Skip to main content
Top
Gepubliceerd in:

28-01-2021 | Original Paper

Identifying Subgroups of Toddlers with DSM-5 Autism Spectrum Disorder Based on Core Symptoms

Auteurs: Holly K. Harris, Collin Lee, Georgios D. Sideridis, William J. Barbaresi, Elizabeth Harstad

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 12/2021

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

The objective of this study was to identify subgroups of toddlers with DSM-5 ASD based on core ASD symptoms using a person-based analytical framework. This is a retrospective study of 500 toddlers (mean age 26 months, 79% male) with DSM-5 ASD. Data were analyzed using latent class analyses in which profiles were formed based on ASD symptomatology. Social communication (SC) symptoms favored a three-class solution, while restricted/repetitive behaviors (RRBs) favored a two-class solution. Classes with higher consistency of SC deficits were younger, with lower developmental functioning. The class with more RRBs was older, with higher functioning. If confirmed in other populations, these classes may more precisely characterize subgroups within the heterogeneous group of toddlers at time of ASD diagnosis.
Bijlagen
Alleen toegankelijk voor geautoriseerde gebruikers
Literatuur
go back to reference Cuccaro, M. L., Shao, Y., Grubber, J., Slifer, M., Wolpert, C. M., Donnelly, S. L., … Pericak-Vance, M. A. (2003). Factor analysis of restricted and repetitive behaviors in autism using the autism diagnostic interview-R. Child Psychiatry and Human Development, 34(1), 3–17.https://doi.org/10.1023/A:1025321707947. Cuccaro, M. L., Shao, Y., Grubber, J., Slifer, M., Wolpert, C. M., Donnelly, S. L., … Pericak-Vance, M. A. (2003). Factor analysis of restricted and repetitive behaviors in autism using the autism diagnostic interview-R. Child Psychiatry and Human Development, 34(1), 3–17.https://​doi.​org/​10.​1023/​A:​1025321707947.
go back to reference Estes, A., Zwaigenbaum, L., Gu, H., St John, T., Paterson, S., Elison, J. T., … Piven, J. (2015). Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life. Journal of Neurodevelopmental Disorders, 7(1), 24.https://doi.org/10.1186/s11689-015-9117-6. Estes, A., Zwaigenbaum, L., Gu, H., St John, T., Paterson, S., Elison, J. T., … Piven, J. (2015). Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life. Journal of Neurodevelopmental Disorders, 7(1), 24.https://​doi.​org/​10.​1186/​s11689-015-9117-6.
go back to reference Georgiades, S., Boyle, M., Szatmari, P., Hanna, S., Duku, E., Zwaigenbaum, L., … Thompson, A. (2014). Modeling the phenotypic architecture of autism symptoms from time of diagnosis to age 6. Journal of Autism and Developmental Disorders, 44(12), 3045–3055.https://doi.org/10.1007/s10803-014-2167-x. Georgiades, S., Boyle, M., Szatmari, P., Hanna, S., Duku, E., Zwaigenbaum, L., … Thompson, A. (2014). Modeling the phenotypic architecture of autism symptoms from time of diagnosis to age 6. Journal of Autism and Developmental Disorders, 44(12), 3045–3055.https://​doi.​org/​10.​1007/​s10803-014-2167-x.
go back to reference Georgiades, S., Szatmari, P., Boyle, M., Hanna, S., Duku, E., Zwaigenbaum, L., … Thompson, A. (2013). Investigating phenotypic heterogeneity in children with autism spectrum disorder: A factor mixture modeling approach. Journal of Child Psychology and Psychiatry and Allied Disciplines, 54(2), 206–215.https://doi.org/10.1111/j.1469-7610.2012.02588. Georgiades, S., Szatmari, P., Boyle, M., Hanna, S., Duku, E., Zwaigenbaum, L., … Thompson, A. (2013). Investigating phenotypic heterogeneity in children with autism spectrum disorder: A factor mixture modeling approach. Journal of Child Psychology and Psychiatry and Allied Disciplines, 54(2), 206–215.https://​doi.​org/​10.​1111/​j.​1469-7610.​2012.​02588.
