Introduction
Methods
Study population
EQ-5D
Main experiment
Secondary experiment
Statistical analysis and exclusions
Secondary experiment
Results
Sample description
Norway % | Strict n (%) | Inclusive n (%) | |||||
---|---|---|---|---|---|---|---|
LT-TTO | Classic TTO | TTO-5 | LT-TTO | Classic TTO | TTO-5 | ||
n
| 411 | 218 | 396 | 484 | 328 | 437 | |
Age | |||||||
18–29 | 20 | 86 (20.9) | 47 (21.6) | 60 (15.2) | 92 (19.0) | 51 (15.5) | 61 (14.0) |
30–39 | 17.8 | 78 (19.0) | 50 (22.9) | 74 (18.7) | 90 (18.6) | 61 (18.6) | 81 (18.5) |
40–49 | 18.7 | 83 (20.2) | 47 (21.6) | 84 (21.2) | 95 (19.6) | 62 (18.9) | 91 (20.8) |
50–59 | 16.3 | 86 (20.9) | 42 (19.3) | 85 (21.5) | 108 (22.3) | 75 (22.9) | 96 (22.0) |
60–69 | 13.7 | 62 (15.1) | 27 (12.4) | 69 (17.4) | 81 (16.7) | 64 (19.5) | 83 (19.0) |
70–79 | 7.7 | 14 (3.4) | 5 (2.39) | 14 (3.5) | 16 (3.3) | 12 (3.7) | 15 (3.4) |
80+ | 5.8 | 2 (0.5) | – | – | 2 (0.4) | 3 (0.9) | – |
Missing | – | – | – | 10 (2.5) | – | – | 10 (2.3) |
Sex | |||||||
Male | 49.6 | 183 (44.5) | 107 (49.1) | 196 (49.5) | 217 (44.8) | 153 (46.6) | 217 (49.7) |
Female | 50.4 | 228 (55.5) | 111 (50.9) | 190 (48.0) | 267 (55.2) | 175 (53.4) | 210 (48.1) |
Missing | – | – | – | 10 (2.5) | – | – | 10 (2.3) |
Education (years) | |||||||
8–10 | 29.8 | 27 (6.6) | 13 (6.0) | 23 (5.8) | 35 (7.2) | 26 (7.9) | 29 (6.6) |
11–13 | 42.9 | 132 (32.1) | 77 (3.3) | 129 (32.6) | 163 (33.7) | 102 (31.1) | 147 (33.6) |
>13 | 27.3 | 252 (61.3) | 128 (58.7) | 234 (59.1) | 286 (59.1) | 200 (61.0) | 251 (57.4) |
Missing | – | – | – | 10 (2.5) | – | – | 10 (2.3) |
Group | Inclusive | Strict | Exclusions | ||||
---|---|---|---|---|---|---|---|
Starting point TTO value |
n
| Mean (SD) |
n
| Mean (SD) |
n (%) | Mean (SD) | |
LT-TTO | 0–>1 | 484 | 0.16 (0.58) | 411 | 0.24 (0.53) | 73 (15) | −0.27 (0.63) |
Group 0 | 0 | 29 | −0.08 (0.61) | 21 | 0.08 (0.52) | 8 (28) | −0.47 (0.64) |
Group 1 | 0.1 | 47 | −0.12 (0.64) | 34 | 0.09 (0.58) | 13 (28) | −0.65 (0.43) |
Group 2 | 0.2 | 45 | 0.13 (0.48) | 38 | 0.2 (0.45) | 7 (16) | −0.27 (0.45) |
Group 3 | 0.3 | 43 | 0.13 (0.53) | 37 | 0.19 (0.5) | 6 (14) | −0.23 (0.52) |
Group 4 | 0.4 | 49 | 0.14 (0.60) | 38 | 0.25 (0.54) | 11 (22) | −0.20 (0.64) |
Group 5 | 0.5 | 54 | 0.18 (0.53) | 48 | 0.27 (0.46) | 6 (11) | −0.59 (0.43) |
Group 6 | 0.6 | 42 | 0.24 (0.53) | 34 | 0.29 (0.49) | 8 (19) | 0.00 (0.58) |
Group 7 | 0.7 | 51 | 0.30 (0.54) | 46 | 0.32 (0.51) | 5 (10) | 0.14 (0.68) |
