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01-12-2008

Health-related quality of life and utilities in primary-care patients with generalized anxiety disorder

Auteurs: Dennis A. Revicki, Nancy Brandenburg, Louis Matza, Mark C. Hornbrook, David Feeny

Gepubliceerd in: Quality of Life Research | Uitgave 10/2008

Abstract

Background

Generalized anxiety disorder (GAD) is prevalent and significantly impacts patient health-related quality of life (HRQL) and disability.

Purpose

This study evaluated the effect of GAD and anxiety symptom severity on the HRQL of primary-care patients with GAD.

Methods

Patients 18 years or older with GAD were recruited from an integrated health care delivery system. Clinical assessments included the Hamilton Anxiety Rating Scale (HAM-A), GAD Questionnaire-IV (GAD-Q-IV), and the Patient Health Questionnaire depression module (PHQ). HRQL was assessed by the Quality of Life Enjoyment and Satisfaction Questionnaire—Short Form (Q-LES-Q-SF), Sheehan Disability Scale (SDS), SF-12 Health Survey (SF-6D), and the Health Utilities Index (HUI2, HUI3).

Results

The sample included 297 patients, 72% women with mean ± standard deviation (SD) age of 47.6 ± 13.7 years. At baseline, the mean HAM-A score was 16.8 ± 7.6 (suggesting the presence of moderate anxiety symptoms). Anxiety and depression symptoms were significantly correlated with mental component summary (MCS), Q-LES-Q-SF, SDS, SF-6D, HUI2, and HUI3 scores (all P < 0.001). The mean HRQL and all of the preference-based measures varied significantly by anxiety severity groups (all P < 0.001). Anxiety and depression symptoms significantly predicted HRQL and preference-based scores (R ² values ranged from 0.22 to 0.57).

Conclusions

Anxiety symptoms reported by GAD patients resulted in significant impairment to HRQL and functional outcomes.

vorige artikel Lower visual acuity predicts worse utility values among patients with type 2 diabetes

volgende artikel Using patient-reported outcomes in clinical practice: proceedings of an International Society of Quality of Life Research conference

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Titel: Health-related quality of life and utilities in primary-care patients with generalized anxiety disorder
Auteurs: Dennis A. Revicki
Nancy Brandenburg
Louis Matza
Mark C. Hornbrook
David Feeny
Publicatiedatum: 01-12-2008
Uitgeverij: Springer Netherlands
Gepubliceerd in: Quality of Life Research / Uitgave 10/2008
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-008-9406-6

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Abstract

Background

Purpose

Methods

Results

Conclusions

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