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Gepubliceerd in: Journal of Autism and Developmental Disorders 1/2019

27-09-2018 | Original Paper

Internalizing Symptoms Mediate the Relation Between Acute Pain and Autism in Adults

Auteurs: D. Garcia-Villamisar, D. Moore, M. Garcia-Martínez

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 1/2019

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Abstract

Research on pain in autism spectrum disorder (ASD) is in its infancy, with almost nothing known about how individual differences may predicting pain response in ASD. In the present study, 45 adults (28 male, age 22–48 years) with diagnoses of autism and intellectual delay were observed during vaccination or dental cleaning and their pain behaviours coded and measures of autism symptom severity, anxiety, depression and obsessivity taken. Our findings showed that greater autism severity predicted greater pain response which was partially mediated by anxiety and depression. These data suggest that mental health symptoms are important when considering pain response in autism. Mood must therefore be considered in future research on pain in ASD as well as clinical pain management.
Literatuur
go back to reference American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th edn.). Arlington: American Psychiatric Publishing.CrossRef American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th edn.). Arlington: American Psychiatric Publishing.CrossRef
go back to reference Anderson, D. K., Lord, C., Risi, S., DiLavore, P. S., Shulman, C., Thurm, A., et al. (2007). Patterns of growth in verbal abilities among children with autism spectrum disorder. Journal of Consulting and Clinical Psychology, 75(4), 594.CrossRef Anderson, D. K., Lord, C., Risi, S., DiLavore, P. S., Shulman, C., Thurm, A., et al. (2007). Patterns of growth in verbal abilities among children with autism spectrum disorder. Journal of Consulting and Clinical Psychology, 75(4), 594.CrossRef
go back to reference Bair, M. J., Poleshuck, E. L., Wu, J., Krebs, E. K., Damush, T. M., Tu, W., & Kroenke, K. (2013). Anxiety but not social stressors predict 12-month depression and pain severity. The Clinical Journal of Pain, 29(2), 95.CrossRef Bair, M. J., Poleshuck, E. L., Wu, J., Krebs, E. K., Damush, T. M., Tu, W., & Kroenke, K. (2013). Anxiety but not social stressors predict 12-month depression and pain severity. The Clinical Journal of Pain, 29(2), 95.CrossRef
go back to reference Bakken, T. L., Helverschou, S. B., Eilertsen, D. E., Heggelund, T., Myrbakk, E., & Martinsen, H. (2010). Psychiatric disorders in adolescents and adults with autism and intellectual disability: A representative study in one county in Norway. Research in Developmental Disabilities, 31(6), 1669–1677.CrossRef Bakken, T. L., Helverschou, S. B., Eilertsen, D. E., Heggelund, T., Myrbakk, E., & Martinsen, H. (2010). Psychiatric disorders in adolescents and adults with autism and intellectual disability: A representative study in one county in Norway. Research in Developmental Disabilities, 31(6), 1669–1677.CrossRef
go back to reference Bottos, S., & Chambers, C. T. (2006). The epidemiology of pain in developmental disabilities. In F. Symons & T. Oberlander (Eds.), Pain in individuals with developmental disabilities (pp. 67–87). Baltimore: Paul H. Brookes. Bottos, S., & Chambers, C. T. (2006). The epidemiology of pain in developmental disabilities. In F. Symons & T. Oberlander (Eds.), Pain in individuals with developmental disabilities (pp. 67–87). Baltimore: Paul H. Brookes.
