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15-07-2020 | Uitgave 11/2020 Open Access

# Health-related quality of life after traumatic brain injury: deriving value sets for the QOLIBRI-OS for Italy, The Netherlands and The United Kingdom

Tijdschrift:
Quality of Life Research > Uitgave 11/2020
Auteurs:
Daphne C. Voormolen, Suzanne Polinder, Nicole von Steinbuechel, Yan Feng, Lindsay Wilson, Mark Oppe, Juanita A. Haagsma, the CENTER-TBI participants and investigators
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## Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s11136-020-02583-6) contains supplementary material, which is available to authorized users.
The members of the CENTER-TBI Participants and Investigators has been included in ‘Acknowledgements’ section.

## Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

## Introduction

Traumatic Brain Injury (TBI) is generally defined as “an alteration in brain function or other evidence of brain pathology, caused by an external force” [ 1]. TBI is one of the leading causes of death and disability worldwide [ 2]. Annually, TBI costs approximately \$US 400 billion worldwide and imposes a massive burden on society [ 3]. Economic evaluations in health care interventions are increasingly being used to inform governments, healthcare funders and policy makers and to prioritize resource allocation [ 4]. Nonetheless, for economic evaluations, preference-based measures (PBMs) are a requirement [ 5] and values have to be assigned to the health states these measures describe [ 6]. Many popular PBMs are generic. However, generic instruments do not always adequately assess specific aspects of health-related quality of life (HRQoL) that are affected by a disease such as cognition [ 7]. Therefore, generic measures, such as the EuroQol-5D (EQ-5D) and Short Form-36 (SF-36), are often combined with condition-specific questionnaires. A TBI-specific instrument is the Quality of Life after Brain Injury overall scale (QOLIBRI-OS) [ 8]. The QOLIBRI-OS instrument is a disease-specific tool for assessing HRQoL after sustaining TBI, which covers areas that are typically affected by TBI [ 9]. It was developed in 2012 and since then has been widely applied in TBI [ 8]. By generating a condition-specific preference-based measure (CSPBM) for TBI, it will potentially provide a more accurate assessment of the impact of heterogeneous outcomes after TBI and a more sensitive measure of the benefit of interventions.
The QOLIBRI-OS is a non-preference-based instrument that yields ordinal data, and therefore has limitations for economic evaluation studies. Transforming QOLIBRI-OS into utility scores will enable the application in economic evaluations and in summary measures of population health (e.g. quality-adjusted life years (QALYs)). Furthermore, a value set for the QOLIBRI-OS will introduce the ability to summarize general population preferences for health states that could be experienced by TBI patients and the HRQoL of TBI patients can be compared with other (patient) groups.
To be able to use health state values in QALYs calculations [ 10], they have to be anchored on a scale from 0 (dead) to 1 (full health). A less than 0 value is given to health states which are reported to be worse than dead. Ultimately, a value set can be generated, which means that each item level of the QOLIBRI-OS has a weight (utility) assigned to it. A lower utility means a higher impact on HRQoL. Each QOLIBRI-OS health state can be converted into a single summary index value with a value set.
Value sets for generic instruments (e.g. EQ-5D and Health Utility Index 2 (HUI2)) [ 11] are widely available and are being used extensively in economic evaluations [ 12]. However, the QOLIRBI-OS currently does not have utilities, which means the instrument cannot be used for QALY calculations [ 13]. To make the QOLIBRI-OS suitable for use in economic evaluations, the health states need to be valued with a preference-elicitation method. Widely used methods are discrete choice experiments (DCE) [ 14, 15] and visual analogue scales (VAS) [ 16]. The DCE and VAS technique are used to quantify health outcomes [ 1721]. DCEs are based on stated preferences and are seen to be a simpler method than the conventional methods such as time trade off (TTO) and standard gamble (SG) [ 22]. The DCE approach makes it possible to predict values for alternatives in hypothetical situations or conditions that cannot be judged in the real world [ 23]. The VAS is a valuation technique that records participants’ views about hypothetical health states on a scale from 0 (worst imaginable health state) to 100 (best imaginable health state) [ 16].
The objective of this study was to develop health utility indices for the QOLIBRI-OS health states. In order to do this, we aimed to develop value sets for the QOLIBRI-OS in three European countries by the use of a web-based DCE and VAS valuation study, which will allow calculation of utility values for the health states measured with the QOLIBRI-OS.

