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Journal of Autism and Developmental Disorders

Gepubliceerd in:

06-09-2017 | Original Paper

Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development

Auteurs: Lisa D. Wiggins, Lin H. Tian, Susan E. Levy, Catherine Rice, Li-Ching Lee, Laura Schieve, Juhi Pandey, Julie Daniels, Lisa Blaskey, Susan Hepburn, Rebecca Landa, Rebecca Edmondson-Pretzel, William Thompson

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 11/2017

Abstract

The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: mild language delay with cognitive rigidity, mild language and motor delay with dysregulation, general developmental delay, and significant developmental delay with repetitive motor behaviors. We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed.

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Titel: Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development
Auteurs: Lisa D. Wiggins
Lin H. Tian
Susan E. Levy
Catherine Rice
Li-Ching Lee
Laura Schieve
Juhi Pandey
Julie Daniels
Lisa Blaskey
Susan Hepburn
Rebecca Landa
Rebecca Edmondson-Pretzel
William Thompson
Publicatiedatum: 06-09-2017
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 11/2017
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-017-3280-4

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