Skip to main content
main-content
Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in: Quality of Life Research 6/2010

01-08-2010

HRQoL in HIV-infected children using PedsQL™ 4.0 and comparison with uninfected children

Auteurs: Tanushree Banerjee, Tripti Pensi, Dipankar Banerjee

Gepubliceerd in: Quality of Life Research | Uitgave 6/2010

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Purpose

To assess the reliability and validity of Pediatric Quality of Life Inventory 4.0 (PedsQLTM 4.0) in children living with HIV. Also to determine the association of HIV infection, treatment regimens, and type of care received on quality of life (QoL) in pediatric patients.

Methods

Study was conducted from January to December 2008 at Dr. Ram Manohar Lohia Hospital, New Delhi, India at the HIV pediatric outpatient department (OPD). PedsQLTM 4.0 was administered to 100 HIV-infected and 200 uninfected children aged 8–12 years and their primary caregivers.

Results

Internal consistency reliability exceeded 0.70 for both proxy-reported and self-reported scales. Intraclass correlation coefficient demonstrated mainly larger values for parent proxy-report (interval of 0.926–0.952 with 95% confidence) than for child self-report (interval of 0.891–0.928 with 95% confidence). Factor analysis was performed and it indicated that five factors were extracted from the PedsQLTM 4.0 and these five factors correspond mainly to the five scales. HIV infection was associated with a negative impact on QoL among children with lower scores for physical, school, and emotional functioning and health symptoms. In contrast, uninfected children had lower social functioning scores. Our results showed antiretroviral treatment to be associated with improved QoL among HIV-infected children. We even identified infected children living at home to be at a higher distress of psychosocial functioning and health symptoms when compared with children living in care homes.