## Methods

The QOLIBRI-OS is a short, six-item version of the Quality of Life after Brain Injury (QOLIBRI), which provides a profile of HRQoL in domains typically affected by brain injury. It addresses well-being and functioning and the psychometric properties have been determined satisfactory to good [ 8]. The QOLIBRI-OS assesses a single overall score, which provides a brief summary measure of HRQoL [ 8]. The six items are satisfaction with physical condition; how brain is working, in terms of concentration, memory and thinking; feelings and emotions; ability to carry out day to day activities; personal and social life; current situation and future prospects. Responses are on a 5-point Likert scale ranging from “not at all satisfied” to “very satisfied”. Ultimately, the current situation and future prospects item from the QOLIBRI-OS was excluded because a general sample might answer this item too subjectively, which may hamper the use of the QOLIBRI-OS value set in populations other than TBI patients. By use of Rasch analysis, the psychometric validity of the QOLIBIR-OS scale was tested and well-functioning items of the QOLIBRI-OS were identified, which ultimately resulted in measures of item difficulty and fit of the QOLIBRI-OS. The scale was examined for redundancy and removing the current situation and future prospects item did not change the properties of the scale (Online Appendix A). In the end, the QOLIBRI-OS scale included 5 items, each with 5 levels, which are shown in Table 1.
Table 1
Five selected items of QOLIBRI-OS
QOLIBRI-OS
1. Satisfied with physical condition
2. Satisfied with how brain is working, in terms of concentration, memory and thinking
3. Satisfied with feelings and emotions
4. Satisfied with ability to carry out day to day activities
5. Satisfied with personal and social life
Item levels: 1-Not at all; 2-Slightly; 3-Moderately; 4-Quite; 5-Very
Developing value sets for the QOLIBRI-OS required three methodological steps (Fig.  1). Each of these steps is described in more detail in the following sections.

### Step-by-step

#### Step 1: Health state selection

Even after reducing the items from the QOLIBRI-OS from 6 to 5, the selected items can generate a large number of possible health states. The 5-item QOLIBRI-OS can generate 3125 (5 5) possible health states, since each dimension has five levels, and this makes it impossible to ask the respondents for a valuation all of them [ 13]. We therefore made a selection of health states to be used in the health state valuation task. For the DCE valuation of the QOLIBRI-OS, 392 health states were selected, which were presented in 196 pairs, based on a method devised by Oppe and van Hout [ 24]. These health states cover the spectrum of severity. For this we used a level-balanced design [ 13], meaning that all levels of each item occurred with the same frequency. The same 392 states were used in the EuroQol EQ-5D-5L value set valuation study [ 2426]. The best and worst health states plus death were selected for the visual analogue scale (VAS) valuation.

#### Step 2: Health state valuation—study design

During this step a panel of judges evaluated the selected health states. The general population was asked to evaluate the possible QOLIBRI-OS health states by assuming what they would consider their quality of life to be, if they were in one of these specific health states. The responses from the general population sample were used to generate the health state values.

### Health state valuation—Survey

The web-based questionnaire included questions regarding the demographics of the respondent (e.g. age, sex, educational and income level, chronic health complaints), sixteen DCE questions and three VAS questions. The DCE pairs were randomly assigned to the participants. During this study, no DCE or VAS data were excluded. The survey and description of health states were translated from English into Dutch and Italian using translation software and subsequently translated back into English. Bilingual native speakers verified the translations independently. The panel of judges consisted of members of the general public aged 18 to 75 years from the United Kingdom (UK), Italy and the Netherlands, which provided an international spread. The samples were also representative of the population in the countries with regard to age, gender and education. A total number of 13,623 respondents filled out the questionnaire (Italy: 5270 respondents; Netherlands 4183 respondents; UK 4170 respondents). The questionnaires were distributed by a market research agency (Survey Sampling International (SSI), nowadays called Dynata) via internet during the period 29 June till 31 July 2017. A second round of data collection took place between 3 February and 16 February 2018 to collect some more responses for the VAS data, especially for the health state ‘dead’, and these were all respondents who had already completed the survey the first round (recontacts).

