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Gepubliceerd in:

01-02-2014 | Original Paper

Incidence and Behavioral Correlates of Epileptiform Abnormalities in Autism Spectrum Disorders

Auteurs: Caitlin K. Mulligan, Doris A. Trauner

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2014

Abstract

Autism spectrum disorders (ASD) are associated with an increased incidence of epilepsy and of epileptiform discharges on electroencephalograms. It is unknown whether epileptiform discharges correlate with symptoms of ASD. We completed a retrospective chart review of 101 patients with ASD who had overnight electroencephalograms. We looked for a relationship between epileptiform abnormalities and diagnosis, history of regression, communication skills, and other features associated with ASD. There was a higher incidence of epileptiform activity in children with stereotypies and aggressive behavior. The incidence of epileptiform abnormalities was significantly lower in Asperger’s compared with more severe forms of autism. Results suggest that increasing severity of autistic symptoms may be associated with higher likelihood of epileptiform abnormalities. Whether treatment alters outcome is unknown.

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Aldenkamp, A., & Arends, J. (2004). The relative influence of epileptic EEG discharges, short non-convulsive seizures, and type of epilepsy on cognitive function. Epilepsia, 45(1), 54–63. PubMedCrossRef

American Psychiatric Association. (2000). Pervasive developmental disorders. In Diagnostic and statistical manual of mental disorders (4 edition—text revision (DSM-IV-TR). Washington, DC, American Psychiatric Association 69–70.

Baird, G., Robinson, R. O., Boyd, S., & Charman, T. (2006). Sleep electroencephalograms in young children with autism with and without regression. Developmental Medicine and Child Neurology, 48(7), 604–608. PubMedCrossRef

Berg, A. T., & Plioplys, S. (2012). Epilepsy and autism: Is there a special relationship? Epilepsy & Behavior, 23(3), 193–198. CrossRef

Bryson, S. E., Clark, B. S., & Smith, I. M. (1988). First report of a Canadian epidemiological study of autistic syndromes. Journal of Child Psychology and Psychiatry, 29(4), 433–445. PubMedCrossRef

Chez, M. G., Chang, M., Krasne, V., Coughlan, C., Kominsky, M., & Schwartz, A. (2006). Frequency of epileptiform EEG abnormalities in a sequential screening of autistic patients with no known clinical epilepsy from 1996 to 2005. Epilepsy & Behavior, 8(1), 267–271. CrossRef

Deonna, T., & Roule-Perez, E. (2010). Early-onset acquired epileptic aphasia (Landau–Kleffner syndrome, LKS) and regressive autistic disorders with epileptic EEG abnormalities: The continuing debate. Brain and Development, 32(9), 746–752. PubMedCrossRef

Ekinci, O., Arman, A. R., Işik, U., Bez, Y., & Berkem, M. (2010). EEG abnormalities and epilepsy in autistic spectrum disorders: Clinical and familial correlates. Epilepsy & Behavior, 17(2), 178–182. CrossRef

Giannotti, F., Cortesi, F., Cerquiglini, A., Miraglia, D., Vagnoni, C., Sebastiani, T., et al. (2008). An investigation of sleep characteristics, EEG abnormalities and epilepsy in developmentally regressed and non-regressed children with autism. Journal of Autism and Developmental Disorders, 38(10), 1888–1897. PubMedCrossRef

Giovanardi Rossi, P., Posar, A., & Parmeggiani, A. (2000). Epilepsy in adolescents and young adults with autistic disorder. Brain and Development, 22(2), 102–106. PubMedCrossRef

Goldberg, W. A., Osann, K., Filipek, P. A., Laulhere, T., Jarvis, K., Modahl, C., et al. (2003). Language and other regression: Assessment and timing. Journal of Autism and Developmental Disorders, 33(6), 607–616. PubMedCrossRef

Hara, H. (2007). Autism and epilepsy: A retrospective follow-up study. Brain and Development, 29(8), 486–490. PubMedCrossRef

