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21-04-2022 | ORIGINAL PAPER

Implications of a “Null” Randomized Controlled Trial of Mindfulness and Compassion Interventions in Healthy Adults

Auteurs: Deanna M. Kaplan, Matthias R. Mehl, Thaddeus W. W. Pace, Lobsang Tenzin Negi, Brendan Ozawa-de Silva, Brooke D. Lavelle, Teri Sivilli, Allison Williams, Tom Comstock, Bryan Price, Vicente Medrano, Megan L. Robbins, Steven P. Cole, W. Edward Craighead, Charles L. Raison

Gepubliceerd in: Mindfulness | Uitgave 5/2022

Abstract

Objectives

Extensive research suggests that short-term meditation interventions may hold therapeutic promise for a wide range of psychosocial outcomes. In response to calls to subject these interventions to more methodologically rigorous tests, a randomized controlled trial tested the effectiveness of a mindfulness meditation intervention and a compassion meditation intervention against an active control in a demographically diverse sample of medically and psychiatrically healthy adults.

Methods

Two hundred and four participants completed a battery of questionnaires to assess psychological experience, participated in a laboratory stress test to measure their biological stress reactivity, and wore the Electronically Activated Recorder (EAR) to assess daily behaviors before and after an eight-week intervention (mindfulness meditation intervention, compassion meditation intervention, or health education discussion group).

Results

Neither meditation intervention reliably impacted participants’ subjective psychological experience, biological stress reactivity, or objectively assessed daily behaviors. Furthermore, post hoc moderation analyses found that neither baseline distress nor intervention engagement significantly moderated effects.

Conclusions

Results from this trial—which was methodologically rigorous and powered to detect all but small effects—were essentially null. These results are an important data point for the body of research about meditation interventions. Implications of these non-significant effects are discussed in the context of prior studies, and future directions for contemplative intervention research are recommended.

Clinical Trial Registry

Registry Number: NCT01643369.

vorige artikel Effect of Mindfulness Versus Loving-kindness Training on Leukocyte Gene Expression in Midlife Adults Raised in Low-Socioeconomic Status Households

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Alderson, P. (2004). Absence of evidence is not evidence of absence. British Medical Journal Publishing Group, 328(7438), 476–477. https://doi.org/10.1136/bmj.328.7438.476CrossRef

Anderson, S. F., & Maxwell, S. E. (2017). Addressing the “replication crisis”: Using original studies to design replication studies with appropriate statistical power. Multivariate Behavioral Research, 52(3), 305–324.CrossRef

Baddeley, J. L., Pennebaker, J. W., & Beevers, C. G. (2013). Everyday social behavior during a major depressive episode. Social Psychological & Personality Science, 4, 445–452. https://doi.org/10.1177/1948550612461654CrossRef

Baer, R. A., Smith, G. T., Hopkins, J., Krietemeyer, J., & Toney, L. (2006). Using self-report assessment methods to explore facets of mindfulness. Assessment, 13(1), 27–45.CrossRef

Beck, A. T., & Steer, R. A. (1984). Internal consistencies of the original and revised Beck Depression Inventory. Journal of Clinical Psychology, 40(6), 1365–1367.CrossRef

Bollich, K. L., Doris, J. M., Vazire, S., Raison, C. L., Jackson, J. J., & Mehl, M. R. (2016). Eavesdropping on character: Assessing everyday moral behaviors. Journal of Research in Personality, 61, 15–21. https://doi.org/10.1016/j.jrp.2015.12.003CrossRefPubMedPubMedCentral

Britton, W. B., Lindahl, J. R., Cooper, D. J., Canby, N. K., & Palitsky, R. (2021). Defining and measuring meditation-related adverse effects in mindfulness-based programs. Clinical Psychological Science, 2167702621996340. https://doi.org/10.1177/2167702621996340

Brown, K. W., Ryan, R. M., & Creswell, J. D. (2007). Mindfulness: Theoretical foundations and evidence for its salutary effects. Psychological Inquiry, 18(4), 211–237.CrossRef

Brown, K. W., Creswell, J. D., & Ryan, R. M. (2015). Handbook of mindfulness: Theory, research, and practice: Guilford Publications.

Cohen, S. (1988a). Perceived stress in a probability sample of the United States. In S. Spacapan & S. Oskamp (Eds.), The social psychology of health (pp. 31–67). Sage Publications Inc.