### Valuation techniques

The responses from the general population sample reflect preferences between different health states [ 10] and these were used to generate and model the value sets.
One of the methods used to evaluate the health states was a DCE [ 2729], which is an ordinal measurement method. With this method, a pair of health states (labelled A and B, Fig.  2), with no reference to the duration of the states, is presented, and respondents have to decide which health state they consider to be better. No indifference option was included. The assumption of a DCE is that the choices among sets of divergent health states are driven by differences in the levels of the dimensions from the QOLIBRI-OS which define the health states. Furthermore, by asking respondents to choose between health states with altering severity levels and different combinations, the opportunity arises to estimate the impact of the preferences based on the changes in levels [ 30]. We used colours in the online survey to indicate the severity level of the attribute, ranging from green indicating very satisfied to red indicating not at all satisfied.
The second method used was the VAS, which is a valuation technique that requires participants to score the injury stage on a vertical scale graded from 0 (worst imaginable health state) to 100 (best imaginable health state). As done previously by Stolk et al. [ 23], a rescaled VAS, based on dead and the best and worst health states, was developed; health preference valuations of 0 to 100 on the VAS were rescaled from 0 to 1. This was done by the use of the following formula:
$${\text{VAS rescaled}} = 100 \times \frac{VAS\,mean - VAS\,dead}{{VAS\,11,111 - VAS\,dead}}.$$
It was necessary to rescale the VAS values in such a way that the value for death was explicitly set at 0 and the best health state (11,111) to 1 [ 23].

#### Step 3. Modelling the DCE health state valuations

Statistical modelling was used to estimate the values for all potential health states according to the responses for the selected health states. The coefficients for each level and attribute were estimated by regression techniques. Whether a level has a positive or negative effect on utility depends on the sign of the coefficient. The relative importance of the level is revealed by the value of the coefficient. A level is considered to be important when the coefficient has been determined to be statistically significant ( p < 0.05) [ 31]. Afterwards, the values for all the health states described by the QOLIBRI-OS were generated from these coefficients [ 32]. A utility score for the QOLIBRI-OS health states is generated from the DCE responses anchored on the VAS. DCE responses were defined as binary outcomes.
As described by Feng et al. [ 32], a 20 parameter model (4 levels × 5 dimensions = 20 parameters) was generated for the QOLIBRI-OS, which estimated four parameters for each dimension and one parameter per level, with the “very satisfied” level used as the reference. This model allowed for the coefficients to differ between dimensions and for the importance of each level of problems to differ between dimensions [ 32]. Regression models were estimated for the DCE in all three countries separately. DCE answers were analysed using a conditional logistic regression. Subsequently, we derived health state values from the DCE data on the QALY scale by anchoring the values on the estimated VAS value for the worst state (55,555). The following formula was used for this process:
$${ }\beta_{anchored\,DCE\,model } = \frac{{\beta_{20\,parameter\,DCE\,model} \times estimated\,VAS_{worst\,state} }}{{estimated\,DCE_{worst\,state} }},$$
where $$\beta_{20\,parameter\,DCE\,model}$$ is the coefficient from the conditional logistic regression DCE model, $$estimated\,VAS_{worst\,state}$$ is the pooled mean value given to the worst health state by all respondents, $$estimated\,DCE_{worst\,state}$$ is the intercept and all “not at all” level coefficients from the DCE model summed up, which generates a $$\beta_{anchored\,DCE\,model }$$ for each attribute and level as output. The utilities are based on and have been calculated by the use of these anchored DCE coefficients.
In addition, we implemented a generalized additive logistic regression using the bamlss package of R [ 33, 34] to relax the assumption of the standard logistic regression on the linear relationship between the predictors and the log-odds of the outcome. We compared the non-parametric model specifying an additive (but otherwise unknown) utility function to the standard model assuming linear utility.

### Statistical analysis

For the statistical analyses, responses on the QOLIBRI-OS were recoded with 1 reflecting “very satisfied” and 5 reflecting “not at all satisfied” (similar to the convention used for the EQ-5D). Therefore, 11,111 was seen as the ‘best health state’ and 55,555 as the ‘worst health state’.
Rasch analysis was performed using Winsteps 3.92 (Winsteps.com, Chicago Illinois, USA).
All other analyses were performed using SPSS version 24 for Windows (IBM SPSS Statistics, SPSS Inc, Chicago, IL) and R (R Core Team (2013). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria).

