Skip to main content
Top
Gepubliceerd in: Neuropraxis 3/2014

01-06-2014 | Artikel

Hoe magnetisme en diffusie kunnen bijdragen aan hersenonderzoek: toepassingen van diffusie-MRI-tractografie

Auteurs: Chantal M. W. Tax, Alexander Leemans

Gepubliceerd in: Neuropraxis | Uitgave 3/2014

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Samenvatting

Met MRI kunnen zachte weefsels in het lichaam afgebeeld worden op een niet-invasieve manier. MRI is daardoor onmisbaar bij de diagnose van veel ziektes. Diffusie-MRI is een relatief nieuwe techniek die, in tegenstelling tot conventionele MRI-technieken, ook de architectuur van weefsels in kaart kan brengen. Hiertoe wordt de MRI-sequentie gevoelig gemaakt voor de willekeurige beweging van deeltjes (diffusie). Watermoleculen bewegen zich in weefsels voort op een dergelijke willekeurige wijze, maar worden daar ook gehinderd door verschillende microstructuren. De eigenschappen van onderliggend weefsel bepalen dus de grootte van diffusie, wat met diffusie-MRI-scans in kaart kan worden gebracht. Veel lichaamsweefsels zijn opgebouwd uit vezelachtige structuren, bijvoorbeeld zenuwvezels in de witte stof van de hersenen. Diffusie-MRI-tractografie is het reconstrueren en visualiseren van vezelpaden die geassocieerd kunnen worden met deze onderliggende zenuwbanen. Hierdoor is het mogelijk om specifieke verbindingen tussen verschillende hersengebieden af te beelden en kwantitatief te bestuderen. Dit artikel gaat in op de werking van diffusie-MRI-tractografie en bespreekt (klinische) toepassingen, valkuilen, en beperkingen die gerelateerd zijn aan deze techniek.
Voetnoten
1
De diffusiecoëfficiënt die geschat wordt uit diffusiebeelden wordt vaak de schijnbare diffusiecoëfficiënt genoemd. Dit komt omdat de diffusie afhangt van een groot aantal factoren, zoals temperatuur en de omliggende microstructuren (bijvoorbeeld celmembranen en myelineschedes).
 