Cohen, J. (1988b). The effect size index: D. Statistical power analysis for the behavioral sciences. Abingdon-on-Thames: Routledge Academic.

Coronado-Montoya, S., Levis, A. W., Kwakkenbos, L., Steele, R. J., Turner, E. H., & Thombs, B. D. (2016). Reporting of positive results in randomized controlled trials of mindfulness-based mental health interventions. PloS one, 11(4), e0153220.CrossRef

Creswell, J. D. (2017). Mindfulness interventions. Annual Review of Psychology, 68, 491–516.CrossRef

Cuijpers, P., Van Straten, A., & Warmerdam, L. (2007). Behavioral activation treatments of depression: A meta-analysis. Clinical Psychology Review, 27(3), 318–326.CrossRef

Davidson, R. J., & Kaszniak, A. W. (2015). Conceptual and methodological issues in research on mindfulness and meditation. American Psychologist, 70(7), 581–592. https://doi.org/10.1037/a0039512CrossRefPubMed

Desbordes, G., Negi, L. T., Pace, T. W., Wallace, B. A., Raison, C. L., & Schwartz, E. L. (2012). Effects of mindful-attention and compassion meditation training on amygdala response to emotional stimuli in an ordinary, non-meditative state. Frontiers in Human Neuroscience, 6, 292. https://doi.org/10.3389/fnhum.2012.00292CrossRefPubMedPubMedCentral

Dickerson, S. S., Gable, S. L., Irwin, M. R., Aziz, N., & Kemeny, M. E. (2009). Social-evaluative threat and proinflammatory cytokine regulation: An experimental laboratory investigation. Psychological Science, 20(10), 1237–1244. https://doi.org/10.1111/j.1467-9280.2009.02437.xCrossRefPubMed

Diener, E., Emmons, R. A., Larsen, R. J., & Griffin, S. (1985). The satisfaction with life scale. Journal of Personality Assessment, 49(1), 71–75.CrossRef

Dimidjian, S., & Segal, Z. V. (2015). Prospects for a clinical science of mindfulness-based intervention. American Psychologist, 70(7), 593–620. https://doi.org/10.1037/a0039589CrossRefPubMed

Dodds, S. E., Pace, T. W., Bell, M. L., Fiero, M., Negi, L. T., Raison, C. L., & Weihs, K. L. (2015). Feasibility of Cognitively-Based Compassion Training (CBCT) for breast cancer survivors: A randomized, wait list controlled pilot study. Supportive Care in Cancer, 23(12), 3599–3608.CrossRef

Eberth, J., & Sedlmeier, P. (2012). The effects of mindfulness meditation: A meta-analysis. Mindfulness, 3(3), 174–189. https://doi.org/10.1007/s12671-012-0101-xCrossRef

Funder, D. C., & Ozer, D. J. (2019). Evaluating effect size in psychological research: Sense and nonsense. Advances in Methods and Practices in Psychological Science, 2(2), 1576-168. https://doi.org/10.1177/2515245919847202

Fydrich, T., Dowdall, D., & Chambless, D. L. (1992). Reliability and validity of the Beck Anxiety Inventory. Journal of Anxiety Disorders, 6(1), 55–61.CrossRef

Goleman, D., & Davidson, R. J. (2017). Altered Traits: Science reveals how meditation changes your mind, brain, and body. Penguin.

Goyal, M., Singh, S., Sibinga, E. M., Gould, N. F., Rowland-Seymour, A., Sharma, R., Berger, Z., Sleicher, D., Maron, D. D., Shihab, H. M., Ranasinghe, P. D., Linn, S., Saha, S., Bass, E. B., & Haythornwaite, J. A. (2014). Meditation programs for psychological stress and well-being: A systematic review and meta-analysis. JAMA Internal Medicine, 174(3), 357–368. https://doi.org/10.1001/jamainternmed.2013.13018CrossRefPubMedPubMedCentral

Harrington, A., & Dunne, J. D. (2015). When mindfulness is therapy: Ethical qualms, historical perspectives. American Psychologist, 70(7), 621–631. https://doi.org/10.1037/a0039460CrossRefPubMed

Heyman, R. E., Lorber, M. F., Eddy, J. M., & West, T. V. (2014). Behavioral observation and coding. In H. T. Reis & C. M. Judd (Eds.), Handbook of research methods in social and personality psychology (pp. 345–372). Cambridge University Press.CrossRef

