Top

Journal of Autism and Developmental Disorders

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in:

28-01-2021 | Original Paper

Identifying Subgroups of Toddlers with DSM-5 Autism Spectrum Disorder Based on Core Symptoms

Auteurs: Holly K. Harris, Collin Lee, Georgios D. Sideridis, William J. Barbaresi, Elizabeth Harstad

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 12/2021

Abstract

The objective of this study was to identify subgroups of toddlers with DSM-5 ASD based on core ASD symptoms using a person-based analytical framework. This is a retrospective study of 500 toddlers (mean age 26 months, 79% male) with DSM-5 ASD. Data were analyzed using latent class analyses in which profiles were formed based on ASD symptomatology. Social communication (SC) symptoms favored a three-class solution, while restricted/repetitive behaviors (RRBs) favored a two-class solution. Classes with higher consistency of SC deficits were younger, with lower developmental functioning. The class with more RRBs was older, with higher functioning. If confirmed in other populations, these classes may more precisely characterize subgroups within the heterogeneous group of toddlers at time of ASD diagnosis.

vorige artikel Profiles of Autonomic Activity in Autism Spectrum Disorder with and without Anxiety

volgende artikel Correction to: Identifying Subgroups of Toddlers with DSM‑5 Autism Spectrum Disorder Based on Core Symptoms

Alleen toegankelijk voor geautoriseerde gebruikers

American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, D.C.: American Psychiatric Association. https://doi.org/10.1176/appi.books.9780890423349. CrossRef

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, D.C.: American Psychiatric Association. https://doi.org/10.1176/appi.books.9780890425596.744053. CrossRef

Anderson, D. K., Liang, J. W., & Lord, C. (2014). Predicting young adult outcome among more and less cognitively able individuals with autism spectrum disorders. Journal of Child Psychology and Psychiatry, 55(5), 485–494. https://doi.org/10.1111/jcpp.12178. CrossRefPubMed

Barbaresi, W. J., Katusic, S. K., Colligan, R. C., Weaver, A. L., & Jacobsen, S. J. (2005). The incidence of autism in Olmsted County, Minnesota, 1976–1997: Results from a population-based study. Archives of Pediatrics and Adolescent Medicine. https://doi.org/10.1001/archpedi.159.1.37. CrossRefPubMed

Barton, M. L., Robins, D. L., Jashar, D., Brennan, L., & Fein, D. (2013). Sensitivity and specificity of proposed DSM-5 criteria for autism spectrum disorder in toddlers. Journal of Autism and Developmental Disorders, 43(5), 1184–1195. https://doi.org/10.1007/s10803-013-1817-8. CrossRefPubMedPubMedCentral

Bayley, N. (2006). Bayley Scales of infant and toddler development, third edition: Administration manual. J Psychoeduc Assess. https://doi.org/10.1177/0734282906297199. CrossRef

Ben-Itzchak, E., Watson, L. R., & Zachor, D. A. (2014). Cognitive ability is associated with different outcome trajectories in autism spectrum disorders. Journal of Autism and Developmental Disorders, 44(9), 2221–2229. https://doi.org/10.1007/s10803-014-2091-0. CrossRefPubMed

Bitsika, V., Sharpley, C. F., & Orapeleng, S. (2008). An exploratory analysis of the use of cognitive, adaptive and behavioural indices for cluster analysis of ASD subgroups. Journal of Intellectual Disability Research, 52(11), 973–985. https://doi.org/10.1111/j.1365-2788.2008.01123. CrossRefPubMed

Bozdogan, H. (1987). Model selection and Akaike’s Information Criterion (AIC): The general theory and its analytical extensions. Psychometrika, 52, 345–370. https://doi.org/10.1007/BF02294361. CrossRef

Carter, A. S., Black, D. O., Tewani, S., Connolly, C. E., Kadlec, M. B., & Tager-Flusberg, H. (2007). Sex differences in toddlers with autism spectrum disorders. Journal of Autism and Developmental Disorders, 37(1), 86–97. https://doi.org/10.1007/s10803-006-0331-7. CrossRefPubMed

Charman, T., Swettenham, J., Baron-Cohen, S., Cox, A., Baird, G., & Drew, A. (1998). An experimental investigation of socialcognitive abilities in infants with autism: Clinical implications. Infant Mental Health Journal, 19(2), 260–275. https://doi.org/10.1002/(SICI)1097-0355(199822)19:2%3c260::AID-IMHJ12%3e3.0.CO;2-W. CrossRef

