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Gepubliceerd in:

01-05-2009

In reply to Berger “don’t test for baseline imbalances unless they are known to be present?”

Auteurs: P. M. Fayers, M. T. King

Gepubliceerd in: Quality of Life Research | Uitgave 4/2009

Excerpt

Berger raises some perceptive, subtle and fascinating issues concerning P values during his query of our caution over the interpretation of P values. When testing a single baseline characteristic, we expect one in 20 of all trials to show a significant difference ( P < 0.05) purely by chance; such is the meaning of type II error. This increases with each baseline characteristic evaluated. For those approximately 5% or greater of trials with P < 0.05, should we suggest that there has been a violation of the randomisation, and that the trial is faulty? Fortunately, most people would never dream of making such accusations of their trialist colleagues. …

vorige artikel Do not test for baseline imbalances unless they are known to be present?

volgende artikel Normative data of the SF-12 health survey with validation using postmyocardial infarction patients in the Dutch population

Thompson, W. C., & Schumann, E. L. (1987). Interpretation of statistical evidence in criminal trials: The prosecutor’s fallacy and the defense attorney’s fallacy. Law and Human Behavior, 11, 167–187. doi: 10.1007/BF01044641. CrossRef

Pocock, S. J. (1983). Clinical trials: A practical approach. Chichester: Wiley & Sons.

Hewitt, C. E., & Torgerson, D. J. (2006). Is restricted randomisation necessary? British Medical Journal, 332, 1506–1508. doi: 10.1136/bmj.332.7556.1506. PubMedCrossRef

Schulz, K. F., & Grimes, D. A. (2002). Generation of allocation sequences in randomised trials: Chance, not choice. Lancet, 359, 515–519. doi: 10.1016/S0140-6736(02)07683-3. PubMedCrossRef

Titel: In reply to Berger “don’t test for baseline imbalances unless they are known to be present?”
Auteurs: P. M. Fayers
M. T. King
Publicatiedatum: 01-05-2009
Uitgeverij: Springer Netherlands
Gepubliceerd in: Quality of Life Research / Uitgave 4/2009
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-009-9458-2

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