2
Met een volume wordt hier een drie-dimensionale MRI-scan bedoeld.
 
Literatuur
1.
go back to reference Aarnink, S.H., Vos, S.B., Leemans, A., Jernigan, T.L., Madsen, K.S. & Baare, W.F., 2014. Automated longitudinal intra-subject analysis (ALISA) for diffusion MRI tractography. Neuroimage, 86, 404–416.PubMedCrossRef Aarnink, S.H., Vos, S.B., Leemans, A., Jernigan, T.L., Madsen, K.S. & Baare, W.F., 2014. Automated longitudinal intra-subject analysis (ALISA) for diffusion MRI tractography. Neuroimage, 86, 404–416.PubMedCrossRef
2.
go back to reference Alexander, A.L., 2010. Deterministic White Matter Tractography. In: Jones, D.K. (Ed.), Diffusion MRI: Theory, Methods, and Applications. Oxford University Press. Alexander, A.L., 2010. Deterministic White Matter Tractography. In: Jones, D.K. (Ed.), Diffusion MRI: Theory, Methods, and Applications. Oxford University Press.
3.
go back to reference Basser, P.J., Mattiello, J. & LeBihan, D., 1994. Estimation of the effective self-diffusion tensor from the NMR spin echo. Journal of Magnetic Resonance, series B, 103, 247–254.CrossRef Basser, P.J., Mattiello, J. & LeBihan, D., 1994. Estimation of the effective self-diffusion tensor from the NMR spin echo. Journal of Magnetic Resonance, series B, 103, 247–254.CrossRef
4.
go back to reference Beaulieu, C., 2002. The basis of anisotropic water diffusion in the nervous system—a technical review. NMR in Biomedine, 15, 435–455.CrossRef Beaulieu, C., 2002. The basis of anisotropic water diffusion in the nervous system—a technical review. NMR in Biomedine, 15, 435–455.CrossRef
5.
go back to reference Chang, L.C., Jones, D.K. & Pierpaoli, C., 2005. RESTORE: robust estimation of tensors by outlier rejection. Magnetic Resonance in Medicine, 53, 1088–1095.PubMedCrossRef Chang, L.C., Jones, D.K. & Pierpaoli, C., 2005. RESTORE: robust estimation of tensors by outlier rejection. Magnetic Resonance in Medicine, 53, 1088–1095.PubMedCrossRef
6.
go back to reference Chen, F., Zhang, X., Li, M., Wang, R., Wang, H.T., Zhu, F., Lu, D.J., Zhao, H., Li, J.W., Xu, Y., Zhu, B. & Zhang, B., 2012. Axial diffusivity and tensor shape as early markers to assess cerebral white matter damage caused by brain tumors using quantitative diffusion tensor tractography. CNS Neuroscience & Therapeutics, 18, 667–673.CrossRef Chen, F., Zhang, X., Li, M., Wang, R., Wang, H.T., Zhu, F., Lu, D.J., Zhao, H., Li, J.W., Xu, Y., Zhu, B. & Zhang, B., 2012. Axial diffusivity and tensor shape as early markers to assess cerebral white matter damage caused by brain tumors using quantitative diffusion tensor tractography. CNS Neuroscience & Therapeutics, 18, 667–673.CrossRef
7.
go back to reference Chun, T., Filippi, C.G., Zimmerman, R.D. & Ulug, A.M., 2000. Diffusion changes in the aging human brain. American Journal of Neuroradiology, 21, 1078–1083.PubMed Chun, T., Filippi, C.G., Zimmerman, R.D. & Ulug, A.M., 2000. Diffusion changes in the aging human brain. American Journal of Neuroradiology, 21, 1078–1083.PubMed
8.
go back to reference Clayden, J.D., Jentschke, S., Munoz, M., Cooper, J.M., Chadwick, M.J., Banks, T., Clark, C.A. & Vargha-Khadem, F., 2012. Normative development of white matter tracts: similarities and differences in relation to age, gender, and intelligence. Cerebral Cortex, 22, 1738–1747.PubMedCrossRef Clayden, J.D., Jentschke, S., Munoz, M., Cooper, J.M., Chadwick, M.J., Banks, T., Clark, C.A. & Vargha-Khadem, F., 2012. Normative development of white matter tracts: similarities and differences in relation to age, gender, and intelligence. Cerebral Cortex, 22, 1738–1747.PubMedCrossRef
9.
go back to reference Deprez, S., Billiet, T., Sunaert, S. & Leemans, A., 2013. Diffusion tensor MRI of chemotherapy-induced cognitive impairment in non-CNS cancer patients: a review. Brain Imaging and Behaviour, 7, 409–435.CrossRef Deprez, S., Billiet, T., Sunaert, S. & Leemans, A., 2013. Diffusion tensor MRI of chemotherapy-induced cognitive impairment in non-CNS cancer patients: a review. Brain Imaging and Behaviour, 7, 409–435.CrossRef