Hofmann, S. G., Grossman, P., & Hinton, D. E. (2011). Loving-kindness and compassion meditation: Potential for psychological interventions. Clinical Psychology Review, 31(7), 1126–1132. https://doi.org/10.1016/j.cpr.2011.07.003CrossRefPubMedPubMedCentral

Johnson, B. T., Scott-Sheldon, L. A., & Carey, M. P. (2010). Meta-synthesis of health behavior change meta-analyses. American Journal of Public Health, 100(11), 2193–2198. https://doi.org/10.2105/AJPH.2008.155200CrossRefPubMedPubMedCentral

Kaplan, D. M., Raison, C. L., Milek, A., Tackman, A. M., Pace, T. W. W., & Mehl, M. R. (2018). Dispositional mindfulness in daily life: A naturalistic observation study. PLoS ONE, 13(11), e0206029. https://doi.org/10.1371/journal.pone.0206029CrossRefPubMedPubMedCentral

Kaplan, D. M., Rentscher, K. E., Lim, M., Reyes, R., Keating, D., Romero, J., Shah, A., Smith, A. D., York, K. A., Milek, A., Tackman, A. M., & Mehl, M. R. (2020). Best practices for Electronically Activated Recorder (EAR) research: A practical guide to coding and processing EAR data. Behavior Research Methods. https://doi.org/10.3758/s13428-019-01333-y

Khoury, B., Sharma, M., Rush, S. E., & Fournier, C. (2015). Mindfulness-based stress reduction for healthy individuals: A meta-analysis. Journal of Psychosomatic Research, 78(6), 519–528. https://doi.org/10.1016/j.jpsychores.2015.03.009CrossRefPubMed

Kirschbaum, C., Pirke, K.-M., & Hellhammer, D. H. (1993). The ‘Trier Social Stress Test’–A tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology, 28(1–2), 76–81. https://doi.org/10.1159/000119004CrossRefPubMed

Kyabgon, T. (2007). The practice of Lojong: Cultivating compassion through training the mind. Shambhala Publications.

Lally, P., Van Jaarsveld, C. H., Potts, H. W., & Wardle, J. (2010). How are habits formed: Modelling habit formation in the real world. European Journal of Social Psychology, 40(6), 998–1009. https://doi.org/10.1002/ejsp.674CrossRef

Lindahl, J. R., Fisher, N. E., Cooper, D. J., Rosen, R. K., & Britton, W. B. (2017). The varieties of contemplative experience: A mixed-methods study of meditation-related challenges in Western Buddhists. PLoS ONE, 12(5), e0176239. https://doi.org/10.1371/journal.pone.0176239CrossRefPubMedPubMedCentral

Lindsay, E. K., Young, S., Smyth, J. M., Brown, K. W., & Creswell, J. D. (2018). Acceptance lowers stress reactivity: Dismantling mindfulness training in a randomized controlled trial. Psychoneuroendocrinology, 87, 63–73.CrossRef

MacCoon, D. G., Imel, Z. E., Rosenkranz, M. A., Sheftel, J. G., Weng, H. Y., Sullivan, J. C., Bonus, K. A., Stoney, C. M., Salomons, T. V., Davidson, R. J., & Lutz, A. (2012). The validation of an active control intervention for Mindfulness Based Stress Reduction (MBSR). Behaviour Research and Therapy, 50(1), 3–12. https://doi.org/10.1016/j.brat.2011.10.011CrossRefPubMed

Marsland, A. L., Walsh, C., Lockwood, K., & John-Henderson, N. A. (2017). The effects of acute psychological stress on circulating and stimulated inflammatory markers: A systematic review and meta-analysis. Brain, Behavior, and Immunity, 64, 208–219. https://doi.org/10.1016/j.bbi.2017.01.011CrossRefPubMedPubMedCentral

Mascaro, J. S., Rilling, J. K., Tenzin Negi, L., & Raison, C. L. (2012). Compassion meditation enhances empathic accuracy and related neural activity. Social Cognitive and Affective Neuroscience, 8(1), 48–55. https://doi.org/10.1093/scan/nss095CrossRefPubMedPubMedCentral

Mehl, M. R. (2017). The Electronically Activated Recorder (EAR): A method for the naturalistic observation of daily social behavior. Current Directions in Psychological Science, 26(2), 184–190. https://doi.org/10.1177/0963721416680611CrossRefPubMedPubMedCentral

Mehl, M. R., Pennebaker, J. W., Crow, D. M., Dabbs, J., & Price, J. H. (2001). The Electronically Activated Recorder (EAR): A device for sampling naturalistic daily activities and conversations. Behavior Research Methods, Instruments, & Computers, 33(4), 517–523. https://doi.org/10.3758/bf03195410CrossRef

Mehl, M. R., & Conner, T. S. (2012). Handbook of research methods for studying daily life. Guilford Press.

