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Gepubliceerd in: Quality of Life Research 9/2021

21-04-2021

Impact of Moringa Oleifera leaves supplementation on quality of life of people living with HIV: A double-blind randomized controlled trial

Auteurs: Aisha Gambo, Indres Moodley, Musa Babashani, Tesleem K. Babalola

Gepubliceerd in: Quality of Life Research | Uitgave 9/2021

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Abstract

Purpose

Advances in antiretroviral therapy (ART) and increased interest on nutritional interventions have led to improvements in life expectancy of people living with HIV (PLHIV). These have led to greater emphasis on their quality of life (QoL). This study was aimed at exploring the effects of Moringa oleifera leaves supplementation on QoL of HIV-positive adults in Nigeria.

Method

A double-blind randomized controlled trial was conducted to determine the six months’ impact of consuming Moringa oleifera leaves powder as a nutritional supplement on the different domains of QoL of PLHIV that are on ART. Two hundred consented patients were randomly allocated to either Moringa Oleifera group (MOG) or control group (COG). The WHOQOL-HIV-BREF was used to assess QoL at baseline and at six-month follow-up.

Results

One hundred and seventy seven patients completed the study. At six-month follow-up, a significant (p < 0.05) increase in the mean scores of all the six domains of QoL was observed in the MOG. However, in the COG, a significant increase was observed in the social relationship, environment, and spirituality/religion/personal beliefs domains. The comparison between the MOG and COG at 6 months’ follow-up showed a significant mean score difference in the MOG in the physical, psychological, level of independence, and social relationships domains of QoL.