Charman, T., Taylor, E., Drew, A., Cockerill, H., Brown, J. A., & Baird, G. (2005). Outcome at 7 years of children diagnosed with autism at age 2: Predictive validity of assessments conducted at 2 and 3 years of age and pattern of symptom change over time. Journal of Child Psychology and Psychiatry and Allied Disciplines. https://doi.org/10.1111/j.1469-7610.2004.00377. CrossRefPubMed

Chawarska, K., Klin, A., Paul, R., Macari, S., & Volkmar, F. (2009). A prospective study of toddlers with ASD: Short-term diagnostic and cognitive outcomes. Journal of Child Psychology and Psychiatry and Allied Disciplines, 50(10), 1235–1245. https://doi.org/10.1111/j.1469-7610.2009.02101. CrossRefPubMed

Cuccaro, M. L., Shao, Y., Grubber, J., Slifer, M., Wolpert, C. M., Donnelly, S. L., … Pericak-Vance, M. A. (2003). Factor analysis of restricted and repetitive behaviors in autism using the autism diagnostic interview-R. Child Psychiatry and Human Development, 34(1), 3–17. https://doi.org/10.1023/A:1025321707947.

Estes, A., Zwaigenbaum, L., Gu, H., St John, T., Paterson, S., Elison, J. T., … Piven, J. (2015). Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life. Journal of Neurodevelopmental Disorders, 7(1), 24. https://doi.org/10.1186/s11689-015-9117-6.

Fountain, C., Winter, A. S., & Bearman, P. S. (2012). Six developmental trajectories characterize children with autism. Pediatrics, 129(5), e1112–e1120. https://doi.org/10.1542/peds.2011-1601. CrossRefPubMedPubMedCentral

Frazier, T. W., Georgiades, S., Bishop, S. L., & Hardan, A. Y. (2014). Behavioral and cognitive characteristics of females and males with autism in the simons simplex collection. Journal of the American Academy of Child and Adolescent Psychiatry, 153(3), 329–340. https://doi.org/10.1016/j.dcn.2011.01.002.The. CrossRef

Georgiades, S., Boyle, M., Szatmari, P., Hanna, S., Duku, E., Zwaigenbaum, L., … Thompson, A. (2014). Modeling the phenotypic architecture of autism symptoms from time of diagnosis to age 6. Journal of Autism and Developmental Disorders, 44(12), 3045–3055. https://doi.org/10.1007/s10803-014-2167-x.

Georgiades, S., Szatmari, P., Boyle, M., Hanna, S., Duku, E., Zwaigenbaum, L., … Thompson, A. (2013). Investigating phenotypic heterogeneity in children with autism spectrum disorder: A factor mixture modeling approach. Journal of Child Psychology and Psychiatry and Allied Disciplines, 54(2), 206–215. https://doi.org/10.1111/j.1469-7610.2012.02588.

Gibbs, V., Aldridge, F., Chandler, F., Witzlsperger, E., & Smith, K. (2012). Brief report: an exploratory study comparing diagnostic outcomes for autism spectrum disorders under DSM-IV-TR with the proposed DSM-5 revision. Journal of Autism and Developmental Disorders, 42(8), 1750–1756. https://doi.org/10.1007/s10803-012-1560-6. CrossRefPubMed

Gotham, K., Pickles, A., & Lord, C. (2012). Trajectories of autism severity in children using standardized ADOS scores. Pediatrics, 130(5), 1278. https://doi.org/10.1542/peds.2011-3668. CrossRef

Guthrie, W., Swineford, L. B., Nottke, C., & Wetherby, A. M. (2013). Early diagnosis of autism spectrum disorder: stability and change in clinical diagnosis and symptom presentation. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 54(5), 582–590. https://doi.org/10.1111/jcpp.12008. CrossRefPubMedPubMedCentral

Harris, P. A., Taylor, R., Thielke, R., Payne, J., Gonzalez, N., & Conde, J. G. (2009). Research electronic data capture (REDCap)-A metadata-driven methodology and workflow process for providing translational research informatics support. Journal of Biomedical Informatics, 42(2), 377–381. https://doi.org/10.1016/j.jbi.2008.08.010. CrossRefPubMed

