Skip to main content
main-content
Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in: Journal of Autism and Developmental Disorders 2/2014

01-02-2014 | Original Paper

Incidence and Behavioral Correlates of Epileptiform Abnormalities in Autism Spectrum Disorders

Auteurs: Caitlin K. Mulligan, Doris A. Trauner

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2014

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Autism spectrum disorders (ASD) are associated with an increased incidence of epilepsy and of epileptiform discharges on electroencephalograms. It is unknown whether epileptiform discharges correlate with symptoms of ASD. We completed a retrospective chart review of 101 patients with ASD who had overnight electroencephalograms. We looked for a relationship between epileptiform abnormalities and diagnosis, history of regression, communication skills, and other features associated with ASD. There was a higher incidence of epileptiform activity in children with stereotypies and aggressive behavior. The incidence of epileptiform abnormalities was significantly lower in Asperger’s compared with more severe forms of autism. Results suggest that increasing severity of autistic symptoms may be associated with higher likelihood of epileptiform abnormalities. Whether treatment alters outcome is unknown.
Literatuur
go back to reference Aldenkamp, A., & Arends, J. (2004). The relative influence of epileptic EEG discharges, short non-convulsive seizures, and type of epilepsy on cognitive function. Epilepsia, 45(1), 54–63. PubMedCrossRef Aldenkamp, A., & Arends, J. (2004). The relative influence of epileptic EEG discharges, short non-convulsive seizures, and type of epilepsy on cognitive function. Epilepsia, 45(1), 54–63. PubMedCrossRef
go back to reference American Psychiatric Association. (2000). Pervasive developmental disorders. In Diagnostic and statistical manual of mental disorders (4 edition—text revision (DSM-IV-TR). Washington, DC, American Psychiatric Association 69–70. American Psychiatric Association. (2000). Pervasive developmental disorders. In Diagnostic and statistical manual of mental disorders (4 edition—text revision (DSM-IV-TR). Washington, DC, American Psychiatric Association 69–70.
go back to reference Baird, G., Robinson, R. O., Boyd, S., & Charman, T. (2006). Sleep electroencephalograms in young children with autism with and without regression. Developmental Medicine and Child Neurology, 48(7), 604–608. PubMedCrossRef Baird, G., Robinson, R. O., Boyd, S., & Charman, T. (2006). Sleep electroencephalograms in young children with autism with and without regression. Developmental Medicine and Child Neurology, 48(7), 604–608. PubMedCrossRef
go back to reference Berg, A. T., & Plioplys, S. (2012). Epilepsy and autism: Is there a special relationship? Epilepsy & Behavior, 23(3), 193–198. CrossRef Berg, A. T., & Plioplys, S. (2012). Epilepsy and autism: Is there a special relationship? Epilepsy & Behavior, 23(3), 193–198. CrossRef
go back to reference Bryson, S. E., Clark, B. S., & Smith, I. M. (1988). First report of a Canadian epidemiological study of autistic syndromes. Journal of Child Psychology and Psychiatry, 29(4), 433–445. PubMedCrossRef Bryson, S. E., Clark, B. S., & Smith, I. M. (1988). First report of a Canadian epidemiological study of autistic syndromes. Journal of Child Psychology and Psychiatry, 29(4), 433–445. PubMedCrossRef
go back to reference Chez, M. G., Chang, M., Krasne, V., Coughlan, C., Kominsky, M., & Schwartz, A. (2006). Frequency of epileptiform EEG abnormalities in a sequential screening of autistic patients with no known clinical epilepsy from 1996 to 2005. Epilepsy & Behavior, 8(1), 267–271. CrossRef Chez, M. G., Chang, M., Krasne, V., Coughlan, C., Kominsky, M., & Schwartz, A. (2006). Frequency of epileptiform EEG abnormalities in a sequential screening of autistic patients with no known clinical epilepsy from 1996 to 2005. Epilepsy & Behavior, 8(1), 267–271. CrossRef
go back to reference Deonna, T., & Roule-Perez, E. (2010). Early-onset acquired epileptic aphasia (Landau–Kleffner syndrome, LKS) and regressive autistic disorders with epileptic EEG abnormalities: The continuing debate. Brain and Development, 32(9), 746–752. PubMedCrossRef Deonna, T., & Roule-Perez, E. (2010). Early-onset acquired epileptic aphasia (Landau–Kleffner syndrome, LKS) and regressive autistic disorders with epileptic EEG abnormalities: The continuing debate. Brain and Development, 32(9), 746–752. PubMedCrossRef