Group 8 | 0.8 | 33 | 0.27 (0.59) | 28 | 0.3 (0.56) | 5 (15) | 0.09 (0.69) |
Group 9 | 0.9 | 46 | 0.27 (0.58) | 44 | 0.28 (0.58) | 2 (4) | 0.25 (0.48) |
Group 10 | 1 | 45 | 0.24 (0.61) | 43 | 0.26 (0.58) | 2 (4) | −0.05 (0.99) |
Classic TTO | 0 | 328 | −0.08 (0.72) | 218 | 0.28 (0.56) | 110 (33) | −0.80 (0.39) |
TTO + 5 | 0.5 | 437 | 0.31 (0.54) | 396 | 0.36 (0.48) | 41 (9) | −0.17 (0.78) |
LT-TTO regression model
EQ-5D health state | Alla
| 11211 | 11312 | 22222 | 11113 | 32211 | 23232 | 32223 | 33333 |
---|---|---|---|---|---|---|---|---|---|
(a) Strict condition (after exclusions)
| |||||||||
Starting point value | 0.194 (<0.001) | 0.140 (0.001) | 0.261 (<0.001) | 0.206 (0.001) | 0.257 (<0.001) |
0.070 (0.333)
| 0.232 (0.003) | 0.197 (0.019) | 0.189 (0.017) |
Age |
−0.000 (0.402)
|
−0.000 (0.452)
|
−0.000 (0.648)
|
0.000 (0.857)
|
−0.000 (0.644)
|
−0.002 (0.150)
|
−0.003 (0.044)
|
0.001 (0.469)
|
−0.001 (0.344)
|
Sex (1 = female, 0 = male) |
−0.005 (0.860)
|
0.005 (0.833)
|
0.056 (0.158)
|
−0.006 (0.872)
|
0.003 (0.930)
|
−0.033 (0.450)
|
−0.041 (0.400)
|
−0.017 (0.730)
|
−0.014 (0.764)
|
Education 1 (11–13 years) |
−0.008 (0.911)
|
−0.045 (0.449)
|
−0.044 (0.615)
|
−0.057 (0.513)
|
−0.059 (0.537)
|
0.002 (0.981)
|
0.028 (0.792)
|
0.064 (0.565)
|
0.046 (0.659)
|
Education 2 (>13 years) |
0.051 (0.450)
|
0.022 (0.692)
|
−0.005 (0.946)
|
0.023 (0.775)
|
−0.035 (0.694)
|
0.027 (0.761)
|
0.129 (0.196)
|
0.123 (0.240)
|
0.128 (0.196)
|
Constant |
0.152 (0.113)
| 0.684 (<0.001) | 0.310 (0.007) | 0.312 (0.006) |
0.190 (0.136)
| 0.372 (0.003) |
0.006 (0.963)
|
−0.257 (0.082)
| −0.394 (0.004) |
(b) Inclusive condition: all participants
| |||||||||
Starting point value | 0.373 (<0.001) | 0.395 (<0.001) | 0.453 (<0.001) | 0.430 (<0.001) | 0.415 (<0.001) | 0.295 (<0.001) | 0.381 (<0.001) | 0.339 (<0.001) | 0.278 (<0.001) |
Age | −0.002 (0.043) | −0.003 (0.009) | −0.003 (0.038) |
−0.002 (0.082)
|
−0.002 (0.094)
| −0.003 (0.029) | −0.003 (0.025) |
−0.000 (0.813)
|
−0.001 (0.455)
|
Sex (1 = female, 0 = male) | −0.086 (0.021) |
−0.059 (0.135)
|
−0.026 (0.550)
|
−0.067 (0.134)
|
−0.103 (0.024)
| −0.111 (0.016) | −0.127 (0.008) |
−0.084 (0.089)
|
−0.107 (0.025)
|
Education 1 (11–13 years) |
0.041 (0.596)
|
0.049 (0.551)
|
0.033 (0.720)
|
0.003 (0.972)
|
−0.006 (0.946)
|
0.078 (0.422)
|
0.075 (0.449)
|
0.065 (0.528)
|
0.032 (0.745)
|
Education 2 (>13 years) |
0.107 (0.145)
| 0.161 (0.041) |