Conclusions

PedsQLTM is an acceptable and valid measure of health-related quality of life (HRQoL) for HIV-infected children and uninfected group. Application of this data will be helpful for program managers to devise care and support programme for both infected and uninfected children.
Literatuur
1.
go back to reference Wu, A. W., Mathews, W. C., Brysk, L. T., et al. (1990). Quality of life in a placebo-controlled trial of zidovudine in patients with AIDS and AIDS-related complex. Journal of Acquired Immune Deficiency Syndromes, 3(7), 683–690. PubMed Wu, A. W., Mathews, W. C., Brysk, L. T., et al. (1990). Quality of life in a placebo-controlled trial of zidovudine in patients with AIDS and AIDS-related complex. Journal of Acquired Immune Deficiency Syndromes, 3(7), 683–690. PubMed
2.
go back to reference Hays, R. D., Cunningham, W. E., Sherbourne, C. D., et al. (2000). Health-related quality of life in patients with human immunodeficiency virus infection in the United States: Results from the HIV Cost and Services Utilization Study. American Journal of Medicine, 108(9), 714–722. CrossRefPubMed Hays, R. D., Cunningham, W. E., Sherbourne, C. D., et al. (2000). Health-related quality of life in patients with human immunodeficiency virus infection in the United States: Results from the HIV Cost and Services Utilization Study. American Journal of Medicine, 108(9), 714–722. CrossRefPubMed
3.
go back to reference Varni, J. W., Seid, M., & Rode, C. A. (1999). The PedsQL TM: Measurement model for the pediatric quality of life inventory. Medical Care, 37, 126–139. CrossRefPubMed Varni, J. W., Seid, M., & Rode, C. A. (1999). The PedsQL TM: Measurement model for the pediatric quality of life inventory. Medical Care, 37, 126–139. CrossRefPubMed
4.
go back to reference Wu, A. W., Rubin, H. R., Mathews, W. C., et al. (1991). A health status questionnaire using 30 items from the Medical Outcomes Study. Preliminary validation in persons with early HIV infection. Medical Care, 29(8), 786–798. CrossRefPubMed Wu, A. W., Rubin, H. R., Mathews, W. C., et al. (1991). A health status questionnaire using 30 items from the Medical Outcomes Study. Preliminary validation in persons with early HIV infection. Medical Care, 29(8), 786–798. CrossRefPubMed
5.
go back to reference Burgess, A., Dayer, M., Catalan, J., Hawkins, D., & Gazzard, B. (1993). The reliability and validity of two HIV-specific health-related Quality-of-Life measures: A preliminary analysis. AIDS, 7(7), 1001–1008. CrossRefPubMed Burgess, A., Dayer, M., Catalan, J., Hawkins, D., & Gazzard, B. (1993). The reliability and validity of two HIV-specific health-related Quality-of-Life measures: A preliminary analysis. AIDS, 7(7), 1001–1008. CrossRefPubMed
6.
go back to reference Hammer, S. M., Squires, K. E., Hughes, M. D., et al. (1997). A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. New England Journal of Medicine, 337(11), 725–733. CrossRefPubMed Hammer, S. M., Squires, K. E., Hughes, M. D., et al. (1997). A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. New England Journal of Medicine, 337(11), 725–733. CrossRefPubMed
7.
go back to reference Detels, R., Munoz, A., McFarlane, G., et al. (1998). Effectiveness of potent antiretroviral therapy on time to AIDS and death in men with known HIV infection duration. Multicenter AIDS Cohort Study Investigators. JAMA, 280(17), 1497–1503. CrossRefPubMed Detels, R., Munoz, A., McFarlane, G., et al. (1998). Effectiveness of potent antiretroviral therapy on time to AIDS and death in men with known HIV infection duration. Multicenter AIDS Cohort Study Investigators. JAMA, 280(17), 1497–1503. CrossRefPubMed
8.
go back to reference Low-Beer, S., Chan, K., Wood, E., et al. (2000). Health related quality of life among persons with HIV after the use of protease inhibitors. Quality of Life Research, 9(8), 941–949. CrossRefPubMed Low-Beer, S., Chan, K., Wood, E., et al. (2000). Health related quality of life among persons with HIV after the use of protease inhibitors. Quality of Life Research, 9(8), 941–949. CrossRefPubMed
9.
go back to reference Saunders, D. S., & Burgoyne, R. W. (2002). Evaluating health-related wellbeing outcomes among outpatient adults with human immunodeficiency virus infection in the HAART era. International Journal of STD and AIDS, 13(10), 683–690. CrossRefPubMed Saunders, D. S., & Burgoyne, R. W. (2002). Evaluating health-related wellbeing outcomes among outpatient adults with human immunodeficiency virus infection in the HAART era. International Journal of STD and AIDS, 13(10), 683–690. CrossRefPubMed
10.
go back to reference Carrieri, P., Spine, B., Duran, S., et al. (2003). Health-related quality of life after 1 year of highly active antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes, 32(1), 38–47. PubMed Carrieri, P., Spine, B., Duran, S., et al. (2003). Health-related quality of life after 1 year of highly active antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes, 32(1), 38–47. PubMed
11.
go back to reference Nieuwkerk, P. T., Gisolf, E. H., Colebunders, R., Wu, A. W., Danner, S. A., & Sprangers, M. A. (2000). Quality of life in asymptomatic- and symptomatic HIV infected patients in a trial of ritonavir/saquinavir therapy. The Prometheus Study Group. AIDS, 14(2), 181–187. CrossRefPubMed Nieuwkerk, P. T., Gisolf, E. H., Colebunders, R., Wu, A. W., Danner, S. A., & Sprangers, M. A. (2000). Quality of life in asymptomatic- and symptomatic HIV infected patients in a trial of ritonavir/saquinavir therapy. The Prometheus Study Group. AIDS, 14(2), 181–187. CrossRefPubMed
12.
