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Gepubliceerd in: Cognitive Therapy and Research 3/2016

12-12-2015 | Original Article

Impact of Comorbid Depressive Disorders on Subjective and Physiological Responses to Emotion in Generalized Anxiety Disorder

Auteurs: Saren H. Seeley, Douglas S. Mennin, Amelia Aldao, Katie A. McLaughlin, Jonathan Rottenberg, David M. Fresco

Gepubliceerd in: Cognitive Therapy and Research | Uitgave 3/2016

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Abstract

Generalized anxiety disorder (GAD) and unipolar depressive disorders (UDD) have been shown to differ from each other in dimensions of affective functioning despite their high rates of comorbidity. We showed emotional film clips to a community sample (n = 170) with GAD, GAD with secondary UDD, or no diagnosis. Groups had comparable subjective responses to the clips, but the GAD group had significantly lower heart rate variability (HRV) during fear and after sadness, compared to controls. While HRV in the GAD and control groups rose in response to the sadness and happiness clips, it returned to baseline levels afterwards in the GAD group, potentially indicating lesser ability to sustain attention on emotional stimuli. HRV in the GAD + UDD group changed only in response to sadness, but was otherwise unvarying between timepoints. Though preliminary, these findings suggest comorbid UDD as a potential moderator of emotional responding in GAD.
Literatuur
go back to reference Aldao, A. (2013). The future of emotion regulation research: Capturing context. Perspectives on Psychological Science, 8(2), 155–172.CrossRefPubMed Aldao, A. (2013). The future of emotion regulation research: Capturing context. Perspectives on Psychological Science, 8(2), 155–172.CrossRefPubMed
go back to reference Aldao, A., Mennin, D. S., Linardatos, E., & Fresco, D. M. (2010). Differential patterns of physical symptoms and subjective processes in generalized anxiety disorder and unipolar depression. Journal of Anxiety Disorders, 24(2), 250–259. Aldao, A., Mennin, D. S., Linardatos, E., & Fresco, D. M. (2010). Differential patterns of physical symptoms and subjective processes in generalized anxiety disorder and unipolar depression. Journal of Anxiety Disorders, 24(2), 250–259.
go back to reference Aldao, A., Sheppes, G., & Gross, J. J. (2015). Emotion regulation flexibility. Cognitive Therapy and Research, 39(3), 263–278. Aldao, A., Sheppes, G., & Gross, J. J. (2015). Emotion regulation flexibility. Cognitive Therapy and Research, 39(3), 263–278.
go back to reference Allen, J. J., Chambers, A. S., & Towers, D. N. (2007). The many metrics of cardiac chronotropy: A pragmatic primer and a brief comparison of metrics. Biological Psychology, 74(2), 243–262.CrossRefPubMed Allen, J. J., Chambers, A. S., & Towers, D. N. (2007). The many metrics of cardiac chronotropy: A pragmatic primer and a brief comparison of metrics. Biological Psychology, 74(2), 243–262.CrossRefPubMed
go back to reference American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: American Psychiatric Publishing. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: American Psychiatric Publishing.
go back to reference Appelhans, B. M., & Luecken, L. J. (2006). Heart rate variability as an index of regulated emotional responding. Review of General Psychology, 10(3), 229.CrossRef Appelhans, B. M., & Luecken, L. J. (2006). Heart rate variability as an index of regulated emotional responding. Review of General Psychology, 10(3), 229.CrossRef
go back to reference Balogh, S., Fitzpatrick, D. F., Hendricks, S. E., & Paige, S. R. (1993). Increases in heart rate variability with successful treatment in patients with major depressive disorder. Psychopharmacology Bulletin, 29(2), 201–206. Balogh, S., Fitzpatrick, D. F., Hendricks, S. E., & Paige, S. R. (1993). Increases in heart rate variability with successful treatment in patients with major depressive disorder. Psychopharmacology Bulletin, 29(2), 201–206.
go back to reference Barrera, T. L., & Norton, P. J. (2009). Quality of life impairment in generalized anxiety disorder, social phobia, and panic disorder. Journal of Anxiety Disorders, 23(8), 1086–1090.CrossRefPubMedPubMedCentral Barrera, T. L., & Norton, P. J. (2009). Quality of life impairment in generalized anxiety disorder, social phobia, and panic disorder. Journal of Anxiety Disorders, 23(8), 1086–1090.CrossRefPubMedPubMedCentral
go back to reference Beck, A. T., Steer, R. A., & Brown, G. K. (1996). Beck depression inventory-II. San Antonio, TX: Psychological Corporation. Beck, A. T., Steer, R. A., & Brown, G. K. (1996). Beck depression inventory-II. San Antonio, TX: Psychological Corporation.
