Skip to main content
Top
Gepubliceerd in: Quality of Life Research 7/2012

01-09-2012

Impact of diabetes mellitus on quality of life in patients with congestive heart failure

Auteurs: Buntaro Fujita, Alexander Lauten, Bjoern Goebel, Marcus Franz, Michael Fritzenwanger, Markus Ferrari, Hans R. Figulla, Friedhelm Kuethe, Christian Jung

Gepubliceerd in: Quality of Life Research | Uitgave 7/2012

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Objectives

Congestive heart failure (CHF) and diabetes mellitus (DM) are increasing in prevalence. There are conflicting data regarding the crosstalk of DM and CHF with respect to the prognostic impact for the patients. Health-related quality of life (Hr-QoL) has been reported to be useful for risk stratification. The purpose of this study was to investigate the impact of DM on Hr-QoL in a CHF population.

Methods

325 consecutive patients with CHF were retrospectively analyzed (age 49 ± 12 years, 74.2% male, 18% had diabetes). After a median follow-up time of 7.4 years, we compared Hr-QoL of patients with and without DM. Hr-QoL was assessed using the Minnesota Living with Heart Failure Questionnaire (MLHFQ). Kaplan–Meier curves were used to compare survival.

Results

The presence of DM reduced Hr-QoL in patients with CHF, indicated by a higher overall MLHFQ score (43.5 vs. 21, P = 0.013). Kaplan–Meier survival curves showed a significant survival difference (P = 0.024). Survival rates of both groups differed significantly after 3 (P = 0.031), 5 (P = 0.006), and 10 years (P = 0.047) favoring the group without DM.

