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Increase of survival in pediatric acute lymphoblastic leukemia (ALL) has made outcomes such as health-related quality of life (HRQL) and economic burden more important. To make informed decisions on the use of healthcare resources, costs as well as utilities need to be taken into account. Among the preference-based HRQL instruments, the Health Utilities Index (HUI) is the most employed in pediatric cancer. Information on utility scores during ALL treatment and in long-term survivors is available, but utility scores in short-term survivors are lacking. This study assesses utility scores, health state, and HRQL in short-term (6 months to 4 years) ALL survivors.
Cross-sectional single-center cohort study of short-term ALL survivors using HUI3 proxy assessments.
Thirty-three survivors (median 1.5 years off treatment) reported 14 unique health states. The majority of survivors (61 %) enjoyed a perfect health, but 21 % had three affected attributes. Overall, HRQL was nonsignificantly lower compared to the norm, although the difference was large and may be clinically relevant. Cognition was significantly impaired (p = 0.03).
Although 61 % of short-term survivors of ALL report no impairment, the health status of the other patients lead to a clinically important impaired HRQL compared to norms. Prospective studies assessing utility scores associated with pediatric ALL should be performed, enabling valid and reliable cost-utility analyses for policy makers to make informed decisions.
Veerman, A., Kamps, W., van den Berg, H., van den Berg, E., Bökkerink, J., Bruin, M., et al. (2009). Dexamethasone-based therapy for childhood acute lymphoblastic leukaemia: results of the prospective Dutch Childhood Oncology Group (DCOG) protocol ALL-9 (1997–2004). Lancet Oncology, 10(10), 957–966. PubMedCrossRef
Barr, R., Furlong, W., Dawson, S., Whitton, A., Strautmanis, I., Pai, M., et al. (1993). An assessment of global health status in survivors of acute lymphoblastic leukemia in childhood. The American Journal of Pediatric Hematology/Oncology, 15(3), 284–290. PubMed
Wright, M., Galea, V., & Barr, R. (2005). Proficiency of balance in children and youth who have had acute lymphoblastic leukemia. Physical Therapy, 85(8), 782–790. PubMed
Barr, R. D., Petrie, C., Furlong, W., Rothney, M., & Feeny, D. (1997). Health-related quality of life during post-induction chemotherapy in children with acute lymphoblastic leukemia in remission: An influence of corticosteroid therapy. International Journal of Oncology, 11(2), 333–339. PubMed
Raat, H., Botterweck, A. M., Landgraf, J. M., Hoogeveen, W. C., & Essink-Bot, M. L. (2005). Reliability and validity of the short form of the child health questionnaire for parents (CHQ-PF28) in large random school based and general population samples. Journal of Epidemiology and Community Health, 59(1), 75–82. PubMedCrossRef
van Litsenburg, R. R., Uyl-de Groot, C. A., Raat, H., Kaspers, G. J., & Gemke, R. J. (2011). Cost-effectiveness of treatment of childhood acute lymphoblastic leukemia with chemotherapy only: The influence of new medication and diagnostic technology. Pediatric Blood & Cancer, 57(6), 1005–1010. CrossRef
Luo, X., Ke, Z., Guan, X., Zhang, Y., Huang, L., & Zhu, J. (2008). The comparison of outcome and cost of three protocols for childhood non-high risk acute lymphoblastic leukemia in China. Pediatric Blood & Cancer, 51(2), 204–209. CrossRef
Barr, R., Gonzalez, A., Longchong, M., Furlong, W., Vizcaino, M., Horsman, J., et al. (2001). Health status and health-related quality of life in survivors of cancer in childhood in Latin America: A MISPHO feasibility study. International Journal of Oncology, 19(2), 413–421. PubMed
Wright, M. J., Galea, V., & Barr, R. D. (2003). Self-perceptions of physical activity in survivors of acute lymphblastic leukemia in childhood. Pediatric Exercise Science, 15, 191–201.
Wakefield, C. E., McLoone, J. K., Butow, P., Lenthen, K., & Cohn, R. J. (2011). Parental adjustment to the completion of their child’s cancer treatment. Pediatric Blood & Cancer, 56(4), 524–531. CrossRef
Maurice-Stam, H., Oort, F. J., Last, B. F., Brons, P. P., Caron, H. N., & Grootenhuis, M. A. (2008). Longitudinal assessment of health-related quality of life in preschool children with non-CNS cancer after the end of successful treatment. Pediatric Blood & Cancer, 50(5), 1047–1051. CrossRef
Buizer, A. I., de Sonneville, L. M., & Veerman, A. J. (2009). Effects of chemotherapy on neurocognitive function in children with acute lymphoblastic leukemia: A critical review of the literature. Pediatric Blood & Cancer, 52(4), 447–454. CrossRef
Fluchel, M., Horsman, J. R., Furlong, W., Castillo, L., Alfonz, Y., & Barr, R. D. (2008). Self and proxy-reported health status and health-related quality of life in survivors of childhood cancer in Uruguay. Pediatric Blood & Cancer, 50(4), 838–843. CrossRef
Whelan, K. F., Stratton, K., Kawashima, T., Waterbor, J. W., Castleberry, R. P., Stovall, M., et al. (2010). Ocular late effects in childhood and adolescent cancer survivors: A report from the childhood cancer survivor study. Pediatric Blood & Cancer, 54(1), 103–109. CrossRef
Stam, H., Grootenhuis, M. A., Brons, P. P., Caron, H. N., & Last, B. F. (2006). Health-related quality of life in children and emotional reactions of parents following completion of cancer treatment. Pediatric Blood & Cancer, 47(3), 312–319. CrossRef
- Health-related quality of life and utility scores in short-term survivors of pediatric acute lymphoblastic leukemia
Raphaële R. L. van Litsenburg
Gertjan J. L. Kaspers
Reinoud J. B. J. Gemke
- Springer Netherlands