go back to reference Berna, G., Ott, L., & Nandrino, J.-L. (2014). Effects of emotion regulation difficulties on the tonic and phasic cardiac autonomic response. PLoS ONE, 9(7), e102971.CrossRefPubMedPubMedCentral Berna, G., Ott, L., & Nandrino, J.-L. (2014). Effects of emotion regulation difficulties on the tonic and phasic cardiac autonomic response. PLoS ONE, 9(7), e102971.CrossRefPubMedPubMedCentral
go back to reference Berntson, G. G., & Stowell, J. R. (1998). ECG artifacts and heart period variability: Don’t miss a beat! Psychophysiology, 35(1), 127–132.CrossRefPubMed Berntson, G. G., & Stowell, J. R. (1998). ECG artifacts and heart period variability: Don’t miss a beat! Psychophysiology, 35(1), 127–132.CrossRefPubMed
go back to reference Borkovec, T. D., Alcaine, O., & Behar, E. (2004). Avoidance theory of worry and generalized anxiety disorder. In R. G. Heimberg, C. L. Turk, & D. S. Mennin (Eds.), Generalized anxiety disorder: Advances in research and practice (pp. 77–108). New York, NY: Guilford Press. Borkovec, T. D., Alcaine, O., & Behar, E. (2004). Avoidance theory of worry and generalized anxiety disorder.  In R. G. Heimberg, C. L. Turk, & D. S. Mennin (Eds.), Generalized anxiety disorder: Advances in research and practice (pp. 77–108). New York, NY: Guilford Press.
go back to reference Bradley, M. M., & Lang, P. J. (2000). Emotion and motivation. In J. T. Cacioppo, L. G. Tassinary, & G. G. Berntson (Eds.), Handbook of psychophysiology (2nd ed., pp. 602–642). Cambridge: Cambridge University Press. Bradley, M. M., & Lang, P. J. (2000). Emotion and motivation. In J. T. Cacioppo, L. G. Tassinary, & G. G. Berntson (Eds.), Handbook of psychophysiology (2nd ed., pp. 602–642). Cambridge: Cambridge University Press.
go back to reference Brown, T. A., & Barlow, D. H. (2005). Dimensional versus categorical classification of mental disorders in the fifth edition of the diagnostic and statistical manual of mental disorders and beyond: Comment on the special section. Journal of Abnormal Psychology, 114(4), 551.CrossRefPubMed Brown, T. A., & Barlow, D. H. (2005). Dimensional versus categorical classification of mental disorders in the fifth edition of the diagnostic and statistical manual of mental disorders and beyond: Comment on the special section. Journal of Abnormal Psychology, 114(4), 551.CrossRefPubMed
go back to reference Brown, T. A., Campbell, L. A., Lehman, C. L., Grisham, J. R., & Mancill, R. B. (2001). Current and lifetime comorbidity of the DSM-IV anxiety and mood disorders in a large clinical sample. Journal of Abnormal Psychology, 110(4), 585.CrossRefPubMed Brown, T. A., Campbell, L. A., Lehman, C. L., Grisham, J. R., & Mancill, R. B. (2001). Current and lifetime comorbidity of the DSM-IV anxiety and mood disorders in a large clinical sample. Journal of Abnormal Psychology, 110(4), 585.CrossRefPubMed
go back to reference Brunoni, A. R., Kemp, A. H., Dantas, E. M., Goulart, A. C., Nunes, M. A., Boggio, P. S., et al. (2013). Heart rate variability is a trait marker of major depressive disorder: Evidence from the sertraline vs. electric current therapy to treat depression clinical study. The International Journal of Neuropsychopharmacology, 16(09), 1937–1949. doi:10.1017/S1461145713000497.CrossRefPubMed Brunoni, A. R., Kemp, A. H., Dantas, E. M., Goulart, A. C., Nunes, M. A., Boggio, P. S., et al. (2013). Heart rate variability is a trait marker of major depressive disorder: Evidence from the sertraline vs. electric current therapy to treat depression clinical study. The International Journal of Neuropsychopharmacology, 16(09), 1937–1949. doi:10.​1017/​S146114571300049​7.CrossRefPubMed
go back to reference Bylsma, L. M., Salomon, K., Taylor-Clift, A., Morris, B. H., & Rottenberg, J. (2014). Respiratory sinus arrhythmia reactivity in current and remitted major depressive disorder. Psychosomatic Medicine, 76(1), 66–73.CrossRefPubMedPubMedCentral Bylsma, L. M., Salomon, K., Taylor-Clift, A., Morris, B. H., & Rottenberg, J. (2014). Respiratory sinus arrhythmia reactivity in current and remitted major depressive disorder. Psychosomatic Medicine, 76(1), 66–73.CrossRefPubMedPubMedCentral
go back to reference Cacioppo, J. T., Tassinary, L. G., & Berntson, G. G. (Eds.). (2007). Handbook of Psychophysiology. Cambridge: Cambridge University Press. Cacioppo, J. T., Tassinary, L. G., & Berntson, G. G. (Eds.). (2007). Handbook of Psychophysiology. Cambridge: Cambridge University Press.
go back to reference Chambers, A. S., & Allen, J. J. (2002). Vagal tone as an indicator of treatment response in major depression. Psychophysiology, 39(6), 861–864.CrossRefPubMed Chambers, A. S., & Allen, J. J. (2002). Vagal tone as an indicator of treatment response in major depression. Psychophysiology, 39(6), 861–864.CrossRefPubMed
go back to reference Chantiluke, K., Halari, R., Simic, M., Pariante, C. M., Papadopoulos, A., Giampietro, V., & Rubia, K. (2012). Fronto-striato-cerebellar dysregulation in adolescents with depression during motivated attention. Biological Psychiatry, 71(1), 59–67.CrossRefPubMed Chantiluke, K., Halari, R., Simic, M., Pariante, C. M., Papadopoulos, A., Giampietro, V., & Rubia, K. (2012). Fronto-striato-cerebellar dysregulation in adolescents with depression during motivated attention. Biological Psychiatry, 71(1), 59–67.CrossRefPubMed
go back to reference Etkin, A., & Schatzberg, A. F. (2011). Common abnormalities and disorder-specific compensation during implicit regulation of emotional processing in generalized anxiety and major depressive disorders. American Journal of Psychiatry, 168(9), 968–978.CrossRefPubMed Etkin, A., & Schatzberg, A. F. (2011). Common abnormalities and disorder-specific compensation during implicit regulation of emotional processing in generalized anxiety and major depressive disorders. American Journal of Psychiatry, 168(9), 968–978.CrossRefPubMed
go back to reference First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (2002). Structured clinical interview for DSM-IV-TR axis I disorders: Research version, patient edition with psychotic screen. New York: Biometrics Research, New York State Psychiatric Institute. First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (2002). Structured clinical interview for DSM-IV-TR axis I disorders: Research version, patient edition with psychotic screen. New York: Biometrics Research, New York State Psychiatric Institute.
