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We sought to determine the association between health-related quality of life (HRQOL) and graft function in renal transplant recipients.
We enrolled 577 kidney transplant recipients aged 18–74 years (response rate 87%). Recipients with multiple or multi-organ transplantation, creatine kinase >200 U/L, acute renal failure or cellular rejection (n = 64), and without creatinine assessments in 3 months pre-enrollment (n = 127) were excluded. The questionnaire included Euro QOL 5 Dimensions (EQ-5D), Health Utility Index III (HUI-III), Kidney Disease Quality of Life-36 (KDQOL36) which include a generic section (RAND SF-12). Data on medical conditions, therapy regimens, and biochemistry results were extracted from clinical charts. We used general linear models adjusted for demographic, socioeconomic, and clinical characteristics to assess the association between HRQOL and severity of chronic kidney disease (CKD).
Patients with more advanced CKD were more likely to be African-American, covered by public insurance, more likely to have shorter time after transplantation, higher phosphorus and lower hemoglobin, serum albumin, and calcium levels. All HRQOL scales were inversely associated with CKD severity. All associations were robust to adjustment for possible confounders.
Several health-related quality of life dimensions may be affected by poor renal function after transplantation.
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Mathew, T., McDonald, S., & Russ, G. (2001). ANZDATA Registry Report 2001. In: Renal transplant outcome beyond 5 years, Chap. 13.
Hays, R. D., et al. (1997). Kidney Disease Quality of Life Short Form (KDQOL-SF), Version 1.3: A Manual for Use and Scoring. pp. 1–39.
Garrat, A., et al. (1993). The SF-36 health survey questionnaire: An outcome measure suitable for routine use within the NHS. BMJ,306(6890), 1440–1444. CrossRef
Hollingsworth, W., et al. (1995). Measuring changes in quality of life following magnetic-resonance- imaging of the knee-SF-36, Euroqol, or Rosser Index. Quality of Life Research,4(4), 325–334. CrossRef
Hsu, C. Y. (2005). Clinical evaluation of kidney function. In A. Greenberg (Ed.), Primer on kidney disease (4th ed., pp. 20–24). Philadelphia: Elsevier-Saunders.
Duan, N. (1983). Smearing estimate: A nonparametric retransformation method. Journal of the American Statistical Association,78(383), 605–610. CrossRef
Rosemberger, J., et al. (2006). Predictors of perceived health status in patients after kidney transplantation. Transplantation,81, 1306–1310. CrossRef
Yeh, S. C. J., Huang, C. H., Chou, H. C., & Wan, T. T. H. (2009). Gender differences in stress and coping among elderly patients on hemodialysis. Sex Roles,60, 44–56. CrossRef
Van Steel, H. F., & Buskens, E. (2006). Comparison of the SF-6D and the EQ-5D in patients with coronary heart disease. Health and Quality of Life Outcomes,4, 20. CrossRef
Walters, S. J., & Brazier, J. E. (2003). What is the relationship between the minimally important difference and health state utility values? The case of the SF-6D. Health and Quality of Life Outcomes, 1(4).
Horsman, J, Furlong, W, Feeny, D, & Torrance, G. W. (2003). The Health Utility Index (HUI): concepts, measurement, properties and applications. Health and Quality of Life Outcomes, 1.
Blanchard, C. M., Cote, I., & Feeny, D. (2004). Comparing short form and RAND physical and mental health summary scores: Results from total hip arthroplasty and high-risk primary care patients. International Journal of Technology Assessment Health Care,20, 230–235.
Sloan, J., Symonds, T., Vargas-Chanes, D., & Fridley, B. (2003). Practical guidelines for assessing the clinical significance of health-related quality of life changes within clinical trials. Drug Information Journal,37(1), 23–31.
Kovacs, A. Z., et al. (2010). Sleep disorders, depressive symptoms and health-related quality of life—a cross-sectional comparison between kidney transplant recipients and waitlisted patients on maintenance dialysis. NDT Advance Access published online on August 4, 2010. Nephrology Dialysis Transplantation. doi: 10.1093/ndt/gfq476.
Pourfarziani, V., Taheri, S., Sharifi-Bonab, M. M., & Mohammadzadeh, M. (2010). Assessment of sleep disturbance in renal transplant recipients and associated risk factors. Saudi Journal of Kidney Diseases Transplantation,21, 433–437.
Johnson, C. D., et al. (1998). Racial and gender differences in quality of life following kidney transplantation. Image Journal of Nursing Scholarship,30(2), 125–130. CrossRef
Franke, G. H., Trampenau, C., & Reimer, J. (2006). Switching from cyclosporine to tacrolimus leads to improved disease-specific quality of life in patients after kidney transplantation. Transplantion Proceedings,38(5), 1293–1294. CrossRef
- Impaired renal function is associated with worse self-reported outcomes after kidney transplantation
Daniel C. Brennan
Paulo R. Salvalaggio
- Springer Netherlands