Gepubliceerd in:
01-12-2014
Het effect van galantamine op de ecg- geleidingstijden
Gepubliceerd in: Tijdschrift voor Gerontologie en Geriatrie | Uitgave 6/2014
Log in om toegang te krijgenThe effect of galantamine on cardiac conduction time
Background
Galantamine, one of the acethylcholinesterase inhibitors (AChEI), is used in the treatment of Alzheimer’s disease. However AChEI have been associated with adverse events, including cardiac events. The objective of this prospective, observational study is to evaluate the association between galantamine and incident cardiac conduction abnormalities.
Methods
A total of 64 patients, who visited an out – patient clinic of a geriatric department were enrolled in the study. All patients were diagnosed with Alzheimer’s disease and started with a capsule containing 8 mg of galantamine. Subsequently, if galantamine was well tolerated, the dosage was raised every 4 weeks, to an eventual dosage of 24 mg/ day. The mean follow – up period was 4 months. ECG parameters were evaluated at baseline and after start of galantamine at each galantamine dose level (8, 16, 24 mg / day).
Results
No significant differences in electrocardiographic measurements before and during treatment with galantamine were found.
Conclusion
No significant changes in ECG parameters relative to baseline were found with galantamine treatment. Also after adjustment for concomitant cardioactive medications and cardiovascular comorbidity, no significant changes were found.