Introduction
Methods
Population
Follow-up
CCTA preparation, acquisition and analysis
Radiation dose
Definition of CAD
Statistical analysis
Results
Population
Variable | Total (n = 1551) |
---|---|
Demographics
| |
Age | 58.0 ± 10.2 |
Women | 968 (62.4 %) |
Body mass index | 26.6 ± 4.5 |
Diabetes | 121 (7.8 %) |
Hba1c (n = 53)a
| 6.8 ± 1.6 |
Hypertension | 464 (29.9 %) |
Hyperlipidaemia | 393 (25.3 %) |
Family history of CADb
| 731 (47.2 %) |
Smoking | 277 (17.9 %) |
eGFR < 60 | 44 (2.8 %) |
Duke clinical score | |
– Low (< 15 %) | 527 (34.0 %) |
– Low-intermediate (15–50 %) | 760 (49.0 %) |
– High-intermediate (50–85 %) | 264 (17.0 %) |
Baseline medication use
| |
Aspirin | 499 (32.2 %) |
Statin | 531 (34.2 %) |
Beta-blocker | 604 (38.9 %) |
ACE-i/ARB | 390 (25.1 %) |
Calcium channel blocker | 96 (6.2 %) |
Nitrate | 49 (3.2 %) |
Acenocoumarol | 38 (2.5 %) |
CCTA data
Variable | Total (n = 1551) |
---|---|
Coronary artery calcium score
| |
0 | 739 (47.6 %) |
0.1–100 | 498 (32.1 %) |
100–400 | 215 (13.9 %) |
> 400 | 99 (6.5 %) |
CCTA results
| |
Normal coronary arteries | 654 (42.2 %) |
Non-obstructive CAD | 683 (44.0 %) |
Obstructive CAD (> 50 %) | 214 (13.8 %) |
1-vessel | 164 (10.6 %) |
2-vessel | 34 (2.2 %) |
3-vessel | 13 (0.8 %) |
Left main | 4 (0.3 %) |
High-risk lesionsa
| 48 (3.1 %) |
Radiation dose
| |
All patients (n = 1551) | 2.4 ± 2.0 mSv |
High-pitch FLASH scans (n = 1130) | 1.6 ± 0.7 mSv |
Prospectively triggered scans (n = 386) | 4.5 ± 2.5 mSv |
Retrospectively triggered scans (n = 35) | 6.5 ± 2.7 mSv |
Follow-up
Independent prognostic value of CACS and CCTA
Variable | HR | 95 % CI |
P-value |
---|---|---|---|
Univariate analysis
| |||
Male gender | 2.18 | 0.96–4.97 | 0.064a
|
Age | 1.02 | 0.98–1.07 | 0.26 |
Diabetes mellitus | 1.15 | 0.55–2.43 | 0.71 |
Hypertension | 2.31 | 1.02–5.24 | 0.045a
|
Family history | 1.76 | 0.76–4.07 | 0.19 |
Smoking | 0.71 | 0.21–2.40 | 0.58 |
Hyperlipidaemia | 1.97 | 0.85–4.55 | 0.11 |
CACS | |||
CACS = 0 | Reference | Reference | - |
CACS 0–100 | 3.71 | 0.72–19.12 | 0.12 |
CACS 100–400 | 15.82 | 3.42–72.23 | < 0.001a
|
CACS > 400 | 26.81 | 5.57–129.09 | < 0.001a
|
Obstructive CAD at CCTA | 15.28 | 6.28–37.14 | < 0.001a
|
Multivariate analysis
| |||
Obstructive CAD at CCTA | 7.03 | 2.57–19.22 | < 0.001 |
CACS | |||
CACS = 0 | Reference | Reference | - |
CACS 0–100 | 2.46 | 0.46–13.14 | 0.29 |
CACS 100–400 | 5.97 | 1.14–31.31 | 0.035 |
CACS > 400 | 7.72 | 1.37–43.55 | 0.021 |