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Gepubliceerd in: Journal of Autism and Developmental Disorders 5/2006

01-07-2006 | Original Paper

Hyperserotoninemia and Altered Immunity in Autism

Auteurs: Nancy K. Burgess, Thayne L. Sweeten, William M. McMahon, Robert S. Fujinami

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 5/2006

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Abstract

One of the most consistent biological findings in autism is elevated whole blood serotonin (5-HT) levels found in about 1/3 of cases. Immune abnormalities are also commonly observed in this disorder. Given 5-HT’s role as an immunomodulator, possible connections between 5-HT and immune abnormalities in autism are explored in this review. Areas of focus include hyperserotoninemia and cellular immune function, autoantibodies to 5-HT receptors, and 5-HT’s role in autoimmunity. Further research is needed to determine the interactions between neuropsychiatric and immune dysfunction in autism and related disorders.
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Metagegevens
Titel
Hyperserotoninemia and Altered Immunity in Autism
Auteurs
Nancy K. Burgess
Thayne L. Sweeten
William M. McMahon
Robert S. Fujinami
Publicatiedatum
01-07-2006
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 5/2006
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-006-0100-7