10.
go back to reference Descoteaux, M., Angelino, E., Fitzgibbons, S. & Deriche, R., 2007. Regularized, fast, and robust analytical Q-ball imaging. Magnetic Resonance in Medicine, 58, 497–510.PubMedCrossRef Descoteaux, M., Angelino, E., Fitzgibbons, S. & Deriche, R., 2007. Regularized, fast, and robust analytical Q-ball imaging. Magnetic Resonance in Medicine, 58, 497–510.PubMedCrossRef
11.
go back to reference Ferda, J., Kastner, J., Mukensnabl, P., Choc, M., Horemuzova, J., Ferdova, E. & Kreuzberg, B., 2010. Diffusion tensor magnetic resonance imaging of glial brain tumors. European Journal of Radiology, 74, 428–436.PubMedCrossRef Ferda, J., Kastner, J., Mukensnabl, P., Choc, M., Horemuzova, J., Ferdova, E. & Kreuzberg, B., 2010. Diffusion tensor magnetic resonance imaging of glial brain tumors. European Journal of Radiology, 74, 428–436.PubMedCrossRef
12.
go back to reference Gideon, P., Thomsen, C. & Henriksen, O., 1994. Increased self-diffusion of brain water in normal aging. Journal of Magnetic Resonance Imaging, 4, 185–188.PubMedCrossRef Gideon, P., Thomsen, C. & Henriksen, O., 1994. Increased self-diffusion of brain water in normal aging. Journal of Magnetic Resonance Imaging, 4, 185–188.PubMedCrossRef
13.
go back to reference Huppi, P.S., Maier, S.E., Peled, S., Zientara, G.P., Barnes, P.D., Jolesz, F.A. & Volpe, J.J., 1998. Microstructural development of human newborn cerebral white matter assessed in vivo by diffusion tensor magnetic resonance imaging. Pediatric Research, 44, 584–590.PubMedCrossRef Huppi, P.S., Maier, S.E., Peled, S., Zientara, G.P., Barnes, P.D., Jolesz, F.A. & Volpe, J.J., 1998. Microstructural development of human newborn cerebral white matter assessed in vivo by diffusion tensor magnetic resonance imaging. Pediatric Research, 44, 584–590.PubMedCrossRef
14.
go back to reference Jeurissen, B., Leemans, A., Jones, D.K., Tournier, J.D. & Sijbers, J., 2011. Probabilistic fiber tracking using the residual bootstrap with constrained spherical deconvolution. Human Brain Mapping, 32, 461–479.PubMedCrossRef Jeurissen, B., Leemans, A., Jones, D.K., Tournier, J.D. & Sijbers, J., 2011. Probabilistic fiber tracking using the residual bootstrap with constrained spherical deconvolution. Human Brain Mapping, 32, 461–479.PubMedCrossRef
15.
go back to reference Jeurissen, B., Leemans, A., Tournier, J.D., Jones, D.K. & Sijbers, J., 2013. Investigating the prevalence of complex fiber configurations in white matter tissue with diffusion magnetic resonance imaging. Human Brain Mapping, 34, 2747–2766.PubMedCrossRef Jeurissen, B., Leemans, A., Tournier, J.D., Jones, D.K. & Sijbers, J., 2013. Investigating the prevalence of complex fiber configurations in white matter tissue with diffusion magnetic resonance imaging. Human Brain Mapping, 34, 2747–2766.PubMedCrossRef
16.
go back to reference Jones, D.K., 2010a. Challenges and limitations of quantifying brain connectivity in vivo with diffusion MRI. Imaging, 2, 341–355.CrossRef Jones, D.K., 2010a. Challenges and limitations of quantifying brain connectivity in vivo with diffusion MRI. Imaging, 2, 341–355.CrossRef
17.
go back to reference Jones, D.K., 2010b. Diffusion MRI: Theory, Methods, and Applications. Oxford University Press, VS.CrossRef Jones, D.K., 2010b. Diffusion MRI: Theory, Methods, and Applications. Oxford University Press, VS.CrossRef
18.
go back to reference Jones, D.K. & Cercignani, M., 2010. Twenty-five pitfalls in the analysis of diffusion MRI data. NMR in Biomedicine, 23, 803–820.PubMedCrossRef Jones, D.K. & Cercignani, M., 2010. Twenty-five pitfalls in the analysis of diffusion MRI data. NMR in Biomedicine, 23, 803–820.PubMedCrossRef
19.
go back to reference Jones, D.K., Knosche, T.R. & Turner, R., 2013. White matter integrity, fiber count, and other fallacies: the do’s and don’ts of diffusion MRI. Neuroimage, 73, 239–254.PubMedCrossRef Jones, D.K., Knosche, T.R. & Turner, R., 2013. White matter integrity, fiber count, and other fallacies: the do’s and don’ts of diffusion MRI. Neuroimage, 73, 239–254.PubMedCrossRef