go back to reference Fotiou, F., Fountoulakis, K. N., Iacovides, A., & Kaprinis, G. (2003). Pattern-reversed visual evoked potentials in subtypes of major depression. Psychiatry Research, 118(3), 259–271.CrossRefPubMed Fotiou, F., Fountoulakis, K. N., Iacovides, A., & Kaprinis, G. (2003). Pattern-reversed visual evoked potentials in subtypes of major depression. Psychiatry Research, 118(3), 259–271.CrossRefPubMed
go back to reference Fresco, D. M., Frankel, A. N., Mennin, D. S., Turk, C. L., & Heimberg, R. G. (2002). Distinct and overlapping features of rumination and worry: The relationship of cognitive production to negative affective states. Cognitive Therapy and Research, 26(2), 179–188.CrossRef Fresco, D. M., Frankel, A. N., Mennin, D. S., Turk, C. L., & Heimberg, R. G. (2002). Distinct and overlapping features of rumination and worry: The relationship of cognitive production to negative affective states. Cognitive Therapy and Research, 26(2), 179–188.CrossRef
go back to reference Friedman, B. H. (2007). An autonomic flexibility-neurovisceral integration model of anxiety and cardiac vagal tone. Biological Psychology, 74(2), 185–199.CrossRefPubMed Friedman, B. H. (2007). An autonomic flexibility-neurovisceral integration model of anxiety and cardiac vagal tone. Biological Psychology, 74(2), 185–199.CrossRefPubMed
go back to reference Frijda, N. H. (1986). The Emotions. London: Cambridge University Press. Frijda, N. H. (1986). The Emotions. London: Cambridge University Press.
go back to reference Garcia, E., Renna, M. E., & Mennin, D. S. (2015). Generalized anxiety disorder. In K. J. Ressler, D. S. Pine, & B. O. Rothbaum (Eds.), Anxiety disorders: Translational perspectives on diagnosis and treatment (pp. 315–328). New York, NY: Oxford University Press. Garcia, E., Renna, M. E., & Mennin, D. S. (2015). Generalized anxiety disorder. In K. J. Ressler, D. S. Pine, & B. O. Rothbaum (Eds.), Anxiety disorders: Translational perspectives on diagnosis and treatment (pp. 315–328). New York, NY: Oxford University Press.
go back to reference Geisler, F. C., Vennewald, N., Kubiak, T., & Weber, H. (2010). The impact of heart rate variability on subjective well-being is mediated by emotion regulation. Personality and Individual Differences, 49(7), 723–728.CrossRef Geisler, F. C., Vennewald, N., Kubiak, T., & Weber, H. (2010). The impact of heart rate variability on subjective well-being is mediated by emotion regulation. Personality and Individual Differences, 49(7), 723–728.CrossRef
go back to reference Gorwood, P. (2004). Generalized anxiety disorder and major depressive disorder comorbidity: An example of genetic pleiotropy? European Psychiatry, 19(1), 27–33.CrossRefPubMed Gorwood, P. (2004). Generalized anxiety disorder and major depressive disorder comorbidity: An example of genetic pleiotropy? European Psychiatry, 19(1), 27–33.CrossRefPubMed
go back to reference Gratz, K. L., & Roemer, L. (2004). Multidimensional assessment of emotion regulation and dysregulation: Development, factor structure, and initial validation of the difficulties in emotion regulation scale. Journal of Psychopathology and Behavioral Assessment, 26(1), 41–54.CrossRef Gratz, K. L., & Roemer, L. (2004). Multidimensional assessment of emotion regulation and dysregulation: Development, factor structure, and initial validation of the difficulties in emotion regulation scale. Journal of Psychopathology and Behavioral Assessment, 26(1), 41–54.CrossRef
go back to reference Gross, J. J. (1998). The emerging field of emotion regulation: An integrative review. Review of General Psychology, 2(3), 271.CrossRef Gross, J. J. (1998). The emerging field of emotion regulation: An integrative review. Review of General Psychology, 2(3), 271.CrossRef
go back to reference Gross, J. J., & Jazaieri, H. (2014). Emotion, emotion regulation, and psychopathology: An affective science perspective. Clinical Psychological Science, 2(4), 387–401.CrossRef Gross, J. J., & Jazaieri, H. (2014). Emotion, emotion regulation, and psychopathology: An affective science perspective. Clinical Psychological Science, 2(4), 387–401.CrossRef
