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01-07-2015 | Original Paper | Uitgave 7/2015

Inter-Pregnancy Intervals and the Risk of Autism Spectrum Disorder: Results of a Population-Based Study

Tijdschrift:: Journal of Autism and Developmental Disorders > Uitgave 7/2015

Auteurs:: Maureen S. Durkin, Lindsay A. DuBois, Matthew J. Maenner

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Abstract

Recent studies have reported an increased risk of autism among second-born children conceived <12 versus >36 months after the birth of a sibling. Confirmation of this finding would point to inter-pregnancy interval (IPI) as a potentially modifiable risk factor for autism. This study evaluated the relationship between IPI and autism spectrum disorder (ASD) risk in a Wisconsin birth cohort of 31,467 second-born children, of whom 160 resided in the study area and were found to have ASD at age 8 years. In adjusted analyses, both short (<12) and long (>84 month) IPIs were associated with a two-fold risk of ASD relative to IPIs of 24–47 months (p < 0.05). The long IPI association was partially confounded by history of previous pregnancy loss.

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Titel: Inter-Pregnancy Intervals and the Risk of Autism Spectrum Disorder: Results of a Population-Based Study
Auteurs:: Maureen S. Durkin
Lindsay A. DuBois
Matthew J. Maenner
Publicatiedatum: 01-07-2015
DOI: https://doi.org/10.1007/s10803-015-2368-y
Uitgeverij: Springer US
Tijdschrift: Journal of Autism and Developmental Disorders
Uitgave 7/2015
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

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