go back to reference Buck, T. R., Viskochil, J., Farley, M., Coon, H., McMahon, W. M., Morgan, J., & Bilder, D. A. (2014). Psychiatric comorbidity and medication use in adults with autism spectrum disorder. Journal of Autism and Developmental Disorders, 44(12), 3063–3071.CrossRef Buck, T. R., Viskochil, J., Farley, M., Coon, H., McMahon, W. M., Morgan, J., & Bilder, D. A. (2014). Psychiatric comorbidity and medication use in adults with autism spectrum disorder. Journal of Autism and Developmental Disorders, 44(12), 3063–3071.CrossRef
go back to reference Castillo, R. C., Wegener, S. T., Heins, S. E., Haythornthwaite, J. A., MacKenzie, E. J., Bosse, M. J., & Group, L. S. (2013). Longitudinal relationships between anxiety, depression, and pain: Results from a two-year cohort study of lower extremity trauma patients. PAIN, 154(12), 2860–2866.CrossRef Castillo, R. C., Wegener, S. T., Heins, S. E., Haythornthwaite, J. A., MacKenzie, E. J., Bosse, M. J., & Group, L. S. (2013). Longitudinal relationships between anxiety, depression, and pain: Results from a two-year cohort study of lower extremity trauma patients. PAIN, 154(12), 2860–2866.CrossRef
go back to reference Charman, T., Pickles, A., Simonoff, E., Chandler, S., Loucas, T., & Baird, G. (2011). IQ in children with autism spectrum disorders: data from the special needs and autism project (SNAP). Psychological Medicine, 41(03), 619–627.CrossRef Charman, T., Pickles, A., Simonoff, E., Chandler, S., Loucas, T., & Baird, G. (2011). IQ in children with autism spectrum disorders: data from the special needs and autism project (SNAP). Psychological Medicine, 41(03), 619–627.CrossRef
go back to reference Courtemanche, A. B., & Black, W. R. (2016). Everyday expressions of pain in children with and without autism spectrum disorder. Research in Autism Spectrum Disorders, 26, 65–70.CrossRef Courtemanche, A. B., & Black, W. R. (2016). Everyday expressions of pain in children with and without autism spectrum disorder. Research in Autism Spectrum Disorders, 26, 65–70.CrossRef
go back to reference Duerden, E. G., Card, D., Roberts, S. W., Mak-Fan, K. M., Chakravarty, M. M., Lerch, J. P., & Taylor, M. J. (2014). Self-injurious behaviours are associated with alterations in the somatosensory system in children with autism spectrum disorder. Brain Structure and Function, 219(4), 1251–1261.CrossRef Duerden, E. G., Card, D., Roberts, S. W., Mak-Fan, K. M., Chakravarty, M. M., Lerch, J. P., & Taylor, M. J. (2014). Self-injurious behaviours are associated with alterations in the somatosensory system in children with autism spectrum disorder. Brain Structure and Function, 219(4), 1251–1261.CrossRef
go back to reference Duerden, E. G., Oatley, H. K., Mak-Fan, K. M., McGrath, P. A., Taylor, M. J., Szatmari, P., & Roberts, S. W. (2012). Risk factors associated with self-injurious behaviors in children and adolescents with autism spectrum disorders. Journal of Autism and Developmental Disorders, 42(11), 2460–2470.CrossRef Duerden, E. G., Oatley, H. K., Mak-Fan, K. M., McGrath, P. A., Taylor, M. J., Szatmari, P., & Roberts, S. W. (2012). Risk factors associated with self-injurious behaviors in children and adolescents with autism spectrum disorders. Journal of Autism and Developmental Disorders, 42(11), 2460–2470.CrossRef
go back to reference Duerden, E. G., Taylor, M. J., Lee, M., McGrath, P. A., Davis, K. D., & Roberts, S. W. (2015). Decreased sensitivity to thermal stimuli in adolescents with autism spectrum disorder: Relation to symptomatology and cognitive ability. The Journal of Pain, 16(5), 463–471.CrossRef Duerden, E. G., Taylor, M. J., Lee, M., McGrath, P. A., Davis, K. D., & Roberts, S. W. (2015). Decreased sensitivity to thermal stimuli in adolescents with autism spectrum disorder: Relation to symptomatology and cognitive ability. The Journal of Pain, 16(5), 463–471.CrossRef