go back to reference Harte, C. B., Liverant, G. I., Sloan, D. M., Kamholz, B. W., Rosebrock, L. E., Fava, M., & Kaplan, G. B. (2013). Association between smoking and heart rate variability among individuals with depression. Annals of Behavioral Medicine, 46(1), 73–80.CrossRefPubMed Harte, C. B., Liverant, G. I., Sloan, D. M., Kamholz, B. W., Rosebrock, L. E., Fava, M., & Kaplan, G. B. (2013). Association between smoking and heart rate variability among individuals with depression. Annals of Behavioral Medicine, 46(1), 73–80.CrossRefPubMed
go back to reference Heide, F. J., & Borkovec, T. D. (1984). Relaxation-induced anxiety: Mechanisms and theoretical implications. Behaviour Research and Therapy, 22(1), 1–12.CrossRefPubMed Heide, F. J., & Borkovec, T. D. (1984). Relaxation-induced anxiety: Mechanisms and theoretical implications. Behaviour Research and Therapy, 22(1), 1–12.CrossRefPubMed
go back to reference Hibbert, A. S., Weinberg, A., & Klonsky, E. D. (2012). Field validity of heart rate variability metrics produced by QRSTool and CMetX. Psychological Assessment, 24(3), 777.CrossRefPubMed Hibbert, A. S., Weinberg, A., & Klonsky, E. D. (2012). Field validity of heart rate variability metrics produced by QRSTool and CMetX. Psychological Assessment, 24(3), 777.CrossRefPubMed
go back to reference Hoehn-Saric, R., & McLeod, D. R. (2000). Anxiety and arousal: Physiological changes and their perception. Journal of Affective Disorders, 61(3), 217–224.CrossRefPubMed Hoehn-Saric, R., & McLeod, D. R. (2000). Anxiety and arousal: Physiological changes and their perception. Journal of Affective Disorders, 61(3), 217–224.CrossRefPubMed
go back to reference Hopp, H., Shallcross, A. J., Ford, B. Q., Troy, A. S., Wilhelm, F. H., & Mauss, I. B. (2013). High cardiac vagal control protects against future depressive symptoms under conditions of high social support. Biological Psychology, 93(1), 143–149.CrossRefPubMedPubMedCentral Hopp, H., Shallcross, A. J., Ford, B. Q., Troy, A. S., Wilhelm, F. H., & Mauss, I. B. (2013). High cardiac vagal control protects against future depressive symptoms under conditions of high social support. Biological Psychology, 93(1), 143–149.CrossRefPubMedPubMedCentral
go back to reference Kemp, A. H., Brunoni, A. R., Santos, I. S., Nunes, M. A., Dantas, E. M., de Figueiredo, R. C., et al. (2014a). Effects of depression, anxiety, comorbidity, and antidepressants on resting-state heart rate and its variability: An ELSA-Brasil cohort baseline study. American Journal of Psychiatry, 171(12), 1328–1334. CrossRefPubMed Kemp, A. H., Brunoni, A. R., Santos, I. S., Nunes, M. A., Dantas, E. M., de Figueiredo, R. C., et al. (2014a). Effects of depression, anxiety, comorbidity, and antidepressants on resting-state heart rate and its variability: An ELSA-Brasil cohort baseline study. American Journal of Psychiatry, 171(12), 1328–1334. CrossRefPubMed
go back to reference Kemp, A. H., Quintana, D. S., Gray, M. A., Felmingham, K. L., Brown, K., & Gatt, J. M. (2010). Impact of depression and antidepressant treatment on heart rate variability: A review and meta-analysis. Biological Psychiatry, 67(11), 1067–1074.CrossRefPubMed Kemp, A. H., Quintana, D. S., Gray, M. A., Felmingham, K. L., Brown, K., & Gatt, J. M. (2010). Impact of depression and antidepressant treatment on heart rate variability: A review and meta-analysis. Biological Psychiatry, 67(11), 1067–1074.CrossRefPubMed
go back to reference Kemp, A. H., Quintana, D. S., Quinn, C. R., Hopkinson, P., & Harris, A. W. F. (2014b). Major depressive disorder with melancholia displays robust alterations in resting state heart rate and its variability: Implications for future morbidity and mortality. Frontiers in Psychology,. doi:10.3389/fpsyg.2014.01387. Kemp, A. H., Quintana, D. S., Quinn, C. R., Hopkinson, P., & Harris, A. W. F. (2014b). Major depressive disorder with melancholia displays robust alterations in resting state heart rate and its variability: Implications for future morbidity and mortality. Frontiers in Psychology,. doi:10.​3389/​fpsyg.​2014.​01387.