Hartley-McAndrew, M., & Weinstock, A. (2010). Autism spectrum disorder: Correlation between aberrant behaviors, EEG abnormalities and seizures. Neurology International, 2(1), e10. PubMedCentralPubMedCrossRef

Hollander, E., Chaplin, W., Soorya, L., Wasserman, S., Novotny, S., Rusoff, J., et al. (2010). Divalproex sodium versus placebo for the treatment of irritability in children and adolescents with autism spectrum disorders. Neuropsychopharmacology, 35(4), 990–998. PubMedCrossRef

Hrdlicka, M., Komarek, V., Propper, L., Kulisek, R., Zumrova, A., Faladova, L., et al. (2004). Not EEG abnormalities but epilepsy is associated with autistic regression and mental functioning in childhood autism. European Child and Adolescent Psychiatry, 13(4), 209–213. PubMedCrossRef

Hughes, J. R., & Melyn, M. (2005). EEG and seizures in autistic children and adolescents: Further findings with therapeutic implications. Clinical EEG and Neuroscience, 36(1), 15–20. PubMedCrossRef

Kim, H. L., Donnelly, J. H., Tournay, A. E., Book, T. M., & Filipek, P. (2006). Absence of seizures despite high prevalence of epileptiform EEG abnormalities in children with autism monitored in a tertiary care center. Epilepsia, 47(2), 394–398. PubMedCrossRef

Lee, H., Kang, H. C., Kim, S. W., Kim, Y. K., & Chung, H. J. (2011). Characteristics of late-onset epilepsy and EEG findings in children with autism spectrum disorders. Korean Journal of Pediatrics, 54(1), 22–28. PubMedCentralPubMedCrossRef

Rossi, P. G., Parmeggiani, A., Bach, V., Santucci, M., & Visconti, P. (1995). EEG features and epilepsy in patients with autism. Brain and Development, 17(3), 169–174. PubMedCrossRef

Saskia, G. M., van Mil, M. A., Reijs, R., van Hall, M. H. J. A., Snoeijen, M. A., & Aldenkamp, A. P. (2009). Behavioral status of children with cryptogenic localization-related epilepsy. Journal of Child Neurology, 24(4), 449–453. CrossRef

Shih, J. J., LeslieMazwi, T., Falcao, G., & Van Gerpen, J. (2009). Directed aggressive behavior in frontal lobe epilepsy: A video–EEG and ictal spect case study. Neurology, 73(21), 1804–1806. PubMedCrossRef

Sinclair, D. B., & Snyder, T. J. (2005). Corticosteroids for the treatment of Landau-kleffner syndrome and continuous spike-wave discharge during sleep. Pediatric Neurology, 32(5), 300–306. PubMedCrossRef

Spence, S. J., & Schneider, M. T. (2009). The role of epilepsy and epileptiform EEGs in autism spectrum disorders. Pediatric Research, 65(6), 599–606. PubMedCentralPubMedCrossRef

Sumer, M. M., Atik, L., Unal, A., Emre, U., & Atasoy, H. T. (2007). Frontal lobe epilepsy presented as ictal aggression. Neurological Sciences, 28(1), 48–51. PubMedCrossRef

Tuchman, R. F., & Rapin, I. (1997). Regression in pervasive developmental disorders: Seizures and epileptiform electroencephalogram correlates. Pediatrics, 99(4), 560–566. PubMedCrossRef

Tuchman, R., & Rapin, I. (2002). Epilepsy in autism. The Lancet Neurology, 1(6), 352–358. CrossRef

Yasuhara, A. (2010). Correlation between EEG abnormalities and symptoms of autism spectrum disorder (ASD). Brain and Development, 32(10), 791–798. PubMedCrossRef

Titel: Incidence and Behavioral Correlates of Epileptiform Abnormalities in Autism Spectrum Disorders
Auteurs: Caitlin K. Mulligan
Doris A. Trauner
Publicatiedatum: 01-02-2014
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 2/2014
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-013-1888-6

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