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24-01-2023 | ORIGINAL PAPER

Intensive Mindfulness Meditation Reduces Frequency and Burden of Migraine: An Unblinded Single-Arm Trial

Auteurs: Madhav Goyal, Jennifer A. Haythornthwaite, Sharat Jain, Barbara Lee Peterlin, Megha Mehrotra, David Levine, Jason D. Rosenberg, Mary Minges, David A. Seminowicz, Daniel E. Ford

Gepubliceerd in: Mindfulness | Uitgave 2/2023

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Abstract

Objectives

Preventing migraine headaches and improving the quality of life for patients with migraine remains a challenge. We hypothesized intensive meditation training would reduce the disease burden of migraine.

Method

An unblinded trial was analyzed as a single cohort exposed to a silent 10-day Vipassana meditation retreat that included 100 hr of sitting meditation. Participants with chronic or episodic migraine were enrolled and followed for 1 year. The primary outcome was a change in mean monthly migraine days at 12 months from baseline. Secondary outcomes included headache frequency and intensity, acute medication use, work days missed, home meditation, sleep quality, general health, quality of life, migraine impact, positive and negative affect, perceived stress, mindfulness, and pain catastrophizing.

Results

Three hundred people were screened and 58 (19%) agreed to participate and enrolled in the intensive meditation training. Forty-six participants with chronic migraine (≥ 15 headaches/month of which ≥ 8 were migraines) and 12 with episodic migraine (< 15 and ≥ 4 migraines/month) attended and 45 (78%) completed the retreat. At 12 months, the average migraine frequency was reduced by 2.7 days (from 16.6 at baseline) per 28 days (95%CI − 4.3, − 1.3) and headaches by 3.4 (20.1 at baseline) per 28 days (− 4.9, − 1.9). Fifty percent responder rate was 29% for migraine. Acute medication use dropped by an average of 2.2 days (− 3.9, − 0.5) per 28 days, and participants reported 2.3 fewer days (− 4.0, − 0.5) on which they reduced their activity due to migraines. The most striking and promising effects were in several secondary outcomes, including migraine-specific quality of life, pain catastrophizing, and perceived stress. The significant improvements observed immediately following the intervention were sustained at 12 months follow-up.

Conclusions

Training in Vipassana meditation via a 10-day retreat may reduce the frequency and burden of migraine.

Preregistration

ClinicalTrials.​gov: NCT00663585.
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Metagegevens
Titel
Intensive Mindfulness Meditation Reduces Frequency and Burden of Migraine: An Unblinded Single-Arm Trial
Auteurs
Madhav Goyal
Jennifer A. Haythornthwaite
Sharat Jain
Barbara Lee Peterlin
Megha Mehrotra
David Levine
Jason D. Rosenberg
Mary Minges
David A. Seminowicz
Daniel E. Ford
Publicatiedatum
24-01-2023
Uitgeverij
Springer US
Gepubliceerd in
Mindfulness / Uitgave 2/2023
Print ISSN: 1868-8527
Elektronisch ISSN: 1868-8535
DOI
https://doi.org/10.1007/s12671-023-02073-z