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Gepubliceerd in:

01-06-2016

Health-related quality of life in Parkinson’s: impact of ‘off’ time and stated treatment preferences

Auteurs: Cicely Kerr, Emily J. Lloyd, Charlotte E. Kosmas, Helen T. Smith, James A. Cooper, Karissa Johnston, Emma McIntosh, Andrew J. Lloyd

Gepubliceerd in: Quality of Life Research | Uitgave 6/2016

Abstract

Purpose

Long-term levodopa therapy and related fluctuating plasma concentrations are associated with between-dose periods of ‘off time’ resulting in substantial variation in symptoms and functioning throughout the day in people with Parkinson’s (PwP).

Methods

PwP across UK, France, Spain and Italy completed an online survey to explore: the impact of ‘off time’ on (1) health-related quality of life (HRQL) and (2) on functioning and ability to undertake usual activities; (3) the value of ‘off time’ relative to other factors associated with Parkinson’s through a stated preference discrete choice experiment (SPDCE).

Results

In total, 305 PwP completed the online survey. Overall mean HRQL (utility) score was significantly lower for ‘off time’ (0.37) than for ‘on time’ (0.60). All attributes within the SPDCE were significant predictors of treatment choice, although increased duration of ‘on time’ (per hour per day: odds ratio (OR) = 1.40) and predictability of ‘off time’ to within 30 min (OR = 1.42) were valued most highly.

Conclusions

‘On time’ and predictability of ‘off time’ are highly valued by PwP. Due to substantial diurnal variation of Parkinson’s symptoms, standard patient-reported outcome (PRO) assessments may not adequately capture the impact of ‘off time’ on HRQL and participation in daily activities.

vorige artikel The impact of taste and smell alterations on quality of life in head and neck cancer patients

volgende artikel Depression treatment and health-related quality of life among adults with diabetes and depression

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Sample excludes 30 pilots, includes those failing the logic and consistency checks.

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Titel: Health-related quality of life in Parkinson’s: impact of ‘off’ time and stated treatment preferences
Auteurs: Cicely Kerr
Emily J. Lloyd
Charlotte E. Kosmas
Helen T. Smith
James A. Cooper
Karissa Johnston
Emma McIntosh
Andrew J. Lloyd
Publicatiedatum: 01-06-2016
Uitgeverij: Springer International Publishing
Gepubliceerd in: Quality of Life Research / Uitgave 6/2016
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-015-1187-0

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Abstract

Purpose

Methods

Results

Conclusions

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