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Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-11-2007 | Original Paper

Hyperserotonemia in Adults with Autistic Disorder

Auteurs: Dubravka Hranilovic, Zorana Bujas-Petkovic, Renata Vragovic, Tomislav Vuk, Karlo Hock, Branimir Jernej

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 10/2007

Abstract

Hyperserotonemia is the most consistent serotonin-related finding in autism. The basis of this phenomenon, and its relationship to the central serotonergic dysfunction remains unclear. Platelet serotonin level (PSL) in 53 autistic adults and 45 healthy controls was measured. Mean PSL in autistic group (75.7 ± 37.4 ng/μL) was significantly higher than the control sample (59.2 ± 16.2 ng/μL) due to a presence of hyperserotonemic subjects which comprised 32% of the patients. PSL of autistic subjects did not correlate with the severity of symptoms, as measured by total CARS score, or the degree of mental retardation. However, significant negative relationship was observed between PSL and speech development, indicating the relationship between the peripheral 5HT concentrations and verbal abilities in autistic subjects.

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Titel: Hyperserotonemia in Adults with Autistic Disorder
Auteurs: Dubravka Hranilovic
Zorana Bujas-Petkovic
Renata Vragovic
Tomislav Vuk
Karlo Hock
Branimir Jernej
Publicatiedatum: 01-11-2007
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 10/2007
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-006-0324-6

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