20.
go back to reference Kreher, B.W., Mader, I. & Kiselev, V.G., 2008. Gibbs tracking: a novel approach for the reconstruction of neuronal pathways. Magnetic Resonance in Medicine, 60, 953–963.PubMedCrossRef Kreher, B.W., Mader, I. & Kiselev, V.G., 2008. Gibbs tracking: a novel approach for the reconstruction of neuronal pathways. Magnetic Resonance in Medicine, 60, 953–963.PubMedCrossRef
21.
go back to reference Langen, M., Leemans, A., Johnston, P., Ecker, C., Daly, E., Murphy, C.M., Dell’acqua, F., Durston, S. & Murphy, D.G., 2012. Fronto-striatal circuitry and inhibitory control in autism: findings from diffusion tensor imaging tractography. Cortex, 48, 183–193.PubMedCrossRef Langen, M., Leemans, A., Johnston, P., Ecker, C., Daly, E., Murphy, C.M., Dell’acqua, F., Durston, S. & Murphy, D.G., 2012. Fronto-striatal circuitry and inhibitory control in autism: findings from diffusion tensor imaging tractography. Cortex, 48, 183–193.PubMedCrossRef
22.
go back to reference Lazar, M., Weinstein, D.M., Tsuruda, J.S., Hasan, K.M., Arfanakis, K., Meyerand, M.E., Badie, B., Rowley, H.A., Haughton, V., Field, A. ? Alexander, A.L., 2003. White matter tractography using diffusion tensor deflection. Human Brain Mapping, 18, 306–321.PubMedCrossRef Lazar, M., Weinstein, D.M., Tsuruda, J.S., Hasan, K.M., Arfanakis, K., Meyerand, M.E., Badie, B., Rowley, H.A., Haughton, V., Field, A. ? Alexander, A.L., 2003. White matter tractography using diffusion tensor deflection. Human Brain Mapping, 18, 306–321.PubMedCrossRef
23.
go back to reference Mori, S., Crain, B.J., Chacko, V.P. & Zijl, P.C. van, 1999. Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging. Annals of Neurology, 45, 265–269. Mori, S., Crain, B.J., Chacko, V.P. & Zijl, P.C. van, 1999. Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging. Annals of Neurology, 45, 265–269.
24.
go back to reference Özarslan, E., Koay, C.G., Shepherd, T.M., Komlosh, M.E., Irfanoglu, M.O., Pierpaoli, C. & Basser, P.J., 2013. Mean apparent propagator (MAP) MRI: a novel diffusion imaging method for mapping tissue microstructure. Neuroimage, 78, 16–32.PubMedCrossRef Özarslan, E., Koay, C.G., Shepherd, T.M., Komlosh, M.E., Irfanoglu, M.O., Pierpaoli, C. & Basser, P.J., 2013. Mean apparent propagator (MAP) MRI: a novel diffusion imaging method for mapping tissue microstructure. Neuroimage, 78, 16–32.PubMedCrossRef
25.
go back to reference Parker, G.J.M., 2010. Probabilistic Fiber Tracking. In: Jones, D.K. (Ed.), Diffusion MRI: Theory, Methods, and Applications. Oxford University Press. Parker, G.J.M., 2010. Probabilistic Fiber Tracking. In: Jones, D.K. (Ed.), Diffusion MRI: Theory, Methods, and Applications. Oxford University Press.
26.
go back to reference Pierpaoli, C., 2010. Artifacts in Diffusion MRI. In: Jones, D.K. (Ed.), Diffusion MRI: Theory, Methods, and Applications. Oxford University Press. Pierpaoli, C., 2010. Artifacts in Diffusion MRI. In: Jones, D.K. (Ed.), Diffusion MRI: Theory, Methods, and Applications. Oxford University Press.
27.
go back to reference Pierpaoli, C., Barnett, A., Pajevic, S., Chen, R., Penix, L.R., Virta, A., Basser, P., 2001. Water diffusion changes in Wallerian degeneration and their dependence on white matter architecture. Neuroimage, 13, 1174–1185.PubMedCrossRef Pierpaoli, C., Barnett, A., Pajevic, S., Chen, R., Penix, L.R., Virta, A., Basser, P., 2001. Water diffusion changes in Wallerian degeneration and their dependence on white matter architecture. Neuroimage, 13, 1174–1185.PubMedCrossRef
28.
