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Gepubliceerd in: Journal of Autism and Developmental Disorders 2/2017

24-11-2016 | Original Paper

Gut Microbiota and Autism: Key Concepts and Findings

Auteurs: Helen T. Ding, Ying Taur, John T. Walkup

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2017

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Abstract

There is an emerging body of evidence linking the intestinal microbiota with autism spectrum disorders (ASD). Studies have demonstrated differences in the composition of gut bacteria between children with ASD and controls. Certain intestinal bacteria have been observed in abundance and may be involved in the pathogenesis of ASD; including members of the Clostridium and Sutterella genus. Evidence from animal models suggest that certain microbial shifts in the gut may produce changes consistent with the clinical picture of autism, with proposed mechanisms including toxin production, aberrations in fermentation processes/products, and immunological and metabolic abnormalities. In this article, we review studies examining the relationship between intestinal bacteria and ASD, and discuss bacterial species that may be implicated and proposed mechanisms.
Literatuur
go back to reference Arndt, T. L., Stodgell, C. J., & Rodier, P. M. (2005). The teratology of autism. International Journal of Developmental Neuroscience: The Official Journal of the International Society for Developmental Neuroscience, 23(2–3), 189–199. doi:10.1016/j.ijdevneu.2004.11.001. CrossRef Arndt, T. L., Stodgell, C. J., & Rodier, P. M. (2005). The teratology of autism. International Journal of Developmental Neuroscience: The Official Journal of the International Society for Developmental Neuroscience, 23(2–3), 189–199. doi:10.1016/j.ijdevneu.2004.11.001. CrossRef
go back to reference Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Pessah, I., & Van de Water, J. (2011). Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain, Behavior, and Immunity, 25(1), 40–45. doi: 10.​1016/​j.​bbi.​2010.​08.​003. CrossRefPubMed Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Pessah, I., & Van de Water, J. (2011). Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain, Behavior, and Immunity, 25(1), 40–45. doi: 10.​1016/​j.​bbi.​2010.​08.​003. CrossRefPubMed
go back to reference Barger, B. D., Campbell, J. M., & McDonough, J. D. (2013). Prevalence and onset of regression within autism spectrum disorders: A meta-analytic review. Journal of Autism and Developmental Disorders, 43(4), 817–828. doi: 10.​1007/​s10803-012-1621-x. CrossRefPubMed Barger, B. D., Campbell, J. M., & McDonough, J. D. (2013). Prevalence and onset of regression within autism spectrum disorders: A meta-analytic review. Journal of Autism and Developmental Disorders, 43(4), 817–828. doi: 10.​1007/​s10803-012-1621-x. CrossRefPubMed
go back to reference Buie, T., Campbell, D. B., Fuchs, G. J. 3rd, Furuta, G. T., Levy, J., Vandewater, J.,… Winter, H. (2010). Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: A consensus report. Pediatrics, 125(Suppl 1), S1–S18. doi: 10.​1542/​peds.​2009-1878C. CrossRefPubMed Buie, T., Campbell, D. B., Fuchs, G. J. 3rd, Furuta, G. T., Levy, J., Vandewater, J.,… Winter, H. (2010). Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: A consensus report. Pediatrics, 125(Suppl 1), S1–S18. doi: 10.​1542/​peds.​2009-1878C. CrossRefPubMed
go back to reference Centers for Disease Control and Prevention, Autism and Developmental Disabilities Monitoring Network Surveillance. (2014). Prevalence of autism spectrum disorder among children aged 8 years: Autism and developmental disabilities monitoring network, 11 sites, United States, 2010. MMWR Surveillance Summaries, 63(2), 1–21. Centers for Disease Control and Prevention, Autism and Developmental Disabilities Monitoring Network Surveillance. (2014). Prevalence of autism spectrum disorder among children aged 8 years: Autism and developmental disabilities monitoring network, 11 sites, United States, 2010. MMWR Surveillance Summaries, 63(2), 1–21.