go back to reference Ekinci, O., Arman, A. R., Işik, U., Bez, Y., & Berkem, M. (2010). EEG abnormalities and epilepsy in autistic spectrum disorders: Clinical and familial correlates. Epilepsy & Behavior, 17(2), 178–182. CrossRef Ekinci, O., Arman, A. R., Işik, U., Bez, Y., & Berkem, M. (2010). EEG abnormalities and epilepsy in autistic spectrum disorders: Clinical and familial correlates. Epilepsy & Behavior, 17(2), 178–182. CrossRef
go back to reference Giannotti, F., Cortesi, F., Cerquiglini, A., Miraglia, D., Vagnoni, C., Sebastiani, T., et al. (2008). An investigation of sleep characteristics, EEG abnormalities and epilepsy in developmentally regressed and non-regressed children with autism. Journal of Autism and Developmental Disorders, 38(10), 1888–1897. PubMedCrossRef Giannotti, F., Cortesi, F., Cerquiglini, A., Miraglia, D., Vagnoni, C., Sebastiani, T., et al. (2008). An investigation of sleep characteristics, EEG abnormalities and epilepsy in developmentally regressed and non-regressed children with autism. Journal of Autism and Developmental Disorders, 38(10), 1888–1897. PubMedCrossRef
go back to reference Giovanardi Rossi, P., Posar, A., & Parmeggiani, A. (2000). Epilepsy in adolescents and young adults with autistic disorder. Brain and Development, 22(2), 102–106. PubMedCrossRef Giovanardi Rossi, P., Posar, A., & Parmeggiani, A. (2000). Epilepsy in adolescents and young adults with autistic disorder. Brain and Development, 22(2), 102–106. PubMedCrossRef
go back to reference Goldberg, W. A., Osann, K., Filipek, P. A., Laulhere, T., Jarvis, K., Modahl, C., et al. (2003). Language and other regression: Assessment and timing. Journal of Autism and Developmental Disorders, 33(6), 607–616. PubMedCrossRef Goldberg, W. A., Osann, K., Filipek, P. A., Laulhere, T., Jarvis, K., Modahl, C., et al. (2003). Language and other regression: Assessment and timing. Journal of Autism and Developmental Disorders, 33(6), 607–616. PubMedCrossRef
go back to reference Hara, H. (2007). Autism and epilepsy: A retrospective follow-up study. Brain and Development, 29(8), 486–490. PubMedCrossRef Hara, H. (2007). Autism and epilepsy: A retrospective follow-up study. Brain and Development, 29(8), 486–490. PubMedCrossRef
go back to reference Hartley-McAndrew, M., & Weinstock, A. (2010). Autism spectrum disorder: Correlation between aberrant behaviors, EEG abnormalities and seizures. Neurology International, 2(1), e10. PubMedCentralPubMedCrossRef Hartley-McAndrew, M., & Weinstock, A. (2010). Autism spectrum disorder: Correlation between aberrant behaviors, EEG abnormalities and seizures. Neurology International, 2(1), e10. PubMedCentralPubMedCrossRef
go back to reference Hollander, E., Chaplin, W., Soorya, L., Wasserman, S., Novotny, S., Rusoff, J., et al. (2010). Divalproex sodium versus placebo for the treatment of irritability in children and adolescents with autism spectrum disorders. Neuropsychopharmacology, 35(4), 990–998. PubMedCrossRef Hollander, E., Chaplin, W., Soorya, L., Wasserman, S., Novotny, S., Rusoff, J., et al. (2010). Divalproex sodium versus placebo for the treatment of irritability in children and adolescents with autism spectrum disorders. Neuropsychopharmacology, 35(4), 990–998. PubMedCrossRef
go back to reference Hrdlicka, M., Komarek, V., Propper, L., Kulisek, R., Zumrova, A., Faladova, L., et al. (2004). Not EEG abnormalities but epilepsy is associated with autistic regression and mental functioning in childhood autism. European Child and Adolescent Psychiatry, 13(4), 209–213. PubMedCrossRef Hrdlicka, M., Komarek, V., Propper, L., Kulisek, R., Zumrova, A., Faladova, L., et al. (2004). Not EEG abnormalities but epilepsy is associated with autistic regression and mental functioning in childhood autism. European Child and Adolescent Psychiatry, 13(4), 209–213. PubMedCrossRef
go back to reference Hughes, J. R., & Melyn, M. (2005). EEG and seizures in autistic children and adolescents: Further findings with therapeutic implications. Clinical EEG and Neuroscience, 36(1), 15–20. PubMedCrossRef Hughes, J. R., & Melyn, M. (2005). EEG and seizures in autistic children and adolescents: Further findings with therapeutic implications. Clinical EEG and Neuroscience, 36(1), 15–20. PubMedCrossRef
go back to reference Kim, H. L., Donnelly, J. H., Tournay, A. E., Book, T. M., & Filipek, P. (2006). Absence of seizures despite high prevalence of epileptiform EEG abnormalities in children with autism monitored in a tertiary care center. Epilepsia, 47(2), 394–398. PubMedCrossRef Kim, H. L., Donnelly, J. H., Tournay, A. E., Book, T. M., & Filipek, P. (2006). Absence of seizures despite high prevalence of epileptiform EEG abnormalities in children with autism monitored in a tertiary care center. Epilepsia, 47(2), 394–398. PubMedCrossRef