Conclusion

This study shows that supplementation with Moringa oleifera leaves for PLHIV that are on ART improves the QoL domains of physical, psychological, level of independence, and social relationships.
Clinical Trial Registry registration number: PACTR201811722056449.
Literatuur
3.
go back to reference Folasire, O. F., Folasire, A. M., & Sanusi, R. A. (2015). Measures of Nutritional Status and Quality of Life in Adult People Living with HIV/AIDS at a Tertiary Hospital in Nigeria. Food and Nutrition Sciences, 6, 412–420.CrossRef Folasire, O. F., Folasire, A. M., & Sanusi, R. A. (2015). Measures of Nutritional Status and Quality of Life in Adult People Living with HIV/AIDS at a Tertiary Hospital in Nigeria. Food and Nutrition Sciences, 6, 412–420.CrossRef
4.
go back to reference Bello, S. I., & Bello, I. K. (2013). Quality of Life of Hiv/Aids Patients in a Secondary Health Care Facility, Ilorin. Nigeria. Proc (Bayl Univ Med Cent), 26(2), 116–119. Bello, S. I., & Bello, I. K. (2013). Quality of Life of Hiv/Aids Patients in a Secondary Health Care Facility, Ilorin. Nigeria. Proc (Bayl Univ Med Cent), 26(2), 116–119.
6.
go back to reference Hsiung, P., Fang, C., Wu, C., Sheng, W., Chen, S., Wang, J., et al. (2011). Validation of the WHOQOL-HIV BREF among HIV infected patients in Taiwan. AIDS Care: Psychological and Socio-medical Aspects of AIDS/HIV., 23(8), 1035–1042.CrossRef Hsiung, P., Fang, C., Wu, C., Sheng, W., Chen, S., Wang, J., et al. (2011). Validation of the WHOQOL-HIV BREF among HIV infected patients in Taiwan. AIDS Care: Psychological and Socio-medical Aspects of AIDS/HIV., 23(8), 1035–1042.CrossRef
7.
go back to reference Peltzer, K., Preez, N. F., Ramlagan, S., & Anderson, J. (2010). Antiretroviral treatment adherence among HIV patients in KwaZulu-Natal. South Africa. BMC Public Health., 10(111), 1–10. Peltzer, K., Preez, N. F., Ramlagan, S., & Anderson, J. (2010). Antiretroviral treatment adherence among HIV patients in KwaZulu-Natal. South Africa. BMC Public Health., 10(111), 1–10.
8.
go back to reference Olisah, V. O., Baiyewu, O., & Sheikh, T. L. (2011). Depression underdiagnosis and the effects on quality of life in outpatients with HIV at a Nigerian university teaching hospital. African Journal of AIDS Research, 10(3), 247–254.CrossRef Olisah, V. O., Baiyewu, O., & Sheikh, T. L. (2011). Depression underdiagnosis and the effects on quality of life in outpatients with HIV at a Nigerian university teaching hospital. African Journal of AIDS Research, 10(3), 247–254.CrossRef
9.
go back to reference da Silva, J., Bunn, K., Bertoni, R. F., Neves, O. A., & Traebert, J. (2013). Quality of life of people living with HIV. AIDS Care, 25(1), 71–76.CrossRef da Silva, J., Bunn, K., Bertoni, R. F., Neves, O. A., & Traebert, J. (2013). Quality of life of people living with HIV. AIDS Care, 25(1), 71–76.CrossRef
10.
go back to reference Bepe, N., Madanhi, N., Mudzviti, T., Gavi, S., Maponga, C. C., & Morse, G. D. (2011). The impact of herbal remedies on adverse effects and quality of life in HIV-infected individuals on antiretroviral therapy. Journal of Infection in Developing Countries, 5(1), 48–53.CrossRef Bepe, N., Madanhi, N., Mudzviti, T., Gavi, S., Maponga, C. C., & Morse, G. D. (2011). The impact of herbal remedies on adverse effects and quality of life in HIV-infected individuals on antiretroviral therapy. Journal of Infection in Developing Countries, 5(1), 48–53.CrossRef
11.
go back to reference Falowo, A. B., Mukumbo, F. E., Idamokoro, E. M., Lorenzo, J. M., Afolayan, A. J., & Muchenje, V. (2018). Multi-functional application of Moringa oleifera Lam. in nutrition and animal food products: A review. Food Res Int, 106, 317–34.CrossRef Falowo, A. B., Mukumbo, F. E., Idamokoro, E. M., Lorenzo, J. M., Afolayan, A. J., & Muchenje, V. (2018). Multi-functional application of Moringa oleifera Lam. in nutrition and animal food products: A review. Food Res Int, 106, 317–34.CrossRef
12.
go back to reference Kou, X., Li, B., Olayanju, J. B., Drake, J. M., & Chen, N. (2018). Nutraceutical or Pharmacological Potential of Moringa oleifera Lam. Nutrients, 10(343), 1–12. Kou, X., Li, B., Olayanju, J. B., Drake, J. M., & Chen, N. (2018). Nutraceutical or Pharmacological Potential of Moringa oleifera Lam. Nutrients, 10(343), 1–12.
13.
go back to reference Alegbeleye, O. O. (2018). How Functional Is Moringa oleifera? A Review of Its Nutritive, Medicinal, and Socioeconomic Potential. Food and Nutrition Bulletin, 39(1), 149–170.CrossRef Alegbeleye, O. O. (2018). How Functional Is Moringa oleifera? A Review of Its Nutritive, Medicinal, and Socioeconomic Potential. Food and Nutrition Bulletin, 39(1), 149–170.CrossRef
14.
go back to reference Vergara-Jimenez, M., Almatrafi, M. M., & Fernandez, M. L. (2017). Bioactive Components in Moringa Oleifera Leaves Protect against Chronic Disease. Antioxidants, 6(91), 1–13. Vergara-Jimenez, M., Almatrafi, M. M., & Fernandez, M. L. (2017). Bioactive Components in Moringa Oleifera Leaves Protect against Chronic Disease. Antioxidants, 6(91), 1–13.