go back to reference de Magistris, L., Familiari, V., Pascotto, A., Sapone, A., Frolli, A., Iardino, P.,… Bravaccio, C. (2010). Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives. Journal of Pediatric Gastroenterology and Nutrition, 51(4), 418–424. doi: 10.​1097/​MPG.​0b013e3181dcc4a5​. CrossRefPubMed de Magistris, L., Familiari, V., Pascotto, A., Sapone, A., Frolli, A., Iardino, P.,… Bravaccio, C. (2010). Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives. Journal of Pediatric Gastroenterology and Nutrition, 51(4), 418–424. doi: 10.​1097/​MPG.​0b013e3181dcc4a5​. CrossRefPubMed
go back to reference DiCicco-Bloom, E., Lord, C., Zwaigenbaum, L., Courchesne, E., Dager, S. R., Schmitz, C.,… Young, L. J. (2006). The developmental neurobiology of autism spectrum disorder. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 26(26), 6897–6906. doi: 10.​1523/​JNEUROSCI.​1712-06.​2006. CrossRef DiCicco-Bloom, E., Lord, C., Zwaigenbaum, L., Courchesne, E., Dager, S. R., Schmitz, C.,… Young, L. J. (2006). The developmental neurobiology of autism spectrum disorder. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 26(26), 6897–6906. doi: 10.​1523/​JNEUROSCI.​1712-06.​2006. CrossRef
go back to reference Finegold, S. M., Molitoris, D., Song, Y., Liu, C., Vaisanen, M. L., Bolte, E.,… Kaul, A. (2002). Gastrointestinal microflora studies in late-onset autism. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 35(Suppl 1), S6–S16. doi: 10.​1086/​341914. CrossRef Finegold, S. M., Molitoris, D., Song, Y., Liu, C., Vaisanen, M. L., Bolte, E.,… Kaul, A. (2002). Gastrointestinal microflora studies in late-onset autism. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 35(Suppl 1), S6–S16. doi: 10.​1086/​341914. CrossRef
go back to reference Gabriele, S., Sacco, R., Cerullo, S., Neri, C., Urbani, A., Tripi, G.,… Persico, A. M. (2014). Urinary p-cresol is elevated in young French children with autism spectrum disorder: A replication study. Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals, 19(6), 463–470. doi: 10.​3109/​1354750X.​2014.​936911. CrossRef Gabriele, S., Sacco, R., Cerullo, S., Neri, C., Urbani, A., Tripi, G.,… Persico, A. M. (2014). Urinary p-cresol is elevated in young French children with autism spectrum disorder: A replication study. Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals, 19(6), 463–470. doi: 10.​3109/​1354750X.​2014.​936911. CrossRef
go back to reference Goehler, L. E., Park, S. M., Opitz, N., Lyte, M., & Gaykema, R. P. (2008). Campylobacter jejuni infection increases anxiety-like behavior in the holeboard: Possible anatomical substrates for viscerosensory modulation of exploratory behavior. Brain, Behavior, and Immunity, 22(3), 354–366. doi: 10.​1016/​j.​bbi.​2007.​08.​009. CrossRefPubMed Goehler, L. E., Park, S. M., Opitz, N., Lyte, M., & Gaykema, R. P. (2008). Campylobacter jejuni infection increases anxiety-like behavior in the holeboard: Possible anatomical substrates for viscerosensory modulation of exploratory behavior. Brain, Behavior, and Immunity, 22(3), 354–366. doi: 10.​1016/​j.​bbi.​2007.​08.​009. CrossRefPubMed
go back to reference Hollander, D. (1999). Intestinal permeability, leaky gut, and intestinal disorders. Current Gastroenterology Reports, 1(5), 410–416. CrossRefPubMed Hollander, D. (1999). Intestinal permeability, leaky gut, and intestinal disorders. Current Gastroenterology Reports, 1(5), 410–416. CrossRefPubMed
go back to reference Ming, X., Stein, T. P., Barnes, V., Rhodes, N., & Guo, L. (2012). Metabolic perturbance in autism spectrum disorders: A metabolomics study. Journal of Proteome Research, 11(12), 5856–5862. doi: 10.​1021/​pr300910n. PubMed Ming, X., Stein, T. P., Barnes, V., Rhodes, N., & Guo, L. (2012). Metabolic perturbance in autism spectrum disorders: A metabolomics study. Journal of Proteome Research, 11(12), 5856–5862. doi: 10.​1021/​pr300910n. PubMed