## Results

### Study population

The characteristics of the survey respondents are shown in Table 2. A total of 13,623 respondents divided over three countries completed the questionnaire. The median age of the respondents was 45 years old. Approximately half of the respondents (51.2%; N = 6981) were employed and 15% ( N = 2068) were retired. One out of two respondents have experienced serious illness in their immediate family and/or reported to have chronic health complaints.
Table 2
Characteristics of the study population

All respondents
UK
The Netherlands
Italy
( N = 13,623)
( N = 5270)
( N = 4183)
( N = 4170)

N (%)
N (%)
N (%)
N (%)
Age a (years)
45 [33–57]
44 [32–57]
46 [33–58]
45 [34–57]
Gender (male)
6736 (49.4%)
2597 (49.3%)
2069 (49.5%)
2070 (49.6%)
Education b

Low
3797 (27.9%)
1205 (22.9%)
1232 (29.5%)
1360 (32.6%)
Middle
6499 (47.7%)
2265 (43.0%)
1901 (45.4%)
2333 (55.9%)
High
3327 (24.4%)
1800 (34.2%)
1050 (25.1%)
477 (11.4%)
Work status c

Employed
6981 (51.2%)
2759 (52.4%)
2214 (52.9%)
2008 (48.2%)
Unemployed
1915 (14.1%)
475 (9.0%)
447 (10.7%)
993 (23.8%)
Looking after others d
699 (5.1%)
358 (6.8%)
177 (4.2%)
164 (3.9%)
Student
849 (6.2%)
294 (5.6%)
270 (6.5%)
285 (6.8%)
Retired
2068 (15.2%)
855 (16.2%)
545 (13.0%)
668 (16.0%)
Unable to work
1111 (8.2%)
529 (10.0%)
530 (12.7%)
52 (1.2%)
Annual household income e

Low
3131 (23.0%)
1126 (21.4%)
759 (18.1%)
1247 (29.9%)
Middle
3315 (24.3%)
1604 (30.4%)
728 (17.4%)
983 (23.6%)
High
5076 (37.3%)
1994 (37.8%)
1787 (42.7%)
1295 (31.1%)
Do not know/do not want to tell
2100 (15.4%)
546 (10.4%)
909 (21.7%)
645 (15.5%)
Experience of serious illness

In you yourself (yes)
3517 (25.8%)
1834 (34.8%)
1068 (25.5%)
615 (14.7%)
7066 (51.9%)
3231 (61.3%)
2864 (68.5%)
971 (23.3%)
In caring for others (yes)
3224 (23.7%)
1689 (32.0%)
924 (22.1%)
611 (14.7%)
Chronic health complaints (yes) f
6896 (50.6%)
2778 (52.7%)
2223 (53.1%)
1895 (45.4%)
aData are displayed as median, with the first and third quartile given within brackets
bEducation was divided up in low (junior school), middle (comprehensive school) and high (college and university)
cWork status was categorized as employed (employee and self-employed), unemployed (consisting out of work for more than and less than 1 year), looking after others (e.g. a carer or parent), a student, retired and unable to work
dE.g. carer or parent
eIncome was grouped as follows low (UK; less than £14,000, Italy and the Netherlands; less than €20,000), middle (UK; £14,000-£27,999, Italy and the Netherlands; €20,000-€39,999) and high (UK; more than £27,999, Italy and the Netherlands; more than €39,999)
fChronic health complaints were defined as asthma, chronic bronchitis, severe heart disease, consequences of a stroke, diabetes, severe back complaints, arthrosis, rheumatism, cancer, memory problems due to neurological disease/dementia, memory problems due to ageing, depression or anxiety disorder, and other chronic health complaints

### DCE data

An upward trend was shown in probability of respondents choosing health state A when the difference in sum score of health state A and B (e.g. probability of choosing health state 11,111; sum score = 5 over health state 123,45; sum score = 15) becomes bigger and more positive, which is what was expected (Online Appendix B).