15.
go back to reference Oduro, I., Ellis, W. O., & Owusu, D. (2008). Nutritional potential of two leafy vegetables: Moringa oleifera and Ipomoea batatas leaves. Scientific Res Essay., 3(2), 57–60. Oduro, I., Ellis, W. O., & Owusu, D. (2008). Nutritional potential of two leafy vegetables: Moringa oleifera and Ipomoea batatas leaves. Scientific Res Essay., 3(2), 57–60.
16.
go back to reference Anwar, F., Latif, S., Ashraf, M., & Gilani, A. H. (2007). Moringa oleifera: A Food Plant with Multiple Medicinal Uses. Phytotherapy Research, 21, 17–25.CrossRef Anwar, F., Latif, S., Ashraf, M., & Gilani, A. H. (2007). Moringa oleifera: A Food Plant with Multiple Medicinal Uses. Phytotherapy Research, 21, 17–25.CrossRef
17.
go back to reference James, A., & Zikankuba, V. (2017). Moringa oleifera a potential tree for nutrition security in sub-Sahara Africa. Am J Res Commun., 5(4), 1–14. James, A., & Zikankuba, V. (2017). Moringa oleifera a potential tree for nutrition security in sub-Sahara Africa. Am J Res Commun., 5(4), 1–14.
18.
go back to reference Monera, T. G., & Maponga, C. C. (2012). Prevalence and patterns of Moringa oleifera use among HIV positive patients in Zimbabwe: a cross-sectional survey. J Public Health Afr., 3(e6), 22–24. Monera, T. G., & Maponga, C. C. (2012). Prevalence and patterns of Moringa oleifera use among HIV positive patients in Zimbabwe: a cross-sectional survey. J Public Health Afr., 3(e6), 22–24.
19.
go back to reference WMA. (2013). World Medical Association Declaration of Helsinki - Ethical Principles for Medical Research Involving Human Subjectss. Clinical Review & Education—Special Communication., 310(20), 2191–4. WMA. (2013). World Medical Association Declaration of Helsinki - Ethical Principles for Medical Research Involving Human Subjectss. Clinical Review & Education—Special Communication., 310(20), 2191–4.
20.
go back to reference Cohen, J. (1988). Statistical power analysis for the behavioral sciences. (2nd ed.). Hillsdale, N J: Lawrence Earlbaum Associates. Cohen, J. (1988). Statistical power analysis for the behavioral sciences. (2nd ed.). Hillsdale, N J: Lawrence Earlbaum Associates.
21.
go back to reference Faul, F., Erdfelder, E., Buchner, A., & Lang, A.-G. (2009). Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses. Behav., 41, 1149–60.CrossRef Faul, F., Erdfelder, E., Buchner, A., & Lang, A.-G. (2009). Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses. Behav., 41, 1149–60.CrossRef
22.
go back to reference Bahadoran, Z., Tohidi, M., Nazeri, P., Mehran, M., Azizi, F., & Mirmiran, P. (2012). Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial. International Journal of Food Sciences and Nutrition, 63(7), 767–771.CrossRef Bahadoran, Z., Tohidi, M., Nazeri, P., Mehran, M., Azizi, F., & Mirmiran, P. (2012). Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial. International Journal of Food Sciences and Nutrition, 63(7), 767–771.CrossRef
23.
go back to reference Tété-Bénissan, A., Quashie, M. I. A., Lawson-Evi, K., Gnandi, K., Kokou, K., & Gbéassor, M. (2013). Influence of Moringa oleifera leaves on atherogenic lipids and glycaemia evolution in HIV-infected and uninfected malnourished patients. J Appl Biosci., 62, 4610–4619.CrossRef Tété-Bénissan, A., Quashie, M. I. A., Lawson-Evi, K., Gnandi, K., Kokou, K., & Gbéassor, M. (2013). Influence of Moringa oleifera leaves on atherogenic lipids and glycaemia evolution in HIV-infected and uninfected malnourished patients. J Appl Biosci., 62, 4610–4619.CrossRef
25.
go back to reference Fatiregun, A. A., Mofolorunsho, K. C., & Osagbemi, K. G. (2009). Quality of life of people living with HIV/AIDS in Kogi State. Nigeria. BJPM., 11(1), 21–27. Fatiregun, A. A., Mofolorunsho, K. C., & Osagbemi, K. G. (2009). Quality of life of people living with HIV/AIDS in Kogi State. Nigeria. BJPM., 11(1), 21–27.
26.
go back to reference Dhakad, A. K., Ikram, M., Sharma, S., Khan, S., Pandey, V. V., & Singh, A. (2019). Biological, nutritional, and therapeutic significance of Moringa oleifera Lam. Phytotherapy Research, 33, 2870–2903.CrossRef Dhakad, A. K., Ikram, M., Sharma, S., Khan, S., Pandey, V. V., & Singh, A. (2019). Biological, nutritional, and therapeutic significance of Moringa oleifera Lam. Phytotherapy Research, 33, 2870–2903.CrossRef
27.
go back to reference Jelsma, J., MacLean, E., Hughes, J., Tinise, X., & Darder, M. (2005). An investigation into the health-related quality of life of individuals living with HIV who are receiving HAART. AIDS Care, 17(5), 579–588.CrossRef Jelsma, J., MacLean, E., Hughes, J., Tinise, X., & Darder, M. (2005). An investigation into the health-related quality of life of individuals living with HIV who are receiving HAART. AIDS Care, 17(5), 579–588.CrossRef
29.