go back to reference Lord, C., Rutter, M., DiLavore, P., Risi, S., Gotham, K., & Bishop, S. (2012a). Autism diagnostic observation schedule, second edition (ADOS-2) manual (Part I): Modules 1–4. Firenze: Giunti OS. Lord, C., Rutter, M., DiLavore, P., Risi, S., Gotham, K., & Bishop, S. (2012a). Autism diagnostic observation schedule, second edition (ADOS-2) manual (Part I): Modules 1–4. Firenze: Giunti OS.
go back to reference Nylund, K. L., Asparouhov, T., & Muthén, B. O. (2007). Structural equation modeling: A multidisciplinary journal deciding on the number of classes in latent class analysis and growth mixture modeling: A Monte Carlo simulation study. Structural Equation Modeling, 14(4), 535–569. https://doi.org/10.1080/10705510701575396.CrossRef Nylund, K. L., Asparouhov, T., & Muthén, B. O. (2007). Structural equation modeling: A multidisciplinary journal deciding on the number of classes in latent class analysis and growth mixture modeling: A Monte Carlo simulation study. Structural Equation Modeling, 14(4), 535–569. https://​doi.​org/​10.​1080/​1070551070157539​6.CrossRef
go back to reference Pierce, K., Gazestani, V. H., Bacon, E., Barnes, C. C., Cha, D., Nalabolu, S., … Courchesne, E. (2019). Evaluation of the diagnostic stability of the early autism spectrum disorder phenotype in the general population starting at 12 months. JAMA Pediatrics, 173(6), 578–587.https://doi.org/10.1001/jamapediatrics.2019.0624. Pierce, K., Gazestani, V. H., Bacon, E., Barnes, C. C., Cha, D., Nalabolu, S., … Courchesne, E. (2019). Evaluation of the diagnostic stability of the early autism spectrum disorder phenotype in the general population starting at 12 months. JAMA Pediatrics, 173(6), 578–587.https://​doi.​org/​10.​1001/​jamapediatrics.​2019.​0624.
go back to reference Ros‐Demarize, R., Bradley, C., Kanne, S. M., Warren, Z., Boan, A., Lajonchere, C., … Carpenter, L. A. (2020). ASD symptoms in toddlers and preschoolers: An examination of sex differences. Autism Research, 13(1), 157–166.https://doi.org/10.1002/aur.2241. Ros‐Demarize, R., Bradley, C., Kanne, S. M., Warren, Z., Boan, A., Lajonchere, C., … Carpenter, L. A. (2020). ASD symptoms in toddlers and preschoolers: An examination of sex differences. Autism Research, 13(1), 157–166.https://​doi.​org/​10.​1002/​aur.​2241.
go back to reference Sparrow, S. S., Cicchetti, D. V., & Balla, D. A. (2005). Vineland-II adaptive behavior scales, second edition. San Antonio: PsychCorp. Sparrow, S. S., Cicchetti, D. V., & Balla, D. A. (2005). Vineland-II adaptive behavior scales, second edition. San Antonio: PsychCorp.
go back to reference Sparrow, S. S., & Cichetti, D. V. (2016). Vineland adaptive behavior scales, third edition (Vineland-3) manual. San Antonio: PsychCorp. Sparrow, S. S., & Cichetti, D. V. (2016). Vineland adaptive behavior scales, third edition (Vineland-3) manual. San Antonio: PsychCorp.
go back to reference Szatmari, P., Georgiades, S., Bryson, S., Zwaigenbaum, L., Roberts, W., Mahoney, W., … Tuff, L. (2006). Investigating the structure of the restricted, repetitive behaviours and interests domain of autism. Journal of Child Psychology and Psychiatry and Allied Disciplines, 47(6), 582–590.https://doi.org/10.1111/j.1469-7610.2005.01537. Szatmari, P., Georgiades, S., Bryson, S., Zwaigenbaum, L., Roberts, W., Mahoney, W., … Tuff, L. (2006). Investigating the structure of the restricted, repetitive behaviours and interests domain of autism. Journal of Child Psychology and Psychiatry and Allied Disciplines, 47(6), 582–590.https://​doi.​org/​10.​1111/​j.​1469-7610.​2005.​01537.