Harris, S. L., & Handleman, J. S. (2000). Age and IQ at intake as predictors of placement for young children with autism: a four- to six-year follow-up. Journal of Autism and Developmental Disorders, 30(2), 137–142. https://doi.org/10.1023/a:1005459606120. CrossRefPubMed

Harstad, E. B., Fogler, J., Sideridis, G., Weas, S., Mauras, C., & Barbaresi, W. J. (2015). Comparing diagnostic outcomes of autism spectrum disorder using DSM-IV-TR and DSM-5 criteria. Journal of Autism and Developmental Disorders, 45(5), 1437–1450. https://doi.org/10.1007/s10803-014-2306-4. CrossRefPubMed

Jashar, D. T., Brennan, L. A., Barton, M. L., & Fein, D. (2016). Cognitive and adaptive skills in toddlers who meet criteria for autism in DSM-IV but not DSM-5. Journal of Autism and Developmental Disorders, 46(12), 3667–3677. https://doi.org/10.1007/s10803-016-2901-7. CrossRefPubMedPubMedCentral

Kang, E., Gadow, K. D., & Lerner, M. D. (2019). Atypical communication characteristics, differential diagnosis, and the autism spectrum disorder phenotype in youth. Journal of Clinical Child & Adolescent Psychology, 49(2), 1–13. https://doi.org/10.1080/15374416.2018.1539912. CrossRef

Kim, H., Keifer, C., Rodriguez-Seijas, C., Eaton, N., Lerner, M., & Gadow, K. (2019). Quantifying the optimal structure of the autism phenotype: A comprehensive comparison of dimensional, categorical, and hybrid models. Journal of the American Academy of Child and Adolescent Psychiatry, 58(9), 876-886.e2. https://doi.org/10.1016/j.jaac.2018.09.431. CrossRefPubMed

Kim, S. H., Bal, V. H., Benrey, N., Choi, Y. B., Guthrie, W., Colombi, C., & Lord, C. (2018). Variability in autism symptom trajectories using repeated observations from 14 to 36 months of age. Journal of the American Academy of Child and Adolescent Psychiatry, 57(11), 837–848.e2. https://doi.org/10.1016/j.jaac.2018.05.026. CrossRefPubMedPubMedCentral

Kim, S. H., Macari, S., Koller, J., & Chawarska, K. (2016). Examining the phenotypic heterogeneity of early autism spectrum disorder: Subtypes and short-term outcomes. Journal of Child Psychology and Psychiatry and Allied Disciplines, 57(1), 93–102. https://doi.org/10.1111/jcpp.12448. CrossRefPubMed

Landry, S. H., & Loveland, K. A. (1988). Communication behaviors in autism and developmental language delay. Journal of Child Psychology and Psychiatry. https://doi.org/10.1111/j.1469-7610.1988.tb01884. CrossRefPubMed

Lawson, L. P., Joshi, R., Barbaro, J., & Dissanayake, C. (2018). Gender differences during toddlerhood in autism spectrum disorder: A prospective community-based longitudinal follow-up study. Journal of Autism and Developmental Disorders, 48(8), 2619–2628. https://doi.org/10.1007/s10803-018-3516-y. CrossRefPubMed

Long, C., Gurka, M. J., & Blackman, J. (2011). Cognitive skills of young children with and without autism spectrum disorder using the BSID-III. Autism Research and Treatment, 2011, 1–7. https://doi.org/10.1155/2011/759289. CrossRef

Lord, C., Luyster, R., Guthrie, W., & Pickles, A. (2012b). Patterns of developmental trajectories in toddlers with autism spectrum disorder. Journal of Consulting and Clinical Psychology, 80(3), 477–489. https://doi.org/10.1037/a0027214. CrossRefPubMedPubMedCentral

Lord, C., & Pickles, A. (1996). Language behaviors level and nonverbal social-communicative in autistic and language-delayed children. Journal of the American Academy of Child & Adolescent Psychiatry. https://doi.org/10.1097/00004583-199611000-00024. CrossRef

Lord, C., Rutter, M., DiLavore, P., Risi, S., Gotham, K., & Bishop, S. (2012a). Autism diagnostic observation schedule, second edition (ADOS-2) manual (Part I): Modules 1–4. Firenze: Giunti OS.