go back to reference Kertz, S. J., Bigda-Peyton, J. S., Rosmarin, D. H., & Björgvinsson, T. (2012). The importance of worry across diagnostic presentations: Prevalence, severity and associated symptoms in a partial hospital setting. Journal of Anxiety Disorders, 26(1), 126–133.CrossRefPubMed Kertz, S. J., Bigda-Peyton, J. S., Rosmarin, D. H., & Björgvinsson, T. (2012). The importance of worry across diagnostic presentations: Prevalence, severity and associated symptoms in a partial hospital setting. Journal of Anxiety Disorders, 26(1), 126–133.CrossRefPubMed
go back to reference Kessler, R. C., Chiu, W. T., Demler, O., & Walters, E. E. (2005). Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry, 62(6), 617–627.CrossRefPubMedPubMedCentral Kessler, R. C., Chiu, W. T., Demler, O., & Walters, E. E. (2005). Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry, 62(6), 617–627.CrossRefPubMedPubMedCentral
go back to reference Kreibig, S. D. (2010). Autonomic nervous system activity in emotion: A review. Biological Psychology, 84(3), 394–421.CrossRefPubMed Kreibig, S. D. (2010). Autonomic nervous system activity in emotion: A review. Biological Psychology, 84(3), 394–421.CrossRefPubMed
go back to reference Licht, C. M., de Geus, E. J., Zitman, F. G., Hoogendijk, W. J., van Dyck, R., & Penninx, B. W. (2008). Association between major depressive disorder and heart rate variability in the Netherlands Study of Depression and Anxiety (NESDA). Archives of General Psychiatry, 65(12), 1358–1367.CrossRefPubMed Licht, C. M., de Geus, E. J., Zitman, F. G., Hoogendijk, W. J., van Dyck, R., & Penninx, B. W. (2008). Association between major depressive disorder and heart rate variability in the Netherlands Study of Depression and Anxiety (NESDA). Archives of General Psychiatry, 65(12), 1358–1367.CrossRefPubMed
go back to reference Liverant, G. I., Brown, T. A., Barlow, D. H., & Roemer, L. (2008). Emotion regulation in unipolar depression: The effects of acceptance and suppression of subjective emotional experience on the intensity and duration of sadness and negative affect. Behaviour Research and Therapy, 46(11), 1201–1209.CrossRefPubMed Liverant, G. I., Brown, T. A., Barlow, D. H., & Roemer, L. (2008). Emotion regulation in unipolar depression: The effects of acceptance and suppression of subjective emotional experience on the intensity and duration of sadness and negative affect. Behaviour Research and Therapy, 46(11), 1201–1209.CrossRefPubMed
go back to reference Llera, S. J., & Newman, M. G. (2010). Effects of worry on physiological and subjective reactivity to emotional stimuli in generalized anxiety disorder and nonanxious control participants. Emotion, 10(5), 640–650. doi:10.1037/a0019351.CrossRefPubMed Llera, S. J., & Newman, M. G. (2010). Effects of worry on physiological and subjective reactivity to emotional stimuli in generalized anxiety disorder and nonanxious control participants. Emotion, 10(5), 640–650. doi:10.​1037/​a0019351.CrossRefPubMed
go back to reference Llera, S. J., & Newman, M. G. (2014). Rethinking the role of worry in generalized anxiety disorder: Evidence supporting a model of emotional contrast avoidance. Behavior Therapy, 45(3), 283–299.CrossRefPubMed Llera, S. J., & Newman, M. G. (2014). Rethinking the role of worry in generalized anxiety disorder: Evidence supporting a model of emotional contrast avoidance. Behavior Therapy, 45(3), 283–299.CrossRefPubMed
go back to reference Lyonfields, J. D., Borkovec, T. D., & Thayer, J. F. (1995). Vagal tone in generalized anxiety disorder and the effects of aversive imagery and worrisome thinking. Behavior Therapy, 26(3), 457–466.CrossRef Lyonfields, J. D., Borkovec, T. D., & Thayer, J. F. (1995). Vagal tone in generalized anxiety disorder and the effects of aversive imagery and worrisome thinking. Behavior Therapy, 26(3), 457–466.CrossRef
go back to reference Mankus, A. M., Aldao, A., Kerns, C., Mayville, E. W., & Mennin, D. S. (2013). Mindfulness and heart rate variability in individuals with high and low generalized anxiety symptoms. Behaviour Research and Therapy, 51(7), 386–391.CrossRefPubMed Mankus, A. M., Aldao, A., Kerns, C., Mayville, E. W., & Mennin, D. S. (2013). Mindfulness and heart rate variability in individuals with high and low generalized anxiety symptoms. Behaviour Research and Therapy, 51(7), 386–391.CrossRefPubMed
go back to reference Mennin, D. S., & Fresco, D. M. (2013). What, me worry and ruminate about DSM-5 and RDoC? The importance of targeting negative self-referential processing. Clinical Psychology: Science and Practice, 20(3), 258–267. Mennin, D. S., & Fresco, D. M. (2013). What, me worry and ruminate about DSM-5 and RDoC? The importance of targeting negative self-referential processing. Clinical Psychology: Science and Practice, 20(3), 258–267.
go back to reference Mennin, D. S., & Fresco, D. M. (2014). Emotion regulation therapy. In J. J. Gross (Ed.), Handbook of emotion regulation (2nd ed., pp. 469–490). New York: Guilford Press. Mennin, D. S., & Fresco, D. M. (2014). Emotion regulation therapy. In J. J. Gross (Ed.), Handbook of emotion regulation (2nd ed., pp. 469–490). New York: Guilford Press.