### VAS data

Table 3 shows the summary statistics for the three VAS health states considering the QOLIBRI-OS data. The lowest mean value was 38.01 (health state dead) and highest mean value was 81.49 (health state 11,111, e.g. very satisfied with every attribute). As expected, when the summary score of the of the health state decreased (e.g. severity of health state becomes lower), which means the health state was comprised of lower attribute levels, the utility mean increased.
Table 3
QOLIBRI-OS summary statistics for the 3 selected VAS health states
Health state
Observations ( N)
Mean VAS
SD
Rescaled mean
Utility mean
116
38.01
40.71
0.00
0.00
55,555 a
138
54.64
33.56
38.26
0.38
11,111 b
245
81.49
22.15
100
1
aWorst possible health state; all attributes have ‘not at all satisfied’ level
bBest possible health state; all attributes have ‘very satisfied’ level
Note: rescaled mean for health state 55,555 per country UK (35.56), NL (26.07), Italy (49.97)

### Value sets

Table 4 shows the 20 parameters model per country for the QOLIBRI-OS which was based on the conditional logistic regression for the DCE data and the anchoring of the DCE coefficients. For all respondents and both the Netherlands and Italy, the lowest estimate for the DCE and anchored DCE data was found for ‘Quite satisfied with feelings and emotions’ and the highest estimate for ‘Not at all satisfied with how brain is working in terms of concentration, memory and thinking’. When looking at the model specifically for the UK, the lowest estimate was found for ‘Moderately satisfied with personal and social life’ and the highest for ‘Not at all satisfied with how brain is working in terms of concentration, memory and thinking’. The biggest increase in weight for all attributes is seen from level four (slightly satisfied) to level five (not at all satisfied). Table 5 introduces an example for the QOLIBRI-OS value set based on the DCE and anchored DCE models. This enables the calculation of a utility weight per health state, which is how the utilities for the QOLIBIR-OS data can be obtained. The utility scores of the anchored DCE model of the QOLIBRI-OS range from 0.383 for health state 55,555 to 1.0 for health state 11,111. Table 6 shows an example of values for a mild, moderate and severe health state. Generally speaking, Italians value these health states lower compared to their counterparts in UK and the Netherlands. Online Appendix C shows the non-parametric models per country for the QOLIBRI-OS and Online Appendix D shows an example of values for a mild, moderate and severe health state based on the non-parametric models.
Table 4
QOLIBRI-OS 20 parameters model per country

All respondents
UK
The Netherlands
Italy

DCE data
Anchored DCE
DCE data
Anchored DCE
DCE data
Anchored DCE
DCE data
Anchored DCE

Estimate
SE
Estimate 1
Estimate
SE
Estimate 1
Estimate
SE
Estimate 1
Estimate
SE
Estimate 1
Physical condition

Quite
0.143
0.028***
0.015
0.171
0.048***
0.017
0.093
0.047*
0.010
0.158
0.051**
0.016
Moderately
0.313
0.028***
0.032
0.345
0.048***
0.035
0.311
0.047***
0.032
0.269
0.050***
0.028
Slightly
0.522
0.028***
0.053
0.500
0.049***
0.051
0.488
0.049***
0.050
0.568
0.051***
0.058
Not at all
1.306
0.031***
0.134
1.339
0.053***
0.137
1.080
0.053***
0.110
1.540
0.057***
0.157
How brain is working, in terms of concentration, memory and thinking

Quite
0.200
0.027***
0.020
0.250
0.046***
0.026
0.105
0.047*
0.011
0.240
0.048***
0.025
Moderately
0.464
0.028***
0.047
0.426
0.047***
0.044
0.433
0.049***
0.044
0.542
0.051***
0.055
Slightly
0.663
0.025***
0.068
0.640
0.044***
0.065
0.609
0.043***
0.062
0.746
0.046***
0.076
Not at all
1.680
0.030***
0.172
1.688
0.052***
0.173
1.369
0.050***
0.140
2.033
0.054***
0.208
Feelings and emotions

Quite
0.050
0.028
0.005
0.071
0.047
0.007
-0.013
0.048
-0.001
0.110
0.050*
0.011
Moderately
0.218
0.027***
0.022
0.159
0.046***
0.016
0.211
0.047***
0.022
0.328
0.050***
0.034
Slightly
0.290
0.026***
0.030
0.207
0.045***
0.021
0.416
0.045***
0.043
0.264
0.046***
0.027
Not at all
0.938
0.029***
0.096
0.967
0.049***
0.099
0.922
0.049***
0.094
0.969
0.052***
0.099
Ability to carry out day to day activities

