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10-11-2018 | Uitgave 4/2019

Quality of Life Research 4/2019

Health-related quality of life assessment among people living with HIV in Rio de Janeiro, Brazil: a cross-sectional study

Quality of Life Research > Uitgave 4/2019
Rodolfo Castro, Raquel B. De Boni, Paula M. Luz, Luciane Velasque, Livia V. Lopes, Antonieta Medina-Lara, Sandra W. Cardoso, Marilia S. De Oliveira, Ruth K. Friedman, Beatriz Grinsztejn, Valdiléa G. Veloso
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The online version of this article (https://​doi.​org/​10.​1007/​s11136-018-2044-8) contains supplementary material, which is available to authorized users.



To assess health-related quality of life (HRQoL) and its associated factors among people living with HIV/AIDS (PLWHA) in Rio de Janeiro, Brazil.


A cross-sectional study including PLWHA receiving usual HIV-care at Instituto Nacional de Infectologia Evandro Chagas (INI/Fiocruz) was conducted between 2014 and 2016 in Rio de Janeiro, Brazil. The EQ-5D-3L assessed HRQoL; PHQ-2 and ASSIST were used for screening depression and substance use, respectively. Clinical variables were obtained from the INI/Fiocruz cohort database, and structured questions evaluated intimate partner violence, sexual abstinence and relationship status. Data were analysed using multivariable Tobit regression model.


A total of 1480 PLWHA were included: 64.7% were male at birth (38.4% men who have sex with men [MSM], 24.3% heterosexual men and 2% transgender women [TGW]); median age was 43.1 years, and 95.8% were receiving antiretroviral therapy. The median EQ-5D-3L utility score was 0.801. Results showed that the following factors: MSM and women; older age; lower educational level; no engagement in a relationship; depression screening positive; polysubstance use; and, detectable viral load were independently associated with worse HRQoL.


PLWHA under care at INI/Fiocruz presented good HRQoL. Polysubstance use, depression and lower educational level were among the factors negatively associated with HRQoL. This was the first time that the EQ-5D-3L utility scores were calculated for a considerable number of PLWHA in Brazil, which is a fundamental piece of information for future cost-effectiveness analysis.

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