Conclusions

In patients with CHF, the coexistence of DM is associated with a reduced Hr-QoL and a particularly poor long-term survival. Our results indicate that CHF patients with DM are at increased risk.
Bijlagen
Alleen toegankelijk voor geautoriseerde gebruikers
Literatuur
1.
go back to reference Fang, J., Mensah, G. A., Croft, J. B., & Keenan, N. L. (2008). Heart failure-related hospitalization in the U.S., 1979 to 2004. Journal of the American College of Cardiology, 52(6), 428–434.PubMedCrossRef Fang, J., Mensah, G. A., Croft, J. B., & Keenan, N. L. (2008). Heart failure-related hospitalization in the U.S., 1979 to 2004. Journal of the American College of Cardiology, 52(6), 428–434.PubMedCrossRef
2.
go back to reference WRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R. J., Brown, T. M., Carnethon, M., Dai, S., De Simone, G., Ferguson, T. B., Ford, E., Furie, K., Gillespie, C., Go, A., Greenlund, K., Haase, N., Hailpern, S., Ho, P. M., Howard, V., Kissela, B., Kittner, S., Lackland, D., Lisabeth, L., Marelli, A., McDermott, M. M., Meigs, J., Mozaffarian, D., Mussolino, M., Nichol, G., Roger, V. L., Rosamond, W., Sacco, R., Sorlie, P., Stafford, R., Thom, T., Wasserthiel-Smoller, S., Wong, N. D., Wylie-Rosett, J., Committee, on behalf of the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Executive Summary: Heart Disease and Stroke Statistics–2010 Update: A Report From the American Heart Association. Circulation, 121(7), 948–954. WRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R. J., Brown, T. M., Carnethon, M., Dai, S., De Simone, G., Ferguson, T. B., Ford, E., Furie, K., Gillespie, C., Go, A., Greenlund, K., Haase, N., Hailpern, S., Ho, P. M., Howard, V., Kissela, B., Kittner, S., Lackland, D., Lisabeth, L., Marelli, A., McDermott, M. M., Meigs, J., Mozaffarian, D., Mussolino, M., Nichol, G., Roger, V. L., Rosamond, W., Sacco, R., Sorlie, P., Stafford, R., Thom, T., Wasserthiel-Smoller, S., Wong, N. D., Wylie-Rosett, J., Committee, on behalf of the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Executive Summary: Heart Disease and Stroke Statistics–2010 Update: A Report From the American Heart Association. Circulation, 121(7), 948–954.
3.
go back to reference Jessup, M., Abraham, W. T., Casey, D. E., Feldman, A. M., Francis, G. S., Ganiats, T. G., Konstam, M. A., Mancini, D. M., Rahko, P. S., Silver, M. A., Stevenson, L. W., & Yancy, C. W. (2009). 2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: Developed in Collaboration With the International Society for Heart and Lung Transplantation. Circulation, 119(14), 1977–2016. Jessup, M., Abraham, W. T., Casey, D. E., Feldman, A. M., Francis, G. S., Ganiats, T. G., Konstam, M. A., Mancini, D. M., Rahko, P. S., Silver, M. A., Stevenson, L. W., & Yancy, C. W. (2009). 2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: Developed in Collaboration With the International Society for Heart and Lung Transplantation. Circulation, 119(14), 1977–2016.
4.
go back to reference Krumholz, H. M., Peterson, E. D., Ayanian, J. Z., Chin, M. H., DeBusk, R. F., Goldman, L., et al. (2005). Report of the national heart, lung, and blood institute working group on outcomes research in cardiovascular disease. Circulation, 111(23), 3158–3166.PubMedCrossRef Krumholz, H. M., Peterson, E. D., Ayanian, J. Z., Chin, M. H., DeBusk, R. F., Goldman, L., et al. (2005). Report of the national heart, lung, and blood institute working group on outcomes research in cardiovascular disease. Circulation, 111(23), 3158–3166.PubMedCrossRef
5.
go back to reference Mommersteeg, P. M. C., Denollet, J., Spertus, J. A., & Pedersen, S. S. (2009). Health status as a risk factor in cardiovascular disease: A systematic review of current evidence. American Heart Journal, 157(2), 208–218.PubMedCrossRef Mommersteeg, P. M. C., Denollet, J., Spertus, J. A., & Pedersen, S. S. (2009). Health status as a risk factor in cardiovascular disease: A systematic review of current evidence. American Heart Journal, 157(2), 208–218.PubMedCrossRef
6.
go back to reference Bekelman, D. B., Havranek, E. P., Becker, D. M., Kutner, J. S., Peterson, P. N., Wittstein, I. S., et al. (2007). Symptoms, depression, and quality of life in patients with heart failure. Journal of Cardiac Failure, 13(8), 643–648.PubMedCrossRef Bekelman, D. B., Havranek, E. P., Becker, D. M., Kutner, J. S., Peterson, P. N., Wittstein, I. S., et al. (2007). Symptoms, depression, and quality of life in patients with heart failure. Journal of Cardiac Failure, 13(8), 643–648.PubMedCrossRef