go back to reference Fanurik, D., Koh, J. L., Schmitz, M. L., Harrison, D. E., & Conrad, T. M. (1999). Children with cognitive impairment: Parent report of pain and coping. Journal of Developmental & Behavioral Pediatrics, 20(4), 228–234.CrossRef Fanurik, D., Koh, J. L., Schmitz, M. L., Harrison, D. E., & Conrad, T. M. (1999). Children with cognitive impairment: Parent report of pain and coping. Journal of Developmental & Behavioral Pediatrics, 20(4), 228–234.CrossRef
go back to reference Fontenelle, I. S., Fontenelle, L. F., Borges, M. C., Prazeres, A. M., Rangé, B. P., Mendlowicz, M. V., & Versiani, M. (2010). Quality of life and symptom dimensions of patients with obsessive–compulsive disorder. Psychiatry Research, 179(2), 198–203.CrossRef Fontenelle, I. S., Fontenelle, L. F., Borges, M. C., Prazeres, A. M., Rangé, B. P., Mendlowicz, M. V., & Versiani, M. (2010). Quality of life and symptom dimensions of patients with obsessive–compulsive disorder. Psychiatry Research, 179(2), 198–203.CrossRef
go back to reference Gavaruzzi, T., Carnaghi, A., Lotto, L., Rumiati, R., Meggiato, T., Polato, F., & Lazzari, F. (2010). Recalling pain experienced during a colonoscopy: Pain expectation and variability. British Journal of Health Psychology, 15(2), 253–264.CrossRef Gavaruzzi, T., Carnaghi, A., Lotto, L., Rumiati, R., Meggiato, T., Polato, F., & Lazzari, F. (2010). Recalling pain experienced during a colonoscopy: Pain expectation and variability. British Journal of Health Psychology, 15(2), 253–264.CrossRef
go back to reference Helverschou, S. B., Bakken, T. L., & Martinsen, H. (2009). The psychopathology in autism checklist (PAC): A pilot study. Research in Autism Spectrum Disorders, 3(1), 179–195.CrossRef Helverschou, S. B., Bakken, T. L., & Martinsen, H. (2009). The psychopathology in autism checklist (PAC): A pilot study. Research in Autism Spectrum Disorders, 3(1), 179–195.CrossRef
go back to reference Jochum, T., Letzsch, A., Greiner, W., Wagner, G., Sauer, H., & Bär, K.-J. (2006). Influence of antipsychotic medication on pain perception in schizophrenia. Psychiatry Research, 142(2), 151–156.CrossRef Jochum, T., Letzsch, A., Greiner, W., Wagner, G., Sauer, H., & Bär, K.-J. (2006). Influence of antipsychotic medication on pain perception in schizophrenia. Psychiatry Research, 142(2), 151–156.CrossRef
go back to reference Joshi, G., Wozniak, J., Petty, C., Martelon, M. K., Fried, R., Bolfek, A., et al. (2013). Psychiatric comorbidity and functioning in a clinically referred population of adults with autism spectrum disorders: A comparative study. Journal of Autism and Developmental Disorders, 43(6), 1314–1325.CrossRef Joshi, G., Wozniak, J., Petty, C., Martelon, M. K., Fried, R., Bolfek, A., et al. (2013). Psychiatric comorbidity and functioning in a clinically referred population of adults with autism spectrum disorders: A comparative study. Journal of Autism and Developmental Disorders, 43(6), 1314–1325.CrossRef
go back to reference Kemani, M. K., Olsson, G. L., Lekander, M., Hesser, H., Andersson, E., & Wicksell, R. K. (2015). Efficacy and cost-effectiveness of acceptance and commitment therapy and applied relaxation for longstanding pain: A randomized controlled trial. The Clinical Journal of Pain, 31(11), 1004–1016.CrossRef Kemani, M. K., Olsson, G. L., Lekander, M., Hesser, H., Andersson, E., & Wicksell, R. K. (2015). Efficacy and cost-effectiveness of acceptance and commitment therapy and applied relaxation for longstanding pain: A randomized controlled trial. The Clinical Journal of Pain, 31(11), 1004–1016.CrossRef
