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Gepubliceerd in: Journal of Behavioral Medicine 5/2015

16-07-2015

Genetic test reporting enhances understanding of risk information and acceptance of prevention recommendations compared to family history-based counseling alone

Auteurs: Jennifer M. Taber, Lisa G. Aspinwall, Tammy K. Stump, Wendy Kohlmann, Marjan Champine, Sancy A. Leachman

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 5/2015

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Abstract

It is unknown whether or why genetic test reporting confers benefits in the understanding and management of cancer risk beyond what patients learn from counseling based on family history. A prospective nonexperimental control group study compared participants from melanoma-prone families who underwent CDKN2A/p16 (p16) genetic testing (27 carriers, 38 noncarriers) to participants from equivalently melanoma-prone families known not to carry a deleterious p16 mutation (31 no-test controls). All participants received equivalent counseling concerning elevated lifetime melanoma risk and corresponding recommendations for prevention and screening. Both immediately and 1 month after counseling, participants receiving a genetic test result reported greater understanding of their risk, decreased derogation of the risk information, and greater personal applicability of prevention recommendations than no-test controls. Decreased derogation of risk information after test reporting predicted further increases in understanding of melanoma risk and applicability of prevention recommendations 1 month later. Results suggest unique benefits of genetic test reporting in promoting understanding and acceptance of information about hereditary cancer risk and its management.
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Literatuur
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Metagegevens
Titel
Genetic test reporting enhances understanding of risk information and acceptance of prevention recommendations compared to family history-based counseling alone
Auteurs
Jennifer M. Taber
Lisa G. Aspinwall
Tammy K. Stump
Wendy Kohlmann
Marjan Champine
Sancy A. Leachman
Publicatiedatum
16-07-2015
Uitgeverij
Springer US
Gepubliceerd in
Journal of Behavioral Medicine / Uitgave 5/2015
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI
https://doi.org/10.1007/s10865-015-9648-z

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