Mehl, M. R., Robbins, M. L., & Deters, F. große. (2012). Naturalistic observation of health-relevant social processes: The Electronically Activated Recorder (EAR) Methodology in Psychosomatics. Psychosomatic Medicine, 74(4), 410–417. https://doi.org/10.1097/PSY.0b013e3182545470

Pace, T. W., Mletzko, T. C., Alagbe, O., Musselman, D. L., Nemeroff, C. B., Miller, A. H., & Heim, C. M. (2006). Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress. American Journal of Psychiatry, 163(9), 1630–1633. https://doi.org/10.1176/ajp.2006.163.9.1630CrossRefPubMed

Pace, T. W., Negi, L. T., Adame, D. D., Cole, S. P., Sivilli, T. I., Brown, T. D., Issa, M. J., & Raison, C. L. (2009). Effect of compassion meditation on neuroendocrine, innate immune and behavioral responses to psychosocial stress. Psychoneuroendocrinology, 34(1), 87–98. https://doi.org/10.1016/j.psyneuen.2008.08.011CrossRefPubMed

Pace, T. W., Negi, L. T., Dodson-Lavelle, B., Ozawa-de Silva, B., Reddy, S. D., Cole, S. P., Danese, A., Craighead, L. W., & Raison, C. L. (2013). Engagement with cognitively-based compassion training is associated with reduced salivary C-reactive protein from before to after training in foster care program adolescents. Psychoneuroendocrinology, 38(2), 294–299. https://doi.org/10.1016/j.psyneuen.2012.05.019CrossRefPubMed

Palitsky, R., Kaplan, D. M., Brenner, S., Mehl, M. R., & Sullivan, D. Worldviews matter for implementation-relevant responses to mindfulness-based interventions: An empirical investigation of existential and religious perspectives. [Manuscript submitted for publication]. Department of Psychiatry and Human Behavior, Brown University.

Palitsky, R., & Kaplan, D. M. (2021). The role of religion for mindfulness-based interventions: Implications for dissemination and implementation. Mindfulness, 12(8), 2076–2089.CrossRef

Pennebaker, J. W., Boyd, R. L., Jordan, K., & Blackburn, K. (2015). The development and psychometric properties of LIWC2015. UT Faculty/Researcher Works.

Podsakoff, P. M., MacKenzie, S. B., Lee, J.-Y., & Podsakoff, N. P. (2003). Common method biases in behavioral research: A critical review of the literature and recommended remedies. Journal of Applied Psychology, 88(5), 879.CrossRef

Podsakoff, P. M., MacKenzie, S. B., & Podsakoff, N. P. (2012). Sources of method bias in social science research and recommendations on how to control it. Annual Review of Psychology, 63, 539–569.CrossRef

Pruessner, J. C., Kirschbaum, C., Meinlschmid, G., & Hellhammer, D. H. (2003). Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology, 28(7), 916–931. https://doi.org/10.1016/s0306-4530(02)00108-7CrossRefPubMed

Reddy, S. D., Negi, L. T., Dodson-Lavelle, B., Ozawa-de Silva, B., Pace, T. W., Cole, S. P., Raison, C. L., & Craighead, L. W. (2013). Cognitive-Based Compassion Training: A promising prevention strategy for at-risk adolescents. Journal of Child and Family Studies, 22(2), 219–230. https://doi.org/10.1007/s10826-012-9571-7CrossRef

Rosenzweig, S., Greeson, J. M., Reibel, D. K., Green, J. S., Jasser, S. A., & Beasley, D. (2010). Mindfulness-based stress reduction for chronic pain conditions: Variation in treatment outcomes and role of home meditation practice. Journal of Psychosomatic Research, 68(1), 29–36. https://doi.org/10.1016/j.jpsychores.2009.03.010CrossRefPubMed

Russell, D., Peplau, L. A., & Cutrona, C. E. (1980). The revised UCLA Loneliness Scale: Concurrent and discriminant validity evidence. Journal of Personality and Social Psychology, 39(3), 472–480. https://doi.org/10.1037//0022-3514.39.3.472CrossRefPubMed

Santorelli, S. F., Kabat-Zinn, J., Blacker, M., Meleo-Meyer, F., & Koerbel, L. (2017). Mindfulness-based stress reduction (MBSR) authorized curriculum guide. Center for Mindfulness in Medicine, Health Care, and Society (CFM). University of Massachusetts Medical School.Schönbrodt, F. D., & Perugini, M. (2013). At what sample size do correlations stabilize? Journal of Research in Personality, 47(5), 609-612.