go back to reference Lee, H., Kang, H. C., Kim, S. W., Kim, Y. K., & Chung, H. J. (2011). Characteristics of late-onset epilepsy and EEG findings in children with autism spectrum disorders. Korean Journal of Pediatrics, 54(1), 22–28. PubMedCentralPubMedCrossRef Lee, H., Kang, H. C., Kim, S. W., Kim, Y. K., & Chung, H. J. (2011). Characteristics of late-onset epilepsy and EEG findings in children with autism spectrum disorders. Korean Journal of Pediatrics, 54(1), 22–28. PubMedCentralPubMedCrossRef
go back to reference Rossi, P. G., Parmeggiani, A., Bach, V., Santucci, M., & Visconti, P. (1995). EEG features and epilepsy in patients with autism. Brain and Development, 17(3), 169–174. PubMedCrossRef Rossi, P. G., Parmeggiani, A., Bach, V., Santucci, M., & Visconti, P. (1995). EEG features and epilepsy in patients with autism. Brain and Development, 17(3), 169–174. PubMedCrossRef
go back to reference Saskia, G. M., van Mil, M. A., Reijs, R., van Hall, M. H. J. A., Snoeijen, M. A., & Aldenkamp, A. P. (2009). Behavioral status of children with cryptogenic localization-related epilepsy. Journal of Child Neurology, 24(4), 449–453. CrossRef Saskia, G. M., van Mil, M. A., Reijs, R., van Hall, M. H. J. A., Snoeijen, M. A., & Aldenkamp, A. P. (2009). Behavioral status of children with cryptogenic localization-related epilepsy. Journal of Child Neurology, 24(4), 449–453. CrossRef
go back to reference Shih, J. J., LeslieMazwi, T., Falcao, G., & Van Gerpen, J. (2009). Directed aggressive behavior in frontal lobe epilepsy: A video–EEG and ictal spect case study. Neurology, 73(21), 1804–1806. PubMedCrossRef Shih, J. J., LeslieMazwi, T., Falcao, G., & Van Gerpen, J. (2009). Directed aggressive behavior in frontal lobe epilepsy: A video–EEG and ictal spect case study. Neurology, 73(21), 1804–1806. PubMedCrossRef
go back to reference Sinclair, D. B., & Snyder, T. J. (2005). Corticosteroids for the treatment of Landau-kleffner syndrome and continuous spike-wave discharge during sleep. Pediatric Neurology, 32(5), 300–306. PubMedCrossRef Sinclair, D. B., & Snyder, T. J. (2005). Corticosteroids for the treatment of Landau-kleffner syndrome and continuous spike-wave discharge during sleep. Pediatric Neurology, 32(5), 300–306. PubMedCrossRef
go back to reference Spence, S. J., & Schneider, M. T. (2009). The role of epilepsy and epileptiform EEGs in autism spectrum disorders. Pediatric Research, 65(6), 599–606. PubMedCentralPubMedCrossRef Spence, S. J., & Schneider, M. T. (2009). The role of epilepsy and epileptiform EEGs in autism spectrum disorders. Pediatric Research, 65(6), 599–606. PubMedCentralPubMedCrossRef
go back to reference Sumer, M. M., Atik, L., Unal, A., Emre, U., & Atasoy, H. T. (2007). Frontal lobe epilepsy presented as ictal aggression. Neurological Sciences, 28(1), 48–51. PubMedCrossRef Sumer, M. M., Atik, L., Unal, A., Emre, U., & Atasoy, H. T. (2007). Frontal lobe epilepsy presented as ictal aggression. Neurological Sciences, 28(1), 48–51. PubMedCrossRef
go back to reference Tuchman, R. F., & Rapin, I. (1997). Regression in pervasive developmental disorders: Seizures and epileptiform electroencephalogram correlates. Pediatrics, 99(4), 560–566. PubMedCrossRef Tuchman, R. F., & Rapin, I. (1997). Regression in pervasive developmental disorders: Seizures and epileptiform electroencephalogram correlates. Pediatrics, 99(4), 560–566. PubMedCrossRef
go back to reference Tuchman, R., & Rapin, I. (2002). Epilepsy in autism. The Lancet Neurology, 1(6), 352–358. CrossRef Tuchman, R., & Rapin, I. (2002). Epilepsy in autism. The Lancet Neurology, 1(6), 352–358. CrossRef
go back to reference Yasuhara, A. (2010). Correlation between EEG abnormalities and symptoms of autism spectrum disorder (ASD). Brain and Development, 32(10), 791–798. PubMedCrossRef Yasuhara, A. (2010). Correlation between EEG abnormalities and symptoms of autism spectrum disorder (ASD). Brain and Development, 32(10), 791–798. PubMedCrossRef
Metagegevens
Titel
Incidence and Behavioral Correlates of Epileptiform Abnormalities in Autism Spectrum Disorders
Auteurs
Caitlin K. Mulligan
Doris A. Trauner
Publicatiedatum
01-02-2014
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 2/2014
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-013-1888-6