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Gepubliceerd in: Quality of Life Research 4/2007

01-05-2007 | Original Paper

Health-related quality of life in HIV-1-infected patients on HAART: a five-years longitudinal analysis accounting for dropout in the APROCO-COPILOTE cohort (ANRS CO-8)

Auteurs: Camelia Protopopescu, Fabienne Marcellin, Bruno Spire, Marie Préau, Renaud Verdon, Dominique Peyramond, François Raffi, Geneviève Chêne, Catherine Leport, Maria-Patrizia Carrieri

Gepubliceerd in: Quality of Life Research | Uitgave 4/2007

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Abstract

Background

The long-term efficacy of Highly Active Antiretroviral Therapies (HAART) has enlightened the crucial role of health-related quality of life (HRQL) among HIV-infected patients. However, any analysis of such extensive longitudinal data necessitates a suitable handling of dropout which may correlate with patients–health status.

Methods

We analysed the HRQL evolution over 5 years for 1,000 patients initiating a protease inhibitor (PI)-containing therapy, using MOS SF-36 physical (PCS) and mental (MCS) scores. In parallel with a classical separate random effects model, we used a joint parameter-dependent selection model to account for non-ignorable dropout.

Results

HRQL evolved according to a two-phase pattern, characterized by an initial improvement during the year following HAART initiation and a relative stabilization thereafter. Immunodepression and self-reported side effects were found to be negative predictors of both PCS and MCS scores. Hepatitis C virus coinfection and AIDS clinical stage were found to affect physical HRQL. Results were not significantly altered when accounting for dropout.

Conclusion

Such results, obtained on a large sample of HIV-infected patients with extensive follow-up, underline the need for a regular monitoring of patients–immunological status and for a better management of their experience with hepatitis C and HAART.
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1
Note that there is no principal effect for the “Number of self-reported symptoms of lipodystrophy–in Table 3, as lipodystrophy symptoms were absent at M0. The coefficient of the first slope is used in this case for the interpretation.
 
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Metagegevens
Titel
Health-related quality of life in HIV-1-infected patients on HAART: a five-years longitudinal analysis accounting for dropout in the APROCO-COPILOTE cohort (ANRS CO-8)
Auteurs
Camelia Protopopescu
Fabienne Marcellin
Bruno Spire
Marie Préau
Renaud Verdon
Dominique Peyramond
François Raffi
Geneviève Chêne
Catherine Leport
Maria-Patrizia Carrieri
Publicatiedatum
01-05-2007
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 4/2007
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-006-9151-7

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