go back to reference Reijmer, Y.D., Leemans, A., Heringa, S.M., Wielaard, I., Jeurissen, B., Koek, H.L. & Biessels, G.J., 2012. Improved sensitivity to cerebral white matter abnormalities in Alzheimer’s disease with spherical deconvolution based tractography. PLoS One, 7, e44074.PubMedCentralPubMedCrossRef Reijmer, Y.D., Leemans, A., Heringa, S.M., Wielaard, I., Jeurissen, B., Koek, H.L. & Biessels, G.J., 2012. Improved sensitivity to cerebral white matter abnormalities in Alzheimer’s disease with spherical deconvolution based tractography. PLoS One, 7, e44074.PubMedCentralPubMedCrossRef
29.
go back to reference Roine, U., Roine, T., Salmi, J., Nieminen-Von, W.T., Leppamaki, S., Rintahaka, P., Tani, P., Leemans, A. & Sams, M., 2013. Increased coherence of white matter fiber tract organization in adults with asperger syndrome: a diffusion tensor imaging study. Autism Research, 6, 642–650.PubMedCrossRef Roine, U., Roine, T., Salmi, J., Nieminen-Von, W.T., Leppamaki, S., Rintahaka, P., Tani, P., Leemans, A. & Sams, M., 2013. Increased coherence of white matter fiber tract organization in adults with asperger syndrome: a diffusion tensor imaging study. Autism Research, 6, 642–650.PubMedCrossRef
30.
go back to reference Schneider, J.F., Confort-Gouny, S., Le, F.Y., Viout, P., Bennathan, M., Chapon, F., Fogliarini, C., Cozzone, P. & Girard, N., 2007. Diffusion-weighted imaging in normal fetal brain maturation. European Radiology, 17, 2422–2429.PubMedCrossRef Schneider, J.F., Confort-Gouny, S., Le, F.Y., Viout, P., Bennathan, M., Chapon, F., Fogliarini, C., Cozzone, P. & Girard, N., 2007. Diffusion-weighted imaging in normal fetal brain maturation. European Radiology, 17, 2422–2429.PubMedCrossRef
31.
go back to reference Tax, C.M.W., 2012. Improved Reconstruction of the Optic Radiation for Epilepsy Surgery. Master thesis, Eindhoven University of Technology. Tax, C.M.W., 2012. Improved Reconstruction of the Optic Radiation for Epilepsy Surgery. Master thesis, Eindhoven University of Technology.
32.
go back to reference Tax, C.M.W., Duits, R., Romeny, B.M., Vilanova, A. & Ossenblok, P., 2012. Tractography of the Optic Radiation for Vision Sparing Epilepsy Surgery. In: Proceedings of the IEEE ICIA, 441–445. Tax, C.M.W., Duits, R., Romeny, B.M., Vilanova, A. & Ossenblok, P., 2012. Tractography of the Optic Radiation for Vision Sparing Epilepsy Surgery. In: Proceedings of the IEEE ICIA, 441–445.
33.
go back to reference Tax, C.M.W., Jeurissen, B., Vos, S.B., Viergever, M.A. & Leemans, A., 2013. Recursive calibration of the fiber response function for spherical deconvolution of diffusion MRI data. Neuroimage 86, 67–80.PubMedCrossRef Tax, C.M.W., Jeurissen, B., Vos, S.B., Viergever, M.A. & Leemans, A., 2013. Recursive calibration of the fiber response function for spherical deconvolution of diffusion MRI data. Neuroimage 86, 67–80.PubMedCrossRef
34.
go back to reference Tax, C.M.W., Otte, W.M., Viergever, M.A., Dijkhuizen, R.M. & Leemans, A., 2014. REKINDLE: Robust Extraction of Kurtosis INDices with Linear Estimation. Magnetic Resonance in Medicine. doi: 10.1002/mrm.25165.PubMed Tax, C.M.W., Otte, W.M., Viergever, M.A., Dijkhuizen, R.M. & Leemans, A., 2014. REKINDLE: Robust Extraction of Kurtosis INDices with Linear Estimation. Magnetic Resonance in Medicine. doi: 10.​1002/​mrm.​25165.PubMed
35.
go back to reference Tournier, J.D., Calamante, F. & Connelly, A., 2007. Robust determination of the fibre orientation distribution in diffusion MRI: non-negativity constrained super-resolved spherical deconvolution. Neuroimage, 35, 1459–1472.PubMedCrossRef Tournier, J.D., Calamante, F. & Connelly, A., 2007. Robust determination of the fibre orientation distribution in diffusion MRI: non-negativity constrained super-resolved spherical deconvolution. Neuroimage, 35, 1459–1472.PubMedCrossRef
38.
go back to reference Jagt, P.K. van der, Dik, P., Froeling, M., Kwee, T.C., Nievelstein, R.A., ten, H.B. & Leemans, A., 2012. Architectural configuration and microstructural properties of the sacral plexus: a diffusion tensor MRI and fiber tractography study. Neuroimage, 62, 1792–1799. Jagt, P.K. van der, Dik, P., Froeling, M., Kwee, T.C., Nievelstein, R.A., ten, H.B. & Leemans, A., 2012. Architectural configuration and microstructural properties of the sacral plexus: a diffusion tensor MRI and fiber tractography study. Neuroimage, 62, 1792–1799.
