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Gepubliceerd in: Journal of Behavioral Medicine 6/2019

19-03-2019 | Brief Report

Glucocorticoid–immune response to acute stress in women and men living with HIV

Auteurs: Liisa Hantsoo, Sara Kornfield, Claudia Iannelli, Jessica Podcasy, David Metzger, Mary D. Sammel, C. Neill Epperson

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 6/2019

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Abstract

Despite high risk for serious non-AIDS events (SNAEs) and accelerated age-related increases in inflammatory markers relative to HIV+ men, HIV+ women have been understudied, particularly in terms of stress impacts on immune parameters. The purpose of this study was to examine sex differences in glucocorticoid–immune stress response in mid-life HIV+ individuals, as poor glucocorticoid control of stress-induced inflammation may contribute to health risk in HIV+ women. Male and female participants completed a threat of shock laboratory stressor. Serum cortisol and cytokines [interleukin (IL)-6, IL-8, IL-10, IL-1β, C-reactive protein (CRP), tumor necrosis factor (TNF)-α, interferon (IFN)-γ] were assessed at six timepoints prior to and in response to the stressor. Participants included 8 HIV− controls (n = 5 female) and 9 HIV+ (n = 5 female) who were virally suppressed. Repeated measures mixed models revealed a significant sex by HIV status by time interaction for IL-10, IL-1β, TNF-α, and cortisol. IL-10 response, an anti-inflammatory cytokine, was larger in males than females, regardless of HIV status. TNF-α response was blunted in HIV+ individuals compared with HIV−, and specifically in HIV+ women, IL-1β and cortisol response were blunted. Individuals living with HIV may have impaired coordination between the immune system and hypothalamic pituitary adrenal (HPA) axis. HIV+ women in particular exhibited dysregulated IL-1β and cortisol response to acute stress. Future work should focus on relationships among proinflammatory cytokines, stress, and SNAEs in HIV, with attention to sex as a biological variable.

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Metagegevens
Titel
Glucocorticoid–immune response to acute stress in women and men living with HIV
Auteurs
Liisa Hantsoo
Sara Kornfield
Claudia Iannelli
Jessica Podcasy
David Metzger
Mary D. Sammel
C. Neill Epperson
Publicatiedatum
19-03-2019
Uitgeverij
Springer US
Gepubliceerd in
Journal of Behavioral Medicine / Uitgave 6/2019
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI
https://doi.org/10.1007/s10865-019-00029-0