Schönbrodt, F. D., & Perugini, M. (2013). At what sample size do correlations stabilize? Journal of Research in Personality, 47(5), 609–612.CrossRef

Shapiro, S. L., & Jazaieri, H. (2015). Mindfulness-based stress reduction for healthy stressed adults. In K.W. Brown, J.D. Creswell & R.M. Ryan (Eds.). Handbook of mindfulness: Theory, research, and practice (pp. 269–282). Guilford Press.

Shonin, E., Van Gordon, W., Dunn, T. J., Singh, N. N., & Griffiths, M. D. (2014). Meditation Awareness Training (MAT) for work-related wellbeing and job performance: A randomised controlled trial. International Journal of Mental Health and Addiction, 12(6), 806–823. https://doi.org/10.1007/s11469-014-9513-2CrossRef

Steer, R. A., Clark, D. A., Beck, A. T., & Ranieri, W. F. (1995). Common and specific dimensions of self-reported anxiety and depression: A replication. Journal of Abnormal Psychology, 104(3), 542–545. https://doi.org/10.1037//0021-843x.104.3.542CrossRefPubMed

Steer, R. A., Clark, D. A., Beck, A. T., & Ranieri, W. F. (1999). Common and specific dimensions of self-reported anxiety and depression: The BDI-II versus the BDI-IA. Behaviour Research and Therapy, 37(2), 183–190. https://doi.org/10.1016/s0005-7967(98)00087-4CrossRefPubMed

The Importance of No Evidence. (2019). Nature Human Behavior, 3(3), 197.

Van Dam, N. T., Van Vugt, M. K., Vago, D. R., Schmalzl, L., Saron, C. D., Olendzki, A., Meissner, T., Lazar, S. W., Kerr, C. E., & Gorchov, J. (2018). Mind the hype: A critical evaluation and prescriptive agenda for research on mindfulness and meditation. Perspectives on Psychological Science, 13(1), 36–61.CrossRef

van Ginkel, J. R., & Kroonenberg, P. M. (2014). Analysis of variance of multiply imputed data. Multivariate Behavioral Research, 49(1), 78–91. https://doi.org/10.1080/00273171.2013.855890CrossRefPubMedPubMedCentral

Von Dawans, B., Kirschbaum, C., & Heinrichs, M. (2011). The Trier Social Stress Test for Groups (TSST-G): A new research tool for controlled simultaneous social stress exposure in a group format. Psychoneuroendocrinology, 36(4), 514–522. https://doi.org/10.1016/j.psyneuen.2010.08.004CrossRef

Watson-Singleton, N. N., Black, A. R., & Spivey, B. N. (2019). Recommendations for a culturally-responsive mindfulness-based intervention for African Americans. Complementary Therapies in Clinical Practice, 34, 132–138. https://doi.org/10.1016/j.ctcp.2018.11.013CrossRefPubMed

Titel: Implications of a “Null” Randomized Controlled Trial of Mindfulness and Compassion Interventions in Healthy Adults
Auteurs: Deanna M. Kaplan
Matthias R. Mehl
Thaddeus W. W. Pace
Lobsang Tenzin Negi
Brendan Ozawa-de Silva
Brooke D. Lavelle
Teri Sivilli
Allison Williams
Tom Comstock
Bryan Price
Vicente Medrano
Megan L. Robbins
Steven P. Cole
W. Edward Craighead
Charles L. Raison
Publicatiedatum: 21-04-2022
Uitgeverij: Springer US
Gepubliceerd in: Mindfulness / Uitgave 5/2022
Print ISSN: 1868-8527
Elektronisch ISSN: 1868-8535
DOI: https://doi.org/10.1007/s12671-022-01861-3

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Abstract

Objectives

Methods

Results

Conclusions

Clinical Trial Registry

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