Mandy, W., Chilvers, R., Chowdhury, U., Salter, G., Seigal, A., & Skuse, D. (2012). Sex differences in autism spectrum disorder: Evidence from a large sample of children and adolescents. Journal of Autism and Developmental Disorders, 42(7), 1304–1313. https://doi.org/10.1007/s10803-011-1356-0. CrossRefPubMed

Mandy, W. P. L., & Skuse, D. H. (2008). Research Review: What is the association between the social-communication element of autism and repetitive interests, behaviours and activities? Journal of Child Psychology and Psychiatry and Allied Disciplines, 49(8), 795–808. https://doi.org/10.1111/j.1469-7610.2008.01911. CrossRefPubMed

Masyn, K. E. (2013). Latent Class analysis and finite mixture modeling. In T.D. Little (Ed.). In The oxford handbook of quantitative methods: Vol 2: Statistical Analysis: Oxford University Press. Retrieved 17 Jun. 2020, from https://www.oxfordhandbooks.com/view/ https://doi.org/10.1093/oxfordhb/9780199934898.001.0001/oxfordhb-9780199934898-e-025.

McFayden, T. C., Albright, J., Muskett, A. E., & Scarpa, A. (2019). Brief report: Sex differences in ASD diagnosis—A brief report on restricted interests and repetitive behaviors. Journal of Autism and Developmental Disorders, 49(4), 1693–1699. https://doi.org/10.1007/s10803-018-3838-9. CrossRefPubMed

Moulton, E., Barton, M. L., Robins, D. L., Abrams, D. N., & Fein, D. A. (2016). Early characteristics of children with ASD who demonstrate optimal progress between age two and four. Journal of Autism and Developmental Disorders, 46(6), 2160–2173. https://doi.org/10.1016/j.coviro.2015.09.001. CrossRefPubMedPubMedCentral

Munson, J., Dawson, G., Sterling, L., Beauchaine, T., Zhou, A., Koehler, E., … Abbott, R. (2008). Evidence for latent classes of IQ in young children with autism spectrum disorder. American Journal on Mental Retardation, 113(6), 439–452. https://doi.org/10.1352/2008.113:439-452.

Nylund, K. L., Asparouhov, T., & Muthén, B. O. (2007). Structural equation modeling: A multidisciplinary journal deciding on the number of classes in latent class analysis and growth mixture modeling: A Monte Carlo simulation study. Structural Equation Modeling, 14(4), 535–569. https://doi.org/10.1080/10705510701575396. CrossRef

Pierce, K., Gazestani, V. H., Bacon, E., Barnes, C. C., Cha, D., Nalabolu, S., … Courchesne, E. (2019). Evaluation of the diagnostic stability of the early autism spectrum disorder phenotype in the general population starting at 12 months. JAMA Pediatrics, 173(6), 578–587. https://doi.org/10.1001/jamapediatrics.2019.0624.

Richler, J., Bishop, S. L., Kleinke, J. R., & Lord, C. (2007). Restricted and repetitive behaviors in young children with autism spectrum disorders. Journal of Autism and Developmental Disorders, 37(1), 73–85. https://doi.org/10.1007/s10803-006-0332-6. CrossRefPubMed

Ros‐Demarize, R., Bradley, C., Kanne, S. M., Warren, Z., Boan, A., Lajonchere, C., … Carpenter, L. A. (2020). ASD symptoms in toddlers and preschoolers: An examination of sex differences. Autism Research, 13(1), 157–166. https://doi.org/10.1002/aur.2241.

Sparrow, S. S., Cicchetti, D. V., & Balla, D. A. (2005). Vineland-II adaptive behavior scales, second edition. San Antonio: PsychCorp.

Sparrow, S. S., & Cichetti, D. V. (2016). Vineland adaptive behavior scales, third edition (Vineland-3) manual. San Antonio: PsychCorp.

Stevens, M. C., Fein, D. A., Dunn, M., Allen, D., Waterhouse, L. H., Feinstein, C., & Rapin, I. (2000). Subgroups of children with autism by cluster analysis: A longitudinal examination. Journal of the American Academy of Child and Adolescent Psychiatry, 39(3), 346–352. https://doi.org/10.1097/00004583-200003000-00017. CrossRefPubMed

Szatmari, P., Georgiades, S., Bryson, S., Zwaigenbaum, L., Roberts, W., Mahoney, W., … Tuff, L. (2006). Investigating the structure of the restricted, repetitive behaviours and interests domain of autism. Journal of Child Psychology and Psychiatry and Allied Disciplines, 47(6), 582–590. https://doi.org/10.1111/j.1469-7610.2005.01537.

