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Quality of Life Research

Gepubliceerd in:

01-08-2007 | Original Paper

Health related quality of life in different states of breast cancer

Auteurs: Mathias Lidgren, Nils Wilking, Bengt Jönsson, Clas Rehnberg

Gepubliceerd in: Quality of Life Research | Uitgave 6/2007

Abstract

Objectives

The aim of this study was to describe the health related quality of life (HRQoL) in different breast cancer disease states using preference-based measures.

Material and Methods

A total of 361 consecutive breast cancer patients attending the breast cancer outpatient clinic at Karolinska University hospital Solna for outpatient visits between April and May 2005 were included in the study. The EQ-5D self classifier and a direct Time Trade Off (TTO) question were used to estimate the HRQoL in different breast cancer disease states.

Results

Patients in their first year after a primary breast cancer had a mean EQ-5D index value of 0.696 (95% confidence interval (CI): 0.634–0.747)). Patients in their first year after a recurrence had a mean EQ-5D index value of 0.779 (CI: 0.700–0.849). Patients who had not had a primary breast cancer diagnosis or a recurrence during the previous year had a mean EQ-5D index value of 0.779 (CI: 0.745–0.811). Patients with metastatic disease reported the lowest HRQoL values, and had a mean EQ-5D index value of 0.685 (CI: 0.620–0.735). The main driver behind the reduction in HRQoL was pain and discomfort as well as anxiety and depression. TTO values were higher for all diseases states compared to the EQ-5D index values.

Conclusion

This study shows that breast cancer is associated with a reduction in HRQoL. This effect is most pronounced for patients with metastatic disease.

vorige artikel US and UK versions of the EQ-5D preference weights: Does choice of preference weights make a difference?

volgende artikel Reliability, validity, and minimally important differences of the SF-6D in systemic sclerosis

First year after primary breast cancer.

First year after recurrence.

Second and following years after primary breast cancer or recurrence.

Metastatic disease.

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Titel: Health related quality of life in different states of breast cancer
Auteurs: Mathias Lidgren
Nils Wilking
Bengt Jönsson
Clas Rehnberg
Publicatiedatum: 01-08-2007
Uitgeverij: Springer Netherlands
Gepubliceerd in: Quality of Life Research / Uitgave 6/2007
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-007-9202-8

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Abstract

Objectives

Material and Methods

Results

Conclusion

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