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20-03-2019 | Original Article | Uitgave 6/2019 Open Access

Netherlands Heart Journal 6/2019

Incidence, angiographic and clinical predictors, and impact of stent thrombosis: a 6-year survey of 6,545 consecutive patients

Tijdschrift:
Netherlands Heart Journal > Uitgave 6/2019
Auteurs:
R. Rozemeijer, C. Wing Wong, G. Leenders, L. Timmers, S. Koudstaal, S. Z. Rittersma, A. Kraaijeveld, M. Bots, P. Doevendans, P. Stella, M. Voskuil
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Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s12471-019-1253-2) contains supplementary material, which is available to authorized users.

Abstract

Objective

We sought to determine the incidence, angiographic predictors, and impact of stent thrombosis (ST).

Background

Given the high mortality after ST, this study emphasises the importance of ongoing efforts to identify angiographic predictors of ST.

Methods

All consecutive patients with angiographically confirmed ST between 2010 and 2016 were 1:4 matched for (1) percutaneous coronary intervention (PCI) indication and (2) index date ±6 weeks to randomly selected controls. Index PCI angiograms were reassessed by two independent cardiologists. A multivariable conditional logistic regression model was built to identify independent predictors of ST.

Results

Of 6,545 consecutive patients undergoing PCI, 55 patients [0.84%, 95% confidence interval (CI) 0.63–1.10%] presented with definite ST. Multivariable logistic regression identified dual antiplatelet therapy (DAPT) non-use as the strongest predictor of ST (odds ratio (OR) 10.9, 95% CI 2.47–48.5, p < 0.001), followed by: stent underexpansion (OR 5.70, 95% CI 2.39–13.6, p < 0.001), lesion complexity B2/C (OR 4.32, 95% CI 1.43–13.1, p = 0.010), uncovered edge dissection (OR 4.16, 95% CI 1.47–11.8, p = 0.007), diabetes mellitus (OR 3.23, 95% CI 1.25–8.36, p = 0.016), and residual coronary artery disease at the stent edge (OR 3.02, 95% CI 1.02–8.92, p = 0.045). ST was associated with increased rates of mortality as analysed by Kaplan-Meier estimates (27.3 vs 11.3%, plog-rank < 0.001) and adjusted Cox proportional-hazard regression (hazard ratio 2.29, 95% CI 1.03–5.10, p = 0.042).

Conclusions

ST remains a serious complication following PCI with a high rate of mortality. DAPT non-use was associated with the highest risk of ST, followed by various angiographic parameters and high lesion complexity.

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Netherlands Heart Journal

Het Netherlands Heart Journal wordt uitgegeven in samenwerking met de Nederlandse Vereniging voor Cardiologie en de Nederlandse Hartstichting. Het tijdschrift is Engelstalig en wordt gratis beschikbaa ...

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