go back to reference Gill, C. J., Griffith, J. L., Jacobson, D., Skinner, S., Gorbach, S. L., & Wilson, I. B. (2002). Relationship of HIV viral loads, CD4 counts, and HAART use to health-related quality of life. Journal of Acquired Immune Deficiency Syndromes, 30(5), 485–492. PubMed Gill, C. J., Griffith, J. L., Jacobson, D., Skinner, S., Gorbach, S. L., & Wilson, I. B. (2002). Relationship of HIV viral loads, CD4 counts, and HAART use to health-related quality of life. Journal of Acquired Immune Deficiency Syndromes, 30(5), 485–492. PubMed
13.
go back to reference Centers for Disease Control and Prevention. (1994). 1994 revised classification system for human immunodeficiency virus infection in children less than 13 years of age. MMWR. Recommendations and Reports, 43(RR-12), 1–10. Centers for Disease Control and Prevention. (1994). 1994 revised classification system for human immunodeficiency virus infection in children less than 13 years of age. MMWR. Recommendations and Reports, 43(RR-12), 1–10.
14.
go back to reference Varmi, J. W., Seid, M., & Kurtin, P. (2001). PedsQL TM 4.0: Reliability and validity of the Pediatric Quality of Life Inventory TM Version 4.0 Generic Core Scales in healthy and patient populations. Medical Care, 39, 800–812. CrossRef Varmi, J. W., Seid, M., & Kurtin, P. (2001). PedsQL TM 4.0: Reliability and validity of the Pediatric Quality of Life Inventory TM Version 4.0 Generic Core Scales in healthy and patient populations. Medical Care, 39, 800–812. CrossRef
15.
go back to reference Cronbach, L. J. (1951). Coefficient alpha and the internal structure of tests. Psychometrika, 16, 297–334. CrossRef Cronbach, L. J. (1951). Coefficient alpha and the internal structure of tests. Psychometrika, 16, 297–334. CrossRef
16.
go back to reference Cohen, J. (1988). Statistical power analysis for the behavioral sciences (2nd ed.). Hillsdale, NJ: Lawrence Earlbaum Associates. Cohen, J. (1988). Statistical power analysis for the behavioral sciences (2nd ed.). Hillsdale, NJ: Lawrence Earlbaum Associates.
17.
go back to reference Storm, D. S., Boland, M. G., Gortmaker, S. L., et al. (2005). Protease inhibitor combination therapy, severity of illness, and quality of life among children with perinatally acquired HIV-1 infection. Pediatrics, 115(2), e173–e182. CrossRefPubMed Storm, D. S., Boland, M. G., Gortmaker, S. L., et al. (2005). Protease inhibitor combination therapy, severity of illness, and quality of life among children with perinatally acquired HIV-1 infection. Pediatrics, 115(2), e173–e182. CrossRefPubMed
18.
go back to reference Campsmith, M. L., Nakashima, A. K., & Davidson, A. J. (2003). Self-reported health-related quality of life in persons with HIV infection: Results from a multi-site interview project. Health and Quality of Life Outcomes, 1(1), 12. CrossRefPubMed Campsmith, M. L., Nakashima, A. K., & Davidson, A. J. (2003). Self-reported health-related quality of life in persons with HIV infection: Results from a multi-site interview project. Health and Quality of Life Outcomes, 1(1), 12. CrossRefPubMed
19.
go back to reference Jones, D. J., Beach, S. R., Forehand, R., et al. (2003). Self-reported health in HIV-positive African American women: The role of family stress and depressive symptoms. Journal of Behavioral Medicine, 26, 577–599. CrossRefPubMed Jones, D. J., Beach, S. R., Forehand, R., et al. (2003). Self-reported health in HIV-positive African American women: The role of family stress and depressive symptoms. Journal of Behavioral Medicine, 26, 577–599. CrossRefPubMed
20.
go back to reference Arpinelli, F., Visona, G., Bruno, R., et al. (2000). Health-related quality of life in asymptomatic patients with HIV: Evaluation of the SF-36 health survey in Italian patients. Pharmacoeconomics, 18, 63–72. CrossRefPubMed Arpinelli, F., Visona, G., Bruno, R., et al. (2000). Health-related quality of life in asymptomatic patients with HIV: Evaluation of the SF-36 health survey in Italian patients. Pharmacoeconomics, 18, 63–72. CrossRefPubMed
21.
go back to reference Miners, A. H., Sabin, C. A., Mocroft, A., et al. (2001). Health-related quality of life in individuals infected with HIV in the era of HAART. HIV Clinical Trials, 2, 484–492. CrossRefPubMed Miners, A. H., Sabin, C. A., Mocroft, A., et al. (2001). Health-related quality of life in individuals infected with HIV in the era of HAART. HIV Clinical Trials, 2, 484–492. CrossRefPubMed
22.
go back to reference Lee, G. M., Gortmarker, S. L., McIntosh, K., Hughes, M. D., Oleske, J. M., & Pediatric AIDS Clinical Trials Group Protocol 219C Team. (2006). Quality of life for children and adolescents: Impact of HIV infection and antiretroviral treatment. Pediatrics, 117(2), 273–283. CrossRefPubMed Lee, G. M., Gortmarker, S. L., McIntosh, K., Hughes, M. D., Oleske, J. M., & Pediatric AIDS Clinical Trials Group Protocol 219C Team. (2006). Quality of life for children and adolescents: Impact of HIV infection and antiretroviral treatment. Pediatrics, 117(2), 273–283. CrossRefPubMed
23.
go back to reference Gurprit, G., Pensi, T., & Banerjee, T. (2007). Behavioural disorders in 6–11-year-old, HIV-infected Indian children. Annals of Tropical Paediatrics, 27, 215–224. CrossRef Gurprit, G., Pensi, T., & Banerjee, T. (2007). Behavioural disorders in 6–11-year-old, HIV-infected Indian children. Annals of Tropical Paediatrics, 27, 215–224. CrossRef
Metagegevens
Titel
HRQoL in HIV-infected children using PedsQL™ 4.0 and comparison with uninfected children
Auteurs
Tanushree Banerjee
Tripti Pensi
Dipankar Banerjee
Publicatiedatum
01-08-2010
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 6/2010
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-010-9643-3

Andere artikelen Uitgave 6/2010

Quality of Life Research 6/2010 Naar de uitgave