0.097 (0.268)
|
0.103 (0.243)
|
0.026 (0.766)
|
0.112 (0.223)
| 0.158 (0.095) |
0.125 (0.202)
|
0.077 (0.416)
|
Constant |
0.062 (0.563)
| 0.482 (<0.001) | 0.198 (0.121) | 0.201 (0.121) |
0.130 (0.321)
| 0.205 (0.124) |
−0.085 (0.538)
| −0.267 (0.062) | −0.368 (0.008) |
EQ-5D health state | Alla
| 11211 | 11312 | 22222 | 11113 | 32211 | 23232 | 32223 | 33333 |
---|---|---|---|---|---|---|---|---|---|
(a) Strict condition (after exclusions)
| |||||||||
Starting point value | 0.161 (0.006) | 0.140 (0.001) | 0.261 (<0.001) | 0.206 (0.001) | 0.257 (<0.001) |
0.070 (0.333)
| 0.232 (0.003) | 0.197 (0.019) | 0.189 (0.017) |
Age |
−0.001 (0.246)
|
−0.000 (0.452)
|
−0.000 (0.648)
|
0.000 (0.857)
|
−0.000 (0.644)
|
−0.002 (0.150)
| −0.003 (0.044) |
0.001 (0.469)
|
−0.001 (0.344)
|
Sex (1 = female, 0 = male) |
−0.018 (0.616)
|
0.005 (0.833)
|
0.056 (0.158)
|
−0.006 (0.872)
|
0.003 (0.930)
|
−0.033 (0.450)
|
−0.041 (0.400)
|
−0.017 (0.730)
|
−0.014 (0.764)
|
Education 1 (11–13 years) |
0.043 (0.584)
|
−0.045 (0.449)
|
−0.044 (0.615)
|
−0.057 (0.513)
|
−0.059 (0.537)
|
0.002 (0.981)
|
0.028 (0.792)
|
0.064 (0.565)
|
0.046 (0.659)
|
Education 2 (>13 years) |
0.114 (0.127)
|
0.022 (0.692)
|
−0.005 (0.946)
|
0.023 (0.775)
|
−0.035 (0.694)
|
0.027 (0.761)
|
0.129 (0.196)
|
0.123 (0.240)
|
0.128 (0.196)
|
Constant |
0.118 (0.261)
| 0.684 (<0.001) | 0.310 (0.007) | 0.312 (0.006) |
0.190 (0.136)
| 0.372 (0.003) |
0.006 (0.963)
|
−0.257 (0.082)
| −0.394 (0.004) |
(b) Inclusive condition: all participants
| |||||||||
Starting point value | 0.343 (<0.001) | 0.395 (<0.001) | 0.453 (<0.001) | 0.430 (<0.001) | 0.415 (<0.001) | 0.295 (<0.001) | 0.381 (<0.001) | 0.339 (<0.001) | 0.278 (<0.001) |
Age | −0.003 (0.014) | −0.003 (0.009) | −0.003 (0.038) |
−0.002 (0.082)
|
−0.002 (0.094)
| −0.003 (0.029) | −0.003 (0.025) |
−0.000 (0.813)
|
−0.001 (0.455)
|
Sex (1 = female, 0 = male) | −0.098 (0.014) |
−0.059 (0.135)
|
−0.026 (0.550)
|
−0.067 (0.134)
| −0.103 (0.024) | −0.111 (0.016) | −0.127 (0.008) |
−0.084 (0.089)
| −0.107 (0.025) |
Education 1 (11–13 years) |
0.070 (0.397)
|
0.049 (0.551)
|
0.033 (0.720)
|
0.003 (0.972)
|
−0.006 (0.946)
|
0.078 (0.422)
|
0.075 (0.449)
|
0.065 (0.528)
|
0.032 (0.745)
|
Education 2 (>13 years) |
0.148 (0.060)
| 0.161 (0.041) |
0.097 (0.268)
|
0.103 (0.243)
|
0.026 (0.766)
|
0.112 (0.223)
|
0.158 (0.095)
|
0.125 (0.202)
|
0.077 (0.416)
|
Constant |
0.052 (0.644)
