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Gepubliceerd in: Journal of Autism and Developmental Disorders 6/2021

06-09-2020 | Original Paper

Interaction of Blood Manganese Concentrations with GSTT1 in Relation to Autism Spectrum Disorder in Jamaican Children

Auteurs: Mohammad H. Rahbar, Maureen Samms-Vaughan, Sepideh Saroukhani, MinJae Lee, Jing Zhang, Jan Bressler, Manouchehr Hessabi, Sydonnie Shakespeare-Pellington, Megan L. Grove, Katherine A. Loveland

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2021

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Abstract

Using data from 266 age- and sex-matched pairs of Jamaican children with autism spectrum disorder (ASD) and typically developing (TD) controls (2–8 years), we investigated whether glutathione S-transferase theta 1 (GSTT1) modifies the association between blood manganese concentrations (BMC) and ASD. After adjusting conditional logistic regression models for socioeconomic status and the interaction between GSTT1 and GSTP1 (glutathione S-transferase pi 1), using a recessive genetic model for GSTT1 and either a co-dominant or dominant model for GSTP1, the interaction between GSTT1 and BMC was significant (P = 0.02, P = 0.01, respectively). Compared to controls, ASD cases with GSTT1-DD genotype had 4.33 and 4.34 times higher odds of BMC > 12 vs. ≤ 8.3 μg/L, respectively. Replication in other populations is warranted.
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Metagegevens
Titel
Interaction of Blood Manganese Concentrations with GSTT1 in Relation to Autism Spectrum Disorder in Jamaican Children
Auteurs
Mohammad H. Rahbar
Maureen Samms-Vaughan
Sepideh Saroukhani
MinJae Lee
Jing Zhang
Jan Bressler
Manouchehr Hessabi
Sydonnie Shakespeare-Pellington
Megan L. Grove
Katherine A. Loveland
Publicatiedatum
06-09-2020
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 6/2021
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-020-04677-z