go back to reference Rasoolinajad, M., Abedinia, N., Noorbala, A. A., Mohraz, M., Badie, B. M., Hamad, A., & Sahebi, L. (2018). Relationship Among HIV.Related Stigma, Mental Health and Quality of life for HIV.Positive Patients in Tehran. AIDS Behav., 22, 3773–82.CrossRef Rasoolinajad, M., Abedinia, N., Noorbala, A. A., Mohraz, M., Badie, B. M., Hamad, A., & Sahebi, L. (2018). Relationship Among HIV.Related Stigma, Mental Health and Quality of life for HIV.Positive Patients in Tehran. AIDS Behav., 22, 3773–82.CrossRef
30.
go back to reference Gopi, S., Jacob, J., Varma, K., Amalraj, A., Sreeraj, T. R., Kunnumakkara, A. B., et al. (2017). Natural sports supplement formulation for physical endurance: a randomized, double-blind, placebo-controlled study. Sport Sci Health., 13, 183–194.CrossRef Gopi, S., Jacob, J., Varma, K., Amalraj, A., Sreeraj, T. R., Kunnumakkara, A. B., et al. (2017). Natural sports supplement formulation for physical endurance: a randomized, double-blind, placebo-controlled study. Sport Sci Health., 13, 183–194.CrossRef
32.
go back to reference Mohamed, A. A., Metwally, M. M. M., Khalil, S. R., Salem, G. A., & Ali, H. A. (2019). Moringa oleifera extract attenuates the CoCl2 induced hypoxia of rat’s brain: Expression pattern of HIF-1α. NF-kB MAO and EPO. Biomed Pharmacother., 109, 1688–1697.CrossRef Mohamed, A. A., Metwally, M. M. M., Khalil, S. R., Salem, G. A., & Ali, H. A. (2019). Moringa oleifera extract attenuates the CoCl2 induced hypoxia of rat’s brain: Expression pattern of HIF-1α. NF-kB MAO and EPO. Biomed Pharmacother., 109, 1688–1697.CrossRef
33.
go back to reference Jamari, H., Rofiee, M. S., Johari, R. J., Salleh, M. Z., & Kek, T. L. (2020). Standardised Extracts of Moringa Oleifera and Centella Asiatica Enhanced the Antioxidant Activity, Learning and Memory Effects by Inhibiting Acetylcholinesterase Activity in D-Galactose Induced Ageing Rats. Pertanika J Sci & Technol., 28(1), 293–310. Jamari, H., Rofiee, M. S., Johari, R. J., Salleh, M. Z., & Kek, T. L. (2020). Standardised Extracts of Moringa Oleifera and Centella Asiatica Enhanced the Antioxidant Activity, Learning and Memory Effects by Inhibiting Acetylcholinesterase Activity in D-Galactose Induced Ageing Rats. Pertanika J Sci & Technol., 28(1), 293–310.
37.
go back to reference Sparman, A., & Thompson, K. (2017). Safety Profile and Effect on Libido of a Combined Bryophyllum pinnatum, Moringa oleifera and Vitamin C Phytotherapeutic Agent. Free Radicals and Antioxidants., 7(2), 156–159.CrossRef Sparman, A., & Thompson, K. (2017). Safety Profile and Effect on Libido of a Combined Bryophyllum pinnatum, Moringa oleifera and Vitamin C Phytotherapeutic Agent. Free Radicals and Antioxidants., 7(2), 156–159.CrossRef
38.
go back to reference Prabsattroo, T., Wattanathorn, J., Iamsaard, S., Somsapt, P., Sritragool, O., Thukhummee, W., et al. (2015). Moringa oleifera extract enhances sexual performance in stressed rats. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 16(3), 179–190.CrossRef Prabsattroo, T., Wattanathorn, J., Iamsaard, S., Somsapt, P., Sritragool, O., Thukhummee, W., et al. (2015). Moringa oleifera extract enhances sexual performance in stressed rats. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 16(3), 179–190.CrossRef
39.
go back to reference Mueller, P. S., Plevak, D. J., & Rummans, T. A. (2001). Religious Involvement, Spirituality, and Medicine: Implications for Clinical Practice. Mayo Clinic Proceedings, 76, 1225–1235.CrossRef Mueller, P. S., Plevak, D. J., & Rummans, T. A. (2001). Religious Involvement, Spirituality, and Medicine: Implications for Clinical Practice. Mayo Clinic Proceedings, 76, 1225–1235.CrossRef
40.
go back to reference Cotton, S., Puchalski, C. M., Sherman, S. N., Mrus, J. M., Peterman, A. H., Feinberg, J., et al. (2006). Spirituality and Religion in Patients with HIV/AIDS. Journal of General Internal Medicine, 21, S5-13.CrossRef Cotton, S., Puchalski, C. M., Sherman, S. N., Mrus, J. M., Peterman, A. H., Feinberg, J., et al. (2006). Spirituality and Religion in Patients with HIV/AIDS. Journal of General Internal Medicine, 21, S5-13.CrossRef
41.
go back to reference Suleiman, B. A., Yahaya, M., Olaniyan, F. A., Sule, A. G., & Sufiyan, M. B. (2020). Determinants of health-related quality of life among human immunodeficiency virus positive (HIV-positive) patients at Ahmadu Bello University teaching hospital, Zaria, Nigeria- 2015. BMC Public Health, 20(531), 1–9. Suleiman, B. A., Yahaya, M., Olaniyan, F. A., Sule, A. G., & Sufiyan, M. B. (2020). Determinants of health-related quality of life among human immunodeficiency virus positive (HIV-positive) patients at Ahmadu Bello University teaching hospital, Zaria, Nigeria- 2015. BMC Public Health, 20(531), 1–9.
Metagegevens
Titel
Impact of Moringa Oleifera leaves supplementation on quality of life of people living with HIV: A double-blind randomized controlled trial
Auteurs
Aisha Gambo
Indres Moodley
Musa Babashani
Tesleem K. Babalola
Publicatiedatum
21-04-2021
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 9/2021
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-021-02842-0

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