go back to reference Koenen, L. R., Icenhour, A., Forkmann, K., Pasler, A., Theysohn, N., Forsting, M., et al. (2017). Greater fear of visceral pain contributes to differences between visceral and somatic pain in healthy women. PAIN, 158(8), 1599–1608.CrossRef Koenen, L. R., Icenhour, A., Forkmann, K., Pasler, A., Theysohn, N., Forsting, M., et al. (2017). Greater fear of visceral pain contributes to differences between visceral and somatic pain in healthy women. PAIN, 158(8), 1599–1608.CrossRef
go back to reference Lautenbacher, S., Bär, K.-J., Eisold, P., & Kunz, M. (2016). Understanding facial expressions of pain in patients with depression. The Journal of Pain, 18, 376–384.CrossRef Lautenbacher, S., Bär, K.-J., Eisold, P., & Kunz, M. (2016). Understanding facial expressions of pain in patients with depression. The Journal of Pain, 18, 376–384.CrossRef
go back to reference Lotan, M., Ljunggren, E. A., Johnsen, T. B., Defrin, R., Pick, C. G., & Strand, L. I. (2009). A modified version of the Non-Communicating Children Pain Checklist-Revised, adapted to adults with intellectual and developmental disabilities: Sensitivity to pain and internal consistency. The Journal of Pain, 10(4), 398–407.CrossRef Lotan, M., Ljunggren, E. A., Johnsen, T. B., Defrin, R., Pick, C. G., & Strand, L. I. (2009). A modified version of the Non-Communicating Children Pain Checklist-Revised, adapted to adults with intellectual and developmental disabilities: Sensitivity to pain and internal consistency. The Journal of Pain, 10(4), 398–407.CrossRef
go back to reference Lotan, M., Moe-Nilssen, R., Ljunggren, A., & Strand, L. (2010). Measurement properties of the non-communicating adult pain checklist (NCAPC): A pain scale for adults with intellectual and developmental disabilities, scored in a clinical setting. Research in Developmental Disabilities, 31(2), 367–375.CrossRef Lotan, M., Moe-Nilssen, R., Ljunggren, A., & Strand, L. (2010). Measurement properties of the non-communicating adult pain checklist (NCAPC): A pain scale for adults with intellectual and developmental disabilities, scored in a clinical setting. Research in Developmental Disabilities, 31(2), 367–375.CrossRef
go back to reference Matson, J. L., Boisjoli, J. A., Gonzalez, M. L., Smith, K. R., & Wilkins, J. (2007). Norms and cut off scores for the autism spectrum disorders diagnosis for adults (ASD-DA) with intellectual disability. Research in Autism Spectrum Disorders, 1(4), 330–338.CrossRef Matson, J. L., Boisjoli, J. A., Gonzalez, M. L., Smith, K. R., & Wilkins, J. (2007). Norms and cut off scores for the autism spectrum disorders diagnosis for adults (ASD-DA) with intellectual disability. Research in Autism Spectrum Disorders, 1(4), 330–338.CrossRef
go back to reference Matson, J. L., Wilkins, J., Boisjoli, J. A., & Smith, K. R. (2008). The validity of the autism spectrum disorders-diagnosis for intellectually disabled adults (ASD-DA). Research in Developmental Disabilities, 29(6), 537–546.CrossRef Matson, J. L., Wilkins, J., Boisjoli, J. A., & Smith, K. R. (2008). The validity of the autism spectrum disorders-diagnosis for intellectually disabled adults (ASD-DA). Research in Developmental Disabilities, 29(6), 537–546.CrossRef
go back to reference McGrath, P. J., Rosmus, C., Canfield, C., Campbell, M. A., & Hennigar, A. (1998). Behaviours caregivers use to determine pain in non-verbal, cognitively impaired individuals. Developmental Medicine and child Neurology, 40(5), 340–343.PubMed McGrath, P. J., Rosmus, C., Canfield, C., Campbell, M. A., & Hennigar, A. (1998). Behaviours caregivers use to determine pain in non-verbal, cognitively impaired individuals. Developmental Medicine and child Neurology, 40(5), 340–343.PubMed
go back to reference Miller, M., & Pisani, E. (1999). The cost of unsafe injections. Bulletin of the World Health Organization, 77(10), 808.PubMedPubMedCentral Miller, M., & Pisani, E. (1999). The cost of unsafe injections. Bulletin of the World Health Organization, 77(10), 808.PubMedPubMedCentral