7.
go back to reference Rector, T. S., Anand, I. S., & Cohn, J. N. (2006). Relationships between clinical assessments and patients’ perceptions of the effects of heart failure on their quality of life. Journal of Cardiac Failure, 12(2), 87–92.PubMedCrossRef Rector, T. S., Anand, I. S., & Cohn, J. N. (2006). Relationships between clinical assessments and patients’ perceptions of the effects of heart failure on their quality of life. Journal of Cardiac Failure, 12(2), 87–92.PubMedCrossRef
8.
go back to reference Hallas, C. N., Wray, J., Andreou, P., & Banner, N. R. (2011). Depression and perceptions about heart failure predict quality of life in patients with advanced heart failure. Heart & Lung: The Journal of Acute and Critical Care, 40(2), 111–121.CrossRef Hallas, C. N., Wray, J., Andreou, P., & Banner, N. R. (2011). Depression and perceptions about heart failure predict quality of life in patients with advanced heart failure. Heart & Lung: The Journal of Acute and Critical Care, 40(2), 111–121.CrossRef
9.
go back to reference Evangelista, L. S., Moser, D. K., Westlake, C., Hamilton, M. A., Fonarow, G. C., & Dracup, K. (2006). Impact of obesity on quality of life and depression in patients with heart failure. European Journal of Heart Failure, 8(7), 750–755.PubMedCrossRef Evangelista, L. S., Moser, D. K., Westlake, C., Hamilton, M. A., Fonarow, G. C., & Dracup, K. (2006). Impact of obesity on quality of life and depression in patients with heart failure. European Journal of Heart Failure, 8(7), 750–755.PubMedCrossRef
10.
go back to reference Kato, N., Kinugawa, K., Seki, S., Shiga, T., Hatano, M., Yao, A., et al. (2011). Quality of life as an independent predictor for cardiac events and death in patients with heart failure. Circulation Journal, 75(7), 1661–1669.PubMedCrossRef Kato, N., Kinugawa, K., Seki, S., Shiga, T., Hatano, M., Yao, A., et al. (2011). Quality of life as an independent predictor for cardiac events and death in patients with heart failure. Circulation Journal, 75(7), 1661–1669.PubMedCrossRef
11.
go back to reference Cohen-Solal, A., Beauvais, F., & Logeart, D. (2008). Heart failure and diabetes mellitus: Epidemiology and management of an alarming association. Journal of Cardiac Failure, 14(7), 615–625.PubMedCrossRef Cohen-Solal, A., Beauvais, F., & Logeart, D. (2008). Heart failure and diabetes mellitus: Epidemiology and management of an alarming association. Journal of Cardiac Failure, 14(7), 615–625.PubMedCrossRef
12.
go back to reference From, A. M., Leibson, C. L., Bursi, F., Redfield, M. M., Weston, S. A., Jacobsen, S. J., et al. (2006). Diabetes in heart failure: Prevalence and impact on outcome in the population. The American Journal of Medicine, 119(7), 591–599.PubMedCrossRef From, A. M., Leibson, C. L., Bursi, F., Redfield, M. M., Weston, S. A., Jacobsen, S. J., et al. (2006). Diabetes in heart failure: Prevalence and impact on outcome in the population. The American Journal of Medicine, 119(7), 591–599.PubMedCrossRef
13.
go back to reference Adams, J. K. F., Fonarow, G. C., Emerman, C. L., LeJemtel, T. H., Costanzo, M. R., Abraham, W. T., et al. (2005). Characteristics and outcomes of patients hospitalized for heart failure in the United States: Rationale, design, and preliminary observations from the first 100, 000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE). American Heart Journal, 149(2), 209–216.PubMedCrossRef Adams, J. K. F., Fonarow, G. C., Emerman, C. L., LeJemtel, T. H., Costanzo, M. R., Abraham, W. T., et al. (2005). Characteristics and outcomes of patients hospitalized for heart failure in the United States: Rationale, design, and preliminary observations from the first 100, 000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE). American Heart Journal, 149(2), 209–216.PubMedCrossRef
14.
go back to reference Kamalesh, M., & Nair, G. (2005). Disproportionate increase in prevalence of diabetes among patients with congestive heart failure due to systolic dysfunction. International Journal of Cardiology, 99(1), 125–127.PubMedCrossRef Kamalesh, M., & Nair, G. (2005). Disproportionate increase in prevalence of diabetes among patients with congestive heart failure due to systolic dysfunction. International Journal of Cardiology, 99(1), 125–127.PubMedCrossRef
