The purpose of our commentary is to underscore key take-home points of the 11 articles in this special series on appraisals and trauma. Two important take-home points relate to (i) the question of whether appraisals mediate the relationship between trauma and trauma-relevant symptoms, and (ii) the methodological innovations presented here. Further, we discuss three features characterizing this special issue. First, it includes papers examining the role of negative appraisals as a correlate, predictor, and potential causal risk factor of posttraumatic stress symptoms; second, the studies use a multifaceted approach to study negative appraisals; third, they range from theory-driven experimental research to applied clinical studies. We conclude by reflecting on challenges raised by these contributions and suggest directions for future research.