go back to reference Moore, D. J. (2015). Acute pain experience in individuals with autism spectrum disorders: A review. Autism, 19(4), 387–399.CrossRef Moore, D. J. (2015). Acute pain experience in individuals with autism spectrum disorders: A review. Autism, 19(4), 387–399.CrossRef
go back to reference Moss, P., Howlin, P., Savage, S., Bolton, P., & Rutter, M. (2015). Self and informant reports of mental health difficulties among adults with autism findings from a long-term follow-up study. Autism, 19(7), 832–841.CrossRef Moss, P., Howlin, P., Savage, S., Bolton, P., & Rutter, M. (2015). Self and informant reports of mental health difficulties among adults with autism findings from a long-term follow-up study. Autism, 19(7), 832–841.CrossRef
go back to reference Nader, R., Oberlander, T. F., Chambers, C. T., & Craig, K. D. (2004). Expression of pain in children with autism. The Clinical Journal of Pain, 20(2), 88–97.CrossRef Nader, R., Oberlander, T. F., Chambers, C. T., & Craig, K. D. (2004). Expression of pain in children with autism. The Clinical Journal of Pain, 20(2), 88–97.CrossRef
go back to reference Oberlander, T. F., Gilbert, C. A., Chambers, C. T., O’donnell, M. E., & Craig, K. D. (1999). Biobehavioral responses to acute pain in adolescents with a significant neurologic impairment. The Clinical Journal of Pain, 15(3), 201–209.CrossRef Oberlander, T. F., Gilbert, C. A., Chambers, C. T., O’donnell, M. E., & Craig, K. D. (1999). Biobehavioral responses to acute pain in adolescents with a significant neurologic impairment. The Clinical Journal of Pain, 15(3), 201–209.CrossRef
go back to reference Rattaz, C., Dubois, A., Michelon, M., Viellard, M., Poinso, F., & Baghdadli, A. (2013). How do children with autism spectrum disorders express pain? A comparison with developmentally delayed and typically developing children. PAIN, 154(10), 2007–2013.CrossRef Rattaz, C., Dubois, A., Michelon, M., Viellard, M., Poinso, F., & Baghdadli, A. (2013). How do children with autism spectrum disorders express pain? A comparison with developmentally delayed and typically developing children. PAIN, 154(10), 2007–2013.CrossRef
go back to reference Wing, L. (1976). Diagnosis, clinical description and prognosis. In L. Wing (Ed.), Early childhood autism (2nd ed.). Oxford: Pergamon Press. Wing, L. (1976). Diagnosis, clinical description and prognosis. In L. Wing (Ed.), Early childhood autism (2nd ed.). Oxford: Pergamon Press.
go back to reference Wing, L. (1996). Autistic spectrum disorders. British Medical Journal, 312(7027), 327–328.CrossRef Wing, L. (1996). Autistic spectrum disorders. British Medical Journal, 312(7027), 327–328.CrossRef
go back to reference Wise, T. N., Fishbain, D. A., & Holder-Perkins, V. (2007). Painful physical symptoms in depression: A clinical challenge. Pain Medicine, 8(s2), S75–S82.CrossRef Wise, T. N., Fishbain, D. A., & Holder-Perkins, V. (2007). Painful physical symptoms in depression: A clinical challenge. Pain Medicine, 8(s2), S75–S82.CrossRef
go back to reference Yasuda, Y., Hashimoto, R., Nakae, A., Kang, H., Ohi, K., Yamamori, H., et al. (2016). Sensory cognitive abnormalities of pain in autism spectrum disorder: A case–control study. Annals of General Psychiatry, 15(1), 8.CrossRef Yasuda, Y., Hashimoto, R., Nakae, A., Kang, H., Ohi, K., Yamamori, H., et al. (2016). Sensory cognitive abnormalities of pain in autism spectrum disorder: A case–control study. Annals of General Psychiatry, 15(1), 8.CrossRef
Metagegevens
Titel
Internalizing Symptoms Mediate the Relation Between Acute Pain and Autism in Adults
Auteurs
D. Garcia-Villamisar
D. Moore
M. Garcia-Martínez
Publicatiedatum
27-09-2018
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 1/2019
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-018-3765-9

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