Quite
0.159
0.028***
0.016
0.136
0.049**
0.014
0.111
0.049*
0.011
0.232
0.051***
0.024
Moderately
0.306
0.028***
0.031
0.263
0.049***
0.027
0.259
0.047***
0.026
0.408
0.051***
0.042
Slightly
0.347
0.029***
0.035
0.268
0.050***
0.027
0.450
0.049***
0.046
0.356
0.052***
0.036
Not at all
1.131
0.028***
0.116
1.164
0.049**
0.119
1.143
0.049***
0.117
1.113
0.051***
0.114
Personal and social life

Quite
0.109
0.028***
0.011
0.082
0.047
0.008
0.104
0.048*
0.011
0.121
0.050*
0.012
Moderately
0.225
0.031***
0.023
0.030
0.053
0.003
0.382
0.053***
0.039
0.252
0.056***
0.026
Slightly
0.421
0.028***
0.043
0.241
0.048***
0.025
0.698
0.049***
0.071
0.330
0.051***
0.034
Not at all
0.986
0.029***
0.101
0.833
0.050***
0.085
1.163
0.050***
0.119
0.963
0.052***
0.098
Constant/intercept
0.000

0.000
0.000

0.000
0.000

0.000
0.000

0.000
aβ anchored DCE model = (β 20 parameter DCE model × (estimated VAS 55,555 / estimated DCE 55,555))
P-value: *** < 0.001. ** < 0.01. * < 0.05.. < 0.1
Table 5
QOLIBRI-OS example: the value for health state 21232

DCE
Anchored DCE
Full health (constant/intercept)
1.000
1.000
Minus constant
0.000
0.000
Quite satisfied with physical condition
0.143
0.015
Very satisfied with how brain is working, in terms of concentration, memory and thinking
0.000
0.000
Quite satisfied with feelings and emotions
0.050
0.005
Moderately satisfied with ability to carry out day to day activities
0.306
0.031
Quite satisfied with personal and social life
0.109
0.011
Utility weight health state 21232
0.392 a
0.938
Note: all respondents
aCalculation of utilities: utility = 1—value
Table 6
Example of values for a mild, moderate and severe health state

Anchored DCE

All respondents
UK
The Netherlands
Italy
Best health state: 11,111
1.000
1.000
1.000
1.000
Mild health state: 21,232
0.902
0.940
0.955
0.918
Moderate health state: 34,343
0.631
0.853
0.799
0.801
Severe health state: 55,455
0.449
0.465
0.472
0.396
Worst health state: 55,555
0.383
0.383
0.383
0.383
DCE Discrete Choice Experiment

## Discussion

Our study demonstrates the first value sets for the QOLIBRI-OS. The main outcomes according to the preferences of our general sample suggested the biggest increase in weight was found when making the step from level slightly satisfied to level not at all satisfied within an attribute, which results in the largest impact on HRoQL. This is also in line with previous EQ-5D value set research [ 32]. Additionally, it was also found that ‘Not at all satisfied with how brain is working in terms of concentration, memory and thinking’ should receive the greatest weight in utility calculations in all three countries.
When looking at the face validity of the value set, it was shown that a lower level of satisfaction within a health state also corresponded to a lower utility.
Strengths of our study include the representativeness of the study sample and the large number of survey respondents included in our survey. A general population sample was used instead of a brain injury group, because then the benefit gained has been determined from a public perspective, who ultimately are the taxpayers and potential patients.

## Conclusions

By transforming the QOLIBRI-OS into utility scores, we have enabled the potential application in economic evaluations and in summary measures of population health, which may inform decision-makers on the best interventions and strategies for TBI patients.

## Compliance with ethical standards

### Conflict of interest

All authors have declared that no competing interests exist.

### Ethical approval:

All participants, as members of a web-based panel, had already provided informed consent to participate in online surveys. Informed consent for the present survey was obtained from all those agreeing to complete the survey. Participants were informed on the welcome page that the survey aimed to better understand the consequences of traumatic brain injury, that it would take approximately 20 min to complete, and that all responses were confidential and anonymous. Consent was obtained when respondents clicked the ‘Go to Survey’ button on this page. This study was part of the CENTER-TBI study (EC grant 602150) and ethics approval was obtained from the Leids Universitair Centrum—Commissie Medische Ethiek (approval P14.222/NV/nv). All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee mentioned above and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

### Informed consent

Informed consent was obtained from all individual participants included in the study and all data gathered during questionnaires were anonymized.

## Publisher's Note

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