15.
go back to reference American Diabetes Association (2006). Diagnosis and Classification of Diabetes Mellitus. Diabetes Care, 29(Suppl 1), s43–s48. American Diabetes Association (2006). Diagnosis and Classification of Diabetes Mellitus. Diabetes Care, 29(Suppl 1), s43–s48.
16.
go back to reference Garin, O., Ferrer, M., Pont, À., Rué, M., Kotzeva, A., Wiklund, I., et al. (2009). Disease-specific health-related quality of life questionnaires for heart failure: A systematic review with meta-analyses. Quality of Life Research, 18(1), 71–85.PubMedCrossRef Garin, O., Ferrer, M., Pont, À., Rué, M., Kotzeva, A., Wiklund, I., et al. (2009). Disease-specific health-related quality of life questionnaires for heart failure: A systematic review with meta-analyses. Quality of Life Research, 18(1), 71–85.PubMedCrossRef
18.
go back to reference Bennett, S. J., Oldridge, N. B., Eckert, G. J., Embree, J. L., Browning, S., Hou, N., et al. (2002). Discriminant properties of commonly used quality of life measures in heart failure. Quality of Life Research, 11(4), 349–359.CrossRef Bennett, S. J., Oldridge, N. B., Eckert, G. J., Embree, J. L., Browning, S., Hou, N., et al. (2002). Discriminant properties of commonly used quality of life measures in heart failure. Quality of Life Research, 11(4), 349–359.CrossRef
19.
go back to reference Reiss, N., Kleikamp, G., Tenderich, G., Tschöpe, D., & Körfer, R. (2008). Diabetes mellitus und Herzinsuffizienz–Inzidenz und chirurgische Therapieoptionen. Herz, 33(3), 206–210.PubMedCrossRef Reiss, N., Kleikamp, G., Tenderich, G., Tschöpe, D., & Körfer, R. (2008). Diabetes mellitus und Herzinsuffizienz–Inzidenz und chirurgische Therapieoptionen. Herz, 33(3), 206–210.PubMedCrossRef
20.
go back to reference Ruo, B., Rumsfeld, J. S., Hlatky, M. A., Liu, H., Browner, W. S., & Whooley, M. A. (2003). Depressive symptoms and health-related quality of life. JAMA: The Journal of the American Medical Association, 290(2), 215–221.CrossRef Ruo, B., Rumsfeld, J. S., Hlatky, M. A., Liu, H., Browner, W. S., & Whooley, M. A. (2003). Depressive symptoms and health-related quality of life. JAMA: The Journal of the American Medical Association, 290(2), 215–221.CrossRef
21.
go back to reference Alla, F., Briançon, S., Guillemin, F., Juillière, Y., Mertès, P.-M., Villemot, J.-P., et al. (2002). Self-rating of quality of life provides additional prognostic information in heart failure. Insights into the EPICAL study. European Journal of Heart Failure, 4(3), 337–343.PubMedCrossRef Alla, F., Briançon, S., Guillemin, F., Juillière, Y., Mertès, P.-M., Villemot, J.-P., et al. (2002). Self-rating of quality of life provides additional prognostic information in heart failure. Insights into the EPICAL study. European Journal of Heart Failure, 4(3), 337–343.PubMedCrossRef
22.
go back to reference Kosiborod, M., Soto, G. E., Jones, P. G., Krumholz, H. M., Weintraub, W. S., Deedwania, P., et al. (2007). Identifying heart failure patients at high risk for near-term cardiovascular events with serial health status assessments. Circulation, 115(15), 1975–1981.PubMedCrossRef Kosiborod, M., Soto, G. E., Jones, P. G., Krumholz, H. M., Weintraub, W. S., Deedwania, P., et al. (2007). Identifying heart failure patients at high risk for near-term cardiovascular events with serial health status assessments. Circulation, 115(15), 1975–1981.PubMedCrossRef
23.
go back to reference Jung, C., Rafnsson, A., Shemyakin, A., Böhm, F., & Pernow, J. (2010). Different subpopulations of endothelial progenitor cells and circulating apoptotic progenitor cells in patients with vascular disease and diabetes. International Journal of Cardiology, 143(3), 368–372.PubMedCrossRef Jung, C., Rafnsson, A., Shemyakin, A., Böhm, F., & Pernow, J. (2010). Different subpopulations of endothelial progenitor cells and circulating apoptotic progenitor cells in patients with vascular disease and diabetes. International Journal of Cardiology, 143(3), 368–372.PubMedCrossRef
24.
go back to reference Hoekstra, T., Lesman-Leegte, I., van Veldhuisen, D. J., Sanderman, R., & Jaarsma, T. (2011). Quality of life is impaired similarly in heart failure patients with preserved and reduced ejection fraction. European Journal of Heart Failure, 13(9), 1013–1018.PubMedCrossRef Hoekstra, T., Lesman-Leegte, I., van Veldhuisen, D. J., Sanderman, R., & Jaarsma, T. (2011). Quality of life is impaired similarly in heart failure patients with preserved and reduced ejection fraction. European Journal of Heart Failure, 13(9), 1013–1018.PubMedCrossRef