go back to reference Nikolov, R. N., Bearss, K. E., Lettinga, J., Erickson, C., Rodowski, M., Aman, M. G.,… Scahill, L. (2009). Gastrointestinal symptoms in a sample of children with pervasive developmental disorders. Journal of Autism and Developmental Disorders, 39(3), 405–413. doi: 10.​1007/​s10803-008-0637-8. CrossRefPubMed Nikolov, R. N., Bearss, K. E., Lettinga, J., Erickson, C., Rodowski, M., Aman, M. G.,… Scahill, L. (2009). Gastrointestinal symptoms in a sample of children with pervasive developmental disorders. Journal of Autism and Developmental Disorders, 39(3), 405–413. doi: 10.​1007/​s10803-008-0637-8. CrossRefPubMed
go back to reference O’Mahony, S. M., Marchesi, J. R., Scully, P., Codling, C., Ceolho, A. M., Quigley, E. M.,… Dinan, T. G. (2009). Early life stress alters behavior, immunity, and microbiota in rats: Implications for irritable bowel syndrome and psychiatric illnesses. Biological Psychiatry, 65(3), 263–267. doi: 10.​1016/​j.​biopsych.​2008.​06.​026. CrossRefPubMed O’Mahony, S. M., Marchesi, J. R., Scully, P., Codling, C., Ceolho, A. M., Quigley, E. M.,… Dinan, T. G. (2009). Early life stress alters behavior, immunity, and microbiota in rats: Implications for irritable bowel syndrome and psychiatric illnesses. Biological Psychiatry, 65(3), 263–267. doi: 10.​1016/​j.​biopsych.​2008.​06.​026. CrossRefPubMed
go back to reference Parracho, H. M., Bingham, M. O., Gibson, G. R., & McCartney, A. L. (2005). Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children. Journal of Medical Microbiology, 54(Pt 10), 987–991. doi: 10.​1099/​jmm.​0.​46101-0. CrossRefPubMed Parracho, H. M., Bingham, M. O., Gibson, G. R., & McCartney, A. L. (2005). Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children. Journal of Medical Microbiology, 54(Pt 10), 987–991. doi: 10.​1099/​jmm.​0.​46101-0. CrossRefPubMed
go back to reference Penders, J., Thijs, C., van den Brandt, P. A., Kummeling, I., Snijders, B., Stelma, F.,… Stobberingh, E. E. (2007). Gut microbiota composition and development of atopic manifestations in infancy: The KOALA Birth Cohort Study. Gut, 56(5), 661–667. doi: 10.​1136/​gut.​2006.​100164. CrossRefPubMed Penders, J., Thijs, C., van den Brandt, P. A., Kummeling, I., Snijders, B., Stelma, F.,… Stobberingh, E. E. (2007). Gut microbiota composition and development of atopic manifestations in infancy: The KOALA Birth Cohort Study. Gut, 56(5), 661–667. doi: 10.​1136/​gut.​2006.​100164. CrossRefPubMed
go back to reference Sandler, R. H., Finegold, S. M., Bolte, E. R., Buchanan, C. P., Maxwell, A. P., Vaisanen, M. L.,… Wexler, H. M. (2000). Short-term benefit from oral vancomycin treatment of regressive-onset autism. Journal of Child Neurology, 15(7), 429–435. CrossRefPubMed Sandler, R. H., Finegold, S. M., Bolte, E. R., Buchanan, C. P., Maxwell, A. P., Vaisanen, M. L.,… Wexler, H. M. (2000). Short-term benefit from oral vancomycin treatment of regressive-onset autism. Journal of Child Neurology, 15(7), 429–435. CrossRefPubMed
go back to reference Santocchi, E., Guiducci, L., Fulceri, F., Billeci, L., Buzzigoli, E., Apicella, F.,… Muratori, F. (2016). Gut to brain interaction in autism spectrum disorders: A randomized controlled trial on the role of probiotics on clinical, biochemical and neurophysiological parameters. BMC Psychiatry, 16, 183. doi: 10.​1186/​s12888-016-0887-5. CrossRefPubMedPubMedCentral Santocchi, E., Guiducci, L., Fulceri, F., Billeci, L., Buzzigoli, E., Apicella, F.,… Muratori, F. (2016). Gut to brain interaction in autism spectrum disorders: A randomized controlled trial on the role of probiotics on clinical, biochemical and neurophysiological parameters. BMC Psychiatry, 16, 183. doi: 10.​1186/​s12888-016-0887-5. CrossRefPubMedPubMedCentral
go back to reference Selmer, T., & Andrei, P. I. (2001). p-Hydroxyphenylacetate decarboxylase from Clostridium difficile. A novel glycyl radical enzyme catalysing the formation of p-cresol. European Journal of Biochemistry, 268(5), 1363–1372. CrossRefPubMed Selmer, T., & Andrei, P. I. (2001). p-Hydroxyphenylacetate decarboxylase from Clostridium difficile. A novel glycyl radical enzyme catalysing the formation of p-cresol. European Journal of Biochemistry, 268(5), 1363–1372. CrossRefPubMed
