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Quality of Life Research
Gepubliceerd in: Quality of Life Research 7/2013

01-09-2013

Impact of hepatitis B and C co-infection on health-related quality of life in HIV positive individuals

Auteurs: Jennifer Gillis, Curtis Cooper, Sean Rourke, Sergio Rueda, Kelly O’Brien, Evan Collins, Anita Rachlis, Trevor A. Hart, Janet Raboud, the OHTN Cohort Study Group

Gepubliceerd in: Quality of Life Research | Uitgave 7/2013

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Abstract

Purpose

Concurrent infection with HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV) often occurs due to the commonality in risk factors for acquisition. Few studies have examined the effect of co-infection on health-related quality of life (HRQOL) in HIV positive individuals.

Methods

Ontario HIV Treatment Network Cohort Study (OCS) participants who completed an annual interviewer-administered questionnaire on up to three occasions were included. Generalized estimating equations (GEE) were used to assess the impact of HBV and HCV co-infection on physical and mental HRQOL component summary scores (range 0–100) as measured by the Medical Outcomes SF-36 health survey.

Results

As of March 2010, 1,223 participants had completed the questionnaire; 964 were HIV mono-infected, 128 were HIV–HBV co-infected, 112 were HIV–HCV co-infected, and 19 were HIV–HBV–HCV tri-infected. Eighty percent were male, median age 46 (IQR 40–53) years, 61 % Caucasian, median CD4 count 464 (IQR 319–636) cells/mm3, and 74 % had undetectable HIV viremia. Physical HRQOL was lower in HIV–HBV and HIV–HCV co-infected individuals (49.4 (IQR 42.0–53.9) and 48.1 (IQR 36.9–52.8) vs. 51.5 (IQR 45.0–55.4); p = 0.01 and <0.0001) compared to mono-infected individuals. In the multivariable GEE model, the negative impact of HCV remained significant (−2.18; p = 0.01) after adjusting for drug use, smoking, age, and gender. Unadjusted mental HRQOL was lower in HIV–HCV co-infected individuals (44.6 (IQR 34.6–54.0) vs. 48.9 (IQR 36.8–55.9); p = 0.03) compared to mono-infected individuals but no association of mental HRQOL with either co-infection was observed in multivariable GEE models.

Conclusions

HCV appears to negatively impact physical HRQOL suggesting a greater health burden for co-infected individuals. HBV and HCV co-infections were not related to lower mental HRQOL among people living with HIV/AIDS.
vorige artikel Health-related quality of life, obesity, and fitness in schoolchildren: the Cuenca study
volgende artikel Health-related quality of life in patients with interstitial cystitis/bladder pain syndrome and frequently associated comorbidities
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Metagegevens
Titel
Impact of hepatitis B and C co-infection on health-related quality of life in HIV positive individuals
Auteurs
Jennifer Gillis
Curtis Cooper
Sean Rourke
Sergio Rueda
Kelly O’Brien
Evan Collins
Anita Rachlis
Trevor A. Hart
Janet Raboud
the OHTN Cohort Study Group
Publicatiedatum
01-09-2013
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 7/2013
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-012-0283-7

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