Szatmari, P., Liu, X. Q., Goldberg, J., Zwaigenbaum, L., Paterson, A. D., Woodbury-Smith, M., … Thompson, A. (2012). Sex differences in repetitive stereotyped behaviors in autism: Implications for genetic liability. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 159 B(1), 5–12. https://doi.org/10.1002/ajmg.b.31238.

Szatmari, P., Georgiades, S., Duku, E., Bennett, T. A., Bryson, S., Fombonne, E., … Pathways in ASD Study Team. (2015). Developmental trajectories of symptom severity and adaptive functioning in an inception cohort of preschool children with autism spectrum disorder. JAMA Psychiatry, 72(3), 276–283. https://doi.org/10.1001/jamapsychiatry.2014.2463.

Thurm, A., Farmer, C., Salzman, E., Lord, C., & Bishop, S. (2019). State of the field: Differentiating intellectual disability from autism spectrum disorder. Frontiers in Psychiatry. https://doi.org/10.3389/fpsyt.2019.00526. CrossRefPubMedPubMedCentral

Tillmann, J., Ashwood, K., Absoud, M., Bölte, S., Bonnet-Brilhault, F., Buitelaar, J. K., … Charman, T. (2018). Evaluating sex and age differences in ADI-R and ADOS scores in a large European multi-site sample of individuals with autism spectrum disorder. Journal of Autism and Developmental Disorders, 48(7), 2490–2505. https://doi.org/10.1007/s10803-018-3510-4.

Trillingsgaard, A., Sørensen, E. U., Němec, G., & Jørgensen, M. (2005). What distinguishes autism spectrum disorders from other developmental disorders before the age of four years? European Child and Adolescent Psychiatry. https://doi.org/10.1007/s00787-005-0433-3. CrossRefPubMed

Ventola, P., Kleinman, J., Pandey, J., Wilson, L., Esser, E., Boorstein, H., … Fein, D. (2007). Differentiating between autism spectrum disorders and other developmental disabilities in children who failed a screening instrument for ASD. Journal of Autism and Developmental Disorders, 37(3), 425–436. https://doi.org/10.1007/s10803-006-0177-z.

Wiggins, L. D., Robins, D. L., Adamson, L. B., Bakeman, R., & Henrich, C. C. (2012). Support for a dimensional view of autism spectrum disorders in toddlers. Journal of Autism and Developmental Disorders, 42(2), 191–200. https://doi.org/10.1007/s10803-011-1230-0. CrossRefPubMedPubMedCentral

Wiggins, L. D., Tian, L. H., Levy, S. E., Rice, C., Lee, L. C., Schieve, L., … Thompson, W. (2017). Homogeneous subgroups of young children with autism improve phenotypic characterization in the study to explore early development. Journal of Autism and Developmental Disorders, 47(11), 3634–3645. https://doi.org/10.1007/s10803-017-3280-4.

Yang, S., Paynter, J. M., & Gilmore, L. (2016). Vineland adaptive behavior scales: II profile of young children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 46(1), 64–73. https://doi.org/10.1007/s10803-015-2543-1. CrossRefPubMed

Zwaigenbaum, L., Bryson, S., & Garon, N. (2013). Early identification of autism spectrum disorders. Behavioural Brain Research, 251, 133–146. https://doi.org/10.1016/j.bbr.2013.04.004. CrossRefPubMed

Titel: Identifying Subgroups of Toddlers with DSM-5 Autism Spectrum Disorder Based on Core Symptoms
Auteurs: Holly K. Harris
Collin Lee
Georgios D. Sideridis
William J. Barbaresi
Elizabeth Harstad
Publicatiedatum: 28-01-2021
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 12/2021
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-021-04879-z

Bohn Stafleu van Loghum

Tip

Swipe om te navigeren naar een ander artikel

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 12/2021

Advances in Our Understanding of Behavioral Intervention: 1980 to 2020 for Individuals Diagnosed with Autism Spectrum Disorder

Profiles of Autonomic Activity in Autism Spectrum Disorder with and without Anxiety

Private music teachers’ knowledge of and attitudes toward students with autism spectrum disorder

“You Must Become a Chameleon to Survive”: Adolescent Experiences of Camouflaging

Correction to: The Adapted ADOS: A New Module Set for the Assessment of Minimally Verbal Adolescents and Adults

Celebrating 40 years since DSM-III