go back to reference Shultz, S. R., Macfabe, D. F., Martin, S., Jackson, J., Taylor, R., Boon, F.,… Cain, D. P. (2009). Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat: Further development of a rodent model of autism. Behavioural Brain Research, 200(1), 33–41. doi: 10.​1016/​j.​bbr.​2008.​12.​023. CrossRefPubMed Shultz, S. R., Macfabe, D. F., Martin, S., Jackson, J., Taylor, R., Boon, F.,… Cain, D. P. (2009). Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat: Further development of a rodent model of autism. Behavioural Brain Research, 200(1), 33–41. doi: 10.​1016/​j.​bbr.​2008.​12.​023. CrossRefPubMed
go back to reference Shultz, S. R., MacFabe, D. F., Ossenkopp, K. P., Scratch, S., Whelan, J., Taylor, R., & Cain, D. P. (2008). Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: Implications for an animal model of autism. Neuropharmacology, 54(6), 901–911. doi: 10.​1016/​j.​neuropharm.​2008.​01.​013. CrossRefPubMed Shultz, S. R., MacFabe, D. F., Ossenkopp, K. P., Scratch, S., Whelan, J., Taylor, R., & Cain, D. P. (2008). Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: Implications for an animal model of autism. Neuropharmacology, 54(6), 901–911. doi: 10.​1016/​j.​neuropharm.​2008.​01.​013. CrossRefPubMed
go back to reference Taur, Y., Xavier, J. B., Lipuma, L., Ubeda, C., Goldberg, J., Gobourne, A.,… Pamer, E. G. (2012). Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 55(7), 905–914. doi: 10.​1093/​cid/​cis580. CrossRef Taur, Y., Xavier, J. B., Lipuma, L., Ubeda, C., Goldberg, J., Gobourne, A.,… Pamer, E. G. (2012). Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 55(7), 905–914. doi: 10.​1093/​cid/​cis580. CrossRef
go back to reference Thomas, R. H., Meeking, M. M., Mepham, J. R., Tichenoff, L., Possmayer, F., Liu, S., & MacFabe, D. F. (2012). The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: Further development of a rodent model of autism spectrum disorders. Journal of Neuroinflammation, 9, 153. doi: 10.​1186/​1742-2094-9-153. CrossRefPubMedPubMedCentral Thomas, R. H., Meeking, M. M., Mepham, J. R., Tichenoff, L., Possmayer, F., Liu, S., & MacFabe, D. F. (2012). The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: Further development of a rodent model of autism spectrum disorders. Journal of Neuroinflammation, 9, 153. doi: 10.​1186/​1742-2094-9-153. CrossRefPubMedPubMedCentral
go back to reference van Duynhoven, J., Vaughan, E. E., Jacobs, D. M., Kemperman, R. A., van Velzen, E. J., Gross, G.,… Van de Wiele, T. (2011). Metabolic fate of polyphenols in the human superorganism. Proceedings of the National Academy of Sciences of the USA, 108(Suppl 1), 4531–4538. doi: 10.​1073/​pnas.​1000098107. CrossRefPubMed van Duynhoven, J., Vaughan, E. E., Jacobs, D. M., Kemperman, R. A., van Velzen, E. J., Gross, G.,… Van de Wiele, T. (2011). Metabolic fate of polyphenols in the human superorganism. Proceedings of the National Academy of Sciences of the USA, 108(Suppl 1), 4531–4538. doi: 10.​1073/​pnas.​1000098107. CrossRefPubMed
go back to reference Vanholder, R., De Smet, R., & Lesaffer, G. (1999). p-cresol: A toxin revealing many neglected but relevant aspects of uraemic toxicity. Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Association-European Renal Association, 14(12), 2813–2815. CrossRef Vanholder, R., De Smet, R., & Lesaffer, G. (1999). p-cresol: A toxin revealing many neglected but relevant aspects of uraemic toxicity. Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Association-European Renal Association, 14(12), 2813–2815. CrossRef
go back to reference Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005). Neuroglial activation and neuroinflammation in the brain of patients with autism. Annals of Neurology, 57(1), 67–81. doi: 10.​1002/​ana.​20315. CrossRefPubMed Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005). Neuroglial activation and neuroinflammation in the brain of patients with autism. Annals of Neurology, 57(1), 67–81. doi: 10.​1002/​ana.​20315. CrossRefPubMed