go back to reference Mennin, D. S., & Fresco, D. M. (2015). Advancing emotion regulation perspectives on psychopathology: The challenge of distress disorders. Psychological Inquiry, 26(1), 80–92.CrossRef Mennin, D. S., & Fresco, D. M. (2015). Advancing emotion regulation perspectives on psychopathology: The challenge of distress disorders. Psychological Inquiry, 26(1), 80–92.CrossRef
go back to reference Mennin, D. S., Heimberg, R. G., Fresco, D. M., & Ritter, M. R. (2008). Is generalized anxiety disorder an anxiety or mood disorder? Considering multiple factors as we ponder the fate of GAD. Depression and Anxiety, 25(4), 289–299. doi:10.1002/da.20493.CrossRefPubMed Mennin, D. S., Heimberg, R. G., Fresco, D. M., & Ritter, M. R. (2008). Is generalized anxiety disorder an anxiety or mood disorder? Considering multiple factors as we ponder the fate of GAD. Depression and Anxiety, 25(4), 289–299. doi:10.​1002/​da.​20493.CrossRefPubMed
go back to reference Mennin, D. S., Holaway, R. M., Fresco, D. M., Moore, M. T., & Heimberg, R. G. (2007). Delineating components of emotion and its dysregulation in anxiety and mood psychopathology. Behavior Therapy, 38(3), 284–302.CrossRefPubMed Mennin, D. S., Holaway, R. M., Fresco, D. M., Moore, M. T., & Heimberg, R. G. (2007). Delineating components of emotion and its dysregulation in anxiety and mood psychopathology. Behavior Therapy, 38(3), 284–302.CrossRefPubMed
go back to reference Meyer, T. J., Miller, M. L., Metzger, R. L., & Borkovec, T. D. (1990). Development and validation of the Penn State Worry questionnaire. Behaviour Research and Therapy, 28(6), 487–495.CrossRefPubMed Meyer, T. J., Miller, M. L., Metzger, R. L., & Borkovec, T. D. (1990). Development and validation of the Penn State Worry questionnaire. Behaviour Research and Therapy, 28(6), 487–495.CrossRefPubMed
go back to reference Monroe, S. M., & Harkness, K. L. (2011). Recurrence in major depression: A conceptual analysis. Psychological Review, 118(4), 655.CrossRefPubMed Monroe, S. M., & Harkness, K. L. (2011). Recurrence in major depression: A conceptual analysis. Psychological Review, 118(4), 655.CrossRefPubMed
go back to reference Movius, H. L., & Allen, J. J. (2005). Cardiac vagal tone, defensiveness, and motivational style. Biological Psychology, 68(2), 147–162.CrossRefPubMed Movius, H. L., & Allen, J. J. (2005). Cardiac vagal tone, defensiveness, and motivational style. Biological Psychology, 68(2), 147–162.CrossRefPubMed
go back to reference Nahshoni, E., Aravot, D., Aizenberg, D., Sigler, M., Zalsman, G., Strasberg, B., et al. (2004). Heart rate variability in patients with major depression. Psychosomatics, 45(2), 129–134.CrossRefPubMed Nahshoni, E., Aravot, D., Aizenberg, D., Sigler, M., Zalsman, G., Strasberg, B., et al. (2004). Heart rate variability in patients with major depression. Psychosomatics, 45(2), 129–134.CrossRefPubMed
go back to reference Nolen-Hoeksema, S., Wisco, B. E., & Lyubomirsky, S. (2008). Rethinking rumination. Perspectives on Psychological Science, 3(5), 400–424.CrossRefPubMed Nolen-Hoeksema, S., Wisco, B. E., & Lyubomirsky, S. (2008). Rethinking rumination. Perspectives on Psychological Science, 3(5), 400–424.CrossRefPubMed
go back to reference Penninx, B. W., Milaneschi, Y., Lamers, F., & Vogelzangs, N. (2013). Understanding the somatic consequences of depression: Biological mechanisms and the role of depression symptom profile. BMC Medicine, 11(129), 1–14. Penninx, B. W., Milaneschi, Y., Lamers, F., & Vogelzangs, N. (2013). Understanding the somatic consequences of depression: Biological mechanisms and the role of depression symptom profile. BMC Medicine, 11(129), 1–14.
go back to reference Pieper, S., Brosschot, J. F., van der Leeden, R., & Thayer, J. F. (2007). Cardiac effects of momentary assessed worry episodes and stressful events. Psychosomatic Medicine, 69(9), 901–909.CrossRefPubMed Pieper, S., Brosschot, J. F., van der Leeden, R., & Thayer, J. F. (2007). Cardiac effects of momentary assessed worry episodes and stressful events. Psychosomatic Medicine, 69(9), 901–909.CrossRefPubMed
go back to reference Porges, S. W., Doussard-Roosevelt, J. A., & Maiti, A. K. (1994). Vagal tone and the physiological regulation of emotion. Monographs of the Society for Research in Child Development, 59, 167–186.CrossRefPubMed Porges, S. W., Doussard-Roosevelt, J. A., & Maiti, A. K. (1994). Vagal tone and the physiological regulation of emotion. Monographs of the Society for Research in Child Development, 59, 167–186.CrossRefPubMed
go back to reference Royster, E. B., Trimble, L. M., Cotsonis, G., Schmotzer, B., Manatunga, A., Rushing, N. N., et al. (2012). Changes in heart rate variability of depressed patients after electroconvulsive therapy. Cardiovascular Psychiatry and Neurology. doi:10.1155/2012/794043.PubMedPubMedCentral Royster, E. B., Trimble, L. M., Cotsonis, G., Schmotzer, B., Manatunga, A., Rushing, N. N., et al. (2012). Changes in heart rate variability of depressed patients after electroconvulsive therapy. Cardiovascular Psychiatry and Neurology. doi:10.​1155/​2012/​794043.PubMedPubMedCentral
go back to reference Salomon, K., Clift, A., Karlsdóttir, M., & Rottenberg, J. (2009). Major depressive disorder is associated with attenuated cardiovascular reactivity and impaired recovery among those free of cardiovascular disease. Health Psychology, 28(2), 157–165. Salomon, K., Clift, A., Karlsdóttir, M., & Rottenberg, J. (2009). Major depressive disorder is associated with attenuated cardiovascular reactivity and impaired recovery among those free of cardiovascular disease. Health Psychology, 28(2), 157–165.