go back to reference Szatmari, P., Liu, X. Q., Goldberg, J., Zwaigenbaum, L., Paterson, A. D., Woodbury-Smith, M., … Thompson, A. (2012). Sex differences in repetitive stereotyped behaviors in autism: Implications for genetic liability. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 159 B(1), 5–12. https://doi.org/10.1002/ajmg.b.31238. Szatmari, P., Liu, X. Q., Goldberg, J., Zwaigenbaum, L., Paterson, A. D., Woodbury-Smith, M., … Thompson, A. (2012). Sex differences in repetitive stereotyped behaviors in autism: Implications for genetic liability. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 159 B(1), 5–12. https://​doi.​org/​10.​1002/​ajmg.​b.​31238.
go back to reference Szatmari, P., Georgiades, S., Duku, E., Bennett, T. A., Bryson, S., Fombonne, E., … Pathways in ASD Study Team. (2015). Developmental trajectories of symptom severity and adaptive functioning in an inception cohort of preschool children with autism spectrum disorder. JAMA Psychiatry, 72(3), 276–283. https://doi.org/10.1001/jamapsychiatry.2014.2463. Szatmari, P., Georgiades, S., Duku, E., Bennett, T. A., Bryson, S., Fombonne, E., … Pathways in ASD Study Team. (2015). Developmental trajectories of symptom severity and adaptive functioning in an inception cohort of preschool children with autism spectrum disorder. JAMA Psychiatry, 72(3), 276–283. https://​doi.​org/​10.​1001/​jamapsychiatry.​2014.​2463.
go back to reference Tillmann, J., Ashwood, K., Absoud, M., Bölte, S., Bonnet-Brilhault, F., Buitelaar, J. K., … Charman, T. (2018). Evaluating sex and age differences in ADI-R and ADOS scores in a large European multi-site sample of individuals with autism spectrum disorder. Journal of Autism and Developmental Disorders, 48(7), 2490–2505.https://doi.org/10.1007/s10803-018-3510-4. Tillmann, J., Ashwood, K., Absoud, M., Bölte, S., Bonnet-Brilhault, F., Buitelaar, J. K., … Charman, T. (2018). Evaluating sex and age differences in ADI-R and ADOS scores in a large European multi-site sample of individuals with autism spectrum disorder. Journal of Autism and Developmental Disorders, 48(7), 2490–2505.https://​doi.​org/​10.​1007/​s10803-018-3510-4.
go back to reference Ventola, P., Kleinman, J., Pandey, J., Wilson, L., Esser, E., Boorstein, H., … Fein, D. (2007). Differentiating between autism spectrum disorders and other developmental disabilities in children who failed a screening instrument for ASD. Journal of Autism and Developmental Disorders, 37(3), 425–436.https://doi.org/10.1007/s10803-006-0177-z. Ventola, P., Kleinman, J., Pandey, J., Wilson, L., Esser, E., Boorstein, H., … Fein, D. (2007). Differentiating between autism spectrum disorders and other developmental disabilities in children who failed a screening instrument for ASD. Journal of Autism and Developmental Disorders, 37(3), 425–436.https://​doi.​org/​10.​1007/​s10803-006-0177-z.
go back to reference Wiggins, L. D., Tian, L. H., Levy, S. E., Rice, C., Lee, L. C., Schieve, L., … Thompson, W. (2017). Homogeneous subgroups of young children with autism improve phenotypic characterization in the study to explore early development. Journal of Autism and Developmental Disorders, 47(11), 3634–3645.https://doi.org/10.1007/s10803-017-3280-4. Wiggins, L. D., Tian, L. H., Levy, S. E., Rice, C., Lee, L. C., Schieve, L., … Thompson, W. (2017). Homogeneous subgroups of young children with autism improve phenotypic characterization in the study to explore early development. Journal of Autism and Developmental Disorders, 47(11), 3634–3645.https://​doi.​org/​10.​1007/​s10803-017-3280-4.
Metagegevens
Titel
Identifying Subgroups of Toddlers with DSM-5 Autism Spectrum Disorder Based on Core Symptoms
Auteurs
Holly K. Harris
Collin Lee
Georgios D. Sideridis
William J. Barbaresi
Elizabeth Harstad
Publicatiedatum
28-01-2021
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 12/2021
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-021-04879-z