25.
go back to reference Lewis, E. F., Lamas, G. A., O’Meara, E., Granger, C. B., Dunlap, M. E., McKelvie, R. S., et al. (2007). Characterization of health-related quality of life in heart failure patients with preserved versus low ejection fraction in CHARM. European Journal of Heart Failure, 9(1), 83–91.PubMedCrossRef Lewis, E. F., Lamas, G. A., O’Meara, E., Granger, C. B., Dunlap, M. E., McKelvie, R. S., et al. (2007). Characterization of health-related quality of life in heart failure patients with preserved versus low ejection fraction in CHARM. European Journal of Heart Failure, 9(1), 83–91.PubMedCrossRef
26.
go back to reference Tsuchihashi-Makaya, M., Hamaguchi, S., Kinugawa, S., Yokota, T., Goto, D., Yokoshiki, H., et al. (2009). Characteristics and outcomes of hospitalized patients with heart failure and reduced vs preserved ejection fraction. A report from the japanese cardiac registry of heart failure in cardiology (JCARE-CARD). Circulation Journal, 73(10), 1893–1900.PubMedCrossRef Tsuchihashi-Makaya, M., Hamaguchi, S., Kinugawa, S., Yokota, T., Goto, D., Yokoshiki, H., et al. (2009). Characteristics and outcomes of hospitalized patients with heart failure and reduced vs preserved ejection fraction. A report from the japanese cardiac registry of heart failure in cardiology (JCARE-CARD). Circulation Journal, 73(10), 1893–1900.PubMedCrossRef
27.
go back to reference Packer, M., Colucci, W. S., Sackner-Bernstein, J. D., Liang, C.-s., Goldscher, D. A., Freeman, I., et al. (1996). Double-blind, placebo-controlled study of the effects of carvedilol in patients with moderate to severe heart failure: The precise trial. Circulation, 94(11), 2793–2799.PubMedCrossRef Packer, M., Colucci, W. S., Sackner-Bernstein, J. D., Liang, C.-s., Goldscher, D. A., Freeman, I., et al. (1996). Double-blind, placebo-controlled study of the effects of carvedilol in patients with moderate to severe heart failure: The precise trial. Circulation, 94(11), 2793–2799.PubMedCrossRef
28.
go back to reference Rogers, W., Johnstone, D., Yusuf, S., Weiner, D., Gallagher, P., Bittner, V., et al. (1994). Quality of life among 5,025 patients with left ventricular dysfunction randomized between placebo and enalapril: The studies of left ventricular dysfunction. The SOLVD Investigators. Journal of the American College of Cardiology, 23(2), 393–400.PubMedCrossRef Rogers, W., Johnstone, D., Yusuf, S., Weiner, D., Gallagher, P., Bittner, V., et al. (1994). Quality of life among 5,025 patients with left ventricular dysfunction randomized between placebo and enalapril: The studies of left ventricular dysfunction. The SOLVD Investigators. Journal of the American College of Cardiology, 23(2), 393–400.PubMedCrossRef
29.
go back to reference Mommersteeg, P. M. C., Kupper, N., Schoormans, D., Emons, W., & Pedersen, S. S. (2010). Health-related quality of life is related to cytokine levels at 12 months in patients with chronic heart failure. Brain, Behavior and Immunity, 24(4), 615–622.CrossRef Mommersteeg, P. M. C., Kupper, N., Schoormans, D., Emons, W., & Pedersen, S. S. (2010). Health-related quality of life is related to cytokine levels at 12 months in patients with chronic heart failure. Brain, Behavior and Immunity, 24(4), 615–622.CrossRef
30.
go back to reference Parissis, J. T., Nikolaou, M., Farmakis, D., Paraskevaidis, I. A., Bistola, V., Venetsanou, K., et al. (2009). Self-assessment of health status is associated with inflammatory activation and predicts long-term outcomes in chronic heart failure. European Journal of Heart Failure, 11(2), 163–169.PubMedCrossRef Parissis, J. T., Nikolaou, M., Farmakis, D., Paraskevaidis, I. A., Bistola, V., Venetsanou, K., et al. (2009). Self-assessment of health status is associated with inflammatory activation and predicts long-term outcomes in chronic heart failure. European Journal of Heart Failure, 11(2), 163–169.PubMedCrossRef
31.
go back to reference Farkas, J., Nabb, S., Zaletel-Kragelj, L., Cleland, J. G. F., & Lainscak, M. (2009). Self-rated health and mortality in patients with chronic heart failure. European Journal of Heart Failure, 11(5), 518–524.PubMedCrossRef Farkas, J., Nabb, S., Zaletel-Kragelj, L., Cleland, J. G. F., & Lainscak, M. (2009). Self-rated health and mortality in patients with chronic heart failure. European Journal of Heart Failure, 11(5), 518–524.PubMedCrossRef