go back to reference Sanchez-Gonzalez, M. A., May, R. W., Koutnik, A. P., Kabbaj, M., & Fincham, F. D. (2013). Sympathetic vasomotor tone is associated with depressive symptoms in young females: A potential link between depression and cardiovascular disease. American Journal of Hypertension, 26(12), 1389–1397. Sanchez-Gonzalez, M. A., May, R. W., Koutnik, A. P., Kabbaj, M., & Fincham, F. D. (2013). Sympathetic vasomotor tone is associated with depressive symptoms in young females: A potential link between depression and cardiovascular disease. American Journal of Hypertension, 26(12), 1389–1397.
go back to reference Segerstrom, S. C., & Nes, L. S. (2007). Heart rate variability reflects self-regulatory strength, effort, and fatigue. Psychological Science, 18(3), 275–281.CrossRefPubMed Segerstrom, S. C., & Nes, L. S. (2007). Heart rate variability reflects self-regulatory strength, effort, and fatigue. Psychological Science, 18(3), 275–281.CrossRefPubMed
go back to reference Silvia, P. J., Nusbaum, E. C., Eddington, K. M., Beaty, R. E., & Kwapil, T. R. (2014). Effort deficits and depression: The influence of anhedonic depressive symptoms on cardiac autonomic activity during a mental challenge. Motivation and Emotion, 38(6), 779–789. doi:10.1007/s11031-014-9443-0.CrossRefPubMedPubMedCentral Silvia, P. J., Nusbaum, E. C., Eddington, K. M., Beaty, R. E., & Kwapil, T. R. (2014). Effort deficits and depression: The influence of anhedonic depressive symptoms on cardiac autonomic activity during a mental challenge. Motivation and Emotion, 38(6), 779–789. doi:10.​1007/​s11031-014-9443-0.CrossRefPubMedPubMedCentral
go back to reference Taylor-Clift, A., Morris, B. H., Rottenberg, J., & Kovacs, M. (2011). Emotion-modulated startle in anxiety disorders is blunted by co-morbid depressive episodes. Psychological Medicine, 41(01), 129–139.CrossRefPubMed Taylor-Clift, A., Morris, B. H., Rottenberg, J., & Kovacs, M. (2011). Emotion-modulated startle in anxiety disorders is blunted by co-morbid depressive episodes. Psychological Medicine, 41(01), 129–139.CrossRefPubMed
go back to reference Thayer, J. F., Åhs, F., Fredrikson, M., Sollers, J. J., & Wager, T. D. (2012). A meta-analysis of heart rate variability and neuroimaging studies: Implications for heart rate variability as a marker of stress and health. Neuroscience & Biobehavioral Reviews, 36(2), 747–756. Thayer, J. F., Åhs, F., Fredrikson, M., Sollers, J. J., & Wager, T. D. (2012). A meta-analysis of heart rate variability and neuroimaging studies: Implications for heart rate variability as a marker of stress and health. Neuroscience & Biobehavioral Reviews, 36(2), 747–756.
go back to reference Thayer, J. F., Friedman, B. H., & Borkovec, T. D. (1996). Autonomic characteristics of generalized anxiety disorder and worry. Biological Psychiatry, 39(4), 255–266.CrossRefPubMed Thayer, J. F., Friedman, B. H., & Borkovec, T. D. (1996). Autonomic characteristics of generalized anxiety disorder and worry. Biological Psychiatry, 39(4), 255–266.CrossRefPubMed
go back to reference Thayer, J. F., & Lane, R. D. (2000). A model of neurovisceral integration in emotion regulation and dysregulation. Journal of Affective Disorders, 61(3), 201–216.CrossRefPubMed Thayer, J. F., & Lane, R. D. (2000). A model of neurovisceral integration in emotion regulation and dysregulation. Journal of Affective Disorders, 61(3), 201–216.CrossRefPubMed
go back to reference Thayer, J. F., & Lane, R. D. (2009). Claude Bernard and the heart–brain connection: Further elaboration of a model of neurovisceral integration. Neuroscience and Biobehavioral Reviews, 33(2), 81–88.CrossRefPubMed Thayer, J. F., & Lane, R. D. (2009). Claude Bernard and the heart–brain connection: Further elaboration of a model of neurovisceral integration. Neuroscience and Biobehavioral Reviews, 33(2), 81–88.CrossRefPubMed
go back to reference Toichi, M., Sugiura, T., Murai, T., & Sengoku, A. (1997). A new method of assessing cardiac autonomic function and its comparison with spectral analysis and coefficient of variation of R–R interval. Journal of the Autonomic Nervous System, 62(1), 79–84.CrossRefPubMed Toichi, M., Sugiura, T., Murai, T., & Sengoku, A. (1997). A new method of assessing cardiac autonomic function and its comparison with spectral analysis and coefficient of variation of R–R interval. Journal of the Autonomic Nervous System, 62(1), 79–84.CrossRefPubMed
