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09-09-2015 | Uitgave 3/2016

Quality of Life Research 3/2016

Impact of Alzheimer’s disease on the family caregiver’s long-term quality of life: results from an ALSOVA follow-up study

Quality of Life Research > Uitgave 3/2016
Tarja H. Välimäki, Janne A. Martikainen, Kristiina Hongisto, Saku Väätäinen, Harri Sintonen, Anne M. Koivisto
Belangrijke opmerkingen
Role of the sponsors The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or the preparation or the submission of the manuscript for publication. One of the sponsors (Novartis Pharma AG) has given separate approval. The other sponsors have no role in approval. All the study sponsors have been informed by progression reports as agreed with each sponsor.



To examine caregivers’ health-related quality of life (HRQoL) and well-being during the first 3 years after their family member’s Alzheimer’s disease (AD) diagnosis and assessed the relationship between caregivers’ HRQoL, well-being, and the severity of AD. Further, to compare of caregivers’ HRQoL to general population.


Longitudinal design (36 months) after AD diagnosis of 236 caregiver–patient dyads. Linear regression was used to assess age- and gender-adjusted association between repeated measurements of caregivers’ HRQoL and the severity of AD. For comparison with general population, the National Health 2011 Health Examination Survey data was utilized.


Caregivers had significantly lower HRQoL than age- and gender-standardized counterparts. Severity of AD was significantly (p < 0.05) associated with the mobility and depression dimensions of caregiver’s HRQoL but not with the total HRQoL index score.


Caregivers’ HRQoL seems to deteriorate earlier than previously noted. The severity of AD has not that great impact on caregiver’s HRQoL as assumed.

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