go back to reference Wang, L., Christophersen, C. T., Sorich, M. J., Gerber, J. P., Angley, M. T., & Conlon, M. A. (2011). Low relative abundances of the mucolytic bacterium Akkermansia muciniphila and Bifidobacterium spp. in feces of children with autism. Applied and Environmental Microbiology, 77(18), 6718–6721. doi: 10.​1128/​AEM.​05212-11. CrossRefPubMedPubMedCentral Wang, L., Christophersen, C. T., Sorich, M. J., Gerber, J. P., Angley, M. T., & Conlon, M. A. (2011). Low relative abundances of the mucolytic bacterium Akkermansia muciniphila and Bifidobacterium spp. in feces of children with autism. Applied and Environmental Microbiology, 77(18), 6718–6721. doi: 10.​1128/​AEM.​05212-11. CrossRefPubMedPubMedCentral
go back to reference Wang, L., Christophersen, C. T., Sorich, M. J., Gerber, J. P., Angley, M. T., & Conlon, M. A. (2012). Elevated fecal short chain fatty acid and ammonia concentrations in children with autism spectrum disorder. Digestive Diseases and Sciences, 57(8), 2096–2102. doi: 10.​1007/​s10620-012-2167-7. CrossRefPubMed Wang, L., Christophersen, C. T., Sorich, M. J., Gerber, J. P., Angley, M. T., & Conlon, M. A. (2012). Elevated fecal short chain fatty acid and ammonia concentrations in children with autism spectrum disorder. Digestive Diseases and Sciences, 57(8), 2096–2102. doi: 10.​1007/​s10620-012-2167-7. CrossRefPubMed
go back to reference Williams, B. L., Hornig, M., Parekh, T., & Lipkin, W. I. (2012). Application of novel PCR-based methods for detection, quantitation, and phylogenetic characterization of Sutterella species in intestinal biopsy samples from children with autism and gastrointestinal disturbances. MBio, 3(1). doi: 10.​1128/​mBio.​00261-11. Williams, B. L., Hornig, M., Parekh, T., & Lipkin, W. I. (2012). Application of novel PCR-based methods for detection, quantitation, and phylogenetic characterization of Sutterella species in intestinal biopsy samples from children with autism and gastrointestinal disturbances. MBio, 3(1). doi: 10.​1128/​mBio.​00261-11.
go back to reference Wong, J. M., de Souza, R., Kendall, C. W., Emam, A., & Jenkins, D. J. (2006). Colonic health: Fermentation and short chain fatty acids. Journal of Clinical Gastroenterology, 40(3), 235–243. CrossRefPubMed Wong, J. M., de Souza, R., Kendall, C. W., Emam, A., & Jenkins, D. J. (2006). Colonic health: Fermentation and short chain fatty acids. Journal of Clinical Gastroenterology, 40(3), 235–243. CrossRefPubMed
go back to reference Yap, I. K., Angley, M., Veselkov, K. A., Holmes, E., Lindon, J. C., & Nicholson, J. K. (2010). Urinary metabolic phenotyping differentiates children with autism from their unaffected siblings and age-matched controls. Journal of Proteome Research, 9(6), 2996–3004. doi: 10.​1021/​pr901188e. CrossRefPubMed Yap, I. K., Angley, M., Veselkov, K. A., Holmes, E., Lindon, J. C., & Nicholson, J. K. (2010). Urinary metabolic phenotyping differentiates children with autism from their unaffected siblings and age-matched controls. Journal of Proteome Research, 9(6), 2996–3004. doi: 10.​1021/​pr901188e. CrossRefPubMed
go back to reference Yokoyama, M. T., & Carlson, J. R. (1981). Production of Skatole and para-Cresol by a Rumen Lactobacillus sp. Applied and Environmental Microbiology, 41(1), 71–76. PubMedPubMedCentral Yokoyama, M. T., & Carlson, J. R. (1981). Production of Skatole and para-Cresol by a Rumen Lactobacillus sp. Applied and Environmental Microbiology, 41(1), 71–76. PubMedPubMedCentral
go back to reference Zhan, Y., Paolicelli, R. C., Sforazzini, F., Weinhard, L., Bolasco, G., Pagani, F.,… Gross, C. T. (2014). Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior. Nature Neuroscience, 17(3), 400–406. doi: 10.​1038/​nn.​3641. CrossRefPubMed Zhan, Y., Paolicelli, R. C., Sforazzini, F., Weinhard, L., Bolasco, G., Pagani, F.,… Gross, C. T. (2014). Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior. Nature Neuroscience, 17(3), 400–406. doi: 10.​1038/​nn.​3641. CrossRefPubMed
Metagegevens
Titel
Gut Microbiota and Autism: Key Concepts and Findings
Auteurs
Helen T. Ding
Ying Taur
John T. Walkup
Publicatiedatum
24-11-2016
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 2/2017
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-016-2960-9