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Journal of Autism and Developmental Disorders

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24-11-2016 | Original Paper

Gut Microbiota and Autism: Key Concepts and Findings

Auteurs: Helen T. Ding, Ying Taur, John T. Walkup

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2017

Abstract

There is an emerging body of evidence linking the intestinal microbiota with autism spectrum disorders (ASD). Studies have demonstrated differences in the composition of gut bacteria between children with ASD and controls. Certain intestinal bacteria have been observed in abundance and may be involved in the pathogenesis of ASD; including members of the Clostridium and Sutterella genus. Evidence from animal models suggest that certain microbial shifts in the gut may produce changes consistent with the clinical picture of autism, with proposed mechanisms including toxin production, aberrations in fermentation processes/products, and immunological and metabolic abnormalities. In this article, we review studies examining the relationship between intestinal bacteria and ASD, and discuss bacterial species that may be implicated and proposed mechanisms.

vorige artikel Divergence of Age-Related Differences in Social-Communication: Improvements for Typically Developing Youth but Declines for Youth with Autism Spectrum Disorder

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Titel: Gut Microbiota and Autism: Key Concepts and Findings
Auteurs: Helen T. Ding
Ying Taur
John T. Walkup
Publicatiedatum: 24-11-2016
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 2/2017
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-016-2960-9

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