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Gepubliceerd in: Journal of Autism and Developmental Disorders 2/2011

01-02-2011 | Original Paper

Increased Serum Levels of Epidermal Growth Factor in Children with Autism

Auteurs: Elvan İşeri, Esra Güney, Mehmet F. Ceylan, Ayşegül Yücel, Arzu Aral, Şahin Bodur, Şahnur Şener

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2011

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Abstract

The etiology of autism is unclear, however autism is considered as a multifactorial disorder that is influenced by neurological, environmental, immunological and genetic factors. Growth factors, including epidermal growth factor (EGF), play an important role in the celluler proliferation and the differentiation of the central and peripheral nervous system. In this study we hypothesized that EGF may play a role in the pathophysiology of autism and examined serum EGF levels in children with autism. We measured serum levels of EGF in the 27 autistic children and 28 age- matched normal controls. The serum levels of EGF in the subjects with autism were significantly higher than those of normal control subjects. However, there were no correlations between serum EGF levels and clinical variables in the subjects with autism. This is the first report demonstrating the increased serum levels of EGF in children with autism. This study suggests that increased levels of EGF might have an importance in the pathophysiology of autism.
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Metagegevens
Titel
Increased Serum Levels of Epidermal Growth Factor in Children with Autism
Auteurs
Elvan İşeri
Esra Güney
Mehmet F. Ceylan
Ayşegül Yücel
Arzu Aral
Şahin Bodur
Şahnur Şener
Publicatiedatum
01-02-2011
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 2/2011
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-010-1046-3

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