32.
go back to reference Subramanian, U., Eckert, G., Yeung, A., & Tierney, W. M. (2007). A single health status question had important prognostic value among outpatients with chronic heart failure. Journal of Clinical Epidemiology, 60(8), 803–811.PubMedCrossRef Subramanian, U., Eckert, G., Yeung, A., & Tierney, W. M. (2007). A single health status question had important prognostic value among outpatients with chronic heart failure. Journal of Clinical Epidemiology, 60(8), 803–811.PubMedCrossRef
33.
go back to reference Heo, S., Moser, D. K., Riegel, B., Hall, L. A., & Christman, N. (2005). Testing the psychometric properties of the Minnesota living with heart failure questionnaire. Nursing Research, 54(4), 265–272.PubMedCrossRef Heo, S., Moser, D. K., Riegel, B., Hall, L. A., & Christman, N. (2005). Testing the psychometric properties of the Minnesota living with heart failure questionnaire. Nursing Research, 54(4), 265–272.PubMedCrossRef
34.
go back to reference Supino, P. G., Borer, J. S., Franciosa, J. A., Preibisz, J. J., Hochreiter, C., Isom, O. W., et al. (2009). Acceptability and psychometric properties of the Minnesota living with heart failure questionnaire among patients undergoing heart valve surgery: Validation and comparison with SF-36. Journal of Cardiac Failure, 15(3), 267–277.PubMedCrossRef Supino, P. G., Borer, J. S., Franciosa, J. A., Preibisz, J. J., Hochreiter, C., Isom, O. W., et al. (2009). Acceptability and psychometric properties of the Minnesota living with heart failure questionnaire among patients undergoing heart valve surgery: Validation and comparison with SF-36. Journal of Cardiac Failure, 15(3), 267–277.PubMedCrossRef
35.
go back to reference Adams, K. F., Jr, Sueta, C. A., Gheorghiade, M., O’Connor, C. M., Schwartz, T. A., Koch, G. G., et al. (1999). Gender differences in survival in advanced heart failure: Insights from the FIRST study. Circulation, 99(14), 1816–1821.PubMedCrossRef Adams, K. F., Jr, Sueta, C. A., Gheorghiade, M., O’Connor, C. M., Schwartz, T. A., Koch, G. G., et al. (1999). Gender differences in survival in advanced heart failure: Insights from the FIRST study. Circulation, 99(14), 1816–1821.PubMedCrossRef
36.
go back to reference Chin, M. H., & Goldman, L. (1998). Gender differences in 1-year survival and quality of life among patients admitted with congestive heart failure. Medical Care, 36(7), 1033–1046.PubMedCrossRef Chin, M. H., & Goldman, L. (1998). Gender differences in 1-year survival and quality of life among patients admitted with congestive heart failure. Medical Care, 36(7), 1033–1046.PubMedCrossRef
37.
go back to reference Simon, T., Mary-Krause, M., Funck-Brentano, C., & Jaillon, P. (2001). Sex differences in the prognosis of congestive heart failure: Results from the cardiac insufficiency bisoprolol study (CIBIS II). Circulation, 103(3), 375–380.PubMedCrossRef Simon, T., Mary-Krause, M., Funck-Brentano, C., & Jaillon, P. (2001). Sex differences in the prognosis of congestive heart failure: Results from the cardiac insufficiency bisoprolol study (CIBIS II). Circulation, 103(3), 375–380.PubMedCrossRef
38.
go back to reference Varela-Roman, A., Shamagian, L. G., Caballero, E. B., Ramos, P. M., Veloso, P. R., & Gonzalez-Juanatey, J. R. (2005). Influence of diabetes on the survival of patients hospitalized with heart failure: A 12-year study. European Journal of Heart Failure, 7(5), 859–864.PubMedCrossRef Varela-Roman, A., Shamagian, L. G., Caballero, E. B., Ramos, P. M., Veloso, P. R., & Gonzalez-Juanatey, J. R. (2005). Influence of diabetes on the survival of patients hospitalized with heart failure: A 12-year study. European Journal of Heart Failure, 7(5), 859–864.PubMedCrossRef
Metagegevens
Titel
Impact of diabetes mellitus on quality of life in patients with congestive heart failure
Auteurs
Buntaro Fujita
Alexander Lauten
Bjoern Goebel
Marcus Franz
Michael Fritzenwanger
Markus Ferrari
Hans R. Figulla
Friedhelm Kuethe
Christian Jung
Publicatiedatum
01-09-2012
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 7/2012
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-011-0039-9

Andere artikelen Uitgave 7/2012

Quality of Life Research 7/2012 Naar de uitgave