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Gepubliceerd in: Journal of Autism and Developmental Disorders 11/2017

02-08-2017 | Original Paper

Interactive Effects of Prenatal Antidepressant Exposure and Likely Gene Disrupting Mutations on the Severity of Autism Spectrum Disorder

Auteurs: Sean Ackerman, Sarah Schoenbrun, Caitlin Hudac, Raphael Bernier

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 11/2017

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Abstract

To examine the interactive effects of two proposed risk factors which may contribute to symptom severity of Autism Spectrum Disorder (ASD): prenatal antidepressant exposure and likely gene-disrupting (LGD) mutations. Participants included 2748 individuals with ASD from the Simons Simplex Collection. We examined the effects of prenatal antidepressant exposure, maternal depression, presence of an LGD mutation and their interaction on ASD severity. We found a significant interactive effect between antidepressant exposure and the presence of an LGD mutation on ASD severity in the ADOS and ADI-R verbal communication domains. We consider a “two-hit” model in which one variable lays the foundation for an initial risk which is compounded by a second variable.
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Metagegevens
Titel
Interactive Effects of Prenatal Antidepressant Exposure and Likely Gene Disrupting Mutations on the Severity of Autism Spectrum Disorder
Auteurs
Sean Ackerman
Sarah Schoenbrun
Caitlin Hudac
Raphael Bernier
Publicatiedatum
02-08-2017
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 11/2017
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-017-3246-6