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30-01-2020 | Uitgave 6/2020

Quality of Life Research 6/2020

Health-related quality of life among transgender and gender expansive youth at a rural gender wellness clinic

Quality of Life Research > Uitgave 6/2020
Jane O’Bryan, Melissa Scribani, Kimberly Leon, Nancy Tallman, Christopher Wolf-Gould, Carolyn Wolf-Gould, Anne Gadomski
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To address a critical gap in the existing Health-Related Quality of Life (HRQOL) literature by quantifying and describing HRQOL among transgender and gender expansive (TG/GE) youth at a rural gender clinic and comparing the HRQOL of these youth to age-stratified United States (U.S.) population standards.


This cross-sectional study includes results of the baseline HRQOL assessment of 141 TG/GE patients enrolled in the Gender Wellness Center (GWC) Pediatric Patient Registry. HRQOL was assessed using the Child Health Questionnaire-Child Form 87 (CHQ-CF87; ages < 18) and the Short Form-36 (SF-36v2; ages 18–21). Mean subscale scores were compared to the most current U.S. population standards available.


On all but one of the CHQ-CF87 subscales, TG/GE youth scored significantly lower than 2015–2016 U.S. general population youth and youth with two chronic conditions. On the SF-36v2, TG/GE youth scored significantly higher than 2009 U.S. standards on all physical health domains but lower on all but one of the mental health domains.


Cross-sectional HRQOL data from a registry of TG/GE youth indicate significantly poorer mental health measures as compared with the U.S. general population. Longitudinal assessments are needed to evaluate whether HRQOL improves with gender-affirming care. Future studies should aim to identify sociocultural factors at the intersection of rurality and health that contribute to diminished HRQOL among rural TG/GE youth.

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