| 0.482 (<0.001) | 0.198 (0.121) | 0.201 (0.121) |
0.130 (0.321)
| 0.205 (0.124) |
−0.085 (0.538)
| −0.267 (0.062) | −0.368 (0.008) |
Comparison of the TTO and TTO + 5
EQ-5D health state | Alla
| 11211 | 11312 | 22222 | 11113 | 32211 | 23232 | 32223 | 33333 |
---|---|---|---|---|---|---|---|---|---|
(a) Strict condition (after exclusions)
| |||||||||
TTO variant (1 = TTO5, 0 = TTO) | 0.085 (0.002) | −0.040 (0.012) |
0.006 (0.858)
|
0.010 (0.770)
| 0.101 (0.009) |
0.027 (0.480)
| 0.168 (<0.001) | 0.202 (<0.001) | 0.206 (<0.001) |
Age |
0.001 (0.273)
|
0.000 (0.389)
|
0.000 (0.622)
| 0.002 (0.036) |
0.001 (0.466)
|
0.000 (0.492)
|
0.000 (0.575)
|
0.001 (0.307)
|
0.000 (0.575)
|
Sex (1 = female, 0 = male) |
0.025 (0.342)
|
−0.001 (0.929)
|
0.013 (0.688)
|
0.041 (0.235)
|
−0.026 (0.470)
|
0.060 (0.101)
|
0.056 (0.141)
|
0.030 (0.420)
|
0.030 (0.407)
|
Education 1 (11–13 years) |
0.026 (0.659)
|
0.029 (0.396)
|
−0.041 (0.576)
|
−0.015 (0.841)
|
0.152 (0.070)
|
0.018 (0.821)
|
0.064 (0.463)
|
0.046 (0.588)
|
−0.039 (0.627)
|
Education 2 (>13 years) |
0.050 (0.378)
|
0.050 (0.119)
|
0.003 (0.955)
|
0.019 (0.797)
|
0.120 (0.131)
|
0.066 (0.401)
|
0.084 (0.306)
|
0.079 (0.331)
|
−0.018 (0.811)
|
Constant | 0.176 (0.024) | 0.789 (<0.001) | 0.494 (<0.001) | 0.339 (<0.001) |
0.128 (0.236)
| 0.274 (0.010) |
−0.092 (0.410)
|
−0.185 (0.093)
| −0.335 (0.001) |
(b) Inclusive condition: all participants
| |||||||||
Starting point value | 0.396 (<0.001) | 0.368 (<0.001) | 0.376 (<0.001) | 0.376 (<0.001) | 0.408 (<0.001) | 0.375 (<0.001) | 0.425 (<0.001) | 0.444 (<0.001) | 0.394 (<0.001) |
Age | −0.006 (<0.001) | −0.010 (<0.001) | −0.008 (<0.001) | −0.006 (<0.001) | −0.006 (<0.001) | −0.007 (<0.001) | −0.005 (<0.001) | −0.004 (0.001) | −0.003 (0.015) |
Sex (1 = female, 0 = male) |
−0.043 (0.228)
|
−0.075 (0.068)
|
−0.068 (0.117)
|
−0.045 (0.311)
| −0.088 (0.036) |
−0.018 (0.668)
|
−0.005 (0.883)
|
−0.027 (0.483)
|
−0.021 (0.547)
|
Education 1 (11–13 years) |
0.043 (0.575)
|
0.052 (0.544)
|
0.010 (0.910)
|
0.025 (0.788)
|
0.122 (0.169)
|
0.019 (0.838)
|
0.078 (0.359)
|
0.050 (0.538)
|
−0.015 (0.833)
|
Education 2 (>13 years) |
0.089 (0.211)
|
0.129 (0.111)
|
0.079 (0.353)
|
0.086 (0.325)
|
0.119 (0.152)
|
0.087 (0.315)
|
0.112 (0.160)
|
0.100 (0.192)
|
0.001 (0.983)
|
Constant |
0.178 (0.087)
| 0.791 (<0.001) | 0.471 (<0.001) | 0.326 (0.011) |
0.162 (0.180)
| 0.286 (0.023) |
−0.100 (0.388)
| −0.170 (0.129) | −0.342 (<0.001) |