39.
go back to reference Zijden, J.P. van der, Toorn, A. van der, Marel, K. van der & Dijkhuizen, R.M., 2008. Longitudinal in vivo MRI of alterations in perilesional tissue after transient ischemic stroke in rats. Experimental Neurology, 212, 207–212. Zijden, J.P. van der, Toorn, A. van der, Marel, K. van der & Dijkhuizen, R.M., 2008. Longitudinal in vivo MRI of alterations in perilesional tissue after transient ischemic stroke in rats. Experimental Neurology, 212, 207–212.
40.
go back to reference Wang, H.C., Hsu, J.L. & Leemans, A., 2012. Diffusion tensor imaging of vascular parkinsonism: structural changes in cerebral white matter and the association with clinical severity. Archives of Neurology, 69, 1340–1348.PubMedCrossRef Wang, H.C., Hsu, J.L. & Leemans, A., 2012. Diffusion tensor imaging of vascular parkinsonism: structural changes in cerebral white matter and the association with clinical severity. Archives of Neurology, 69, 1340–1348.PubMedCrossRef
41.
go back to reference Wedeen, V.J., Hagmann, P., Tseng, W.Y., Reese, T.G. & Weisskoff, R.M., 2005. Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging. Magnetic Resonance in Medicine, 54, 1377–1386.PubMedCrossRef Wedeen, V.J., Hagmann, P., Tseng, W.Y., Reese, T.G. & Weisskoff, R.M., 2005. Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging. Magnetic Resonance in Medicine, 54, 1377–1386.PubMedCrossRef
42.
go back to reference Wimberger, D.M., Roberts, T.P., Barkovich, A.J., Prayer, L.M., Moseley, M.E &, Kucharczyk, J., 1995. Identification of ‘premyelination’ by diffusion-weighted MRI. Journal of Computer Assisted Tomography, 19, 28–33. Wimberger, D.M., Roberts, T.P., Barkovich, A.J., Prayer, L.M., Moseley, M.E &, Kucharczyk, J., 1995. Identification of ‘premyelination’ by diffusion-weighted MRI. Journal of Computer Assisted Tomography, 19, 28–33.
43.
go back to reference Wu, O., Nentwich, L., Chutinet, A. & Bayrlee, A., 2010. Diffusion in Acute Stroke. In: Jones, D.K. (Ed.), Diffusion MRI: Theory, Methods, and Applications. Oxford University Press. Wu, O., Nentwich, L., Chutinet, A. & Bayrlee, A., 2010. Diffusion in Acute Stroke. In: Jones, D.K. (Ed.), Diffusion MRI: Theory, Methods, and Applications. Oxford University Press.
44.
go back to reference Yamada, K., Sakai, K., Akazawa, K., Yuen, S. & Nishimura, T., 2009. MR tractography: a review of its clinical applications. Magnetic Resonance in Medical Sciences, 8, 165–174.PubMedCrossRef Yamada, K., Sakai, K., Akazawa, K., Yuen, S. & Nishimura, T., 2009. MR tractography: a review of its clinical applications. Magnetic Resonance in Medical Sciences, 8, 165–174.PubMedCrossRef
45.
go back to reference Yasmin, H., Nakata, Y., Aoki, S., Abe, O., Sato, N., Nemoto, K., Arima, K., Furuta, N., Uno, M., Hirai, S., Masutani, Y. & Ohtomo, K., 2008. Diffusion abnormalities of the uncinate fasciculus in Alzheimer’s disease: diffusion tensor tract-specific analysis using a new method to measure the core of the tract. Neuroradiology, 50, 293–299.PubMedCrossRef Yasmin, H., Nakata, Y., Aoki, S., Abe, O., Sato, N., Nemoto, K., Arima, K., Furuta, N., Uno, M., Hirai, S., Masutani, Y. & Ohtomo, K., 2008. Diffusion abnormalities of the uncinate fasciculus in Alzheimer’s disease: diffusion tensor tract-specific analysis using a new method to measure the core of the tract. Neuroradiology, 50, 293–299.PubMedCrossRef
Metagegevens
Titel
Hoe magnetisme en diffusie kunnen bijdragen aan hersenonderzoek: toepassingen van diffusie-MRI-tractografie
Auteurs
Chantal M. W. Tax
Alexander Leemans
Publicatiedatum
01-06-2014
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Neuropraxis / Uitgave 3/2014
Print ISSN: 1387-5817
Elektronisch ISSN: 1876-5785
DOI
https://doi.org/10.1007/s12474-014-0050-3

Andere artikelen Uitgave 3/2014

Neuropraxis 3/2014 Naar de uitgave

Signalement

Signalement