go back to reference Udupa, K., Sathyaprabha, T. N., Thirthalli, J., Kishore, K. R., Lavekar, G. S., Raju, T. R., & Gangadhar, B. N. (2007). Alteration of cardiac autonomic functions in patients with major depression: A study using heart rate variability measures. Journal of Affective Disorders, 100(1), 137–141.CrossRefPubMed Udupa, K., Sathyaprabha, T. N., Thirthalli, J., Kishore, K. R., Lavekar, G. S., Raju, T. R., & Gangadhar, B. N. (2007). Alteration of cardiac autonomic functions in patients with major depression: A study using heart rate variability measures. Journal of Affective Disorders, 100(1), 137–141.CrossRefPubMed
go back to reference Van der Kooy, K. G., van Hout, H. P. J., van Marwijk, H. W. J., de Haan, M., Stehouwer, C. D. A., & Beekman, A. T. F. (2006). Differences in heart rate variability between depressed and non-depressed elderly. International Journal of Geriatric Psychiatry, 21(2), 147–150. doi:10.1002/gps.1439.CrossRefPubMed Van der Kooy, K. G., van Hout, H. P. J., van Marwijk, H. W. J., de Haan, M., Stehouwer, C. D. A., & Beekman, A. T. F. (2006). Differences in heart rate variability between depressed and non-depressed elderly. International Journal of Geriatric Psychiatry, 21(2), 147–150. doi:10.​1002/​gps.​1439.CrossRefPubMed
go back to reference Verkuil, B., Brosschot, J. F., Borkovec, T. D., & Thayer, J. F. (2009). Acute autonomic effects of experimental worry and cognitive problem solving: Why worry about worry? International Journal of Clinical and Health Psychology, 9(3), 439–453. Verkuil, B., Brosschot, J. F., Borkovec, T. D., & Thayer, J. F. (2009). Acute autonomic effects of experimental worry and cognitive problem solving: Why worry about worry? International Journal of Clinical and Health Psychology, 9(3), 439–453.
go back to reference Watson, D. (2005). Rethinking the mood and anxiety disorders: A quantitative hierarchical model for DSM-V. Journal of Abnormal Psychology, 114(4), 522.CrossRefPubMed Watson, D. (2005). Rethinking the mood and anxiety disorders: A quantitative hierarchical model for DSM-V. Journal of Abnormal Psychology, 114(4), 522.CrossRefPubMed
go back to reference Watson, D., Clark, L. A., & Tellegen, A. (1988). Development and validation of brief measures of positive and negative affect: The PANAS scales. Journal of Personality and Social Psychology, 54(6), 1063.CrossRefPubMed Watson, D., Clark, L. A., & Tellegen, A. (1988). Development and validation of brief measures of positive and negative affect: The PANAS scales. Journal of Personality and Social Psychology, 54(6), 1063.CrossRefPubMed
go back to reference Weinberg, A., Klein, D. N., & Hajcak, G. (2012). Increased error-related brain activity distinguishes generalized anxiety disorder with and without comorbid major depressive disorder. Journal of Abnormal Psychology, 121(4), 885.CrossRefPubMedPubMedCentral Weinberg, A., Klein, D. N., & Hajcak, G. (2012). Increased error-related brain activity distinguishes generalized anxiety disorder with and without comorbid major depressive disorder. Journal of Abnormal Psychology, 121(4), 885.CrossRefPubMedPubMedCentral
go back to reference Williams, D. P., Cash, C., Rankin, C., Bernardi, A., Koenig, J., & Thayer, J. F. (2015). Resting heart rate variability predicts self-reported difficulties in emotion regulation: A focus on different facets of emotion regulation. Frontiers in Psychology, 6(261), 1–8. Williams, D. P., Cash, C., Rankin, C., Bernardi, A., Koenig, J., & Thayer, J. F. (2015). Resting heart rate variability predicts self-reported difficulties in emotion regulation: A focus on different facets of emotion regulation. Frontiers in Psychology, 6(261), 1–8.
go back to reference Wilson, T. D., Reinhard, D., Westgate, E. C., Gilbert, D. T., Ellerbeck, N., Hahn, C., et al. (2014). Just think: The challenges of the disengaged mind. Science, 345, 75–77.CrossRefPubMedPubMedCentral Wilson, T. D., Reinhard, D., Westgate, E. C., Gilbert, D. T., Ellerbeck, N., Hahn, C., et al. (2014). Just think: The challenges of the disengaged mind. Science, 345, 75–77.CrossRefPubMedPubMedCentral
go back to reference Zimmerman, M., & Chelminski, I. (2003). Generalized anxiety disorder in patients with major depression: Is DSM-IV’s hierarchy correct? American Journal of Psychiatry, 160(3), 504–512.CrossRefPubMed Zimmerman, M., & Chelminski, I. (2003). Generalized anxiety disorder in patients with major depression: Is DSM-IV’s hierarchy correct? American Journal of Psychiatry, 160(3), 504–512.CrossRefPubMed
Metagegevens
Titel
Impact of Comorbid Depressive Disorders on Subjective and Physiological Responses to Emotion in Generalized Anxiety Disorder
Auteurs
Saren H. Seeley
Douglas S. Mennin
Amelia Aldao
Katie A. McLaughlin
Jonathan Rottenberg
David M. Fresco
Publicatiedatum
12-12-2015
Uitgeverij
Springer US
Gepubliceerd in
Cognitive Therapy and Research / Uitgave 3/2016
Print ISSN: 0147-5916
Elektronisch ISSN: 1573-2819
DOI
https://doi.org/10.1007/s10608-015-9744-y

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