of Life Research,22(9), 2443–2454.PubMedCrossRef Petersen, M Aa, Giesinger, J. M., Holzner, B., Arraras, J. I., Conroy, T., Gamper, E. M., et al. (2013). Psychometric evaluation of the EORTC computerized adaptive test (CAT) fatigue item pool. Quality of Life Research,22(9), 2443–2454.PubMedCrossRef
12.
go back to reference Petersen, M Aa, Aaronson, N. K., Arraras, J. I., Chie, W.-C., Conroy, T., Costantini, A., et al. (2013). The EORTC computer-adaptive tests measuring physical functioning and fatigue exhibited high levels of measurement precision and efficiency. Journal of Clinical Epidemiology,66(3), 330–339.PubMedCrossRef Petersen, M Aa, Aaronson, N. K., Arraras, J. I., Chie, W.-C., Conroy, T., Costantini, A., et al. (2013). The EORTC computer-adaptive tests measuring physical functioning and fatigue exhibited high levels of measurement precision and efficiency. Journal of Clinical Epidemiology,66(3), 330–339.PubMedCrossRef
13.
go back to reference Petersen, M Aa, Aaronson, N. K., Chie, W.-C., Conroy, T., Costantini, A., Hammerlid, E., et al. (2016). Development of an item bank for computerized adaptive test (CAT) measurement of pain. Quality of Life Research,25(1), 1–11.PubMedCrossRef Petersen, M Aa, Aaronson, N. K., Chie, W.-C., Conroy, T., Costantini, A., Hammerlid, E., et al. (2016). Development of an item bank for computerized adaptive test (CAT) measurement of pain. Quality of Life Research,25(1), 1–11.PubMedCrossRef
14.
go back to reference Petersen, M Aa, Gamper, E. M., Costantini, A., Giesinger, J. M., Holzner, B., Johnson, C., et al. (2016). An emotional functioning item bank of 24 items for computer adaptive testing (CAT) was established. Journal of Clinical Epidemiology,70, 90–100.PubMedCrossRef Petersen, M Aa, Gamper, E. M., Costantini, A., Giesinger, J. M., Holzner, B., Johnson, C., et al. (2016). An emotional functioning item bank of 24 items for computer adaptive testing (CAT) was established. Journal of Clinical Epidemiology,70, 90–100.PubMedCrossRef
15.
go back to reference Thamsborg, L. H., Petersen, M Aa, Aaronson, N. K., Chie, W.-C., Costantini, A., Holzner, B., et al. (2014). Development of a lack of appetite item bank for computer-adaptive testing (CAT). Supportive Care in Cancer,23(6), 1541–1548.PubMedCrossRef Thamsborg, L. H., Petersen, M Aa, Aaronson, N. K., Chie, W.-C., Costantini, A., Holzner, B., et al. (2014). Development of a lack of appetite item bank for computer-adaptive testing (CAT). Supportive Care in Cancer,23(6), 1541–1548.PubMedCrossRef
16.
go back to reference Liegl, G., Petersen, M Aa, Groenvold, M., Aaronson, N. K., Costantini, A., Fayers, P. M., et al. (2019). Establishing the European Norm for the health-related quality of life domains of the computer-adaptive test EORTC CAT Core. European Journal of Cancer,107, 133–141.PubMedCrossRef Liegl, G., Petersen, M Aa, Groenvold, M., Aaronson, N. K., Costantini, A., Fayers, P. M., et al. (2019). Establishing the European Norm for the health-related quality of life domains of the computer-adaptive test EORTC CAT Core. European Journal of Cancer,107, 133–141.PubMedCrossRef
17.
go back to reference Fayers, P. M., Aaronson, N. K., Bjordal, K., Groenvold, M., Curran, D., & Bottomley, A. (2001). The EORTC QLQ-C30 scoring manual (third). Brussels: European Organisation for Research and Treatment of Cancer. Fayers, P. M., Aaronson, N. K., Bjordal, K., Groenvold, M., Curran, D., & Bottomley, A. (2001). The EORTC QLQ-C30 scoring manual (third). Brussels: European Organisation for Research and Treatment of Cancer.
18.
go back to reference Oken, M. M., Creech, R. H., Tormey, D. C., Horton, J., Davis, T. E., McFadden, E. T., et al. (1982). Toxicity and response criteria of the Eastern Cooperative Oncology Group. American Journal of Clinical Oncology,5(6), 649–655.PubMedCrossRef Oken, M. M., Creech, R. H., Tormey, D. C., Horton, J., Davis, T. E., McFadden, E. T., et al. (1982). Toxicity and response criteria of the Eastern Cooperative Oncology Group. American Journal of Clinical Oncology,5(6), 649–655.PubMedCrossRef
19.
go back to reference Reise, S. P., & Revicki, D. A. (2015). Handbook of item response theory modeling: Applications to typical performance assessment. New York: Routledge. Reise, S. P., & Revicki, D. A. (2015). Handbook of item response theory modeling: Applications to typical performance assessment. New York: Routledge.
20.
go back to reference Fayers, P. M., & Machin, D. (2016). Quality of life—The assessment, analysis and reporting of patient-reported outcomes (3rd ed.). Chichester, West Sussex: Wiley. Fayers, P. M., & Machin, D. (2016). Quality of life—The assessment, analysis and reporting of patient-reported outcomes (3rd ed.). Chichester, West Sussex: Wiley.
21.
go back to reference Jabbarian, L. J., Groenvold, M., Petersen, M Aa, Christensen, C. A., Deliens, L., van der Heide, A., et al. (2018). Assessing emotional functioning with increased power: Relative validity of a customized EORTC short form in the international ACTION Trial. Value in Health,22, 92–98.PubMedCrossRef Jabbarian, L. J., Groenvold, M., Petersen, M Aa, Christensen, C. A., Deliens, L., van der Heide, A., et al. (2018). Assessing emotional functioning with increased power: Relative validity of a customized EORTC short form in the international ACTION Trial. Value in Health,22, 92–98.PubMedCrossRef
22.
go back to reference Wilcox, R. R. (2012). Introduction to Robust Estimation and Hypothesis Testing (3rd). San Diego: Academic Press, Elsevier Inc. Wilcox, R. R. (2012). Introduction to Robust Estimation and Hypothesis Testing (3rd). San Diego: Academic Press, Elsevier Inc.
Metagegevens
Titel
International validation of the EORTC CAT Core: a new adaptive instrument for measuring core quality of life domains in cancer
Auteurs
Morten Aa. Petersen
Neil K. Aaronson
Thierry Conroy
Anna Costantini
Johannes M. Giesinger
Eva Hammerlid
Bernhard Holzner
Colin D. Johnson
Jacobien M. Kieffer
Marieke van Leeuwen
Sandra Nolte
John K. Ramage
Krzysztof A. Tomaszewski
Annika Waldmann
Teresa Young
Paola Zotti
Mogens Groenvold
on behalf of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group
Publicatiedatum
18-01-2020
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 5/2020
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-020-02421-9

Andere artikelen Uitgave 5/2020

Quality of Life Research 5/2020 Naar de uitgave