Head Circumferences in Twins With and Without Autism Spectrum Disorders
- 01-09-2013
- Original Paper
Gepubliceerd in:
- Auteurs
- Wendy Froehlich
- Sue Cleveland
- Andrea Torres
- Jennifer Phillips
- Brianne Cohen
- Tiffany Torigoe
- Janet Miller
- Angie Fedele
- Jack Collins
- Karen Smith
- Linda Lotspeich
- Lisa A. Croen
- Sally Ozonoff
- Clara Lajonchere
- Judith K. Grether
- Joachim Hallmayer
- Gepubliceerd in
- Journal of Autism and Developmental Disorders | Uitgave 9/2013
Abstract
To determine the genetic relationship between head circumference (HC) and Autism Spectrum Disorders (ASDs). Twin pairs with at least one twin with an ASD were assessed. HCs in affected and unaffected individuals were compared, as were HC correlations in monozygotic and dizygotic pairs. 404 subjects, ages 4–18, were included. 20 % of males and 27 % of females with an ASD had macrocephaly. Unaffected co-twins showed similar rates (16 % of males and 22 % of females). Statistical analysis revealed no significant difference in HCs between affected and unaffected twins. Twins with ASDs and unaffected co-twins have similar HCs and increased rates of macrocephaly. Correlations demonstrated partial inheritance of HCs. Thus, macrocephaly may represent an endophenotype in ASDs.
- Titel
- Head Circumferences in Twins With and Without Autism Spectrum Disorders
- Auteurs
-
Wendy Froehlich
Sue Cleveland
Andrea Torres
Jennifer Phillips
Brianne Cohen
Tiffany Torigoe
Janet Miller
Angie Fedele
Jack Collins
Karen Smith
Linda Lotspeich
Lisa A. Croen
Sally Ozonoff
Clara Lajonchere
Judith K. Grether
Joachim Hallmayer
- Publicatiedatum
- 01-09-2013
- Uitgeverij
- Springer US
- Gepubliceerd in
-
Journal of Autism and Developmental Disorders / Uitgave 9/2013
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432 - DOI
- https://doi.org/10.1007/s10803-012-1751-1
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